Human Cell & Tissue Products · Human Cell & Tissue Products Revolutionary •Regenerative...
1
Amniotic Fluid Lipoaspirate Bone Marrow Aspirate Amniotic Matrix Amniotic Membrane Platelet Rich Plasma Umbilical Cord Matrix Platelet Rich Plasma - Heated Umbilical Cord Blood Steroid, NSAID, Synthetic HA... Peripheral Blood Pharma Placenta Umbilical Cord Bone Marrow Adipose Tissue Source Products Autologous (from you) Allogeneic (from others) General Cytokines Growth Factor Cytokines Scaffolding Cytokines Homeostatic Cytokines Mesenchymal Stem Cells (MSC) Viable MSC Counts Biologically Young Source Characteristics Platelet Rich Plasma PRP Blood is drawn from the patient and then placed into a centrifuge 1 Blood is spun through the centrifuge to separate the platelets and their growth factors 1 This concentrated serum of platelets is then re-injected into the patient 1 • • • PRP - Heated Heat Shock Blood is drawn from the patient and incubated at a slightly elevated temperature for 24 hours After 24 hours the blood is spun through the centrifuge and the middle layer is extracted and re-injected into the patient 2 • • Umbilical Cord Matrix Wharton’s Jelly MSC The Wharton’s jelly of the umbilical cord is extracted and processed to yield a high concentration of: • Cytokines, growth factors and hyaluronic acid 4 • Mesenchymal stem cells • Umbilical Cord Blood HSC Blood is extracted from the umbilical cord and is processed to isolate hematopoietic stem cells (HSC) and mesenchymal stem cells 3 The concentration of MSCs is therapeutically insignificant 7 • • Bone Marrow Aspirate Bone Marrow MSC Bone marrow is extracted from the iliac crest and then spun down through a specially designed tube and centrifuge that will isolate the MSCs 5 This concentrated fluid is then re-injected into the patient • • Adipose Extraction Lipoaspirate MSC Fat tissue is removed through a mini-liposuction procedure The adipose that is extracted is then placed into a processing kit and spun down through a centrifuge to isolate MSCs 6 This cell pellet is then re-injected into the patient • • • x 1. Storrs, C. (2009, December 12). Is Platelet Rich Plasma and Effective Healing Therapy? Retrieved from https://www.scientificamerican.com/article/platelet-rich-plasma-therapy-dennis-cardone-sports-medicine-injury/ 2. Graham, T. (2012). The Body That Heals Itself. Retrieved from http://www.mensjournal.com/magazine/the-body-that-heals-itself-20140217 3. Sibov T.T., Severino P., Marti L.C., Pavon L.F., Oliveira D.M., Tobo P.R., Campos A.H., Paes A.T., Amaro E. Jr., F. Gamarra L., & Moreira-Filho C.C. (2012). Mesenchymal stem cells from umbilical cord blood: parameters for isolation, characterization and adipogenic differentiation. Cytotechnology, 64(5), 511-521. 4. Kalazczynska I., & Ferdyn K. (2015). Wharton’s jelly derived mesenchymal stem cells: future of regenerative medicine? Recent findings and clinical significance. BioMed Research International, 2015: 430847. 5. Pontikoglou C., Deschaseaux F., Sensebé L., & Papadaki H.A. (2011). Bone marrow mesenchymal stem cells: biological properties and their role in hematopoiesis and hematopoetic stem cell transplantation. Stem Cell Reviews, 7(3), 569-589. 6. Minteer D., Marra K.G., & Rubin J.P. (2013). Adipose-derived mesenchymal stem cells: biology and potential applications. Advances in Biochemical Engineering/Biotechnology, 2013(129), 59-71. 7. Mareschi K., Biasin E., Piacibello W., Aglietta M., Madon E., & Fagioli F. (2001). Isolation of human mesenchymal stem cells: bone marrow versus umbilical cord blood. Haematologica, 86(10), 1099-1100. Human Cell & Tissue Products Revolutionary • Regenerative • Therapeutic All data represented on this grid is informed by either or all available literature, external validation and internal testing. Empty data fields indicate quantities either found in trace amounts, or quantities not specified in literature. Citations and references on file with Predictive Biotech. MKT-0026, 28 May 2019
Transcript of Human Cell & Tissue Products · Human Cell & Tissue Products Revolutionary •Regenerative...
AmnioticFluid
LipoaspirateBone MarrowAspirate
AmnioticMatrix
AmnioticMembrane
Platelet RichPlasma
Umbilical CordMatrix
Platelet RichPlasma - Heated
Umbilical CordBlood
Steroid, NSAID,Synthetic HA...
Peripheral BloodPharma Placenta Umbilical Cord Bone Marrow Adipose Tissue Source
Products
Autologous (from you)
Allogeneic (from others)
General Cytokines
Growth Factor Cytokines
Scaffolding Cytokines
Homeostatic Cytokines
Mesenchymal Stem Cells (MSC)
Viable MSC Counts
Biologically Young Source
Ch
ara
cte
rist
ics
Platelet Rich Plasma
PRPBlood is drawn from the patient and then placed into a centrifuge1
Blood is spun through the centrifuge to separate the platelets and their growth factors1
This concentrated serum of platelets is then re-injected into the patient1
•
•
•
PRP - Heated
Heat ShockBlood is drawn from the patient and incubated at a slightly elevated temperature for 24 hours
After 24 hours the blood is spun through the centrifuge and the middle layer is extracted and re-injected into the patient2
•
•
Umbilical Cord Matrix
Wharton’s Jelly MSCThe Wharton’s jelly of the umbilical cord is extracted and processed to yield a high concentration of:
• Cytokines, growth factors and hyaluronic acid4
• Mesenchymal stem cells
•
Umbilical Cord Blood
HSCBlood is extracted from the umbilical cord and is processed to isolate hematopoietic stem cells (HSC) and mesenchymal stem cells3
The concentration of MSCs is therapeutically insignificant7
•
•
Bone Marrow Aspirate
Bone Marrow MSC Bone marrow is extracted from the iliac crest and then spun down through a specially designed tube and centrifuge that will isolate the MSCs5
This concentrated fluid is then re-injected into the patient
•
•
Adipose Extraction
Lipoaspirate MSC Fat tissue is removed through a mini-liposuction procedure
The adipose that is extracted is then placed into a processing kit and spun down through a centrifuge to isolate MSCs6
This cell pellet is then re-injected into the patient
•
•
•
x
1. Storrs, C. (2009, December 12). Is Platelet Rich Plasma and E�ective Healing Therapy? Retrieved from https://www.scienti�camerican.com/article/platelet-rich-plasma-therapy-dennis-cardone-sports-medicine-injury/2. Graham, T. (2012). The Body That Heals Itself. Retrieved from http://www.mensjournal.com/magazine/the-body-that-heals-itself-201402173. Sibov T.T., Severino P., Marti L.C., Pavon L.F., Oliveira D.M., Tobo P.R., Campos A.H., Paes A.T., Amaro E. Jr., F. Gamarra L., & Moreira-Filho C.C. (2012). Mesenchymal stem cells from umbilical cord blood: parameters for isolation, characterization and adipogenic di�erentiation. Cytotechnology, 64(5), 511-521.4. Kalazczynska I., & Ferdyn K. (2015). Wharton’s jelly derived mesenchymal stem cells: future of regenerative medicine? Recent �ndings and clinical signi�cance. BioMed Research International, 2015: 430847.5. Pontikoglou C., Deschaseaux F., Sensebé L., & Papadaki H.A. (2011). Bone marrow mesenchymal stem cells: biological properties and their role in hematopoiesis and hematopoetic stem cell transplantation. Stem Cell Reviews, 7(3), 569-589.6. Minteer D., Marra K.G., & Rubin J.P. (2013). Adipose-derived mesenchymal stem cells: biology and potential applications. Advances in Biochemical Engineering/Biotechnology, 2013(129), 59-71.7. Mareschi K., Biasin E., Piacibello W., Aglietta M., Madon E., & Fagioli F. (2001). Isolation of human mesenchymal stem cells: bone marrow versus umbilical cord blood. Haematologica, 86(10), 1099-1100.
Human Cell & Tissue Products
R e v o l u t i o n a r y • R e g e n e r a t i v e • T h e r a p e u t i c
All data represented on this grid is informed by either or all available literature, external validation and internal testing. Empty data fields indicate quantities either found in trace amounts, or quantities not specified in literature. Citations and references on file with Predictive Biotech.
MKT-0026, 28 May 2019
