LPPDLPPDA. Linninger, BIOE Seminar, Oct 2003 - 1

Developing A Volume Sensor for Use in the Ventricular System of the Brain

Developing A Volume Sensor for Use in the Ventricular System of the Brain

Seminar Presentation in the Department of Chemical Engineering, University of Illinois at Chicago, Chicago, IL, August 5, 2004.

Joel StanfieldProfessor Andreas Linninger

NSF-REU Summer 2004

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OverviewOverview

• Background

• Box Volume Sensor

• Submersible Volume Sensor

• Communicating Vessels

• Future Research

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The Human BrainThe Human Brain

• Brain Parenchyma• Ventricular System-Ventricles, Choroid Plexus, Cerebrospinal Fluid (CSF)

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HydrocephalusHydrocephalus

Normal Hydrocephalus

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Volume Sensor Model Volume Sensor Model

AC

Volt Meter

VM

AC Power Supply

Inner Electrodes

Container (glass)

Tap Water

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Box Volume SensorBox Volume Sensor

Procedure- 100 mL of solution initially- 5 mL of solution added every

minute- Voltage Drop recorded at the

end of every minute- Final Measurement at 275 mL

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Box Volume Sensor ExperimentTap Water

1.901.95

2.002.05

2.102.15

95 115 135 155 175 195 215 235 255 275

Volume (mL)

Volta

ge D

rop (

volts

) Experiment 1Experiment 2Experiment 3Experiment 4Experiment 5

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Submersible Volume SensorSubmersible Volume Sensor

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0.901.001.101.201.301.401.501.601.70

90 140 190 240 290

Volume(mL)

Volta

ge D

rop(v

olts) Trial 1

Trial 2Trial 3Trial 4Trial 5

Submersible SensorTap Water

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Communicating VesselsCommunicating Vessels

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Communicating Vessels

11.051.1

1.151.2

1.251.3

1.351.4

95 145 195 245

Volume(mL)

Volta

ge D

rop(

volts

) Comm. 1Comm. 2Comm. 3Single 1Single 2Single 3

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Future ResearchFuture Research

• Design of a Better Submersible Sensor

• Physics of the Sensor

• Test Accuracy