fVIIa
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fVIIa TF TF TF TF TF TF TF TF TF TF TF TF fVIIa TF TF fVIIa: 1% of total FVII
description
TF. TF. fVIIa. TF. TF. TF. TF. TF. TF. fVIIa: 1% of total FVII. fVIIa. TF. TF. TF. TF. TF. TF. TF. TF. aPlt. Va. ATIII. Va. VIIIa. XIa. IXa. Xa. IIa. VIIa. fVIIa. fVIIa. Ca. Ca. TFPI. Xa. Va. Xa. TF. TF. Plt. V. VIII. XI. X. IX. II. fVIIa. TF. VII. - PowerPoint PPT Presentation
Transcript of fVIIa
fVIIaTF
TFTF
TFTF
TFTF TF
TF TF
TF
TF
fVIIa
TF
TF
fVIIa: 1% of total FVII
fVIIaTF
TFTF
TF
TF
TF
TF TF
TF TF
TF
fVIIa
Anionic membrane
II IIa
Plt
V
VIII
XI
X
IX
XaIXa
Initiation
TFCafVIIa
prothrombinase
Ext tenase
VIIXa Va
Ca
Xa
VIIa
TFPI
Va
aPlt
Va
VIIIa
XIa
ATIII
Active Platelet
TM
IX
X II
Int tenase
prothrombinasepropagation
Main path of XI
Plt
V
VIII
XI
CaVIIIa
IXaXa
CaVa
XIII VII
aPlt
Va
VIIIa
XIIIa VIIaIIa
IIa
APCIXa
VIIIa
XIa
Va
XIa
IXa
Symptom(+) Lab (+) and Sym(-)
Screen Lab:APTT, PT and PLt
Confirmatory test
mixted aPTT; mixed PT 0 and 2 hour
If corrected (N+P < buffer+normal)
Factor deficiency
Or weak antibody
If not antibody
1. Anti phospholipid Ab ( no clincal importance) on 0 hr
2. Factor antibody ex: VIII ab ( delay titier: 2 hr more long)
(-)
(+)
See YouClinical significant???Factor
F XII deficiencyPrekallikrein deficiencyHigh-molecular-weight kinogen deficiencyMild to moderate factor VII deficiency
lpus anticoagulantsExcess citrate anticoagulant (e with HCT>60%)
vWDPlt function
In release; Scott syndromeFactor
FXIIIHeterozygous carriere of inherited coagulation diorder:
FIX deficiency Mild inherited coagulation disorder:
FXI deficiencyDysfibrinogenemiaFibrinolysis
Plasmin inhibitor deficiencyElegated of plasminogen activator
Hereditary hemorrhagic telangiectasisAllergic and other vascular purpura
