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EMBRYOLOGY OF THEC RDIOV SCUL R
SYSTEM
Achmad aminuddin
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EST BLISHMENT OF THEC RDIOGENIC FIELD
THE VASCULAR SYSTEM APPEAR IN THE MIDDLE OF THETHIRD WEEK.
CARDIAC PROGENITOR CELLS LIE IN THE EPIBLASTLATERAL TO PRIMITI VE STREAK.
CELLS MIGRATE TOWARD ROSTRAL TO THEBUCCOPHARYNGEAL MEMBR BRANE AND NEURAL FOLDS,IN THE SPLANCHNIC LAYER OF THE LATERAL PLATEMESODER.
THEY ARE INDUCE BY THE UNDERLYING PHARYNGEALENDODERM TO FORM CARDIAC MYOBLAST.
BLOOD ISLANDS APPEAR IN THIS MESODERM. THE ISLANDS UNITE TO FORM A HORSESHOE-SHAPED
ENDOTHELIAL-LINED TUBE SURROUNDED BY MYOBLAST ISKNOWN AS CARDIOGENIC FIELD
THE INTRAEMBRYONIC CAVITY DEVELOP INTOPERICARDIAL CAVITY.
BLOOD ISLANDS APPEAR TO FORM THE DORSAL AORTAE.
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FORM TION ND POSITIONOF THE HE RT TUBE
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FORM TION ND POSITIONOF THE HE RT TUBE
THE RESULT OF GROWTH OF THE BRAIN AND CEPHALICFOLDING, THE BUCCOPHARYNGEAL MEMBRANE IS PULLEDFORWARD, THE HEART AND PERICARDIAL CAVITY MOVETO CERVIX THEN TO THE THORAX.
THE RESULT OF THE EMBRYO FOLDS IS THE CAUDALREGION OF THE PAIRED CARDIAC PRIMORDIA MERGEEXCEPT AT THEIR CAUDAL MOST ENDS.
THE CRESCENT PART OF THE HORSESHO- SHAPED AREAEXPANDS TO FORM THE FUTURE OUTFLOW TRACT ANDVENTRICLE
THE HEART BECOMES A CONTINUOUS EXPADED TUBE,AND RECEIVES VENOUS DRAINAGE AT IT CAUDAL POLEAND BEGINS TO PUMP BLOOD OUT OF THE FIRST AORTICARCH INTO THE DORSAL AORTA.
THE DEVELOPING HEART TUBE BULGES IN TO THEPERICARDIALCAVITY, AND ATTACHED TO THE DORSALSIDE - DORSAL MESOCARDIUM .
PROEPICARDIUM FORM MOST OF THE EPICARDIUM.
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FORM TION OF THEC RDI C LOOP
ON DAY 23 HEART TUBE , CEPHALIC PORTION BENDVENTRAL LY, CAUDALLY AND TO THE RIGHT , CAUDALPORTION ( ATRIUM ) SHIFTS DORSOCRANIALLY AND TOTHE LEFT IT IS COMPLETE BY DAY 28.
ATRIAL PORTION FORM A COMMON ATRIUM. ATRIOVENTRICULAR JUNCTION FORM THE
ATRIOVENTRICULAR CANAL.
BULBUS CORDIS WILL FORM THE TRABECULATED PART OFTHE RIGHT VENTRICLE.
CONUS CORDIS WILL FORM THE OUTFLOW TRAC OF BOTH
VENTRICLES. TRUNCUS ARTERIOSUS WILL FORM THE ROOT AND PROX.
PART OF THE AORTA AND PULMONARY ARTERY.
THE JUNCTION BETWEEN BULBUS CORDIS BULBUS CORDIIS THE PRIMARY INTERVENTRICULAR FORAMEN
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THE DEVELOPMENT OFTHE SINUS VENOSUS
THE LEFT COMMON CARDINAL V IS OBLITERATED AT 10WEEK ALL THAT REMAINS OF THE LEFT SINUS HORN ISOBLIQUE VEIN OF THE LEFT ATRIUM AND THE CORONARYSINUS.
LEFT TO THE RIGHT SHUNT RIGHT SINUS HORN ANDVEINS ENLARGE - THE RIGHT HORN FORM THE SMOOTH-WALLED PART OF THE RIGHT ATRIUM.
SINUATRIAL ORIFICE.
SEPTUM SPURIUM.
LEFT VENOUS VALVE AND SEPTUM SPURIUM FUSE WITH
THE DEVELOPING ATRIAL SEPTUM. THE INFERIOR PORTION OF THE RIGHT VENOUS VALVE
FORM THE VALVE OF THE I.V. C. AND THE VALVE OF THECORONARY SINUS.
CRISTA TERMONALIS
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FORM TION OF THEC RDI C SEPT
FORMED BETWEEN THE 27THAND 37THDAYS OFDEVELOPMENT.
ENDOCARDIAL CUSHION DEVELOP INTO
- ATRIAL AND VENTRICULAR SEPTA.
- AV CANAL AND VALVE.
- AORTIC AND PULMONARY CHANAL.
FORMED BY MERGING OF TWO EXPANDING
PORTION OF THE WALL OF THE HEART BUTNEVER COMPLE TELY, ITS USUALLY CLOSED BYNEIGHBOURING PROLIFERATION TISSUE.
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CLINIC L CORREL TION
ATRIAL SEPTAL DEFECT.
VENTRICULAR SEPTAL DEFECT. TRANSPOSITION OF THE GREAT
VESSELS.
TETRALOGY OF FALLOT.
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SEPTUM FORM TION INTHE COMMON TRIUM
AT THE END OF THE 4THWEK IS FORMED SEPTUMPRIMUM AND OSTIUM PRIMUM.
OSTIUM PRIMUM IS CLOSED BY ENDOCARDIALCUSHION AND CELLS DEATH PRODUCES OSTIUMSECUNDUM.
APPEAR SEPTUM SECUNDUM WITH OVALFORAMEN.
SEPTUM PRIMUM BECOME VALVE OF THE OVALFORAMEN.
AT BIRTH LUNG CIRCULATION BEGIN ANDSEPTUM PRIMUM IS PRESSED AGAINST SEPTUMSECUNDUM OBLITERATING THE OVALFORAMEN
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FURTHER DIFFERENTI TIONOF THE TRI
PULMONARY VEIN DEVELOP AT THE POSTERIORLEFT ATRIAL WALL AND GAIN CONNECTION WITHVEINS OF THE DEVELOPING LUNG BUD.
THE PULMONARY VEIN AND ITS BRANCHES AREINCORPORATED INTO THE LEFT ATRIUM,FORMING THE SMOOTH-WALLED PART OF THE
ATRIUM.
THE TRABECULATED ATRIAL APPENDAGE ARISEFROM THE ORIGINAL EMBRYONIC LEFT ATRIUM.
THE RIGHT ATRIAL APPENDAGE ARISE FROM THEORIGINAL EMBRYONIC RIGHT ATRIUM.
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SEPTUM FORM TION IN THETRIOVENTRICUL R C N L AT THE END OF THE 4THWEEK APPEAR AV
ENDOCARDIAL CUSHION.
INITIALLY AV CANAL GIVES ACCESS ONLY TO THE
PRIMITIVE LEFT VENTRICLE, AND BY THEDEVELOPMENT OF THE BULBOVENT RICULARFLANGE SHIFT TO THE RIGHT ANDENLARGEMENT OF THE AV CANAL BLOODPASSING THROUGH THE AV ORIFICE NOW HAS
DIRECT ACCES TO THE PRIMITIVE LEFT ANDRIGHT VENTRICLE.
THE SUPERIOR AND INFERIOR CUSHIONSPROJECT INTO THE LUMEN AND FUSE LEFT
AND RIGHT ORIFICE IS FORMED ( 5THWEEK )
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FORM TION OF THESEPTUM IN THE V C N L
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FORM TION OF THETRIOVENTRICUL R
V LVES EACH AV ORIFICE IS SURROUNDED BY LOCAL
PROLIFERATION OF MESENCHYMAL TISSUE.
THE BLOOD STREAM HOLLOWS OUT AND THINSTISSUE.
VALVES FORM AND REMAIN ATTACH ED TO THEVENTRICULAR WALL BY MUSCULAR CORD.
MUSCULAR TISSUE IS REPLACED BYDENSECONNECTIVE TISSUE.
THE VALVE CONSIST CONNECTIVE TISSUECOVERED BY ENDOCARDIUM AND CONNECTEDTO THE WALLOF THE VENTRICLE BY PAPILLARYMUSCLES AND CHORDAE TENDINEAE.
BICUSPID VALVE FORM IN THE LEFT AV CANAL.
TRICUSPID VALVE FORM ON THE RIGHT AVCANAL.
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FORM TION OF THE VV LVES ND CHORD E
TENDINE E
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HE RT DEFECTS
ETIOLOGY
- COMPLEX INTERPLAY BETWEEN
GENETIC AND ENVIRONMENT.
- GENETIC FACTOR.
- ENVIRONMENTAL AGENTS
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C RDIOV SCUL RTER TOGEN
RUBELLA VIRUS.
THALIDOMIDE.
ISOTRETINOIN ( VITAMIN A ).
ALCOHOL.
MATERNAL DISEASES
- INSULIN- DEPENDENT DIABETES.
- HYPERTENSION.
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CHROMOSOM LBNORM LITY
TRISOMY 18.
GENETIC SYNDROME SUCH AS DIGEORGE,GOLDENHAR AND DOWN SYNDROME,
MUTATION IN HEART-SPECIFIYING GENE;- NKX2.5, ON CHROMOSOME 5q35,
- ASD
- TETRALOGY OF FALOT.
- A-V CONDUCTION DELAYS.- TBX5 HOLT- ORAM SYNDROME.
- LIMB ABNORMALITIES.
- A.S.D.
- V.S.D.( MUSCULAR PORTION )
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TRI L SEPT L DEFECT OSTIUM SECUNDUM DEFECT
excessive cells death and resortion of
the septum primum or by inadequatedevelopment of the septum secundum
COR TRILOCULARE BIVENTRICULRE
complete absence of the atrial septum. PREMATURE CLOSURE OF THE OVAL
FORAMEN.
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TRICUSPID TRESI INVOLVES OBLITERATION OF THE RIGHT
A-V ORIFICE.
ALWAYS ASSOCIATED WITH ;
- PATENCY OF THE OVAL FORAMEN.
- VENTRICULAR SEPTAL DEFECT.
- UNDERDEVELOPMENT OF THE
RIGHT VENTRICLE.- HYPERTROPHY OF THE LEFT
VENTRICLE.
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SEPTUM FORM TION IN THETRUNCUS RTERIOSUS ND
CONUS CORDIS IN THE TRUNCUS, DURING THE 5THWEEK
APPEAR
- RIGHT SUPERIOR TRC. SWELLING.
- LEFT INFERIOR TRC. SWELLIG
GROWING TOWARD THE AORTIC SAC
THE SWELLING TWIST AROUND EACH
OTHER.after complete fusion the ridge form the
AORTICO PULMONARY SEPTUM, dividing
truncus into AORTIC AND PULMONARY
CHANAL
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SEPTUM FORM TION INTHE CONUS CORDIS
IN THE CONUS CORDIS APPEAR
- RIGHT DORSAL SWELLING.
- LEFT VENTRAL SWELLING.WHEN THE TWO CONUS SWELLINGHAVE FUSED, THE SEPTUM DEVIDESTHE CONUS INTO
- THE OUTFLOW TRACT OF THE R.V.
- THE OUT FLOW TRACT OF THE L.V.
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THE NEUR L CREST CELLSIN THE HIND BR IN
ABNORMAL MIGRATION, PROLIFERA
TION OR DIFFERENTIATION RESULT- TETRALOGY OF FALLOT.
- PULMONARY STENOSIS.
- P.D.A.- TRANSPOSITION OF GREAT VESEL
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SEPTUM FORM TION INTHE VENTRICLES
BY THE END OF THE 4THWEEK
- GROWTH OF THE MYOCARDIUM
WITH DIVERTICULATION AND TRABE
CULATION.
- THE MEDIAL WALL OF THE EXPANDING VENTRICLES BECOME APPO
SED AND MERGE, forming THE MUSC
CULAR INTERVENTRICULAR SEPTUM AND
THE INTERVENTRICULAR FORAMEN.
- OUT GROWTH OF THE INFERIOR ENDOCARDIAL
CUSHION CLOSE THE FORAMEN.
- COMPLETE CLOSURE OF THE INTERVENTRICULAR
FORAMEN forms THE MEMBRANOUS PART OF THE
INTERVENTRICULAR SEPTUM
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FORM TION OF THESEMILUN R V LVES
WHEN PARTITIONING OF THETRUNCUS IS ALMOST COMPLETE,PRIMORDIA OF THE SEMILUNARVALVES BECOME VISIBLE.
A THIRD TUBERCLE APPEARS INBOTH CHANELS OPPOSITE THE
FUSED TRUNCUS SWELLINGS. THE TUBERCLES FORMS THE
SEMILUNAR VALVES.
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TETR LOGY OF F LLOT
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TR NSPOSITION OF THEGRE T VESSELS
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PERSISTENT TRUNCUSRTERIOSUS
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ECTOPI CORDIS
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DEVELOPMENT OF THERTERI L SYSTEM
AORTIC ARCHES
during the 4thand 5thweek aortic sac
form FIVE ARCHES I, II, III, IV, DAN VI. DEVELOPMENT OF THE AORTIC SAC
IS FORM ;
- THE BRACHIOCEPHALIC ARTERY.
- AORTIC ARCH.
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