Download - Novel Synthesis of 7-Fluoro-8-(trifluoromethyl)-1H-1,6-naphthyridin-4-one Derivatives: Intermolecular Cyclization of an N-Silyl-1-azaallyl Anion with Perfluoroalkene and Subsequent

Transcript

2007

Fused pyridine derivativesR 0450 Novel Synthesis of 7-Fluoro-8-(trifluoromethyl)-1H-1,6-naphthyridin-4-one De-

rivatives: Intermolecular Cyclization of an N-Silyl-1-azaallyl Anion with Perfluo-roalkene and Subsequent Intramolecular Skeletal Transformation of the Result-ing Pentasubstituted Pyridines. — The title naphthyridinones are of biological inter-est. — (SUZUKI, H.; SAKAI, N.; IWAHARA, R.; FUJIWAKA, T.; SATOH, M.; KAKEHI, A.; KONAKAHARA*, T.; J. Org. Chem. 72 (2007) 15, 5878-5881; Dep. Pure Appl. Chem., Fac. Sci. Technol., Sci. Univ. Tokyo, Noda, Chiba 278, Japan; Eng.) — Jannicke

49- 164