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1. The Opioid Class of Analgesics
2. Legal Terms and Conditions
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3. Opioid Class of Analgesics: Slide 3
4. Legal Terms and Conditions (contd.)
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5. Program Objectives
6. Definitions
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7. Opioids
8. Opioids & Receptor Activity
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9. Mu () Receptor Activation
10. Dose-response Curves
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11. How does this correlate to clinical pain management?
12. Opioid Agonists: Structural Pharmacology
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13. Opioid Rotation (OR)
14. Codeine
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15. Codeine
16. Morphine
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17. Morphine
18. M-3-G (morphine-3-glucuronide)
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19. M-6-G (morphine-6-glucuronide)
20. M-6-G and M-3-G (continued)
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21. Renal Dysfunction and Morphine
22. Hepatic Dysfunction and Morphine
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23. Pruritus and Morphine
24. Oxycodone
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25. Oxycodone
26. Oxycodone
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27. Hydrocodone
28. Hydromorphone (HM)
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29. Biotransformation of HM
30. Metabolite Profile of Hydromorphone
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31. Potential Role of HM Metabolites
32. Methadone
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33. Methadone
34. Methadone
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35. Propoxyphene
36. Meperidine
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37. Normeperidine
38. Fentanyl
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39. Levorphanol and Congeners
40. Buprenorphine
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41. Agonist-antagonists
42. Opioid Antagonists
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43. Summary
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