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J Nephrol. 2004 Jan-Feb;17(1):166-71.

The development of the clearance concept.

Seldin DW.

Department of Internal Me dicine , The University of Texas Southwestern Medical Sch ool, Dallas, Texas 75 390-9 030, USA.ann.welch@utsouthwestern.edu

Abstract

The clearance concept is central to three critical areas o f nephrology; it was a key feature to early conceptual analysis of

the nature of urine formation, it was utilized as a measure of kidney function in adva ncing renal disease s, and it was a

pivotal concept to elucidate the physiology of the kidneys. This paper describes the clearance concept as currently

understood and then it examines how clearance was utilized to understand these various aspects of kidney function.

PMID: 15151274 [Pub Med - in dexed for MEDLINE]

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