ADCT, CRT sign agreements to develop ADCs against cancer AND Secrets of
Parasites' Replication Unraveled
David Cano QuinteroMedical student III
UPBAugust 13 2012
INTRUDUCTION
The mitosis is the more important part in the DNA
replication and in it, we find the principal step of the regulation
Cancer is the most important problem of the DNA and involve the replication, mediate by the
DNA polymerase.
ADCT, CRT sign agreements to develop ADCs against cancer
Cancer Research Technology (CRT), the commercial arm of
Cancer Research UK, and Switzerland-based ADC
Therapeutics Sarl (ADCT) announce today that they
have signed agreements to develop cancer treatments
called Antibody Drug Conjugates (ADCs) using
CRT antibodies and peptides, and ADCT's 'warhead' and
linker chemistries.ADCT, CRT sign agreements
to develop ADCs against cancer
News Medical July 6 2012
ADCT, CRT sign agreements to develop ADCs against cancer
Its important in the investigation of
cancer treatment
which are internalized into the cancer cell
while avoiding damage to healthy
tissue
The antibody component selectively
targets the cancer cells to deliver tumor-destroying chemicals
ADCT, CRT sign agreements to develop ADCs against cancer
ADCT's toxic chemicals interact with DNA without disrupting the double helix structure
which avoids triggering DNA repair processes - with the prospect that this will prevent drug resistance
ADCT, CRT sign agreements to develop ADCs against cancer
• Once inside the cancer cell, the linker degrades and the active toxin is released, binding to the cell's DNA and killing the cancer cell.
1
• ADCT's toxic chemicals interact with DNA without disrupting the double helix structure which avoids triggering DNA repair processes - with the prospect that this will prevent drug resistance
2
• ADCT's warheads are based on proprietary pyrrolobenzodiazepines (PBDs) technology developed by London-based Spirogen Limited
3
OBSERVATION
I think that this new is very relevant in the way that is a big base to future studies of cancer and all types of treatments about it and with that they can be a beginning to help a lot of lives
Secrets of Parasites' Replication Unraveled
Advances have not come easily, in part because
these parasites have the most complex mitochondrial genome structure in nature,
say Klingbeil and Concepción-Acevedo
Klingbeil says, "so if we can inhibit the replication
process and take away the kDNA, the parasites will die. That's one way we might be
able to kill them.“ScienceDaily July 10, 2012
Secrets of Parasites' Replication Unraveled
They finally could have an idea
around how can do more
investigations about DNA taking
part of the parasities
Advances have not come easily, in part because these parasites have the most
complex mitochondrial
genome structure in
nature
report the first detailed characterization of the way key proteins in the
model parasite Trypanosoma
brucei organize to replicate its
mitochondrial DNA
Secrets of Parasites' Replication Unraveled
Klingbeil says, "so if we can inhibit the replication process and take away the kDNA, the parasites will die. That's one way we might be able to kill them."
kDNA is found as a nucleoid in the mitochondrion, where it holds many copies of catenated or networked minicircles and maxicircles
These molecules pass information on to daughter cells via DNA polymerases whose job it is to copy all circles in the network
Trypanosomes have six mtDNA polymerases, while humans have just
one
To figure out how these trypanosomal polymerases know when to initiate DNA replication set up immunofluorescence
experiments focused on tracking mtDNA polymerase ID (POLID)
Their ultimate success would be to find a chemical to inhibit POLID from
carrying out its role during replication and target all parasites with kDNA
structures
Secrets of Parasites' Replication Unraveled
OBSERVATION
In my opinion this new start to take relevance in the way that use this investigation in parasites, to make more studies about the mitochondrial DNA but in humans and with that can make some important findings
MEDICAL UTILITY
This provides a very promising and rapid route to develop ADCs for cancer therapy
ADCT, CRT sign agreements to develop
ADCs against cancer
MEDICAL UTILITY
Potent PBD-based warheads combined with CRT's leading tumor-targeting antibodies and peptides
ADCT, CRT sign agreements to develop
ADCs against cancer
MEDICAL UTILITY
It is an important step to do investigation about the hereditary obesity in humans
The mitochondrial DNA is relationship with this hereditary problem
Secrets of Parasites' Replication Unraveled
MEDICAL UTILITY
This important discovery explains how POLID engages in kDNA replication and opens up new avenues to study and intervene in mitochondrial protein dynamics
Secrets of Parasites' Replication Unraveled
BIBLIOGRAPHY
Martinez S, Lina Maria. Biología Molecular. 7 ed Medellín: UPB. Fac Medicina
ADCT, CRT sign agreements to develop ADCs against cancer. News Medical. (July 6, 2012)
Secrets of Parasites' Replication Unraveled. ScienceDaily. (July 10, 2012)
THANKS