WORKSHOP SESSIONS DAY 3（October 30[Tue]） · 64 The 66th Annual Meeting of the Japanese Society...

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Virus Research Insight and Serendipity

WORKSHOP SESSIONS DAY 3（October 30［Tue］）

WORKSHOP SESSIONS DAY 3（October 30［Tue］）WorkshopRoom 1（1F Terrsa Hall） Day 3　October 30 [Tue]　12：50～13：50

Diversity and evolution 2Chairs：Shinya Suzu（ Centre for AIDS Research, Kumamoto University）

Yasumasa Iwatani（ Clinical Research Center, National Hospital Organization Nagoya Medical Center）

W3-1-01 Tracing the evolution of great ape lentiviruses focusing on the functional relationship between Vif and APOBEC3GYusuke Nakano1），Keisuke Yamamoto1），Andrew J Soper1），Kei Sato1,2,3），Yoshio Koyanagi1）

1）Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University，2）Division of Systems Virology, Institute of Medical Science, The University of Tokyo，3）CREST, JST

W3-1-02 HIV-1 group O Vif proteins counteract human A3D, A3F and A3H independently of DRMR and FH motifsKeisuke Yamamoto1），Yusuke Nakano1），Kei Sato1,2,3），Yoshio Koyanagi1）

1）Institute for Frontier Life and Medical Sciences, Kyoto University，2）CREST, JST, Saitama，3）Division of Systems Virology, Department of Infectious Disease Control, Institute of Medical Science, The University of Tokyo

W3-1-03 Impact of host HLA allele influencing HIV-1 pathogenesisIzumi Kimura1,2），Takamasa Ueno3），Kei Sato1,4,5），Yoshio Koyanagi1）

1）Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University，2）Graduate School of Pharmaceutical Sciences, Kyoto University，3）Center for AIDS Research, Kumamoto University，4）Division of Systems Virology, The Institute of Medical Science, University of Tokyo，5）CREST, JST

W3-1-04 New World feline APOBEC3 potently controls inter-genus lentiviral transmissionYoriyuki Konno1），Shumpei Nagaoka1,2），Izumi Kimura1,3），Keisuke Yamamoto1,4），Yumiko Kagawa1,5），Ryuichi Kumata1,6），Hirofumi Aso1,3），Mahoko Takahashi Ueda7），So Nakagawa7,8），Tomoko Kobayashi9），Yoshio Koyanagi1），Kei Sato1,10,11）

1）Laboratory of Systems Virology, Institute for Frontier Life and Medical Sciences, Kyoto University，2）Graduate School of Biostudies, Kyoto University，3）Graduate School of Pharmaceutical Sciences, Kyoto University，4）Graduate School of Medicine, Kyoto University，5）Faculty of Medicine, Kyoto University，6）Faculty of Science, Kyoto University，7）Micro/Nano Technology Center, Tokai University，8）Department of Molecular Life Science, Tokai University School of Medicine, Tokai University，9）Department of Animal Science, Faculty of Agriculture, Tokyo University of Agriculture，10）CREST, Japan Science and Technology Agency, Saitama, Japan，11）Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo

W3-1-05 Distinct role of the 182th amino acid residue between HIV-1 and HIV-2 capsids in CPSF6 bindingKyotaro Nohata1），Akatsuki Saito1），Hirotaka Ode2），Hisaki Ohmori1），Emi E Nakayama1），Yasumasa Iwatani2），Tatsuo Shioda1）

1）Research Institute for Microbial Diseases, Osaka University, Osaka, Japan，2）Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan

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The 66th Annual Meeting of the Japanese Society for Virology

WorkshopRoom 1（1F Terrsa Hall） Day 3　October 30 [Tue]　13：50～14：26

Acquired immunity and vaccines 5Chairs：Shigeyoshi Harada（ AIDS Research Center, National Institute of Infectious Diseases）

Hiroyuki Yamamoto（ AIDS Research Center, National Institute of Infectious Diseases）

W3-1-06 Characterization of neutralizing antibody responses induced in highly neutralization-resistant SIVmac239 infectionYoshiaki Kanno1,2），Takushi Nomura1），Trang Thi Thu Hau1,3），Tetsuro Matano1,2,3,4），Hiroyuki Yamamoto1）

1）AIDS Research Center, National Institute of Infectious Diseases，2）Graduate School of Medicine, University of Tokyo，3）Graduate School of Medical Sciences and Center of AIDS Research, Kumamoto University，4）The Institute of Medical Science, University of Tokyo

W3-1-07 Protective and non-protective MHC-I haplotype-associated CD8+ T-cell responses in simian immunodeficiency virus-infected rhesus macaquesTrang Thi Thu Hau1,2），Takushi Nomura1），Sayuri Seki1），Midori Nakamura-Hoshi1,4），Hiroshi Ishii1），Taeko K. Naruse3），Akinori Kimura3），Tetsuro Matano1,2,4），Hiroyuki Yamamoto1）

1）AIDS Research centre, National Institute of Infection Diseases, Japan，2）Graduate School of Medical Sciences and Center for AIDS research, Kumamoto University, Japan，3）Medical Research Institute, Tokyo Medical and Dental University, Japan，4）Institute of Medical Science, University of Tokyo, Japan

W3-1-08 In vitro sieving assay identifies amino acid residues in SIV Env that broadly affect neutralization sensitivityNami Iwamoto1），Jianfei Hu2），Amy Ransier2），Farida Laboune2），Rosemarie Mason1），Hugh Welles1），Daniel Douek2），Mario Roederer1）

1）ImmunoTechnology Section, Vaccine Research Center, NIAID, NIH, U.S.A.，2）Human Immunology Section, Vaccine Research Center, NIAID, NIH, U.S.A.


Acquired immunity and vaccines 6Chairs：Ai Tachikawa(kawana)（ AIDS Research Center, National Institute of Infectious Diseases）

Mari Kannagi（ Department of Immunotherapy, Tokyo Medical and Dental University）

W3-1-09 Functional analysis and characterization of HIV-specific chimeric antigen receptor (CAR)-T cellsJun-ichi Nunoya1），Lishan Su2），Michiaki Masuda1）

1）Department of Microbiology, Dokkyo Medical University，2）Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill

W3-1-10 Functional analysis of HIV-1 specific CTL rejuvenated by iPS cell technologyShoji Miki1），Yohei Kawai2），Shin Kaneko2），Kazutaka Terahara3），Yasuko Tsunetsugu-Yokota3），Tetsuro Matano1），Ai Kawana-Tachikawa1）

1）AIDS Research Center, National Institute of Infectious Diseases，2）Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University，3）Department of Immunology, National Institute of Infectious Diseases

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W3-1-11 Generation of HIV-1 polymorphism via coevolution of multiple HIV-1-specific T cells with HIV-1Tomohiro Akahoshi1），Hiroyuki Gatanaga1,2），Nozomi Kuse1），Takayuki Chikata1），Hayato Murakoshi1），Naoki Ishizuka3），Shinichi Oka1,2），Masafumi Takiguchi1,4）

1）Center for AIDS Research, Kumamoto University，2）AIDS Clinical Center, National Center for Global Health and Medicine，3）Clinical Trial Department, Cancer Institute Hospital，4）University of Oxford

W3-1-12 Selection of GagRI8 mutants by HLA-B*52:01-restricted GagRI8-specific CTLs controlling HIV-1 in HIV-1-infected Japanese individualsYu ZhangCenter for AIDS Research, Kumamoto University, Kumamoto, Japan


Acquired immunity and vaccines 7Chairs：Hirotomo Nakata（ Infectious disease, Kumamoto University Hospital）

Hiroshi Ishii（ AIDS Research Center, National Institute of Infectious Diseases）

W3-1-13 Crossreactivity of vaccine-induced CD8+ T cells targeting a Gag epitopeTakushi Nomura1），Kazutaka Terahara2），Hiroshi Ishii1），Hiroyuki Yamamoto1），Tomoyuki Miura3），Tetsuro Matano1,4）

1）AIDS Research Center, National Institute of Infectious Diseases, Japan，2）Department of Immunology, National Institute of Infectious Diseases, Japan，3）Institute for Frontier Life and Medical Sciences, Kyoto University, Japan，4）Institute of Medical Science, University of Tokyo, Japan

W3-1-14 Protective effects of immunization using urease-deficient BCG, vaccinia LC16m8d, and Sendai virus expressing SIV genesHisatoshi Shida5），Seiichi Kato1,2），Tomotaka Okamura1），Tetsu Mukai3），Makoto Inoue4），Tugumine Shu4），Tomoyuki Miura5），Yasuhiro Yasutomi1），Kazuhiro Matsuo2）

1）Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition，2）Japan BCG Laboratory，3）Leprosy Research Center, National Institute of Infectious Diseases，4）ID Pharma Co., LTD.，5）Institute for Frontier Life and Medical Sciences, Kyoto University

W3-1-15 Identification of novel HTLV-1 specific CD4 epitopes in ATL patients after hematopoietic stem cell transplantationUndrakh Ganbaatar1），Atsuhiko Hasegawa1），Yotaro Tamai1），Ryuji Tanosaki2），Yasuhiro Maeda3），Ilseung Choi4），Youko Suehiro5），Mari Kannagi1）

1）Department of Immunotherapeutics, Tokyo Medical and Dental University，2）Center for Transfusion Medicine and Cell Therapy, Keio Univ., Tokyo, Japan，3）Department of Hematology, National Hospital Organization Osaka Minami Medical Center., Osaka, Japan，4）Department of Hematology, National Kyushu Cancer Center., Fukuoka, Japan，5）Department of Cell Therapy and Hematology, National Kyushu Cancer Center., Fukuoka, Japan

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WorkshopRoom 2（2F AV Study Room） Day 3　October 30 [Tue]　12：50～13：26

Virus entry 3Chairs：Tomohiko Sadaoka（ Division of Clinical Virology, Center for Infectious Diseases, Graduate School of Medicine,

Kobe University）Tadahiro Suenaga（ Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka

University）

W3-2-01 Glycosylation of glycoprotein B is involved in tropism of herpes simplex virusAkihito Sakoguchi1,2），Tadahiro Suenaga1,2），Yasushi Kawaguchi3），Hisashi Arase1,2）

1）Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University，2）Laboratory Immunochemistry, WPI Immunology Frontier Research Center, Osaka University，3）Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo

W3-2-02 Identification of the functional domain of HHV-6 glycoprotein Q2 responsible for receptor recognitionAika Wakata，Mitsuhiro Nishimura，Yasuko MoriDivision of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine

W3-2-03 Analyses of the enhancement of guinea pig CMV infection by two components of the pentameric complex that is required for cell tropismsMisaki Okumura，Reina Makino，Kazuki Nagashima，Miku Matsuura，Takuya Miura，Naoki InoueLaboratory of Microbiology and Immunology, Gifu Pharmaceutical University


Genome and gene expression 6Chairs：Hiroshi Kimura（ Deparment of Virology, Nagoya University Graduate School of Medicine）

Tadashi Watanabe（ Department of Cell Biology, Kyoto Pharmaceutical University）

W3-2-04 Interaction of the PLSCR1 with Epstein-Barr virus BZLF1 results in the repression of BZLF1-mediated lytic transcriptionShuichi Kusano，Masanori IkedaDivision of Persistent and Oncogenic Viruses, Center for Chronic Viral Diseases, Kagoshima University

W3-2-05 CDK2 complexes stabilize the Epstein-Barr virus BDLF4 protein to temporally control late gene transcriptionYoshitaka Sato1），Takahiro Watanabe1），Chihiro Suzuki1），Yuichi Abe2），H. M. Abdullah Al Masud1），Fumi Goshima1），Takayuki Murata1,3），Hiroshi Kimura1）

1）Department of Virology, Nagoya University Graduate School of Medicine，2）Laboratory of Proteome Research, National Institutes of Biomedical Innovation, Health and Nutrition，3）Department of Virology and Parasitology, Fujita Health University School of Medicine

W3-2-06 Loss of C promoter increased transformation activity of Epstein-Barr virusFumiya Hijioka1），Yusuke Okuno2），Yoshitaka Sato1），Takahiro Watanabe1），Fumi Goshima1），Takayuki Murata1,3），Hiroshi Kimura1）

1）Department of Virology, Nagoya University Graduate School of Medicine，2）Department of Pediatrics, Nagoya University Graduate School of Medicine，3）Department of Virology and Parasitology, Fujita Health University School of Medicine

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W3-2-07 The BOLF1 lytic gene of Epstein-Barr Virus Is required for efficient progeny productionH. M. Abdullah Al Masud1），Takahiro Watanabe1），Yoshitaka Sato1），Fumi Goshima1），Hiroshi Kimura1），Takayuki Murata1,2）

1）Department of Virology, Nagoya University Graduate School of Medicine，2）Department of Virology and Parasitology, Fujita Health University School of Medicine


Genome and gene expression 7Chairs：Yasuaki Harabuchi（ Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical Universtiy）

Yoshitaka Sato（ Department of Virology, Nagoya University Graduate School of Medicine）

W3-2-08 The functional analysis of EBV tegument protein BSRF1Yusuke Yanagi1），Takayuki Murata2），Takahiro Watanabe1），H. M. Abdullah Al Masud1），Yoshitaka Sato1），Fumi Goshima1），Hiroshi Kimura1）

1）Department of Virology, Nagoya University Graduate School of Medicine，2）Department of Virology and Parasitology, Fujita Health University

W3-2-09 Analysis of BART transcript high expression in EBV-positive NK / T lymphoma cell linesHyoji Kim1），Hisashi Iizasa1），Shiori Ueno1），Seina Tanaka1），Yuichi Kanehiro1），Norio Shimizu2），Hironori Yoshiyama1）

1）Department of Microbiology, Faculty of Medicine, Shimane University，2）Center for Stem Cell and Regenerative Medicine, Institute of Research, Tokyo Medical and Dental University

W3-2-10 Kaposi's sarcoma-associated herpesvirus ORF66 is essential for virus production and late gene expressionTadashi Watanabe1），Mayu Nishimura1），Kazushi Kuriyama1），Aya Hashimoto1），Kohei Hosokawa1），Mel Campbell2），Ryan Davis3），Clifford G. Tepper3），Yoshihiro Izumiya2,3），Masahiro Fujimuro1）

1）Department of cell biology, Kyoto pharmaceutical university，2）Dermatology, UC Davis Comprehensive Cancer Center，3）Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center


Assembly and release 4Chairs：Akihisa Kato（ Division of Molecular Virology Department of Microbiology and Immunology, The Institute of

Medical Science, The University of Tokyo）Tetsuo Koshizuka（ Microbiology and Immunology, Gifu Pharmaceutical University）

W3-2-11 A single amino acid substitution in HSV-1 UL31 at an inter-hexamer contact site abrogates primary envelopment and viral growthJun Arii，Kosuke Takeshima，Yuhei Maruzuru，Naoto Koyanagi，Akihisa Kato，Yasushi KawaguchiThe Institute of Medical Science, The University of Tokyo

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W3-2-12 Residues in α-helix 9 of HSV-1 UL31 is critical for interaction with UL25 and incorporation of capsid into vesicles in the perinuclear spaceKosuke Takeshima，Jun Arii，Yuhei Maruzuru，Naoto Koyanagi，Akihisa Kato，Yasushi KawaguchiDivision of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo

W3-2-13 Efficient VLP assembly of human parvovirus B19 VP1 and VP2 expressed in mammalian and bacterial cellsSakika Kimura1），Kensuke Kamata1），Hirotaka Ebina2），Eiji Morita1）

1）Department of Biochemistry and Molecular Biology, Hirosaki University，2）The Research Foundation for Microbial Diseases of Osaka University

WorkshopRoom 3（2F Medium Conference Room） Day 3　October 30 [Tue]　12：50～13：38

Diversity and evolution 3Chairs：Masayuki Horie（ Hakubi Center for Advanced Research, Kyoto University）

Yoshii Nishino（ Faculty of Life Sciences, Kyoto Sangyo University）

W3-3-01 Evolutionally dynamics of Egyptian H9N2 avian influenza virus in nature conferred enhanced replication ability in humansYasuha Arai1），Ibrahim Madiha2），Elgendy Emad2），Tomo Daidoji1），Takaaki Nakaya1），Yohei Watanabe1）

1）Department of Infectious Diseases, Graduate School of Medicine, Kyoto Prefectural University of Medicine，2）Faculty of Veterinary Medicine, Damanhour University, Egypt

W3-3-02 Analysis of genetic dynamics of influenza A(H1N1)pdm09 viruses in upper and lower respiratory tracts using next-generation sequencingIkuyo Takayama1），Binh Gia Nguyen2），Van Tuong Vu Thi2），Phuong Thai Truong2），Van Do Thanh2），Thuy Phuong Pham Thi2），Seiichiro Fujisaki1），Takato Odagiri1），Tsutomu Kageyama1），Noriko Nakajima3）

1）Influenza Virus Research Center, National Institute of Infectious Diseases，2）Bach Mai Hospital, Hanoi, Vietnam，3）Department of Pathology, National Institute of Infectious Diseases

W3-3-03 Intra-host diversity of Borna disease virusRyo Komorizono1），Akiko Makino1,2），Keizo Tomonaga1,2,3）

1）Lab. of RNA viruses, Institute for Frontier Life and Medical Sciences, Kyoto University，2）Department of Mammalian Regulatory Network, Graduate School of Biostudies, Kyoto University，3）Department of Molecular Virology, Graduate School of Medicine, Kyoto University

W3-3-04 Determination of interacting host factors of an endogenous bornavirus-like element-derived protein in miniopterid bat cellsYahiro Mukai1,2），Masayuki Horie1,4），Yuki Kobayashi5），Shohei Kojima1,2），Ken Maeda6），Keizo Tomonaga1,2,3）

1）Laboratory of RNA Viruses, Institute for Frontier Life and Medical Sciences, Kyoto University，2）Department of Mammalian Regulatory Network, Graduate School of Biostudies, Kyoto University，3）Department of Molecular Virology, Graduate School of Medicine, Kyoto University，4）Hakubi Center for Advanced Research, Kyoto University，5）Nihon University Veterinary Research Center，6）Laboratory of Veterinary Microbiology, Joint Faculty of Veterinary Medicine, Yamaguchi University

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Antivirals 2Chairs：Makoto Hijikata（ Laboratory of Tumor Viruses, Institute for Frontier Life and Medical Sciences, Kyoto

University）Tian Cheng Li（ Department of Virology Ⅱ, National Institute of Infectious Diseases）

W3-3-05 Antiviral effects of second-generation NS5A inhibitor evaluated in Hepatitis C virus cell culture system with full-genome infectious clonesAsako Murayama1），Kei Fujiwara2），Norie Yamada1），Masaaki Shiina3），Masamichi Muramatsu1），Takaji Wakita1），Takanobu Kato1）

1）Department of Virology II, National Institute of Infectious Diseases，2）Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences，3）Department of Gastroenterology and Hepatology, Shin-Yurigaoka General Hospital

W3-3-06 Analysis of host and viral factors contributing to resistant acquisition for the preclinical anti-HCV drugs, N-89 and N-251Weilin Gu，Youki Ueda，Shinya Satoh，Hiromichi Dansako，Nobuyuki KatoDepartment of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

W3-3-07 Mechanism of GPAM suppression by Anti-HCV drug ribavirinDaichi Onomura，Shinya Satoh，Youki Ueda，Hiromichi Dansako，Nobuyuki KatoDepartment of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

W3-3-08 Identification of aryl hydrocarbon receptor ligands inhibiting the lipid accumulation and hepatitis C virus productionKazane Nishioka1,2），Hirofumi Ohashi1,2），Ryosuke Suzuki1），Hideki Aizaki1），Masamichi Muramatsu1），Takaji Wakita1），Koichi Watashi1,2）

1）Department of Virology II, National Institute of Infectious Diseases，2）Tokyo University of Science Graduate School of Science and Technology


Antivirals 3Chairs：Hiromichi Dansako（ Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and

Pharmaceutical Sciences）Kouichi Kitamura（ Graduate School of Medical Sciences, Kanazawa University）

W3-3-09 Drug screening for suppression of lipogenesis through downregulation of C/EBPαShinya Satoh1），Daichi Onomura1），Koichi Watashi2），Youki Ueda1），Hiromichi Dansako1），Masao Honda3），Shuichi Kaneko3），Nobuyuki Kato1）

1）Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences，2）Department of Virology II, National Institute of Infectious Disease，3）Department of Gastroenterology, Kanazawa University Graduate School of Medicine

W3-3-10 Topoisomerase II inhibitor triggers cyclic GMP-AMP synthase-dependent innate immune response in human immortalized hepatocyte NKNT-3Hirotaka Imai，Hiromichi Dansako，Youki Ueda，Shinya Satoh，Nobuyuki KatoDepartment of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

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W3-3-11 Ponesimod suppresses early step of HBV life cycleYuzy Fauzyah，Chikako Ono，Takasuke Fukuhara，Tomokazu Tamura，Hiroyuki Mori，Asuka Sato，Takuma Izumi，Toru Okamoto，Yoshiharu MatsuuraDepartment of Molecular Virology, Research Institute for Microbial Diseases, Osaka University


Antivirals 4Chairs：Keiji Ueda（ Division of Virology, Deparment of Microbiology and Immunology, Osaka University Graduate School

of Medicine）Yasuhito Tanaka（ Department of Virology Liver Unit, Nagoya City University Graduate School of Medical

Science）

W3-3-12 Bardoxolon methyl suppresses the proliferation of both hepatitis B and C viruses in culture cellsYuichi Akahori1,2），Hitomi Okamura1,2），Machiko Sasai1,2），Hikari Hasegawa1,2），Koichi Watashi3），Takaji Wakita3），Yasuhito Tanaka4），Yasunori Nio5），Makoto Hijikata1,2）

1）Laboratory of Human Tumor Viruses, Institute for Virus Research, Kyoto University，2）Graduate School of Biostudies, Kyoto University，3）Department of Virology II, National Institute of Infectious Diseases，4）Department of Virology and Liver Unit, Nagoya City University，5）Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited

W3-3-13 Mechanistical study of antiviral activity of snake venom sPLA2 against HBV and HCVYohei Miyayama1,2），Ming Chen3），Chie Aoki-Utsubo3），Lin Deng4），Keiko Shindo1），Takeshi Noda1），Michinori Kohara5），Koichi Watashi6），Takaji Wakita6），Makoto Hijikata1,2），Haku Hotta3,7）

1）Institute for Frontier Life and Medical Sciences ,Kyoto University，2）Graduate School of Biostudies, Kyoto University，3）Graduate School of Health Sciences, Kobe University，4）Graduate School of Medicine, Kobe University，5）Tokyo Metropolitan Institute of Medical Science，6）National Institute of Infectious Diseases，7）Faculty of Clinical Nutrition and Dietetics, Konan Women's University

W3-3-14 Development of in vivo delivery system of CRISPR/Cas9 targeting hepatitis B virusMohammad Enamul Hoque Kayesh1），Yutaka Amako2），Shuko Murakami3），Yasuhito Tanaka3），Michinori Kohara2），Kyoko Tsukiyama-Kohara1）

1）Kagoshima university，2）Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science，3）Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences

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WorkshopRoom 4（3F Conference Room B & C） Day 3　October 30 [Tue]　12：50～13：26

Virus entry 4Chairs：Asuka Nanbo（ Graduate School of Medicine, Hokkaido University）

Yasuteru Sakurai（ National Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University）

W3-4-01 Single nucleotide polymorphisms in human NPC1 influence filovirus entry into cellsTatsunari Kondoh1），Michael Letko2），Vincent J. Munster2），Rashid Manzoor1），Junki Maruyama1），Wakako Furuyama1），Hiroko Miyamoto1），Asako Shigeno1），Daisuke Fujikura3），Yoshihiro Takadate1），Reiko Yoshida1），Manabu Igarashi1），Heinz Feldmann2），Andrea Marzi2），Ayato Takada1）

1）Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan，2）Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA，3）Division of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan

W3-4-02 Differential filovirus tropism controlled by the polymorphism of bat Niemann-Pick C1 proteinsYoshihiro Takadate1），Tatsunari Kondoh1），Junki Maruyama1,2），Rashid Manzoor1），Makoto Kuroda1,3），Hirohito Ogawa4,5,6），Masahiro Sato1），Wakako Furuyama1,7），Reiko Yoshida1），Manabu Igarashi1,8），Ayato Takada1,5,8）

1）Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan，2）Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, USA，3）Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA，4）Hokudai center for Zoonosis Control in Zambia, School of Veterinary Medicine, University of Zambia, Lusaka, Zambia，5）Department of Disease Control, School of Veterinary Medicine, University of Zambia, Lusaka, Zambia，6）Department of Virology, Graduate School of Medicine, Density, and Pharmaceutical Sciences, Okayama University, Okayama, Japan，7）Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA，8）Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education, Hokkaido University, Sapporo, Japan

W3-4-03 Lassa virus infection of the human bronchial epitheliumHelena Mueller，Sarah Katharina Fehling，Thomas StreckerInstitute of Virology, Philipps-University Marburg, Marburg, Germany


Genome and gene expression 8Chairs：Kaoru Takeuchi（ Division of Biomedical Science, Laboratory of Enviromental Microbiology, Faculty of Medicine,

University of Tsukuba）Takashi Irie（ Department of Virology, Graduate School of biomedical sciences, Hiroshima University）

W3-4-04 A stable panhandle structure in genomic promoter is required for Hazara virus polymerase activityYusuke Matsumoto，Keisuke Ohta，Machiko NishioDepartment of Microbiology, School of Medicine, Wakayama Medical University

W3-4-05 The R2TP complex modulates viral RNA synthesis of mumps virusHiroshi Katoh1），Tsuyoshi Sekizuka2），Masafumi Sakata1），Yuichiro Nakatsu1），Reiko Nakagawa3），Minoru Kidokoro1），Makoto Kuroda2），Makoto Takeda1）

1）Department of Virology III, National Institute of Infectious Diseases，2）Pathogen Genomics Center, National Institute of Infectious Diseases，3）RIKEN, BDR, Laboratory for Phyloinformatics

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W3-4-06 Alternative splicing regulates diverse subcellular localization of Borna disease virus nucleoproteinShohei Kojima1,2），Ryo Sato3），Mako Yanai1,2），Yumiko Komatsu1,4），Manabu Igarashi5），Masayuki Horie1,6），Keizo Tomonaga1,2,7）

1）Laboratory of RNA virus, Institute for Frontier Life and Medical Sciences, Kyoto University，2）Department of Mammalian Regulatory Network, Graduate School of Biostudies, Kyoto University，3）Faculty of Medicine, Kyoto University，4）Keihanshin Consortium for Fostering the Next Generation of Global Leaders in Research，5）Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University，6）Hakubi Center, Kyoto University，7）Department of Molecular Virology, Graduate School of Medicine, Kyoto University


Assembly and release 5Chairs：Takeshi Noda（ Institute for Frontier Life and Medical Sciences, Kyoto University）

Hiroaki Kariwa（ Division of Veterinary Medicine, Department of Preventive Veterinary Medicine, Laboratory of Public Health, Faculty of Veterinary Medicine, Hokkaido University）

W3-4-07 YxxL motif of Ebola virus VP24 protein is crucial for the transport of nucleocapsid-like structureYuki Takamatsu1），Larissa Kolesnikova1），Stephan Becker1,3）

1）Institute of Virology, Philipps-University Marburg，2）Lab. of Ultrastructural Virology, Institute for Frontier Life and Medical Sciences, Kyoto University，3）German Center of Infection Research (DZIF), partner site Giessen-Marburg-Langen, Marburg, Germany

W3-4-08 Budding of Ebola virus particles requires the Rab11-dependent endocytic recycling pathwayAsuka Nanbo，Yusuke OhbaDepartment of Cell Physiology, Graduate School of Medicine, Hokkaido University

W3-4-09 Determining the molecular mechanism underlying interaction of Lassa virus Z protein with the host factor KIF13ASarah Katharina Fehling1），Svenja Wolff1），Shuzo Urata2），Jiro Yasuda2），Thomas Strecker1）

1）Institute of Virology, Philipps-University Marburg, Marburg, Germany，2）Department of Emerging Infectious Diseases, Nagasaki University, Japan

WorkshopRoom 5（3F Conference Room D） Day 3　October 30 [Tue]　12：50～13：26

Diversity and evolution 4Chairs：Yuta Kanai（ Department of Virology, Research Institute for Microbial Diseases, Osaka University）

Jun Sasaki（ Department of Virology and Parasitology, Fujita Health University School of Medicine）

W3-5-01 Selective pressure of free chlorine disinfection on murine norovirusAndri Taruna Rachmadi1），Masaaki Kitajima1），Kozo Watanabe3），Sakiko Yaegashi3,5），Joeselle Serrana3），Arata Nakamura1），Toyoko Nakagomi4），Osamu Nakagomi4），Kazuhiko Katayama6），Satoshi Okabe1），Daisuke Sano2）

1）Division of Environmental Engineering, Faculty of Engineering, Hokkaido University，2）Department of Civil and Environmental Engineering, Tohoku University, Miyagi, Japan，3）Department of Civil and Environmental Engineering, Ehime University, Ehime，4）Department of Hygiene and Molecular Epidemiology, Nagasaki University，5）Department of Civil and Environmental Engineering, University of Yamanashi, Yamanashi，6）Laboratory of Viral Infection I, Department of Infection Control and Immunology, Kitasato Institute for Life Science, Kitasato University

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W3-5-02 Continuous circulation of dengue virus serotype-3 in GabonHaruka Abe1），Yuri Ushijima1），Marguerite M Loembe2），Selidji T Agnandji2），Bertrand Lell2），Jiro Yasuda1）

1）Department of Emerging Infectious Diseases, Institute of Tropical Medicine, Nagasaki University，2）Centre de Recherches Medicale de Lambarene

W3-5-03 Presence of chlorine-resistant virus strain leads to insufficient chlorination in drinking water treatment plantShotaro Torii，Akihiko Hata，Hiroyuki KatayamaDepartment of Urban Engineering, the University of Tokyo


Antivirals 5Chairs：Tsutomu Murakami（ AIDS Research Center, National Institute of Infectious Diseases）

Naoyoshi Maeda（ Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University）

W3-5-04 Development of new membrane fusion inhibitors against HIV-1 by dimerization strategyTsutomu Murakami1），Kento Ebihara2），Masayuki Fujino1），Yuzuna Honda2），Takuya Kobayakawa2），Wataru Nomura2），Hirokazu Tamamura2）

1）AIDS Research Center, National Institute of Infectious Diseases，2）Department of Medicinal Chemistry, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University

W3-5-05 A novel PKC activator 10-Methyl-Aplog-1 in combination with JQ1 showed high potency as LRA for shock and kill therapyAyaka Washizaki1），Megumi Murata1），Yohei Seki1），Tang Pui Yin1），Hiroyuki Kangawa2），Kazuhiro Irie3），Hirofumi Akari1,2）

1）Primate Research Institute, Kyoto University，2）Institute for Frontier Life and Medical Sciences, Kyoto University，3）Graduate School of Agriculture, Kyoto University

W3-5-06 Establishment of cell lines to investigate nuclear localization of flavivirus core proteinsMakoto Tokunaga1），Toru Okamoto1），Yoichi Miyamoto2），Masahiro Oka2），Takasuke Fukuhara1），Yoshiharu Matsuura1）

1）Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University，2）Laboratory of Nuclear Transport Dynamics, National Institutes of Biomedical Innovation, Health and Nutrition

W3-5-07 Development of 2'-β Seleno Nucleoside Analogs as Irreversible Inhibitors for Viral PolymerasesYasuaki Kimura1），Yushi Niimi1），Hideo Katakura1），Tetsuro Suzuki2），Tsutomu Murakami3），Eiichi Kodama4），Hiroshi Abe1）

1）Department of Chemistry, Graduate School of Science, Nagoya University，2）Department of Virology and Parasitology, Hamamatsu University School of Medicine，3）AIDS Research Center Laboratory III, National Infectious Diseases，4）Division of Infectious Diseases, International Research Institute of Disaster Science, Tohoku University

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Antivirals 6Chairs：Takemasa Sakaguchi（ Department of Virology, Graduate School of Biomedical & Health Sciences, Hiroshima

University）Jun-ichirou Yasunaga（ Laboratory of Virus Control, Institute for Frontier Life and Medical Sciences, Kyoto

University）

W3-5-08 Drug-repositioning screening for anti-viral therapeutics of mumps virus infectionIori Okabe1），Satoshi Shindo1），Yuma Sato1），Marie Kubota1），Ayako Ueo1），Satoko Otsuguro2），Katsumi Maenaka2,3），Yusuke Yanagi1），Takao Hashiguchi1）

1）Department of Virology, Faculty of Medicine, Kyushu University，2）Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University，3）Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University

W3-5-09 A method for detection of anti-cytomegalovirus compounds with secreted luciferase recombinant virusTetsuo Koshizuka1,2），Yuko Sato2），Shoe Kobiyama2），Mami Oshima2），Tatsuo Suzutani2）

1）Department of Microbiology and Immunology, Gifu Pharmaceutical University，2）Department of Microbiology, Fukushima Medical University School of Medicine

W3-5-10 Anti-HTLV-1 effects of a recombinant vesicular stomatitis virus encoding HTLV-1 receptor in a mouse model and application to a simian modelKazu Okuma，Kenta Tezuka，Madoka Kuramitsu，Sahoko Matsuoka，Isao HamaguchiDepartment of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases


Antivirals 7Chairs：Shigeru Morikawa（ Department of Veterinary Medicine, National Institute of Infectious Diseases）

Hideki Tani（ Department of Virology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama）

W3-5-11 Cholesterol, fatty acid and triglyceride synthesis pathways are required for efficient replication of SFTSVShuzo Urata，Jiro YasudaInstitute of Tropical Medicine (NEKKEN), Nagasaki University

W3-5-12 Identification of inhibitors of SFTS virus and Heartland virus RNA synthesis using minigenome systemsHideki Ebihara，Crystal Mendoza，Carla Weisend，Satoko YamaokaDepartment of Molecular Medicine, Mayo Clinic

W3-5-13 Therapeutic effects of human monoclonal antibodies to SFTS virusMasayuki Shimojima1），Taishi Onodera2），Yoshimasa Takahashi2），Satoko Sugimoto1），Shuetsu Fukushi1），Takeshi Kurosu1），Tomoki Yoshikawa1），Masayuki Saijo1）

1）Department of Virology I, National Institute of Infectious Diseases，2）Department of Immunology, National Institue of Infectious Diseases

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WorkshopRoom 6（3F Conference Room No.2） Day 3　October 30 [Tue]　12：50～13：38

Virus entry 5Chairs：Eiko Matsuo（ Graduate School of Agricultural Science, Kobe University）

Tomoichiro Oka（ Department of VirologyⅡ, National Institute of Infectious Diseases）

W3-6-01 Evaluation of mechanism of bile-requiring GII.3 human norovirus replication in human intestinal enteroidsKosuke Murakami1,2），Victoria R. Tenge2），Umesh Karandikar2），Sasirekha Ramani2），Khalil Ettayebi2），Xi-Lei Zeng2），Sue E. Crawford2），Kazuhiko Katayama4），Robert L. Atmar3），Mary K. Estes2,3）

1）Department of Virology II, National Institute of Infectious Diseases，2）Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA，3）Department of Medicine, Baylor College of Medicine, Houston, Texas, USA，4）Laboratory of Viral Infection I, Department of Infection Control and Immunology, Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University

W3-6-02 Study of the mechanism of norovirus infectionReiko Todaka1），Chihong Song2），Akira Fujimoto1），Masaru Yokoyama3），Naoyuki Miyazaki4），Kenji Iwasaki4），Kazuyoshi Murata2），Kazuhiko Katayama1）

1）Laboratory of Viral Infection I, Department of Infection Control and Immunology, Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University.，2）National Institute for Physiological Sciences，3）National Institute of Infectious Diseases，4）Institute for Protein Research, Osaka University

W3-6-03 Nelson Bay reovirus σC body domain is associated with strain-specific differences in viral replicationTakahiro Kawagishi1），Yuta Kanai1），Yusuke Sakai2），Ryotaro Nouda1），Hideki Tani3），Masayuki Shimojima4），Masayuki Saijo4），Yoshiharu Matsuura5），Takeshi Kobayashi1）

1）Department of Virology, Research Institute for Microbial Diseases, Osaka University，2）Laboratory of Veterinary Pathology, Joint Faculty of Veterinary Medicine, Yamaguchi University，3）Department of Virology, Faculty of Medicine, University of Toyama，4）Department of Virology I, National Institute of Infectious Diseases，5）Depatment of Molecular Virology, Research Institute for Microbial Diseases, Osaka University

W3-6-04 Visualization of epizootic hemorrhagic disease virus entry and protein synthesisEiko Matsuo1），Hiroko Omori2），Keiichi Saeki1），Junichi Kawano1）

1）Division of Animal science, Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University，2）Research Institute for Microbial Diseases, Osaka University

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Viral spread and transmission 1Chairs：Yohei Watanabe（ Department of Infectious Diseases, Kyoto Prefectural University of Medicine）

Tomo Daidoji（ Department of Infectious Diseases, Kyoto Prefectural University of Medicine）

W3-6-05 A systematic study to reveal distinct evolution of predominant H5 highly pathogenic avian influenza viruses in Vietnam during 2014-2017Lam Thanh Nguyen1,2），Simon Firestone3），Mark Stevenson3），Neil Young3），Les Sims4），Huy Duc Chu5），Tien Ngoc Tien6），Thanh Long To7），Tung Thanh Le5），Hung Van Nguyen5），Dat Tien Do5），Long Van Nguyen5），Tien Ngoc Nguyen5），Keita Matsuno1,8），Masatoshi Okamatsu1），Hiroshi Kida8,9），Yoshihiro Sakoda1,8）

1）Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University，2）Department of Veterinary Medicine, College of Agriculture and Applied Biology, Can Tho University, Vietnam，3）Asia-Pacific Centre for Animal Health, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Australia，4）Asia Pacific Veterinary Information Services, Australia，5）Department and Sub-Departments of Animal Health, Ministry of Agriculture and Rural Development, Vietnam，6）Regional Animal Health Office VII, Department of Animal Health, Ministry of Agriculture and Rural Development, Vietnam，7）National Center for Veterinary Diagnostics, Department of Animal Health, Ministry of Agriculture and Rural Development, Vietnam，8）Global Institution for Collaborative Research and Education, Hokkaido University, Japan，9）Research Center for Zoonosis Control, Hokkaido University, Japan

W3-6-06 Genome coverage as a better diagnostic parameter than read count for metagenomic identification of viral pathogens in clinical stool samplesWai Chi Chan1），Lin-Yao Zhang1），Grace Lui2），Kit Yun Yeoh1），Margaret Ip1），Mamie Hui1），Zigui Chen1），Wai-Tat Wong3），Ting Fung Leung4），Raymond Lai1），David Hui2），Paul Chan1），Kirsty Kwok1）

1）Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China，2）Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China，3）Department of Anaesthesia and Intensive Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China，4）Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China

W3-6-07 Emergence, spread and extinction of G1, G3, and G8 rotavirus A strains bearing P[8] and DS-1 backbones in VietnamNguyen Thi Hoa-Tran1），Osamu Nakagomi2），Hung Manh Vu1），Toyoko Nakagomi2），Chikako Kataoka3），Trang Thi Thu Nguyen1），Taichiro Takemura2），Futoshi Hasebe2）

1）Department of Virology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam，2）Nagasaki University, Nagasaki, Japan，3）Hokkaido University, Sapporo, Japan

W3-6-08 Frequent horizontal transmission is associated with high prevalence of STLV-1 infection in Japanese macaquesMegumi Murata1），Ayaka Washizaki1），Jun-ichiro Yasunaga2），Yohei Seki1），Masao Matsuoka2），Hirofumi Akari1,2）

1）Primate Research Institute, Kyoto University，2）Institute for Frontier Life and Medical Sciences, Kyoto University

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Viral spread and transmission 2Chairs：Yuta Shirogane（ Department of Virology, Faculty of Medicine, Kyushu University）

Hirofumi Sawa（ Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University）

W3-6-09 Measles virus V protein is required for the efficient viral propagation in neuronal cellsShotaro Uchida，Hiroki Sato，Tetsuro Arai，Fusako Ikeda，Chieko Kai，Misako YonedaLaboratory Animal Research Center, The Institute of Medical Science, The University of Tokyo

W3-6-10 Exosomes produced by mammalian and mosquito cells are able to transfer Japanese encephalitis virus-derived replicon RNATomohiro Ishikawa，Michiaki MasudaDepartment of Microbiology, Dokkyo Medical University School of Medicine

W3-6-11 Indigenous distribution of mosquito-borne arbovirusesRyusei Kuwata1），Shun Torii1），Hiroshi Shimoda1），Supriyono Supriyono1），Ai Takano1），Keita Noguchi1），Kenzo Yonemitsu1），Shohei Minami1），Yudai Kuroda1），Phichitrasilp Thanmaporn2），Prasertsincharoen Noppadol2），Abella Alexander Jose3），Dargantes Alan3），Baltazar Emmanuel3），Simborio Luzviminda3），Upik Kesumawati Hadi4），Agungpriyono Srihadi4），Rerkamnuaychoke Worawut2），Eiichi Hondo5），Ken Maeda1）

1）Joint Faculty of Veterinary Medicine, Yamaguchi University，2）Kasetsart University，3）Central Mindanao University，4）Bogor Agricultural University，5）Nagoya University

Workshop Day 3

WORKSHOP SESSIONS DAY 3（October 30[Tue]） · 64 The 66th Annual Meeting of the Japanese Society...

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