AmnioticFluid

LipoaspirateBone MarrowAspirate

AmnioticMatrix

AmnioticMembrane

Platelet RichPlasma

Umbilical CordMatrix

Platelet RichPlasma - Heated

Umbilical CordBlood

Steroid, NSAID,Synthetic HA...

Peripheral BloodPharma Placenta Umbilical Cord Bone Marrow Adipose Tissue Source

Products

Autologous (from you)

Allogeneic (from others)

General Cytokines

Growth Factor Cytokines

Scaffolding Cytokines

Homeostatic Cytokines

Mesenchymal Stem Cells (MSC)

Viable MSC Counts

Biologically Young Source

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Platelet Rich Plasma

PRPBlood is drawn from the patient and then placed into a centrifuge1

Blood is spun through the centrifuge to separate the platelets and their growth factors1

This concentrated serum of platelets is then re-injected into the patient1

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PRP - Heated

Heat ShockBlood is drawn from the patient and incubated at a slightly elevated temperature for 24 hours

After 24 hours the blood is spun through the centrifuge and the middle layer is extracted and re-injected into the patient2

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Umbilical Cord Matrix

Wharton’s Jelly MSCThe Wharton’s jelly of the umbilical cord is extracted and processed to yield a high concentration of:

• Cytokines, growth factors and hyaluronic acid4

• Mesenchymal stem cells

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Umbilical Cord Blood

HSCBlood is extracted from the umbilical cord and is processed to isolate hematopoietic stem cells (HSC) and mesenchymal stem cells3

The concentration of MSCs is therapeutically insignificant7

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Bone Marrow Aspirate

Bone Marrow MSC Bone marrow is extracted from the iliac crest and then spun down through a specially designed tube and centrifuge that will isolate the MSCs5

This concentrated fluid is then re-injected into the patient

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Adipose Extraction

Lipoaspirate MSC Fat tissue is removed through a mini-liposuction procedure

The adipose that is extracted is then placed into a processing kit and spun down through a centrifuge to isolate MSCs6

This cell pellet is then re-injected into the patient

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1. Storrs, C. (2009, December 12). Is Platelet Rich Plasma and E�ective Healing Therapy? Retrieved from https://www.scienti�camerican.com/article/platelet-rich-plasma-therapy-dennis-cardone-sports-medicine-injury/2. Graham, T. (2012). The Body That Heals Itself. Retrieved from http://www.mensjournal.com/magazine/the-body-that-heals-itself-201402173. Sibov T.T., Severino P., Marti L.C., Pavon L.F., Oliveira D.M., Tobo P.R., Campos A.H., Paes A.T., Amaro E. Jr., F. Gamarra L., & Moreira-Filho C.C. (2012). Mesenchymal stem cells from umbilical cord blood: parameters for isolation, characterization and adipogenic di�erentiation. Cytotechnology, 64(5), 511-521.4. Kalazczynska I., & Ferdyn K. (2015). Wharton’s jelly derived mesenchymal stem cells: future of regenerative medicine? Recent �ndings and clinical signi�cance. BioMed Research International, 2015: 430847.5. Pontikoglou C., Deschaseaux F., Sensebé L., & Papadaki H.A. (2011). Bone marrow mesenchymal stem cells: biological properties and their role in hematopoiesis and hematopoetic stem cell transplantation. Stem Cell Reviews, 7(3), 569-589.6. Minteer D., Marra K.G., & Rubin J.P. (2013). Adipose-derived mesenchymal stem cells: biology and potential applications. Advances in Biochemical Engineering/Biotechnology, 2013(129), 59-71.7. Mareschi K., Biasin E., Piacibello W., Aglietta M., Madon E., & Fagioli F. (2001). Isolation of human mesenchymal stem cells: bone marrow versus umbilical cord blood. Haematologica, 86(10), 1099-1100.

Human Cell & Tissue Products

R e v o l u t i o n a r y • R e g e n e r a t i v e • T h e r a p e u t i c

All data represented on this grid is informed by either or all available literature, external validation and internal testing. Empty data fields indicate quantities either found in trace amounts, or quantities not specified in literature. Citations and references on file with Predictive Biotech.

MKT-0026, 28 May 2019