Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.

Institute of Food Research

IFR FORWARDOPEN DAY 2006

7 September 2006

2

GutBiology

Nutrition,Diet & Health

MolecularMicrobiology

FoodBiophysics

IFR Science Skills Base

3

GutBiology

Understanding gut health and function

Good Guys

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Eat for Life

5

4

GutBiology


A volunteer’s life

How our diet influences our long-term health

Human Nutrition Unit

11

Obesity Trends* Among U.S. AdultsBRFSS, 1985

No Data <10% 10%–14%

Source: Behavioral Risk Factor Surveillance System, CDC

No Data <10% 10%–14%



No Data <10% 10%–14% 15%–19%



No Data <10% 10%–14% 15%–19% ≥20



No Data <10% 10%–14% 15%–19% 20%–24% ≥25%



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GutBiology



Understanding and controlling bacterial foodborne pathogens

Good Guys

11

Bad guys

10,15

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GutBiology



FoodBiophysics

Maintaining food quality with a healthy diet

Feelgood foods

oil7

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GutBiology



FoodBiophysics

Gut

IFR Science Skills Base

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New Research Leaders

●Systems Biology

●Gut Biology

●Molecular Immunology

●Molecular nutrition

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● ‘omics Transcriptomics –

microarrays Proteomics Metabolomics

● Imaging TEM, SEM, Light

Microscopy Nmr Atomic Force

Microscopy

IFR Technology Skills Base

15

11

Oh Me, Oh my – omics and Where’s Wally3

2

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Exploitation Platforms

●Sustainability of food chain Keith Waldron

●Magnetic Resonance Imaging Brian Hills

●Model Gut Martin Wickham

●National Collection of Yeast Cultures Ian Roberts

●Food Databanks Paul Finglas

●Microbial Ecology Tim Brocklehurst

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●Facilitates a knowledge-based industry

●Helps develops relationships between IFR and its industry stakeholders that bring mutual benefits

●Cost-effective knowledge-sharing

www.foodandhealthnetwork.com - promoting an environment where food Industry professionals can network with research scientists

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Activities

Regular Cluster meetings on relevant topics

Cross-cluster meetings on areas of more general interest at locations convenient to industry (North and South). Proposed topics now available on FHN stand

FHN Direct: 1:1 consultations on confidential basis at IFR or on-site

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●The Clusters & their Leaders

Allergy – Clare Mills

Co-product exploitation – Keith Waldron

Food Structure & Nutrition – Pete Wilde

Pathways to personalised nutrition – Siân Astley

Predictive Microbiology & Risk Analysis – Jòzsef Baranyi

Quality throughout Shelf-Life – Reg Wilson

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Food & Health Network “Direct”

●One-to-one collaboration with the food industry

●Your issues – our complementary skills

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Norwich Research Park

IFR

UEA Triangle

JIC

HospitalNNUH

UEA Main Campus

PBL

UEA● Institute of Health

Medical School● Computer Science● Chemistry & Pharmacy● Biology

PBL• Licensing• Patent Protection• Market Research

NNUH● Clinicians within IFR● Histo-pathology● Tissue Bank● Numerous depts

Youare

here

John Innes Centre• Plant/microbe genetics• Crop development

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European Agenda

●Member of Initiative Group (with Wageningen and Unilever) for development of a vision document for a

European Technology Platform: Food for Life

Food and Health Food Quality and

ManufacturingConsumer and the

integrated food chain

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● ‘omics Transcriptomics –

microarrays Proteomics Metabolomics

● Imaging TEM, SEM, Light

Microscopy Nmr Atomic Force

Microscopy

●Bioinformatics Statistics Modelling High-throughput

analysis

●Human Nutrition Unit

●National Collection of Yeast Cultures

IFR Technology Skills Base

8

12

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Strategic Plan: Vision and Mission

Mission

●Undertake international quality scientific research relevant to food and human health

●Work in partnership with others to provide underpinning science for consumers, policy makers, the food industry and academia

Vision

●to be a world-leading contributor to harnessing food for health and controlling food-related disease

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IFR

● The Institute of Food Research (IFR) is a not-for-profit company with charitable status

● Sponsored by the Biotechnology & Biological Sciences Research Council

IFR and IFR Enterprises Ltd are registered to the quality standard ISO 9001

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Strategic Plan: “Objectives”

●Gastrointestinal Tract Biology: Understanding gut health and function

●Nutrition, Diet and Health: Understanding how our diet influences our long-term health

●Food Innovation: Maintaining food quality with a healthy diet

●Food Safety: Understanding and controlling bacterial foodborne pathogens

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IFR

Turnover ~ £15m pa

● 190 scientific staff, 18 PhD students

● Admin Support joint with JIC

9.1

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Outputs

●High-quality science base Research papers

●Underpinning evidence for policy – especially for Government (FSA, Defra, DH) Influence on policy

●Knowledge Transfer – especially for industry Collaboration Licensing, spin-outs etc

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GI TractBiology

NutritionDiet & Health

FoodInnovation

FoodSafety

Mass Spectrom

etry

Met

abol

omic

s

Functional Genomics


Ato

mic F

orce

Micro

scop

yC

on

foca

lS

EM

, T

EM

FTIR

Animal Facilities

BasicScience

Micro-biologists

Bio-chem

ists

An

alyt

ical

C

hem

ists

Ph

ysicists

Physiol-

ogists

Physical

Chemists

Pla

nt

Sci

enti

sts

Nutritionists

Social

Scientists

Mat

hemat

-

icia

ns

43

GI TractBiology


FoodInnovation

FoodSafety

Mass Spectrom

etry

Met

abol

omic

s

Functional Genomics


Ato

mic F

orce

Micro

scop

yC

on

foca

lS

EM

, T

EM

FTIR

Animal Facilities

Micro-biologists

Bio-chem

ists

An

alyt

ical

C

hem

ists

Ph

ysicists

Physiol-

ogists

Physical

Chemists

Pla

nt

Sci

enti

sts

Nutritionists

Social

Scientists

Mat

hemat

-

icia

ns

Allergy

Obesity

Emerging Pathogens

Microbiol safety of the food chain

Waste / Sustainability

Bioterrorism

Ageing Population

Quality in the food chain

Diet and Disease

Strategic Relevance

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GI TractBiology


FoodInnovation

FoodSafety

Mass Spectrom

etry

Met

abol

omic

s

Functional Genomics


Ato

mic F

orce

Micro

scop

yC

on

foca

lS

EM

, T

EM

FTIR

Animal Facilities

Micro-biologists

Bio-chem

ists

An

alyt

ical

C

hem

ists

Ph

ysicists

Physiol-

ogists

Physical

Chemists

Pla

nt

Sci

enti

sts

Nutritionists

Social

Scientists

Mat

hemat

-

icia

ns

ClostridiaGM identity

Authenticity

Micronutrientdeficiency

Pathogen Elimination

GM andNovel Foods

Colon Health

FSA

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Influence on policy

The institute has made important contributions to the development of UK policy on e.g.:

●Dietary fibre (throughout the 1990s)

●Fruits and vegetables (development of 5-a-day advice - 1998)

●n-3 fatty acid consumption (from fish - 1999)

●Mineral nutrition (1990s and 2000s)

●Colonic health (late 1990s)

●Shelf-life of chilled foods (2000s)

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Delivery

●Programmes

●Partnerships

●Exploitation Platforms

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Programmes

Shortform title Prog Leader

●GI tract biology and health Ian Johnson

●Commensals & microflora Mike Gasson

●Phytochemicals & Health Richard Mithen

●Micronutrients Sue F-Tait

●Personalised (mol) Nutrition to be appointed

●Structuring foods for health Clare Mills

●Pathogens: mol microbiol Jay Hinton

●Pathogens: Phys & Pred Ecol Mike Peck

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Internal Partnerships

●Bioinformatics and statistics Kate Kemsley

●Technologies for Systems Biology Transcriptomics

Tony Michael Proteomics Metabolomics

●Risk & Consumer Science Nigel Lambert

● Imaging Vic Morris

● [Support Units] [HNU, North SiteUEA]

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Research Collaborations

●Our scientific research collaboration stretches across the world through informal and formal partnerships. Examples:

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Molecular Microbiology

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Nutrition, Diet and Health

Obesity

Body Mass Index (BMI): a measure of an adult’s weight in relation to height, specifically the adult’s weight in kilograms divided by the square of his or her height in meters.

Obesity: having a very high amount of body fat in relation to lean body mass, or Body Mass Index (BMI) of 30 or higher.

Overweight: a BMI between 25 and 30.

Case 2: Obesity

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Gut Biology

56

Norwich Research Park

IFR

UEA Triangle

JIC

HospitalNNUH

UEA Main Campus

PBL

UEA● Institute of Health

Medical School● Computer Science● Chemistry & Pharmacy● Biology

PBL• Licensing• Patent Protection• Market Research

NNUH● Clinicians within IFR● Histo-pathology● Tissue Bank● Numerous depts

Sainsbury Laboratory

Youare

here

57

GutBiology



FoodBiophysics

IFR Skills Base

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Functional Genomics / Systems Biology

Genome SequencesPathogensSalmonella entericaCampylobacter jejuniClostridium botulinum

CommensalsLactococcus lactisLactobacillus johnsoniiBifidobacterium breve

L. LactisMG1363

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Bacterial Microarrays @ IFR 2006• “SALSA” 4 Salmonella serovars 5600 genes

• “ShE. Coli” 6500 genesE. coli O157 & Shigella flexneri

+ 150 EPEC/ ETEC virulence genes

• Campylobacter jejuni 1800 genes, plus plasmids

• Clostridium botulinum 3456 genes

• Lactococcus lactis 2587 genes

• Coming soon: Bifidobacterium breveLactobacillus johnsonii

6012 Macrophage J774-A.1 SL134404 Macrophage J774-A.1 SL1344

0.01

0.1

1

10

100 Normalized Intensity(log scale)

Normalised Macrophage infection 100

10

1

0.1

0.01

Salmonella Compendium Database 1.0

Macs 4,8,12hHeLa 2,4,6h

hns

pH3.0hilACD

MM-low glucose ATR pH5.5

phoP

SPI1 caught napping?

• Hierarchical clustering of EnviCom

• SPI1 genes cluster with 5 nap genes

• A co-regulatory mechanism?

• Do the nap genes play a role in invasion?

napFDHBC

SPI1

SPI1

GutBiology



FoodBiophysics

IFR Skills Base

Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.

Documents

Transcript of Institute of Food Research IFR FORWARD OPEN DAY 2006 7 September 2006.