CS273a Lecture 14, Fall 08, Batzoglou CS273a Lecture 14, Fall 2008 Finding Conserved Elements (1) Binomial method 25-bp window in the human genome
Evolution at the DNA level …ACGGTGCAGTTACCA… …AC----CAGTCCACCA… Mutation SEQUENCE EDITS REARRANGEMENTS Deletion Inversion Translocation Duplication.
CS273a Lecture 11, Aut 08, Batzoglou Multiple Sequence Alignment.
Lecture 10 Genes, genomes and chromosomes Repeated and transposable elements
Building synteny maps Recommended local aligners BLASTZ Most accurate, especially for genes Chains local alignments WU-BLAST Good tradeoff of efficiency/sensitivity.
Short Primer on Comparative Genomics Today: Special guest lecture 12pm, Alway M108 Comparative genomics of animals and plants Adam Siepel Assistant Professor.
