ZAHRA MADJD, MD PhD

PERSONAL DETAILS

Address: Dep of Pathology, Faculty of Medicine

Oncopathology Research Centre

Dep of Molecular Medicine, Faculty of Advanced Technologies in Medicine

Cellular Molecular Research Centre, Iran University of Medical Sciences (IUMS)

Hemmat Highway, Next to Milad tower, Tehran, Iran

Post code: 64441-64141

Tel/fax:+494699144189

Zahra.madjd@yahoo.com,

madjd.z@iums.ac.ir

Academic Activities

Position Dates Place

Associate Professor Sep 4864- present Dep Pathology, Iran University of

Medical Sciences (IUMS)

Sabbatical , visiting scientist May-June 4864

December 4864- March

4861

Molecular Medicine Lab, Dep

Dermatology, University of British

Columbia, Vancouver, Canada

Head of Research Centres

Coordinating Office (RCCO)

April- Oct 4862 Iran University of Medical Sciences

Head Dep. Molecular Medicine

4884- present Iran University of Medical Sciences

Research Deputy of Oncopathology

Research Centre

4882 - present Iran University of Medical Sciences

Core member of Cancer Research

Centre (CRC)

4882 - present Shahid Beheshti University, Shohada

Hospital, Tehran

Member of Research Committee 4882- present Dep Pathology, Iran University of

Medical Sciences

Member of Scientific committee of

Cellular Molecular Research Centre

4882- 4864 Iran University of Medical Sciences

Member of Scientific committee of 4884- 4864 Iran University of Medical Sciences

2

Razi Drug Research Centre,

Assistant Professor August 4881- Sep 4864 Dep of Pathology, IUMS

Previous appointments

Dates Description of qualification Place obtained

6499 -6441 Doctorate in Medicine Tehran, Iran

6441- 4888 Medical practice as GP Tehran, Iran

4888-4886 Courses in MSc Oncology University of Nottingham, UK

4886- 4881 PhD, Cancer Immunology (Supervisors: Prof

Lindy Durrant and prof Ian. O Ellis)

CRUK Clinical Oncology, University

of Nottingham, City Hospital,

Nottingham, UK

4881-4881 Post-doctoral Research Fellow CRUK Clinical Oncology, University

of Nottingham, City Hospital,

Nottingham, UK

Honours and Prizes

1) EACR-69 (European Association of Cancer Research) award, July 4884,

Insbruke, Austria.

2) BACR (British Association of Cancer Research) award , ECCO62 meeting,

October 4881, Paris

3) BACR award at the EACR 48, July 4889, Lyon, France

4) Young Researcher award, Iranian Ministry of Health and Education, December

4889

5) Distinguished Researcher award , Iran University of Medical Sciences, Dec 4864

Editorial Board of Journal:

Iranian Journal of Cancer Prevention (IJCP), Iran

Razi Journal of Medical Sciences (RJMS) (In Farsi)

Case Reports in Oncological Medicine, USA

Journal of Solid Tumours, Canada

Reviewer:

Cancer Letters

Stem Cells

Cancer Research

PLOS ONE

Tumour Biology

Journal of Solid Tumours, Canada

Expert Opinion On Therapeutic Targets

Case Reports in Oncological Medicine, USA

Iranian Journal of Cancer Prevention (IJCP), Iran

Razi Journal of Medical Sciences (RJMS)

Many other Journals

3

Memberships

6) BACR (British Association for Cancer Research)

4) EACR (European Association for Cancer Research)

Research Interests:

6) Cancer Stem cells

4) Targeted therapy of Cancer Stem cells

2) Cancer stem Cell Vaccine

4) Translational Cancer Research

1) Biomarkers of solid tumours (breast cancer, prostate cancer, lung cancer,

melanomas)

PUBLICATIONS

6102

6. Differential role of Wnt signaling and base excision repair pathways in gastric

adenocarcinoma aggressiveness. Korourian A, Roudi R, Shariftabrizi A, Kalantari

E, Sotoodeh K, Madjd Z. Clin Exp Med. 4861 Dec 6

4. Evaluation of circulating cellular DCLK6 protein, as the most promising

colorectal cancer stem cell marker, using immunoassay based methods.A Mirzaei,

Z Madjd, AA Kadijani, M Tavakoli-Yaraki, MH Modarresi, Cancer Biomarkers,

4861, 6-66

2. Coenzyme Q68 Ameliorates Trimethyltin Chloride Neurotoxicity in Experimental

Model of Injury in Dentate Gyrus of Hippocampus: A Histopathological and

Behavioral Study.MH Sakhaie, M Soleimani, V Pirhajati, SS Asl, Z Madjd, M

Mehdizadeh. Iranian Red Crescent Medical Journal, 4861

4. Reduced expression of CXCR4, a novel renal cancer stem cell marker, is

associated with high-grade renal cell carcinoma.A Rasti, M Abolhasani, LS

Zanjani, M Asgari, M Mehrazma, Z Madjd. Journal of Cancer Research and

Clinical Oncology, Sep 4861, 6-68

1. Probiotic feeding affects T cell populations in blood and lymphoid organs in

chickens. Asgari F, Madjd Z, Falak R, Bahar MA, Nasrabadi MH, Raiani M,

Shekarabi M. Benef Microbes. 4861 Jun 4986-9

1. Expression of CD622 cancer stem cell marker in melanoma: a systematic review and

meta-analysiS. Zahra Madjd, Elham Erfani, Elmira Gheytanchi, Maziar Moradi-

Lakeh, Ahmad Shariftabrizi , Mohsen Asadi-Lari. Int J Biol Markers 4861.

4

2. Evidence for embryonic stem-like signature and epithelial-mesenchymal transition

features in the spheroid cells derived from lung adenocarcinoma. Roudi R, Madjd Z,

Ebrahimi M, Najafi A, Korourian A, Shariftabrizi A, Samadikuchaksaraei A. Tumour

Biol. 4861 Apr 1.

9. Expression of Cancer Stem Cell Markers OCT4 and CD622 in Transitional Cell

Carcinomas. Sedaghat S, Gheytanchi E, Asgari M, Roudi R, Keymoosi H, Madjd

Z. Appl Immunohistochem Mol Morphol. 4861 Mar 2.

4. Accuracy of c-KIT in Lung Cancer Prognosis; a Systematic Review Protocol"

.Roudi R, Kalantari E, Keshtkar A, Madjd Z. Asian Pac J Cancer Prev.

4861;62(4):912-1.

01. Increased Expression of ALDH6A6 in Prostate Cancer is Correlated With Tumor

Aggressiveness: A Tissue Microarray Study of Iranian Patients. Kalantari E,

Saadi FH, Asgari M, Shariftabrizi A, Roudi R, Madjd Z. Appl Immunohistochem

Mol Morphol. 4861 Feb 69.

66. Diagnostic and prognostic accuracy of miR-46 in renal cell carcinoma: a

systematic review protocol. Rasti A, Mehrazma M, Madjd Z, Keshtkar AA,

Roudi R, Babashah S.BMJ Open. 4861 Jan

64. Impaired Memory and Evidence of Histopathology in CA6 Pyramidal Neurons

through Injection of Aβ6-44 Peptides into the Frontal Cortices of Rat. Eslamizade

MJ, Madjd Z, Rasoolijazi H, Saffarzadeh F, Pirhajati V, Aligholi H, Janahmadi

M, Mehdizadeh M. Basic Clin Neurosci. 4861 Jan;2(6):26-46.

62. Evaluation of anaplastic lymphoma kinase (ALK) expression in nonsmall cell

lung cancer; a tissue microarray analysis. Raheleh Roudi,Gholamreza Haji, Zahra

Madjd, Ahmad Shariftabrizi, Mitra Mehrazma. Journal of Cancer Research and

Therapeutic. 4861

6102

64. Comparative gene-expression profiling of CD622+ and CD622- D68 melanoma

cells. Roudi R, Ebrahimi M, Sabet MN, Najafi A, Nourani MR, Fomeshi MR,

Samadikuchaksaraei A, Shariftabrizi A, Madjd Z. Future Oncol (IF=4.1). 4861

Aug 6486-66 (Corresponding author)

61. A new insight into cancer stem cell markers: Could local and circulating cancer

stem cell markers correlate in colorectal cancer? Mirzaei A, Tavoosidana G, Rad

AA, Rezaei F, Tavakoli-Yaraki M, Kadijani AA, Khalili E, Madjd Z.Tumour

Biol. 4861 Sep 62

61. Comparative expression analysis of putative cancer stem cell markers CD44 and

ALDH6A6 in various skin cancer subtypes, Elham Erfani6, Raheleh Roudi,

Azadeh Rakhshan, Mehrdad Nasrollahzadeh Sabet, Ahmad Shariftabrizi, Zahra

Madjd, Int J Biomedical Markers.4861. (Corresponding author)

62. A Simple, Rapid, and Efficient Method for Isolating Mesenchymal Stem Cells

from the Entire Umbilical Cord. Dehkordi MB, Madjd Z, Chaleshtori MH,

Meshkani R, Nikfarjam L, Kajbafzadeh A. Cell Transplant. 4861 Aug

64(Corresponding author)

69. PI2K/Akt inhibition and down-regulation of BCRP re-sensitize MCF2 breast

cancer cell line to mitoxantrone chemotherapy. Komeili-Movahhed T, Fouladdel

5

S, Barzegar E, Atashpour S, Hossein Ghahremani M, Nasser Ostad S, Madjd Z,

Azizi E.Iran J Basic Med Sci. 4861 May;69(1):424-2.

64. Differential expression of cancer stem cell markers ALDH6 and CD622 in

various lung cancer subtypes, Raheleh Roudi, Alireza Korourian, Ahmad

Shariftabrizi, and Zahra Madjd. Cancer Invest (IF=4.81). 4861 Jun 1. (

corresponding Author)

48. Study of NGEP expression in androgen sensitive prostate cancer cells: A potential

target for immunotherapy. Mohsenzadegan M, Tajik N, Madjd Z, Shekarabi M,

Farajollahi MM. Med J Islam Repub Iran. 4861 Jan 62;448614

46. Study of NGEP expression pattern in cancerous tissues provides novel insights

into prognostic marker in prostate cancer. Mohsenzadegan M, Shekarabi M,

Madjd Z, Asgari M, Abolhasani M, Tajik N, Farajollahi MM. Biomark Med

(IF=4.1). 4861; 4(4):246-486.

44. Effect of Copper Sulfate on Expression of Endogenous L6 Retrotransposons in

HepG4 Cells (Hepatocellular Carcinoma).Karimi A, Majidzadeh-A K, Madjd Z,

Akbari A, Habibi L, Akrami SM. Biol Trace Elem Res (IF=6.1). 4861

Jun;611(4):626-4.

42. Upregulation of circulating cancer stem cell marker, DCLK6 but not Lgr1, in

chemoradiotherapy-treated colorectal cancer patients. Mirzaei A, Tavoosidana G,

Modarressi MH, Rad AA, Fazeli MS, Shirkoohi R, Tavakoli-Yaraki M, Madjd Z.

Tumour Biol. (IF=4.9) 4861 Jan 44. (Corresponding author)

6104

44. Tissue microarrays, a revolution in pathology research, Elham Kalantari , Zahra

Madjd, BCCR, 4864. ( Corresponding author).

41. Prognostic relevance of putative cancer stem cell marker, CD44 in different

histological sub-types of lung cancer. Raheleh Roudi, Zahra Madjd, Alireza

Korourian, Mitra Mehrazma, Ahmad Shariftabrizi, SaadatMolanae. Cancer

Biomarkers 64 (4864) 412–412 (IF= 6.69) ( Corresponding author).

41. Co-Expression of Putative Cancer Stem Cell Markers, CD622 and Nestin, in Skin

Tumors. Mehrdad Nasrollahzadeh Sabet , Azadeh Rakhshan , Elham Erfani ,

Zahra Madjd, Asian Pac J Cancer Prev, 61 (64), 9616-9614. (IF= 6.42) (

Corresponding author

42. Tissue Microarray-based investigation PLAC6 expression in Prostate Carcinoma.

Roya Ghods, Mohammad Hossein Ghahremani, Zahra Madjd , Mojgan Asgari

Maryam Abolhasani, Sanaz Tavassoli , Ahmad Reza Mahmoudi, Mahmood

Jeddi-Tehrani, Maryam Darzi, Amir-Hassan Zarnani, Cancer Immunology

Immunotherapy (IF=2.44), 4864 Sep 4.

49. A comparative study of mesenchymal stem cell transplantation with its paracrine

effect on control of hyperglycemia in type 6 diabetic rats. Aali E,

Mirzamohammadi S, Ghaznavi H, Madjd Z, Larijani B, Rayegan S, Sharifi AM.J

Diabetes Metab Disord. 4864 Aug 66;62(6):21. doi: 68.669114416-1196-62-21.

44. Exposure of hepatocellular carcinoma cells to low-level As4O2 causes an extra

toxicity pathway via L6 retrotransposition induction. Karimi A, Madjd Z, Habibi

L, Akrami SM. Toxicol Lett( IF=2.1). 4864 Jun 46; 444(6):666-662.

6

28. Evaluating the Extent of LINE-6 Mobility Following Exposure to Heavy Metals

in HepG4 Cells. Karimi A, Madjd Z, Habibi L, Akrami SM. Biol Trace Elem

Res (IF=6.1). 4864 Jul;618 (6):642-16. 4864 Jun 1. ( Corresponding Author)

26. Expression of Ki-12, p12 and VEGF in pediatric neuroblastoma. Gheytanchi E,

Mehrazma M, Madjd Z. Asian Pac J Cancer Prev ( IF=6.42). 4864; 61 (2):

2811-28.

24. ALDH6 in combination with CD44 as putative cancer stem cell markers are

correlated with poor prognosis in urothelial carcinoma of the urinary bladder.

Keymoosi H, Gheytanchi E, Asgari M, Shariftabrizi A, Madjd Z. Asian Pac J

Cancer Preventation (IF=6.42). 4864; 61(1):4862-48. (Corresponding author)

33. Expression of EMSY, a novel BRCA4-link protein, is associated with lymph

node metastasis and increased tumour size in breast carcinomas. Zahra Madjd,

Mohammad E. Akbari; Amir Hassan Zarnani, Maryam Khayam zadeh, Elham

Kalantari, Nazanin Mojtabavi., Asian Pacific J Can Prevention( IF=6.42),

Volume 64, Issue 4 (Corresponding author)

6103

24. The expression of p12 and MDM4 in oral, laryngeal and cutaneous squamous

cell carcinoma: A comparative study by tissue microarray Sami Jabar, Seta

Sarkis, Zahra Madjd, Elham Kalantari, European Scientific Journal, December

4862

21. CD44 and CD44 markers cannot act as cancer stem cell markers in human lung

adenocarcinoma cell line A144. Raheleh Roudi. Marzieh Ebrahimi, Ali

Samadikuchaksaraei, Zahra Madjd. CELLULAR & MOLECULAR

BIOLOGY LETTERS (IF=6.4), 62 Dec 4862. (Corresponding author)

21. Evaluation of methylation of MGMT (O1- methyl guanine methyltransferase)gene

promoter by Methylation Specific-PCR in meningiomas with atypical features

and its comparison between tumor grades I, II, and III, Leila Larijani, Zahra

Madjd et al, accepted to be included in Asian Pacific J Can Prevention (

IF=6.42), Volume 64, Issue 4.

22. Expression of prostate stem cell antigen (PSCA) in prostate cancer; a tissue

microarray study of Iranian patients. Jaleh Taeb, Mojgan Asgari, Maryam

Abolhasani, Mohammad M Farajollahi, Zahra Madjd. Pathol Res Pract (

IF=6.4). 4862 Oct 66 ( Corresponding author)

29. Reduced expression of NGEP is associated with high grade prostate cancers: a

tissue microarray analysis. Monireh Mohsenzadegan , Zahra Madjd, Mojgan

Asgari, Maryam Abolhasani, Mehdi Shekarabi , Jaleh Taeb, Ahmad

Shariftabrizi, Cancer Immunology Immunotherapy, Cancer Immunology

Immunotherapy ( IF=2.44). 4862 Oct; 14 (68) ( Corresponding author)

7

24. Application of Stem Cells in Targeted Therapy of Breast Cancer: A Systematic

Review. Madjd Z, Gheytanchi E, Erfani E, Asadi-Lari M. Asian Pac J Cancer

Prev. 4862;64(1):4294-4988. (Corresponding Author)

48. Chronic Ritalin Administration during Adulthood Increases Serotonin Pool in Rat

Medial Frontal Cortex.Daniali S, Nahavandi A, Madjd Z, Shahbazi A, Niknazar

S, Shahbazzadeh D. Iran Biomed J. 4862 Jul;62(2):624-4.

46. Expression of stem cell markers, CD622 and CD44 in pediatric solid tumours, a

study using Tissue microarray. Mitra Mehrazma, Zahra Madjd, Elham Kalantari,

Mahshid Panahi, Alireza Hendi. Fetal Pediatr Pathol. 4862 Jun; 24(2):644-484.

( Corresponding author)

6106

44. High expression of stem cell marker ALDH6 is associated with mutated

BRCA6in invasive breast carcinomas, Zahra Madjd, Babak Ramezani , Mohsen

Asadi Lari, Saadat Molanae, Asian Pac J Cancer Prev. 4864;62(1):4422-9

(Corresponding Author)

42. Do clinical and demographic features of patients with upper-gastrointestinal

cancer affect their health-related quality of life? Ali Esmaili-Hesari, Fatemeh

Homai, Abbas Motevallian, Zahra Madjd, Masoud Solaymani-Dodaran, Mohsen

Asadi-Lari. Int J Prev Med. 4864 Nov; 2(66):292-48.

44. The clinicopathologic association of c-MET overexpression in Iranian gastric

carcinomas; an immunohistochemical study of tissue microarrays. Sotoudeh K,

Hashemi F, Madjd Z, Sadeghipour A, Molanaei S, Kalantari E. Diagn Pathol.

4864 May 49; 2812.

41. Apelin-62 Protects the Brain Against Ischemic Reperfusion Injury and Cerebral

Edema in a Transient Model of Focal Cerebral Ischemia. Khaksari M, Aboutaleb

N, Nasirinezhad F, Vakili A, Madjd Z. J Mol Neurosci. 4864 Sep;49(6):486-9.

6100

41. Occult Hepatitis C Virus Infection in Iranian Patients with Chronic Liver Disease

with Unknown Etiology, Farah Bokharaei Salim, Hossein keyvani, Seyed Moayed

Alavian, Seyed Hamid Reza Monavari, Zahra Madjd, Mohsen Nasiri Tousi,

Amir Houshang Alizadeh, Journal of Medical Virology, 4866, June (IF=4.1).

42. Neuroprotective Effect of Exogenous Melatonin on Dopaminergic Neurons of the

Substantia Nigra in Ovariectomized Rats. Fereshteh Mehraein, Reza Talebi,

Behnamedin Jameie, Mohammad Taghi Joghataie and Zahra Madjd, Iranian

Biomedical Journal 61 (6 & 4): 44-18 (April & January 4866).

49. BRCA6 protein expression level and CD44+ phenotype in breast cancer patients.

Zahra Madjd, Adel Karimi, Saadat Molanae, Mohsen Asadi-Lari. CELL

JOURNAL (Yakhteh), Vol 62, No 2, Autumn 4866 ( Corresponding Author)

8

44. Immunohistochemical localization of endothelial nitric oxide synthase in

testicular cells of men with non- obstructive azospermia, Khadijeh Foghi ,

Marefat Ghaffari Novin., Zahra Madjd, Tohid Najafi., Mohammad Hasan

Heidari., Abouzar Rostampour Yasoori. Iranian Journal of Reproductive

Medicine Vol.4. No.4. pp:422-498, Autumn 4866.

18. Expression of BRCA6 Protein in Invasive and In Situ Carcinomas and its

Relation with Marker of Breast Cancer Stem Cells (CD44) and Prognostic Factors

in Breast Cancer Patients. Madjd Z, Karimi A, Hashemi F, Molanae S, Razi

Journal of Medical Sciences Vol. 62, No. 98 & 96, Feb/Mar 4868-4866 ( In

Persian)

16. The immunohistochemical assessment of ALDH6 activity in breast cancer and

it’s correlation with pathologic features. Babak Ramezani, Zahra Madjd, Maryam

Kadivar, Saadat Molanae. Tehran University Medical Journal; Vol. 14, No. 4,

December 4866: 144-121( In Persian)

6112

14. CD44+ cancer cells express higher levels of the anti-apoptotic protein Bcl-4 in

breast tumours.Madjd Z, Zare Mehrjerdi A, Sharifi A , Molanaei S, Zohourian S,

Asadi Lari M. Cancer Immunity. April 4884.vol4.p4.

12. The Concept of Palliative Care Practice among Iranian General Practitioners.

Asadi-Lari M, Madjd Z, Afkari ME, Goushegir A, Baradaran HR. . Iranian

Journal of Cancer Prevention. Vol.4, No 2, summer 4884.

14. OCT4, an embryonic stem cell marker, is expressed in breast, brain and thyroid

carcinomas compared to testicular carcinoma. Madjd Z, Hashemi F, Shayanfar N,

Farahani E , Zarnani AH, Sharifi AM. Iranian Journal of Cancer Prevention.

Vol.4, No 4, autum 4884.

6112

11. The need for palliative care services in Iran; an introductory commentary. Asadi-

Lari M, Madjd Z, Akbari ME. Iranian Journal of Cancer Prevention. Vol.6, No6,

6-1, .4889. Jan

11. Spiritual care at the end of life in the Islamic context, a systematic review, Asadi-

Lari M, Madjd Z, Gooshegir. Iranian Journal of Cancer Prevention. Vol.6, No 4,

July 4889.

12. Gaps in the provision of spiritual care for terminally ill patients in Islamic

societies, a systematic review. Mohsen Asadi-Lari, Zahra Madjd, Sayyed

Ashrafeddin Goushegir. Advances in Palliative Medicine 4889, 22–98.

6112

9

19. The ubiquitin-binding protein p14 is expressed in breast cancers showing features

of aggressive disease. Rolland P, Madjd Z, Durrant L, Ellis IO, Layfield R,

Spendlove I. Endocrine Related Cancer (IF: 1.642). 4882 Mar;64(6):22-98.

14. Up-regulation of MICA on high-grade breast carcinomas. Madjd Z, Pinder SE,

Spendlove I, Watson NFS, Moss R, Bevan S, Durrant LG. Cancer immunity,

4882

6112

18. Expression of the stress related protein MICA is an independent indicator of good

prognosis in colorectal cancer patients. Watson NFS, Spendlove I, Madjd Z,

Moss R, Green A, Ellis IO, Durrant LG, Scholefield JH. International J Cancer

(IF: 1.882). 4881 Mar 61; 669(1):6441-14.

16. Cytoplasmic expression p42 KIP-6 is associated with a favourable prognosis in

colorectal cancer patients. NFS Watson, LG Durrant, JH Scholefield, Z Madjd,

D Scrimgeour, I Spendlove, IO Ellis, PM Patel. World J Gastroenterology

(IF=4.422). 4881 Oct 46,64(24).

14. The p12 Positive Bcl-4 Negative Phenotype is an independent marker of

prognosis in breast cancer. Phil Rolland, Ian Spendlove, Zahra Madjd, Emad A

Rakha, ,Patel Poulam, Ian O. Ellis, Lindy Durrant. International J Cancer (IF:

1.882), 44 Dec 4881 .

12. Immunosurveillance is active in colorectal cancer as downregulation but not

complete loss of MHC Class I expression correlates with a poor prognosis in early

stage patients. Watson NFS, Ramage J, Madjd Z, Spendlove I, Ellis IO,

Scholefield J, Durrant LG. Int J Cancer (IF: 1.882) . 4881 Jan 6; 669(6): 1-68.

6112

14. Evidence that the p12 negative / Bcl-4 positive phenotype is an independent

indicator of good prognosis in colorectal cancer: A tissue microarray study of 418

patients. Watson NFS, Madjd Z, Ellis IO, Scholefield J, Spendlove I. Durrant

LG. World J Surg Oncology (IF: 6.48). 4881 Jul 64; 2842.

11. Expression of the Membrane Complement Regulatory Protein CD14 (Protectin) is

Associated with Reduced Survival in Colorectal Cancer patients. Watson NFS,

Durrant LG, Madjd Z, Ellis IO, Scholefield J, and Spendlove I. Cancer

Immunology Immunotherapy (4882 IF: 2.44) . 4881 Sep 2;6-9

11. Over-expression of Lewis y/b antigens is associated with decreased survival in

lymph node negative breast carcinomas. Madjd Z, Parsons T, Watson NFS,

Spendlove I, Ellis IO and Durrant LG. Breast Cancer Research. (IF: 1.99);

2(1):R298-2. 4881 Jul 49.

12. Do poor prognosis breast tumours express membrane cofactor proteins (CD41)?

Madjd Z, Durrant LG, Pinder SE, Ellis IO, Ronan J, Rushmere NK and

Spendlove. Cancer Immunology Immunotherapy (IF: 2.44), 4881;14(4):644-11

01

19. Total loss of MHC class I molecules is an independent indicator of good

prognosis in breast cancers. Madjd Z, Pinder SE, Spendlove I, Ellis IO, and

Durrant LG. International J Cancer (IF: 1.882). 4881 Nov 6; 662(4): 449-11.

6113- 6114

14. Loss of CD11 is associated with aggressive breast tumours. Madjd Z, Durrant

LG, Bradley R, Spendlove I, Ellis IO, Pinder SE. Clinical Cancer Research

(IF: 9.642), 4884, 68: 4242-4982

28. Loss of CD14 expression in breast tumours correlates with poor survival. Madjd

Z, Pinder S E, Paish C, Ellis IO, Carmichael J, Durrant L G. J Pathology.(IF:

2.22), 4882, 488: 122-124.

Book:

6. Cancer and Immune system in "Iran Cancer Report", in Farsi, 4889, By

Cancer Research Centre, Shahid Beheshti University of Medical Sciences

4. Tissue Microarrays, Evolutionary in Pathology Research, in Farsi, 4884, By

Oncopathology Research Centre, IUMS

2. What we should know about Breast Cancer, hundreds questions and answers

about Breast cancer , in Farsi, 4868, Oncopathology Research Centre, IUMS

4. Complement Regulatory Proteins in Breast Cancer, Madjd Z and Durrant LG

In English, 4868, ISBN (429-2-9292-2214-4), published by LAP LAMBERT

Academic Publishing AG & Co. KG, Germany, Distribution by Amazon.

www.amazon.com

Supervision of PhD/ MSc / resident (SpR) projects

6. Evaluation of biological characteristics and telomerase activity in cancer stem

cells (CSCs) compared with non- CSCs (low tumorogenic cells) in renal cancer

(supervisor of PhD, IUMS)

4. The effect of silencing of transcription factor SMAD4 on stemness characteristics

of cancer stem cells compared with non- CSCs (low tumorogenic cells) in renal

cancer (supervisor of PhD, IUMS)

2. Gene expression and protein detection of cancer stem cells of Melanoma, skin

squamous cell and basal cell carcinoma compared to non-tumorogenic cells using

cDNA microarrays and tissue microarrays (supervisor of PhD, Molecular

Medicine, IUMS)

4. Comparison of gene expression and protein detection of cancer stem cells

(Tumorigenic) with non-tumorigenic lung cancer cells (supervisor of PhD,

Molecular Medicine, IUMS)

1. Molecular imaging of prostate cancer by magnetic nanoprobes conjugated anti-

PSCA antibody and assessment of PSCA expression in prostate cancer tissues

(supervisor of PhD, Molecular Medicine, IUMS)

00

1. Analysis the induction of L6 Retrotransposon and toxicity by heavy metals on

NSCs (H4 hESC-Derived) (second supervisor of PhD, Molecular Medicine,

IUMS)

2. In vitro study of the role of microRNA-26 (miR-26) in mediating 1-FU

chemoresistance and metastasis of gastric cancer cell line (AGS) (supervisor of

PhD, Molecular Medicine, IUMS)

9. Differentiation of umbilical cord stem cells into Germ cells (second supervisor of

PhD, Molecular Medicine, Tehran University of Medical sciences)

4. Application of colorectal cancer stem cell markers (DCLK6 و Lgr1) in blood and

tissue to monitor the patients, using Ligand Proximity Assay (supervisor of PhD,

Molecular Medicine, Tehran University of Medical sciences)

68. Clinical significance of ALDH6 and CD44 as cancer stem cell markers in Bladder

carcinomas (Supervisor of resident (SpR) of Pathology, IUMS)

66. Investigation of OCT4, as an embryonic stem cell marker and its correlation with

clinicopathological parameters in bladder carcinomas (Supervisor of resident

(SpR) of Pathology, IUMS)

64. Methylation of promotogene MGMT(O1- methyl guanine methyl transferase) in

Atypic Meningioma compared to Grade I, II and III tumours (supervisor of MSc,

Genetic , Azad University, finished)

62. Expression of BRCA6 protein and its relation with markers of breast cancer stem

cells (CD44) and prognostic factors in breast cancer patients ( Supervisor of

resident (SpR) of Pathology, IUMS, finished)

64. Immunohistochemical assessment of ALDH6enzyme activity as a functional

marker of stem cells and precursor cells of breast (Supervisor of resident (SpR) of

Pathology, IUMS, finished)

61. Study of expression of OCT4 using immunohistochemistry and its association

with clinicaopathological features of bladder transitional cell carcinoma

(Supervisor of resident (SpR) of Pathology, IUMS, finished)

Advisor of PhD/ MSc / resident (SpR) projects:

6. Targeting extracellular domain of NGEP using polyclonal antibody in prostate cancer

(advisor, PhD of Immunology, IUMS)

4. Molecular study of effect of siRNA on expression and function of BCRP and the role

of PI2K/AKT pathway in reducing drug resistance to Mithoxantron in stem cell and

non stem cells of breast and colorectal cancer cell lines (MCF2, HT44) (advisor, PhD

of Molecular Medicine, TUMS)

2. Investigation of abuse of Ritalin on medial frontal cortex of male rat (advisor, PhD of

Physiology, IUMS)

4. The effect of Apelin-62 on brain damage, brain edema and neurologic disorders in

ischemic model of brain infarction of male rat (advisor, PhD of Physiology, IUMS)

1. Studying the Co-administration of GCSF and Mesenchymal stem cell in STZ-

induced diabetes in rat(advisor, PhD of Pharmacology, IUMS)

1. Immunohistochemical expression of C-MET in Gastric Adenoma carcinomas in

patients referring to Rasool- Akram and Firozgar hospitals between years 6292-6299

using Tissue Microarray (advisor, resident (SpR) of Pathology, IUMS)

02

2. Determination of MGMT promoter hypermethylation in meningioma grade 6,4,2

using tissue microarray (advisor, resident (SpR) of Pathology, Shahid Beheshti

University of Medical sciences)

9. Clinicopathologic features of meningioma in correlation with ER, PR, Ki12, P12 and

Her4/neu, using tissue microarray (TMA)

4. Clinicopathologic features of Craniopharyngioma in correlation with TMA of ER,

PR, Ki12, P12 and Her4/neu

68. The nueroprotective effects of melatonin on the nerve toxicity caused by beta

amyloidal and NF-kB of the rat model (advisor, PhD of Neurosciences, IUMS)

66. Study of the nueroprotective effects of exogenous melatonin on the dopaminergic

neurons of the substantia nigra of the rat menopausal model (advisor, MSC of

Anatomy, IUMS)

64. Expression of esoform of enos in testis of obstructive azoespermia compared to

non-obstructive azoespermia male ( advisor, MSc of Anatomy, Shahid Beheshti

Medical University)

Teaching lectures in Tehran University of Medical Sciences:

6. For undergraduate students (Medical students): General pathology

4. For post graduate students (PhD and MSc students): Molecular basis of cancer,

advanced immunology, cancer immunology, general pathology, molecular techniques,

immunohistochemistry, CISH

PREVIOUS TEACHING EXPERIENCE:

6) Supervision of clinical research fellow (surgery) for study of prognostic factors in

colorectal tissue microarray, University of Nottingham: 4881

4) Supervision of clinical research fellow (gynaecology) for study of prognostic factor in

breast tissue array, University of Nottingham: 4881

2) Supervision of MSc student (oncology) for making breast tissue array and study of

prognostic factors in breast tumours, University of Nottingham: 4881

4) Demonstration for BioMed Science students, University of Nottingham: 4884

1) Demonstration for pharmacy students, University of Nottingham: 4884

1) Supervision of undergraduate students for lab skills in the Department of Clinical

Oncology during PhD course: 4886-4884

2) Short courses for administrative and health professionals in the Department of School

Health: 6444

9) Running workshops and short courses for health allies in health centres

Teaching in the following workshops:

1) Occupational Cancers, TUMS, 44 Oct 4881

2) Immunohistochemistry and Tissue microarray, Annual Pathology Congress, Nov

4881

3) How to write your thesis, Nursing PhD students, Nov 4882

4) End note , reference manager, in Royan Institue, Nov 4882

5) Cancer stem cell workshop, Cellular Molecular Research Centre, Feb 4868

03

Career Development Fellowship, Post doctorate Scientist, University of Cambridge,

Addenbrock's Hospital, MRC Dunn Human Nutrition Unit, Diet and Cancer research

group

Outline of study: DNA adducts, differences in gene expression and DNA damage and

histochemistry of tumour samples

Post-doctoral Research Fellow

University of Nottingham, City Hospital, Dep. Of Clinical Oncology

Outline of study: Study of immune-surveillance pathway in Breast tumours

Research Experience

A) MD dissertation:

Supervisor: Professor Freidoon Azizi

“Characteristics of thyroid disorders before and after iodized salt consumption in Tehran

during 6442-1”.

This study was conducted among patients with thyroid disorders referred to a major

Thyroid Referral Centre consisting a population of 64888 patients, that was presented in

oral season in 4th International Congress of Endocrine Disorders, Tehran Nov 6441.

B) PhD projects:

Expression of complement regulatory proteins (CIPs) and MHC class I molecules in

breast carcinomas. These antigens (CIPs) are targets for monoclonal antibody therapy

(mab), as over-expression of CIPs limits the effectiveness of mab therapy.

DETAILS OF RESEARCH EXPERIENCE of PhD:

6. Immunohistochemstry ( single and Double staining)

4. Preparing Tssue Microarray

2. CISH technique (chromatin in situ hybridization)

4. Tissue culture (a variety of cell lines derived from solid tumours)

1. Producing monoclonal antibody from hybridoma

1. ELISA:

2. FACS (Flow cytometry):

9. SDS polyacrylamide gel electrophoresis (SDS-PAGE) and Western-Blotting:

4. RT-PCR

COURSES during Phd

6. Multi Disciplinary Course on Breast Disease, Nottingham Breast Institute. 4881.

4. Core of Knowledge (laser/IPL therapy), Laser Training &Education Centre, 4881.

2. Leicester/ Nottingham MRCPath Teaching Course (Sep-Dec 4884)

4. Prognostic Testing in Cancer, BIR, London, 2 Nov 4884 (1 CPD Credits)

1. Summer school: Cancer Research at Nottingham Summer School and European

Association for Cancer Research Symposium, Nottingham, 4884 (64 CPD Credits)

2. 02th EACR meeting, July 4884, Innsbruck, Austria (44 credit points).

2. Courses in MSc Oncology (University of Nottingham), 6110-6116

Diagnostic Pathology of Cancer (61 credits)

Techniques in Cellular and Molecular Biology (61 credits)

Tumour physiology and immunology (68 credits)

04

2. Intensive course in English and study Skills

Full-time English Language and Study Skills Course at Centre for English Language

Education (CELE), University of Nottingham, for 2 months, September 4888-December

4888.

2. Several Short term courses (University of Nottingham): 6110-6113

ABSTRACTS AND CONFERENCE PROCEEDINGS

6. Madjd Z, Asadi-Lari M, Azizi F. Characteristics of thyroid disorders before and after

iodized salt consumption. Proceeding of 4th International Congress on Endocrine

Disorders, Nov 6441

4. Madjd Z, Pinder S, Ellis I O, Carmichael J, Durrant LG. CD14 and CD11 as

independent indicator of poor prognosis in breast cancer patients. British J of

Cancer. 22, 6116.

2. Madjd Z, Spendlove I, Pinder SE, Moss R, Bradley R, Durrant L. Expression of

complement regulatory proteins CD11 and CD14 on breast cancer. Clinical Cancer

Research, 6113 proceeding of the AACR.

4. Madjd Z, Pinder SE, Spendlove I, and Durrant LG. Expression of CD11 (Decay

Accelerating Factor) in breast carcinomas and its prognostic significance.

Immunology Letters. 6113, 22, P:612 (Abstracts of the 61th European

Immunology Congress (EFIS 4882).

1. Madjd Z, Pinder SE, Spendlove I and Durrant LG. Unexpectedly loss of CD11 and

CD14 is associated with aggressive breast tumours. FASEB Journal, Vol.02, Issue

2, 6113. (4882 Proceeding of the AAI).

1. Madjd Z, Pinder SE, Spendlove I, Durrant LG. Prognostic value of complement

regulatory proteins CD11 and CD14 in breast cancer. British J Cancer. Supplement

July, 6113.

2. Madjd Z, Pinder SE, Spendlove I, Durrant LG. Which complement regulatory

proteins could be a good target for a breast cancer vaccine? European J Cancer. Vol

0 No 2, Sep 6113.

9. Madjd Z, Bevin S, Spendlove I, Moss R, Durrant LG. Expression of MHC class I-

related molecule MICA in breast carcinomas and its prognostic significance.

Immunology. Supplement. December 6113.

4. Madjd Z, Spendlove I, Pinder SE, Rushmere NK, Morgan BP and Lindy G Durrant.

Expression of membrane cofactor protein (CD41) on breast tumours. Clinical

Cancer Research, 6114 proceeding of the AACR.

68. Madjd Z, Pinder SE, Spendlove I, Moss R, Bevin S, Durrant LG. Up-regulation of

stress inducible MICA on high-grade breast carcinomas. Supplement Cancer

Detection and Prevention Strategy, Jan 6114.

66. Madjd Z, Pinder S E, Spendlove I, Ellis I O, and Durrant L G. Unexpected up

regulation of MHC class I molecules in poor prognosis breast cancer. British J

Cancer. Supplement June 6114. [presented orally in BCRM, 4884, Manchester]

64. Madjd Z, Pinder S E, Ian Spendlove, John Ronan and Lindy G Durrant. Loss of

MHC class I molecules in breast tumours results in susceptibility to natural killer cell

activation. European J Cancer, Supplement, July 6114.

62. Madjd Z, Pinder S E, Spendlove I, Ellis I O, and Durrant LG. Loss of HLA class I is

associated with good prognosis in breast cancer patients. Proceeding of BIR, Nov

6114. [presented orally in Prognostic Testing in Cancer, BIR, London, Nov 4884]

05

64. Madjd Z, Pinder S E, Spendlove I, Ellis I O, and Durrant LG. Loss of MHC Class I

is an independent indicator of good prognosis in breast Cancer. Proceeding of

AACR, 6112. 61. Madjd Z, Spendlove I, Ellis IO, Parsons T, and Durrant LG. Prognostic significance

of SC686, a monoclonal Antibody against Lewisy/b in breast tumours. Proceeding of

AACR, 6112. 61. Madjd Z, Pinder S E, Spendlove I, Ellis IO, and Durrant LG. Prognostic significance

of membrane cofactor protein (CD41) on breast tumours. Immunology 6114, 003

(S0), British Society for Immunology, Harrogate 6114 . 62. Watson NFS, Scholefield J, Madjd Z, Green A, Moss R, Spendlove, Ellis IO,

Durrant LG. Prognostic value of MICA expression in colorectal carcinoma.

Immunology 6114; 003: (s0) late supplement. British Society for Immunology,

Harrogate 6114 . 69. NFS Watson, JH Scholefield, Z Madjd, A Green, R Moss, I Spendlove, IO Ellis and

LG Durrant. Prognostic value of MICA expression in colorectal carcinoma. The

Ninety-Ninth Annual General Meeting of the Physicians of Great Britain and Ireland,

Nottingham, April 6112 . 64. NFS Watson, I Spendlove, Z Madjd, R Moss, A Green, IO Ellis, LG Durrant, JH

Scholefield. The prognostic significance of MICA expression in colorectal cancer: An

immunohistochemical study using prognostic tissue microarrays. The association of

coloproctology of Great Britain and Ireland, The Royal Dublin Society, 2-2 July

6112 (oral). 48. Zahra Madjd, Ahmad Al-Attar, Nicholas FS Watson Ian Spendlove, Ian Ellis and

Lindy G Durrant.High expression of SC686 antibody is associated with decreased

survival in lymph node negative carcinomas. ncri. October 4881. Birmingham

46. Zahra Madjd, Ahmad Al-Attar, Nicholas FS Watson Ian Spendlove, Ian Ellis and

Lindy G Durrant Stat6 expression is an independent indicator of prognosis in lymph

node positive carcinomas. ncri. October 4881. Birmingham

44. Zahra Madjd, Ahmad Al-Attar, Nicholas FS Watson Ian Spendlove, Ian Ellis and

Lindy G Durrant. Prognostic significant of IFN receptor (IFNGR6) in breast

carcinomas. ECCO 62. Paris NOV 4881

42. Ahmad Al-Attar, Zahra Madjd, Nicholas FS Watson, Ian Spendlove, Duncan

Scrimgeour, Ian Ellis and Lindy G Durrant. Co-expression of P42 kip6/p46 is an

independent indicator of good prognosis in lymph node positive breast carcinomas.

ECCO62. Paris NOV 4881

44. NFS Watson, Z Madjd, D Scrimgeour, A Al-Attar, I Spendlove, IO Ellis, JH

Scholefield and LG Durrant Cytoplasmic p42 KIP-6 expression is an indicator of good

prognosis in colorectal carcinomas. ECCO62. Paris NOV 4881

41. NFS Watson, R Moss, Z Madjd, I Spendlove, JH Scholefield and LG Durrant.

Prognostic impact of Stat6 expression in colorectal cancer patients. Immunology

4881, British Society for Immunology, Harrogate, Dec 4881

41. Madjd Z, Hashemi F, Kadivar M, Rakhshani N, Asadi Lari. Prevalence of cancer

stem cells and its association with ER, PR and Erb4 in breast cancer patients.

European Conference on Cancer and Ageing Warsaw, Poland, October 4-1, 4882

42. Madjd Z, Zare Mehrjerdi A, Sharifi A, Molanaei S, Zohoorian S, Sadeghipour A,

Asadi Lari M. Can breast cancer stem cells resist apoptosis through the regulation of

06

Bcl4? An immunohisochemistry study of 488 breast tumours. Iranian Congress of

Pathology. Nov 6112.

49. Madjd Z, Durrant LG, and Pinder SE. Can complement regulatory proteins use as a

target for cancer vaccine in breast cancer patients? APCC, Dec 4882.

CONFERENCES

6. British Association of Cancer Research, July 4886, Leeds

4. British Association of Cancer Research, July 4884,Glasgow

2. Progress in vaccine against Cancer (PIVAC), July 4884, Nottingham

4. American Association of Cancer Research, March 4882.

1. 61th European Immunology Congress (EFIS), 4882.

1. American Association of Immunology (AAI), May 4882

2. British Association of Cancer Research (BACR), July 4882, Bournemouth

9. Federation of European Cancer Societies (FECS), ECCO 64, September 4882,

Copenhagen.

4. British Society of Immunology (BSI) December 4882, Harrogate.

68. American Association of Cancer Research (AACR) March 4884, Orlando

66. Cancer Detection and Prevention Strategy, Jan 4884, Nice, France.

64. British Cancer Research Meeting (BCRM), Manchester, June 4884.

62. European Association of Cancer Research (EACR), July 4884, Innsbruck, Austria.

64. NCRI (National Cancer Research Institute), Birmingham, Oct 4881.

61. ECCO62 (European Cancer Conference), Paris, Nov 4881.

61. International Royan Congress, Sep 4881, TehranInternational Royan Congress, Sep

4881, Tehran

62. Second Congress of Breast, 4-68 Nov, 4881, Tehran

69. 9thCongress of Iranian Society of Pathology, 4-4 Nov 4881, Tehran

64. CD14 as an independent indicator of poor prognosis in breast carcinomas , a tissue

microarray study of 148 patients, presented in 9thCongress of Iranian Society of

Pathology , 4-4 Nov 4881, Tehran

48. Breast Cancer congress, Cancer Research Centre, Shahid Beheshti Universty of

Medical Sciences, Feb 4882.

46. Lectures in Pathology CME, Iran University of Medical Sciences, May 4882

44. Expression of Glycolipid Monoclonal Antibody, SC684, improved survival in

colorectal cancer patients, A tissue microarray study. Madjd Z, Watson NF, Ellis IO,

Durrant LG. The 4th annual Congress of Iranian Pathology, Nov 4882.

42. Can Breast Cancer Stem cells resist Apoptosis through the regulation of Bcl4?

Madjd z, Zare Mehrjerdi,.. The 4th annual Congress of Iranian Pathology, Nov 4882.

44. Can complement regulatory proteins use as a target for cancer vaccine in breast

cancer patients? Madjd Z, Durrant LG,Pinder SE, APPCC, Nov 4882

41. Will Cancer Stem cells use as a new target for cancer treatment? International

anatomy Conference, Cell therapy, May 4889

41. Lectures in Pathology CME, Iran University of Medical Sciences, May 4889

42. Cancer Stem cells resist Apoptosis through the regulation of Bcl4. EACR 48, Lyon,

France, July 4889

49. Human embryonic stem cell genes OCT4 and NANOG are expressed in breast, brain

and thyroid carcinomas compared to testicular carcinoma, 4th international breast

cancer conference, Feb 4884, Tehran

44. Prevalence of cancer stem cells and its association with clinical outcome and

prognostic factors in breast cancer patients, ncri, Birmengham, Oct 4884, UK

07

28. Expression of embryonic stem cell markers, OCT4 and NANOG, in breast, thyroid,

brain and colorectal carcinomas , ncri, Birmengham, Oct 4884, UK

26. The clinical significance of stem cell marker CD622 in pediatric solid tumours, a

study using Tissue microarray , Pathology congress, Tehran, Oct 4866.

24. High expression of stem cell marker, ALDH6 is associated with mutated BRCA6in

invasive breast carcinomas, 2 th NCRI (National Cancer Research Institute) Cancer

Conference, Nov 4866, UK

22. Expression and clinical significance of stem cell marker CD622 in pediatric solid

tumours, a study using Tissue microarray, 2 th NCRI Cancer Conference, Nov 4866,

UK

24. Do clinical and demographic features of patients with upper-gastrointestinal cancer

affect their health-related quality of life? 2 th NCRI Cancer Conference, Nov 4866,

UK

21. Analysis of EMSY, a novel BRCA4-link protein, in primary breast tumors; a study

using tissue microarray, Breast Cancer Conference, Shahid Beheshti Uni, Cancer

research centre, Tehran, Feb 4864

21. 64 th annual meeting of International Society for Stem Cell Research (ISSCR),

Vancouver, Canada, June 4864.