REPLICATION BY: LUIS FELIPE ÁLVAREZ HERNÁNDEZ

INTRODUCTION

Fruitfly sperm cells reveal intricate

coordination in stem cell replication

Stem cell populations reside

in areas called niches deep

within different types of

organs.

Scientists think that these

niches control stem cell

behavior, that is "telling" the

stem cell when to produce

more stem cells or when to

produce daughter cells

Fruitfly sperm cells reveal intricate

coordination in stem cell replication

DiNardo and Lenhart showed

that the division of these stem

cells is regulated at the final

stage of replication, called

cytokinesis, right before the

two daughter cells separate.

Fruitfly sperm cells reveal intricate

coordination in stem cell replication

Fruitfly sperm cells reveal intricate

coordination in stem cell replication

In the fruitfly testis niche, previous

studies have shown that different

stem cell types had to coordinate

with each other.

If their respective functions were

uncoupled from each other, by

mutation for example, the testis

could not make sperm.

PERSONAL COMMENT: I think the

investigation is on track, and that

these advancements can combat the

irregular gene expression and cell

division for medical purposes

Fruitfly sperm cells reveal intricate

coordination in stem cell replication

Forks colliding: How DNA breaks during

re-replication

Forks colliding: How DNA breaks during

re-replication

Improved analysis have

uncovered the genetic

alterations in amplification

and methods of redress

Forks colliding: How DNA breaks during

re-replication

DNA breaks are

mended in one of two

ways

: (NHEJ) is rapid but

prone to mistakes

(HR) takes longer but

is much more

accurate.

Forks colliding: How DNA breaks during

re-replication

Now they can begin to

isolate the individual

components involved in

the repair pathways,

resolve their precise roles

Forks colliding: How DNA breaks during

re-replication

PERSONAL COMMENT: this

kind of progress however

small are huge in molecular

biology and lets continue to

create benefits

MEDICAL

UTILITY

MEDICAL UTILITY

The discover where

DNA damage is

repaired , will enable

can find better gene

therapy

MEDICAL UTILITY

Proper use of stem cell

discoveries will provide

greatest advances in tissue

reconstruction

MEDICAL UTILITY

Will enable create the

"superman" to the bad

genetic odds, without

irreparable alteration

BIBLIOGRAPHY

• 1. University of Pennsylvania School of Medicine. "Fruitfly sperm

cells reveal intricate coordination in stem cell replication: Basic cell

biology study lends new view of early steps of tissue regeneration."

ScienceDaily. ScienceDaily, 15 July 2015.

www.sciencedaily.com/releases/2015/07/150715122354.htm.

• 2. Whitehead Institute for Biomedical Research. "Forks colliding:

How DNA breaks during re-replication." ScienceDaily. ScienceDaily,

4 June 2015.

www.sciencedaily.com/releases/2015/06/150604141527.htm.

“Development is just around the corner”