The ins and outs of

Human Challenge studies

John Oxford DSc FRCPE

Professor of Virology,

Queen Mary College, London

Influenza Specific Protein

Responses- Baseline

SUMMARY

Technical

1.Virus wild type to GMP level.

2.Sourced by WHO laboratory (A/Bergen/2016?)

3.HI antibody of <15 still important.

Volunteers

1.Healthy, young.

2.Older and even asthmatic.

3.Attention to nearby A&E department.

4.Tamiflu stock

Ethics

1. Hippocratic oath.

Pathology/Safety

1.Phase I study of drug/vaccine.

2.Virus is pre-studied and titrated.

3.However, the mixture is novel.