3D Visualization of Drugs-Protein Complexes • Goal: Develop better understanding of Protein Database and its entries • Plan – Introductory information about…
Slide 1 Multiple Sequence Alignments Algorithms Slide 2 MLAGAN: progressive alignment of DNA Given N sequences, phylogenetic tree Align pairwise, in order of the tree (LAGAN)…
Slide 1 Alignment Problem (Optimal) pairwise alignment consists of considering all possible alignments of two sequences and choosing the optimal one. Sub-optimal (heuristic)…
II-L1-1 AUG 96 L1 Alignments L1 Alignments L1 Alignments L1 Alignments L1 Alignments L1 Alignments L1 Alignments L1 Alignments L1 Alignments L1 Alignments L1 Alignments L1…
II-L2-1 SEP 94 L2 Alignments L2 Alignments L2 Alignments L2 Alignments L2 Alignments L2 Alignments L2 Alignments L2 Alignments L2 Alignments L2 Alignments L2 Alignments L2…
II-L2-1 OCT 95 L2 Alignments L2 Alignments L2 Alignments L2 Alignments L2 Alignments L2 Alignments L2 Alignments L2 Alignments L2 Alignments L2 Alignments L2 Alignments L2…
II-E1-1 SEP 97 E1 Alignments E1 Alignments E1 Alignments E1 Alignments E1 Alignments E1 Alignments E1 Alignments E1 Alignments E1 Alignments E1 Alignments E1 Alignments E1…
II-L2-1 SEP 97 L2 Alignments L2 Alignments L2 Alignments L2 Alignments L2 Alignments L2 Alignments L2 Alignments L2 Alignments L2 Alignments L2 Alignments L2 Alignments L2…
Multiple Sequence Alignment CMSC 423 Multiple Sequence Alignment Multiple sequence alignment: find more subtle patterns find common patterns between all sequence MSA Input:…
Pairwise alignments Introduction to Bioinformatics B!GRe Bioinformatique des Génomes et Réseaux Jacques van Helden [email protected] Aix-Marseille Université…
II-E6-1 SEP 94 E6 Alignments E6 Alignments E6 Alignments E6 Alignments E6 Alignments E6 Alignments E6 Alignments E6 Alignments E6 Alignments E6 Alignments E6 Alignments E6…
Slide 1 Supplementary material Figure S1. Cumulative histogram of the fitness of the pairwise alignments of random generated ESSs. In order to assess the statistical significance…
Pairwise alignments Introduction to Bioinformatics B!GRe Bioinformatique des Génomes et Réseaux Jacques van Helden Jacquesvan-Helden@univ-amufr Université d’Aix-Marseille…
B I O I N F O R M A T I C S Kristel Van Steen, PhD 2 Montefiore Institute - Systems and Modeling GIGA - Bioinformatics ULg [email protected] Bioinformatics Chapter…
Classification by Pairwise Coupling TREVOR HASTIE * Stanford University and ROBERT TIBSHIRANI t University of Toronto Abstract We discuss a strategy for polychotomous classification…
Multiple sequence alignment Irit Orr Shifra Ben-Dor An example of Multiple Alignment VTISCTGSSSNIGAG-NHVKWYQQLPGQLPG VTISCTGTSSNIGS--ITVNWYQQLPGQLPG LRLSCSSSGFIFSS--YAMYWVRQAPGQAPG…
Multiple Sequence Multiple Sequence AlignmentsAlignments Multiple alignment • Pairwise alignment – Infer biological relationships from string similarity • Multiple…
Pairwise sequence alignments & BLAST The point of sequence alignment • If you have two or more sequences, you may want to know – How similar are they? (A quanCtaCve…
Pairwise Multiple sequence alignments Urmila Kulkarni-Kale Bioinformatics Centre University of Pune, Pune 411 007 [email protected] mailto:[email protected] Jan…
Pairwise Alignment Searching for the op5mal alignment… Solu5on: Dynamic programming TCGCA TCCA Filling a scoring matrix What did…