Introduction to Molecular Evolution Mike Thomas October 3, 2002.
CS273a Lecture 14, Fall 08, Batzoglou CS273a Lecture 14, Fall 2008 Finding Conserved Elements (1) Binomial method 25-bp window in the human genome
Evolution at the DNA level …ACGGTGCAGTTACCA… …AC----CAGTCCACCA… Mutation SEQUENCE EDITS REARRANGEMENTS Deletion Inversion Translocation Duplication.
CS273a Lecture 11, Aut 08, Batzoglou Multiple Sequence Alignment.
Distantly related organisms share structural similarities Function varies Explicable by common ancestry grasping leaping flying swimming running Homology.
Phylogenetics II. Character-based methods for constructing phylogenies In this approach, trees are constructed by comparing the characters of the corresponding.
Inferring phylogenetic trees: Maximum likelihood methods Prof. William Stafford Noble Department of Genome Sciences Department of Computer Science and.
Character-Based Phylogeny Reconstruction
Inferring phylogenetic trees: Maximum likelihood methods
Building synteny maps Recommended local aligners BLASTZ Most accurate, especially for genes Chains local alignments WU-BLAST Good tradeoff of efficiency/sensitivity.
Short Primer on Comparative Genomics Today: Special guest lecture 12pm, Alway M108 Comparative genomics of animals and plants Adam Siepel Assistant Professor.
Inferring phylogenetic trees: Distance methods