REPLICATION BY: LUIS FELIPE ÁLVAREZ HERNÁNDEZ
INTRODUCTION
Fruitfly sperm cells reveal intricate
coordination in stem cell replication
Stem cell populations reside
in areas called niches deep
within different types of
organs.
Scientists think that these
niches control stem cell
behavior, that is "telling" the
stem cell when to produce
more stem cells or when to
produce daughter cells
Fruitfly sperm cells reveal intricate
coordination in stem cell replication
DiNardo and Lenhart showed
that the division of these stem
cells is regulated at the final
stage of replication, called
cytokinesis, right before the
two daughter cells separate.
Fruitfly sperm cells reveal intricate
coordination in stem cell replication
Fruitfly sperm cells reveal intricate
coordination in stem cell replication
In the fruitfly testis niche, previous
studies have shown that different
stem cell types had to coordinate
with each other.
If their respective functions were
uncoupled from each other, by
mutation for example, the testis
could not make sperm.
PERSONAL COMMENT: I think the
investigation is on track, and that
these advancements can combat the
irregular gene expression and cell
division for medical purposes
Fruitfly sperm cells reveal intricate
coordination in stem cell replication
Forks colliding: How DNA breaks during
re-replication
Forks colliding: How DNA breaks during
re-replication
Improved analysis have
uncovered the genetic
alterations in amplification
and methods of redress
Forks colliding: How DNA breaks during
re-replication
DNA breaks are
mended in one of two
ways
: (NHEJ) is rapid but
prone to mistakes
(HR) takes longer but
is much more
accurate.
Forks colliding: How DNA breaks during
re-replication
Now they can begin to
isolate the individual
components involved in
the repair pathways,
resolve their precise roles
Forks colliding: How DNA breaks during
re-replication
PERSONAL COMMENT: this
kind of progress however
small are huge in molecular
biology and lets continue to
create benefits
MEDICAL
UTILITY
MEDICAL UTILITY
The discover where
DNA damage is
repaired , will enable
can find better gene
therapy
MEDICAL UTILITY
Proper use of stem cell
discoveries will provide
greatest advances in tissue
reconstruction
MEDICAL UTILITY
Will enable create the
"superman" to the bad
genetic odds, without
irreparable alteration
BIBLIOGRAPHY
• 1. University of Pennsylvania School of Medicine. "Fruitfly sperm
cells reveal intricate coordination in stem cell replication: Basic cell
biology study lends new view of early steps of tissue regeneration."
ScienceDaily. ScienceDaily, 15 July 2015.
www.sciencedaily.com/releases/2015/07/150715122354.htm.
• 2. Whitehead Institute for Biomedical Research. "Forks colliding:
How DNA breaks during re-replication." ScienceDaily. ScienceDaily,
4 June 2015.
www.sciencedaily.com/releases/2015/06/150604141527.htm.
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