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CHM 500 The Responsible Conduct of Research in Chemistry
6 weeks; 2.5 hours per week
Grading: PDF
Students will discuss and evaluate the role that professional researchers have in dealingwith reporting of research, responsible authorship, animal studies, human studies,
misconduct and fraud in science, professionalism in scientific relationships, and
intellectual property. Successful completion is based on attendance, reading, and activeparticipation in the discussion sessions. Students are expected to read the materials prior
to attending each course. This course is designed to satisfy the requirements of federal
funding agencies for training research scientists in the ethical practice of science.
Lecturer: Michael Kelly, Ph.D.
Syllabus
Week 1: Research Integrity and Scientific Practice
Week 2: Mentorship, Personal Behavior, and Conflict of Interest
Week 3: Communication of Research and Research Misconduct
Week 4: Collaborative Research and Intellectual Property, Export Control
Week 5: Animal and Human Subjects
Week 6: Science and Society
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Week 1: Research Integrity and Scientific Practice
What is the ethical and moral framework that guides the practice of research today?
What do we owe others?
Reading:
University Plan for Training in Responsible Conduct of Research
http://www.princeton.edu/orpa/documents/RCR_Plan_2010_Final.pdf
Scientists behaving badly,Nature2005
On Being A Scientist: Responsible Conduct In Research
http://www.nap.edu/openbook.php?record_id=4917&page=R1
The Chemical Professionals Code of Conduct
http://portal.acs.org/portal/acs/corg/content?_nfpb=true&_pageLabel=PP_ARTICLEMAIN&node_id=1095&content_id=CTP_004007&use_sec=true&sec_url_var=region1
What is Ethics in Research & Why is It Important? by David B. Resnik, J.D., Ph.D.
http://www.niehs.nih.gov/research/resources/bioethics/whatis.cfm
Research Timeline of bioethics
http://www.niehs.nih.gov/research/resources/bioethics/timeline.cfm
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Week 2: Mentorship, Personal Behavior, and Conflict of Interest
How do you choose an advisor? What are the responsibilities that mentors have to their
trainees? What are the responsibilities that trainees have to their mentors? This week we
will discuss a variety of mentoring, teaching and learning related ethical dilemmas.
These will include ethical approaches to teaching, collaborative relationships, integrity inthe learning process, responsibilities and rights of research assistants, and the role of the
mentor.
Reading:
Postdoctoral Fellows and Mentorshttp://www.aamc.org/research/postdoccompact/postdoccompact.pdf
A Guide to Training and Mentoring in the Intramural Research Program at NIH
http://www1.od.nih.gov/oir/sourcebook/ethic-conduct/mentor-guide.htm
Mentor Expectations and Student Responsibilities in Undergraduate Research
http://www.cur.org/conferences/responsibility/Monte.pdf
Mentoring the Mentors: The Yoda Factor in Promoting Scientific Integrity
http://muse.jhu.edu/journals/american_journal_of_bioethics/v002/2.4motta.pdf
RCR Mentoring: The Responsible Mentoring of Research
http://ccnmtl.columbia.edu/projects/rcr/rcr_mentoring/foundation/index.html
Princeton Conflict of Interest in Research Policy
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Week 3: Research Misconduct and the Communication of Research
What is research misconduct? What are plagiarism, fraud, fabrication, and falsification?
What is data selection? Can you use Photoshop to prepare images for publication?
Research communications in the form of seminars, posters, or publications are primaryresults of research. How do you decide what to publish, when to publish, and who should
receive authorship? What is the responsibility to make scientific articles or data available
to the public? How does the peer review process work?
Reading:
Baltimore Casehttp://en.wikipedia.org/wiki/David_Baltimore
Cold fusion
http://en.wikipedia.org/wiki/Cold_fusion
NIH peer review, Jan 2006
NIH Peer Review, Spring 2008
Misconduct of others Prevention Techniques for ResearchersAPS observer
Taking on the cheats,Nature2005CSI: cell biology,Nature2005
ACS Ethical Guidelines for Publishing
Council of Science Editors: White paper on Promoting Integrity in Scientific Journal
Publications
Journals Find Fakery in Many Images Submitted to Support Research
http://chronicle.com/free/2008/05/3028n.htm
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Week 5: Animal and Human Subjects
What are the ethical issues in laboratory animal research? How do researchers justify the
utilization of animals to gain knowledge? What is the Animal Welfare Act? What
mechanisms of oversight govern animal experimentation?
What is bioethics? How do researchers safeguard human subjects in research?
Reading:
Princeton University IACUC general policy
Princeton University Institutional Review Panel for Human Subjects
Institutional Policies and Responsibilities
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Week 6: Science and Society
Why is basic research funded? What is the level of public versus private funding? Who
sets the priorities for research funding? What are the public perceptions of the scientific
enterprise? What are the political and economic factors that affect scientific research?
Reading:
Browse the website for the Office of Science and Technology Policyhttp://www.ostp.gov/
FY 2009 Administration Research and Development Budget Prioritieshttp://www.ostp.gov/galleries/Budget09/FY2009FINALOMB-
OSTPRDPriorityMemo.pdf
Science Advisors Says that Pruning is Key to a Healthy Budget
http://www.sciencemag.org/cgi/reprint/315/5814/927.pdf
Browse NIH Websitehttp://grants.nih.gov/grants/oer.htm
A Timely Harvest,Nature2007
Of power maniacs and unethical geniuses: science
and scientists in fiction film, Public Understand. Sci. 2003
Gods formula and Devils contribution: Science in the press, Public Understand. Sci.2003