fVIIaTF

TFTF

TFTF

TFTF TF

TF TF

TF

TF

fVIIa

TF

TF

fVIIa: 1% of total FVII

fVIIaTF

TFTF

TF

TF

TF

TF TF

TF TF

TF

fVIIa

Anionic membrane

II IIa

Plt

V

VIII

XI

X

IX

XaIXa

Initiation

TFCafVIIa

prothrombinase

Ext tenase

VIIXa Va

Ca

Xa

VIIa

TFPI

Va

aPlt

Va

VIIIa

XIa

ATIII

Active Platelet

TM

IX

X II

Int tenase

prothrombinasepropagation

Main path of XI

Plt

V

VIII

XI

CaVIIIa

IXaXa

CaVa

XIII VII

aPlt

Va

VIIIa

XIIIa VIIaIIa

IIa

APCIXa

VIIIa

XIa

Va

XIa

IXa

Symptom(+) Lab (+) and Sym(-)

Screen Lab:APTT, PT and PLt

Confirmatory test

mixted aPTT; mixed PT 0 and 2 hour

If corrected (N+P < buffer+normal)

Factor deficiency

Or weak antibody

If not antibody

1. Anti phospholipid Ab ( no clincal importance) on 0 hr

2. Factor antibody ex: VIII ab ( delay titier: 2 hr more long)

(-)

(+)

See YouClinical significant???Factor

F XII deficiencyPrekallikrein deficiencyHigh-molecular-weight kinogen deficiencyMild to moderate factor VII deficiency

lpus anticoagulantsExcess citrate anticoagulant (e with HCT>60%)

vWDPlt function

In release; Scott syndromeFactor

FXIIIHeterozygous carriere of inherited coagulation diorder:

FIX deficiency Mild inherited coagulation disorder:

FXI deficiencyDysfibrinogenemiaFibrinolysis

Plasmin inhibitor deficiencyElegated of plasminogen activator

Hereditary hemorrhagic telangiectasisAllergic and other vascular purpura