Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.

Institute of Food Research

IFR FORWARDOPEN DAY 2006

7 September 2006

GutBiology

Nutrition,Diet & Health

MolecularMicrobiology

FoodBiophysics

IFR Science Skills Base

GutBiology

Understanding gut health and function

Good Guys

Eat for Life

GutBiology

A volunteer’s life

How our diet influences our long-term health

Human Nutrition Unit

Obesity Trends* Among U.S. AdultsBRFSS, 1985

No Data <10% 10%–14%

Source: Behavioral Risk Factor Surveillance System, CDC

No Data <10% 10%–14%

No Data <10% 10%–14% 15%–19%

No Data <10% 10%–14% 15%–19% ≥20

No Data <10% 10%–14% 15%–19% 20%–24% ≥25%

GutBiology

Understanding and controlling bacterial foodborne pathogens

Good Guys

Bad guys

GutBiology

FoodBiophysics

Maintaining food quality with a healthy diet

Feelgood foods

GutBiology

FoodBiophysics

IFR Science Skills Base

New Research Leaders

●Systems Biology

●Gut Biology

●Molecular Immunology

●Molecular nutrition

● ‘omics Transcriptomics –

microarrays Proteomics Metabolomics

● Imaging TEM, SEM, Light

Microscopy Nmr Atomic Force

Microscopy

IFR Technology Skills Base

Oh Me, Oh my – omics and Where’s Wally3

Exploitation Platforms

●Sustainability of food chain Keith Waldron

●Magnetic Resonance Imaging Brian Hills

●Model Gut Martin Wickham

●National Collection of Yeast Cultures Ian Roberts

●Food Databanks Paul Finglas

●Microbial Ecology Tim Brocklehurst

●Facilitates a knowledge-based industry

●Helps develops relationships between IFR and its industry stakeholders that bring mutual benefits

●Cost-effective knowledge-sharing

www.foodandhealthnetwork.com - promoting an environment where food Industry professionals can network with research scientists

Activities

Regular Cluster meetings on relevant topics

Cross-cluster meetings on areas of more general interest at locations convenient to industry (North and South). Proposed topics now available on FHN stand

FHN Direct: 1:1 consultations on confidential basis at IFR or on-site

●The Clusters & their Leaders

Allergy – Clare Mills

Co-product exploitation – Keith Waldron

Food Structure & Nutrition – Pete Wilde

Pathways to personalised nutrition – Siân Astley

Predictive Microbiology & Risk Analysis – Jòzsef Baranyi

Quality throughout Shelf-Life – Reg Wilson

Food & Health Network “Direct”

●One-to-one collaboration with the food industry

●Your issues – our complementary skills

Norwich Research Park

UEA Triangle

HospitalNNUH

UEA Main Campus

UEA● Institute of Health

Medical School● Computer Science● Chemistry & Pharmacy● Biology

PBL• Licensing• Patent Protection• Market Research

NNUH● Clinicians within IFR● Histo-pathology● Tissue Bank● Numerous depts

Youare

John Innes Centre• Plant/microbe genetics• Crop development

European Agenda

●Member of Initiative Group (with Wageningen and Unilever) for development of a vision document for a

European Technology Platform: Food for Life

Food and Health Food Quality and

ManufacturingConsumer and the

integrated food chain

● ‘omics Transcriptomics –

microarrays Proteomics Metabolomics

● Imaging TEM, SEM, Light

Microscopy Nmr Atomic Force

Microscopy

●Bioinformatics Statistics Modelling High-throughput

analysis

●Human Nutrition Unit

●National Collection of Yeast Cultures

IFR Technology Skills Base

Strategic Plan: Vision and Mission

Mission

●Undertake international quality scientific research relevant to food and human health

●Work in partnership with others to provide underpinning science for consumers, policy makers, the food industry and academia

Vision

●to be a world-leading contributor to harnessing food for health and controlling food-related disease

● The Institute of Food Research (IFR) is a not-for-profit company with charitable status

● Sponsored by the Biotechnology & Biological Sciences Research Council

IFR and IFR Enterprises Ltd are registered to the quality standard ISO 9001

Strategic Plan: “Objectives”

●Gastrointestinal Tract Biology: Understanding gut health and function

●Nutrition, Diet and Health: Understanding how our diet influences our long-term health

●Food Innovation: Maintaining food quality with a healthy diet

●Food Safety: Understanding and controlling bacterial foodborne pathogens

Turnover ~ £15m pa

● 190 scientific staff, 18 PhD students

● Admin Support joint with JIC

Outputs

●High-quality science base Research papers

●Underpinning evidence for policy – especially for Government (FSA, Defra, DH) Influence on policy

●Knowledge Transfer – especially for industry Collaboration Licensing, spin-outs etc

GI TractBiology

NutritionDiet & Health

FoodInnovation

FoodSafety

Mass Spectrom

Functional Genomics

Animal Facilities

BasicScience

Micro-biologists

Bio-chem

ysicists

Physiol-

ogists

Physical

Chemists

Nutritionists

Social

Scientists

GI TractBiology

FoodInnovation

FoodSafety

Mass Spectrom

Functional Genomics

Animal Facilities

Micro-biologists

Bio-chem

ysicists

Physiol-

ogists

Physical

Chemists

Nutritionists

Social

Scientists

Allergy

Obesity

Emerging Pathogens

Microbiol safety of the food chain

Waste / Sustainability

Bioterrorism

Ageing Population

Quality in the food chain

Diet and Disease

Strategic Relevance

GI TractBiology

FoodInnovation

FoodSafety

Mass Spectrom

Functional Genomics

Animal Facilities

Micro-biologists

Bio-chem

ysicists

Physiol-

ogists

Physical

Chemists

Nutritionists

Social

Scientists

ClostridiaGM identity

Authenticity

Micronutrientdeficiency

Pathogen Elimination

GM andNovel Foods

Colon Health

Influence on policy

The institute has made important contributions to the development of UK policy on e.g.:

●Dietary fibre (throughout the 1990s)

●Fruits and vegetables (development of 5-a-day advice - 1998)

●n-3 fatty acid consumption (from fish - 1999)

●Mineral nutrition (1990s and 2000s)

●Colonic health (late 1990s)

●Shelf-life of chilled foods (2000s)

Delivery

●Programmes

●Partnerships

●Exploitation Platforms

Programmes

Shortform title Prog Leader

●GI tract biology and health Ian Johnson

●Commensals & microflora Mike Gasson

●Phytochemicals & Health Richard Mithen

●Micronutrients Sue F-Tait

●Personalised (mol) Nutrition to be appointed

●Structuring foods for health Clare Mills

●Pathogens: mol microbiol Jay Hinton

●Pathogens: Phys & Pred Ecol Mike Peck

Internal Partnerships

●Bioinformatics and statistics Kate Kemsley

●Technologies for Systems Biology Transcriptomics

Tony Michael Proteomics Metabolomics

●Risk & Consumer Science Nigel Lambert

● Imaging Vic Morris

● [Support Units] [HNU, North SiteUEA]

Research Collaborations

●Our scientific research collaboration stretches across the world through informal and formal partnerships. Examples:

Molecular Microbiology

Nutrition, Diet and Health

Obesity

Body Mass Index (BMI): a measure of an adult’s weight in relation to height, specifically the adult’s weight in kilograms divided by the square of his or her height in meters.

Obesity: having a very high amount of body fat in relation to lean body mass, or Body Mass Index (BMI) of 30 or higher.

Overweight: a BMI between 25 and 30.

Case 2: Obesity

Gut Biology

Norwich Research Park

UEA Triangle

HospitalNNUH

UEA Main Campus

UEA● Institute of Health

Medical School● Computer Science● Chemistry & Pharmacy● Biology

PBL• Licensing• Patent Protection• Market Research

NNUH● Clinicians within IFR● Histo-pathology● Tissue Bank● Numerous depts

Sainsbury Laboratory

Youare

GutBiology

FoodBiophysics

IFR Skills Base

Functional Genomics / Systems Biology

Genome SequencesPathogensSalmonella entericaCampylobacter jejuniClostridium botulinum

CommensalsLactococcus lactisLactobacillus johnsoniiBifidobacterium breve

L. LactisMG1363

Bacterial Microarrays @ IFR 2006• “SALSA” 4 Salmonella serovars 5600 genes

• “ShE. Coli” 6500 genesE. coli O157 & Shigella flexneri

+ 150 EPEC/ ETEC virulence genes

• Campylobacter jejuni 1800 genes, plus plasmids

• Clostridium botulinum 3456 genes

• Lactococcus lactis 2587 genes

• Coming soon: Bifidobacterium breveLactobacillus johnsonii

6012 Macrophage J774-A.1 SL134404 Macrophage J774-A.1 SL1344

100 Normalized Intensity(log scale)

Normalised Macrophage infection 100

Salmonella Compendium Database 1.0

Macs 4,8,12hHeLa 2,4,6h

pH3.0hilACD

MM-low glucose ATR pH5.5

SPI1 caught napping?

• Hierarchical clustering of EnviCom

• SPI1 genes cluster with 5 nap genes

• A co-regulatory mechanism?

• Do the nap genes play a role in invasion?

napFDHBC

GutBiology

FoodBiophysics

IFR Skills Base

Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.

Documents

Transcript of Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.

IFR 6000 Manual

Ifr 050914

Ifr 032114

Guarantee Card IFR 100 Microlife IFR 100 Microlife IFR 100chde.pl/wp-content/uploads/2017/05/IB-IFR-100-EN-PL-1917.pdf · Microlife IFR 100 Microlife IFR 100 Ear measurement Forehead

Ifr 120914

BaBar IFR Upgrades

New Ifr Ss2009

Ifr 060614

FS ACADEMY IFR

IFR ASIA - dl.magazinedl.comdl.magazinedl.com/magazinedl/IFR Asia/2020/IFR Asia... · IFR Asia is a sister publication of International Financing Review. The contents of this publication,

IFR Decision Making

Central Bank of Bahrain Instructions for Insurance Firm Return · IFR 20.80 and 20.90 04/2009 IFR 30.11 01/2007 IFR 30.20 10/2012 IFR 30.21 01/2007 IFR 30.30 and 30.40 01/2007 ...

IFR Communications

Ifr 021415

IFR Instrument Navigation

Ifr 080814

Ifr 101813

Guarantee Card IFR 100 Microlife IFR 100 Microlife IFR 100€¦ · Microlife IFR 100 Guarantee Card IFR 100 Name of Purchaser / Imię i nazwisko nabywcy Serial Number / Numer seryjny

VUELO IFR USAF

IFR Esports Edition