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A CLOSER LOOK

Obstructive sleep apnea (OSA) is a serious medical condition that affects

an estimated 15 million US adults and is characterized by repeated

episodes of upper airway obstruction, recurrent arousals and episodic

oxyhemoglobin desaturations during sleep. These abnormalities contribute

to subclinical alterations in vascular function that increase the risk of

cardiovascular disease morbidity and mortality. In contrast, exercise

confers cardioprotection through improvements in vascular health.

The SAVE study is a National Institutes of Health Academic Research

Enhancement Award (AREA) aimed at evaluating whether the beneficial

effects of exercise on vascular function are attenuated in obese individuals

suffering from untreated OSA. The project is in its second year of funding

and involves collaborators from the Johns Hopkins School of Medicine and

the Pulmonary and Critical Care Associates of Baltimore. The overarching

goal of this project is to provide Towson University faculty and students

and their healthcare partners with an appropriate springboard in the 21st

century in preparation for effective delivery of preventative care. The study

is currently recruiting overweight, sedentary adults to take part in this

clinical trial.

SERVICES

• Overnight diagnostic sleep (polysomnography) studies

• Dual energy x-ray absorptiometry (dxa) studies

• Central artery pressure waveform analysis and pulse wave velocity

analysis

• Six weeks of monitored exercise training

CONTACT Devon Dobrosielski, PhDKinesiologyPhone: 410-704-5604 | Email: [email protected]

Susheel Patil, MD, PhDPulmonary and Critical Care Medicine, Johns Hopkins School of MedicinePhone: 410-704-0572 | Email: [email protected]

Hyunjeong Park, PhD, MPH, MSN, ANP, RNDepartment of NursingPhone: 410-704-4514 | Email: [email protected]

PARTNER ORGANIZATION

Pulmonary and Critical Care Associates of Baltimorewww.pccab.com

SLEEP APNEA, CARDIOVASCULAR AND EXERCISE (SAVE) STUDYDeveloping a state of the art training/research program capable of clinically relevant instruction and research excellence

clinicaltrials.gov/ct2/show/NCT03219749