The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge...

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The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London

Transcript of The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge...

Page 1: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza

The ins and outs of

Human Challenge studies

John Oxford DSc FRCPE

Professor of Virology,

Queen Mary College, London

Page 2: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza
Page 3: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza
Page 4: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza
Page 5: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza
Page 6: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza
Page 7: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza
Page 8: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza
Page 9: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza
Page 10: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza
Page 11: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza
Page 12: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza
Page 13: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza
Page 14: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza
Page 15: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza
Page 16: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza
Page 17: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza
Page 18: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza
Page 19: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza
Page 20: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza
Page 21: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza
Page 22: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza

Influenza Specific Protein

Responses- Baseline

Page 23: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza
Page 24: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza
Page 25: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza
Page 26: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza
Page 27: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza

SUMMARY

Technical

1.Virus wild type to GMP level.

2.Sourced by WHO laboratory (A/Bergen/2016?)

3.HI antibody of <15 still important.

Volunteers

1.Healthy, young.

2.Older and even asthmatic.

3.Attention to nearby A&E department.

4.Tamiflu stock

Ethics

1. Hippocratic oath.

Pathology/Safety

1.Phase I study of drug/vaccine.

2.Virus is pre-studied and titrated.

3.However, the mixture is novel.

Page 28: The ins and outs of Human Challenge studies - WHO€¦ · The ins and outs of Human Challenge studies John Oxford DSc FRCPE Professor of Virology, Queen Mary College, London . Influenza