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File:SyllabusBiomedicalImaging.docx1/5 QT06.02/Rev.03

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SYLLABUS

Date/Revision :30January2017/1Faculty :LifeSciencesApproval :Dean,FacultyofLifeSciences

SUBJECT:BiomedicalImaging

1. IdentificationofSubject:

NameofSubject :BiomedicalImagingCodeofSubject :SKS :4Semester :6StudyProgram :BiomedicalEngineering(BME)Lecturer :ZahrinaMardina,ST.,M.Sc.

2. CompetencyInthissubjectstudentswilllearnvariousconceptsrelevanttomedicalimaging.Variousfundamentalsthatweregiveninthe1stfivesemesterswillbeutilzedinthiscourseandwillbeappliedtovariousmodesofimagingthatarecurrentlyavailableinthemedicalfield.Thecoursewillpreparethestudentstobecomemoreknowledgeableinthefieldofmedicalimagingalongwiththesystemsandbiophysicsaswellassafetythatarerelatedtoit.

3. DescriptionofSubject:Varioustopicsinmedicalimagingwillbecoveredinthiscoursestartingwiththebasicsofradiationsand imaging, to diagnostic radiology such as theuse of X-ray and radiography, mammography,Fluoroscopy. This is then followed by the basic of computed tommography and its furtherdiscussion inMagnetic resonance basics,Magnetic resonance imaging, Aswell as ultrasound andNuclearimaging/emissiontommographysuchasPETscan.

4. LearningApproachApproach :Expository,inquiry,collaborativeMethod :Lecturepresentation,FocusgroupdiscussionStudentTask :Appraisal,grouppresentationaboutbiomaterialinnovationMedia :PowerPointpresentation,printoutofjournals


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5. Evaluation

a) Absencemaximum :25%b) Discussionandappraisal :20pointsc) DailyQuiz :20pointsd) FinalExamination(Project+Finaltest) :60points

Total :100points

6. Contents/TopicsofLecturing:Week Topics Content Remark1 IntroductiontoMedical

ImagingandRadiationandInteractionofRadiationwithmatter

IntroductiontoImaging(2x50minutes):• TheModalities• ImagePropertiesRadiationandInteractionwithmatter(2x50minutes):• RadiationandStructureofatom

(revies)• Particleinteractions• X-Ray&GammaRayinteractions• AbsorptionofEnergyfromX-rayand

Gammaray• ImpartedEnergy,EquivalentDose,

EffectiveDose

Bushberg,Siebert,Leidholdt,Boone,Chapter1,2,31x4x50minutes

2 ImageQuality • Spatialresolution,Convolution,PhysicalMechanismsofBlurring

• TheFrequencydomain• Contrastresolution• Noisetexture• Contrast,andContrasttonoiseratio• Signaltonoiseratio• ContrastDetailDiagram• DetectiveQuantumEfficiency• Receiveroperatingcharacteristics

Curves

Bushberg,Siebert,Leidholdt,Boone,Chapter41x4x50minutes

3 MedicalImaginginformatics • AnalogandDigitalRepresentationofData

• DigitalRadiologicalImages• DigitalComputers• Informationstoragedevices• DisplayofDigitalImages• Computernetworks’PACSand

Teleradiology• ImageProcessing



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• Security4 X-rayproduction,X-raytubes

andX-raygeneratorsAndRadiography(part-1)

X-Ray(2x50minutes):• Productionofx-rays• X-raytubes• X-rayGenerators• Powerrating,heatloadingandcooling• FactorsAffectingX-rayemissionRadiography(2x50minutrs)• Geometryofprojectionradiography• Screenfilmradiography• ChargeCoupledDevice/metaloxide

semiconductordetector

Bushberg,Siebert,Leidholdt,Boone,Chapter6and71x4x50minutes

5 Radiography(part2) • Flatpannelthinfilmtransistorarraydetectors

• Techniquesfactors• Scintillators&Intensifyingscreen• AbsorptionefficiencyandConversion

efficiency• Otherconsiderations• Radiographicdetectors,patientdose,

exposureindex• Dualenergyradiography• Scatteredradiationinimaging


6 MammographyandFluoroscopy

Mammography(2x50minutes)• X-raytube&Beamfiltration• X-raygenerationandPhototimer

system• Compression,scatteredradiationand

magnification• Screenfilmcassettesandfilm

processing• Digitalmammography• Radiationdosimetry• RegulatoryrequirementsFluoroscopy(2x50minutes):• Functionality• Fluoroscopicimagingchain

components• FluoroscopicDetectorsystems• Automaticexposureratecontrol• ImageQuality• Fluoroscopicsuites• Radiationdose

Bushberg,Siebert,Leidholdt,Boone,Chapter8and91x4x50minutes


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7 ComputedTommography

• Clinicaluse• CTSystemdesign• ModesofCTacquisition• CTreconstruction• ImageQuality• CTimageartifacts• CTgeneration


8 X-raydosimetryinProjectionImagingandComputedTommography

AttenuationofX-rayintissue• Doserelatedmetricsinradiography

andfluoroscopy• MonteCarloDosecomputation• Equivalentdose• Organdose• Absorbeddoseinradiographyand

fluoroscopy• CTdosimetryandorgandose• Computationofradiationrisk• Diagnosticsreferencelevel• IncreasingRadiationburdenfrom

medicalimaging• Summary:doseestimationinpatients


9 Magneticresonancebasis:Magneticfields,Nuclearmagnetics,Tissuecontrast,imageacquisition

• Magnetisms,magneticfieldsandmagnet

• Magneticresonancesignal• Mahnetizationpropertiesoftissues• BasicAcquisitionparameters• BasicPulsesequences• MRSignalLocalization• K-Spacedataacquisitionandimage

reconstruction


10 MagneticResonanceimaging • Imageacquisitiontime• MRimagecharacteristics• Signalfromflow• PerfusionandDiffusionContrast

imaging• MagnetizationTransfercontrast• MRArtifacts• MagneticResonancespectroscopy• Ancillarycomponents• MRbioeffectsandsafety


11 Ultrasound • Characteristicsofsound• Interactionofultrasoundwith

matter• Ultrasoundtransducers• Ultrasoundbeamproperties

Bushberg,Siebert,Leidholdt,Boone,Chapter14


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• Imagedataacquisition• TwodimensionalImagedisplay

andstorage• Dopplerultrasound• Ultrasoundimagequalityand

artifacts• Ultrasoundsystemperformance

andqualityassurance• AccousticPowerandbioeffects

1x4x50minutes

13 Nuclearimaging:Scintillationcameraandemissiontommography

• Planarnuclearimaging• Computersinnuclearimaging• FocalplaneTommographyin

nuclearmedicine• Singlephotonemissioncomputed

tommography• Positronemissiontommography

(PET)• DualmodalityImaging:PET/MRI,

PET/CT,SPECT/CT• ClinicalAspect,comparisonofPET

andSPECTanddose

Bushberg,Siebert,Leidholdt,Boone,Chapter18,191x4x50minutes

14 Review/evaluation/quizes Review/evaluation/quizes 1x4x50minutes

15-16 FinalExam7. BookReference:

1. The essential of Physics of Medical Imaging, Jerrold Bushberg, J Anthony Seibert, Edwin M Leidholdt, Jr., John M. Boone, Publisher: Wolter Kluwer/Lippincott Williams and Wilkins, International edition

2. Medical Imaging: Essenstial for Physiscians, Anthony B Wolbarst, Patrizio Capasso, Andrew Wyant, Wiley Blackwell

3. Introduction to Biomedical Imaging, Andrew G. Webb, ISBN: 978-0-471-23766-2, Wiley