WISC 2016 - World Allergy Organization · WISC 2016 WAO INTERNATIONAL ... United Arab Emirates...

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WISC 2016 WAO INTERNATIONAL SCIENTIFIC CONFERENCE 2016 6-9 December 2016 Jerusalem, Israel www.facebookcom/worldallergyorg @worldallergy www.worldallergy.org/wisc2016 A meeting of the In collaboration with and their mutually collaborating partner PRELIMINARY PROGRAM Outstanding Allergy, Clinical Immunology and Cultural Heritage Registraon and Abstract Submission Now Open!

Transcript of WISC 2016 - World Allergy Organization · WISC 2016 WAO INTERNATIONAL ... United Arab Emirates...

WISC 2016WAO INTERNATIONAL SCIENTIFIC CONFERENCE 20166-9 December 2016Jerusalem, Israel

www.facebookcom/worldallergyorg @worldallergy

www.worldallergy.org/wisc2016

A meeting of the In collaboration with and their mutually collaborating partner

PRELIMINARY PROGRAM

Outstanding Allergy, Clinical Immunology and Cultural Heritage

Registration and Abstract Submission Now Open!

Abstract Submission and Online Registration Now Open!Check the Conference website for frequent updates: www.worldallergy.org/wisc2016

Invitation to ParticipateDear Colleagues,

We are delighted to invite you to participate in the WAO International Scientific Conference (WISC 2016) in Jerusalem, Israel, 6-9 December 2016. The theme of the Conference is Outstanding Allergy, Clinical Immunology and Cultural Heritage.

As a global alliance of national and regional allergy, asthma and clinical immunology societies, WAO is proud to partner with the Israel Association of Allergy and Clinical Immunology (IAACI) and their mutually collaborating partner Allergists for Israel (AFI) to host WISC 2016.

The WAO International Scientific Conference has grown and evolved from one edition to the next, and the meeting in Jerusalem will continue to build on the hugely successful preceding Conferences in Dubai, United Arab Emirates (2010), Hyderabad, India (2012), and Rio de Janeiro, Brazil (2014). Delegates may count on a diverse and stimulating scientific program, highly relevant to both the theory and practice of allergy, asthma and clinical immunology.

WAO organizes these scientific Conferences in recognition of:

• The increasing prevalence and more complex forms of allergic diseases and asthma worldwide, especially in children

• The need to create a more integrated approach to the diagnosis and management of allergic diseases and asthma

• The need to expand the knowledge and practice of allergy and provide more practical knowledge to young professionals

The 2016 Conference on Outstanding Allergy, Clinical Immunology and Cultural Heritage will provide a forum for the most useful combination of the latest research, review of current theory and practice, and hands-on, problem-based learning. Our aim is that participants gain insight into the most effective advances in the diagnosis and management of complex and severe allergies and asthma and in their preventive strategies.

We look forward to seeing you in Jerusalem, Israel!

Jonathan A. Bernstein AFI President

Nancy Agmon-Levin IAACI President

Chair, Local Organizing Committee

Mario Sánchez Borges WAO President Conference

President

Lanny J. Rosenwasser WAO Past-President

Abstract Submission and Online Registration Now Open!Check the Conference website for frequent updates: www.worldallergy.org/wisc2016

Ignacio J. AnsoteguiWAO President-Elect

Conference Chair

TABLE OF CONTENTSAbout WAO ............................................................................... 2

About IAACI ............................................................................... 2

About AFI .................................................................................. 2

Conference Information............................................................ 3

Scientific Program Information ................................................. 3

What-to-Know .......................................................................... 4

Abstract Submission – Now Open! ........................................... 5

Program At-A-Glance ................................................................ 6

WISC 2016 Keynote Speakers ................................................. 10

Preliminary Scientific Program—Tuesday, 6 December ......... 12

Preliminary Scientific Program—Wednesday, 7 December ... 14

Preliminary Scientific Program—Thursday, 8 December ....... 16

Preliminary Scientific Program—Friday, 9 December ............ 18

Registration ............................................................................. 19

Accommodations .................................................................... 20

WISC 2016 6-9 December 2016 Jerusalem, Israel 1

About WAOThe World Allergy Organization (WAO) is an international alliance of 97 regional and national allergy, asthma and clinical immunology societies. Through collaboration with the Member Societies, WAO provides a wide range of educational and outreach programs, symposia and lectureships to allergists/immunologists around the globe and conducts initiatives relating to clinical practice, service provision, and physician training in order to better understand and address the challenges facing allergists/immunologists worldwide.

About IAACIThe Israel Association for Allergy and Clinical Immunology (IAACI), founded in 1949, is a non-profit association, with a mission to promote education, good clinical practice and research in a wide spectrum of allergic and immune mediated diseases in Israel, under the umbrella of the Israel Medical Association (IMA). The IAACI is dedicated to promoting collaborations between Allergists/Clinical Immunologists and physicians from other disciplines in Israel, aiming to expand knowledge and improve patient care. This is achieved by promoting joint meetings and producing Israeli collaborative recommendations on various topics.

About AFIAllergists for Israel (AFI) was founded in 1984 and the evolving vision of the group is to develop camaraderie of Allergists/Immunologists and other supporters of allergy by gathering in the USA, Israel and around the world. AFI strives to establish collegial relations between America and Israel.

CONFERENCE COMMITTEESConference President Mario Sánchez Borges, Venezuela

Steering Committee Nancy Agmon-Levin, IsraelIgnacio J. Ansotegui, SpainJonathan A. Bernstein, United StatesLeonard Bielory, United StatesMotohiro Ebisawa, JapanAharon Kessel, IsraelRuby Pawankar, JapanLanny J. Rosenwasser, United StatesMenachem Rottem, IsraelMario Sánchez Borges, Venezuela

Local Organizing CommitteeNancy Agmon-Levin, Chair, IsraelIlan Dalal, IsraelAlon Hershko, IsraelYitzhak Katz, IsraelAharon Kessel, IsraelYossi Mekori, IsraelMenachem Rottem, IsraelValery Teplitsky, Israel

Organizing CommitteeIgnacio J. Ansotegui, SpainJonathan A. Bernstein, United StatesMotohiro Ebisawa, JapanStanley Fineman, United StatesRoy Gerth van Wijk, NetherlandsLyndon Mansfield, United StatesRuby Pawankar, JapanNelson Rosário Filho, Brazil

2016-2017 WAO BOARD OF DIRECTORS

Mario Sánchez Borges, President, VenezuelaIgnacio J. Ansotegui, President-Elect, SpainMotohiro Ebisawa, Secretary-General, JapanFrancesca Levi-Schaffer, Treasurer, IsraelLanny J. Rosenwasser, Past-President, United

StatesRuby Pawankar, Historian, JapanMübeccel Akdis, SwitzerlandSuwat Benjaponpitak, ThailandSergio Bonini, ItalyWesley Burks, United StatesLuis Caraballo, ColombiaZeinab Awad El-Sayed, EgyptStanley Fineman, United StatesPaul Greenberger, United StatesElham Hossny, EgyptJose Antonio Ortega-Martell, MexicoHirohisa Saito, JapanMimi Tang, AustraliaMario Zernotti, ArgentinaLuo Zhang, China

2013-2016 IAACI BOARD OF DIRECTORS

Nancy Agmon-Levin, President, IsraelIlan Dalal, Past President, IsraelAharon Kessel, Secretary, IsraelValery Teplitsky, Treasurer, IsraelAlon Hershko, Member, Israel

Lanny J. Rosenwasser, United StatesMario Sánchez Borges, VenezuelaWilliam Silvers, United StatesMario Zernotti, Argentina

Scientific Program CommitteeIgnacio J. Ansotegui, Co-Chair, SpainClaus Bachert, Co-Chair, BelgiumJonathan A. Bernstein, Co-Chair, United StatesNancy Agmon-Levin, IsraelMübeccel Akdis, SwitzerlandLeonard Bielory, United StatesSergio Bonini, ItalyWesley Burks, United StatesLuis Caraballo, ColombiaIlan Dalal, IsraelMotohiro Ebisawa, JapanRoy Gerth van Wijk, NetherlandsEdgardo Jares, ArgentinaYitzhak Katz, IsraelGideon Lack, United KingdomFrancesca Levi-Schaffer, IsraelRichard Lockey, United StatesDean Metcalfe, United StatesJosh Milner, United StatesRuby Pawankar, JapanSusan Prescott, AustraliaNelson Rosário Filho, BrazilLanny J. Rosenwasser, United StatesMarc Rothenberg, United StatesHugh Sampson, United StatesMario Sánchez Borges, VenezuelaDana Wallace, United States

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CMEMore information regarding CME will be announced later in 2016. Please visit www.worldallergy.org/wisc2016 for frequent updates.

SESSION TYPESPLENARY SESSIONSPlenary presentations will set the stage with context and background through overviews and literature reviews to define unmet needs.

KEYNOTE LECTURESKeynote Lectures offer attendees the opportunity to attend a lecture on a specific topic from one of the key opinion leaders in the field.

SYMPOSIASymposia will address specific topics, providing the opportunity for in-depth and detailed exploration.

POSTER SESSIONSAccepted abstracts will be presented during Poster Sessions. Presenting Authors will stand with their posters, answer questions and discuss their research.

Scientific Program InformationABSTRACTSABSTRACT SUBMISSION NOW OPEN!WISC 2016 invites you to submit an abstract to be considered for inclusion in the Scientific Program. Accepted abstracts will be presented in thematic Poster Sessions.

Please visit www.worldallergy.org/wisc2016 to view submission guidelines.

NOTIFICATION OF ACCEPTANCENotification of acceptance/rejection will be emailed September 2016. The Presenting Author will receive all correspondence regarding abstract status, presentation type, and date and time, via the email that is provided in the abstract submission.

REGISTRATIONThe Presenting Author must register for WISC 2016. Registration now open!

TRAVEL AND ACCOMMODATIONSAbstract presenters are responsible for arranging and covering all costs related to registration, travel and hotel accommodations.

TRAVEL GRANTSSuccessful awardees must have an accepted WISC 2016 abstract submission (abstract submission notifications will be sent in September 2016). Awarded Travel Grant funds are non-transferrable. If you receive an award and your attendance status for the Conference changes for any reason, your award is forfeited. Please visit the WISC 2016 website (www.worldallergy.org/wisc2016) for a Travel Grant application.

Conference InformationKEY REASONS TO ATTEND:Be on the leading edge of medical education and learning!

• Attend state-of-the-art lectures by world experts on allergy, asthma and clinical immunology

• Participate in practical, clinic-friendly workshops on Immunotherapy, Food Allergy, Anaphylaxis, Skin Allergies, Drug Allergy, Asthma, Rhinitis, COPD, Sleep Disorders, and more

• Network with others in your field and areas of interest including: Asthma, Allergy, Immunology, Pediatrics, Pulmonology, Ophthalmology, Gastroenterology, Dermatology and ENT

• Showcase your own achievements to key international opinion leaders and interact with international and regional colleagues

OBJECTIVES:• To provide insights into the fundamentals and

mechanisms of allergic/immunologic diseases by reviewing and evaluating the origins and severity of each disease

• To highlight the most recent advances in the treatment and prevention of allergic and immunological diseases

• To provide an integrated approach to the diagnosis and management of severe and more complex forms of allergies

• To identify unmet needs and areas of research priorities

WHO SHOULD ATTEND:The Conference will be attended by delegates from all over the world. Delegates will be specialists, general practitioners, researchers, and other allied health professionals with interest in:

• Allergy • Immunology• Asthma • Ophthalmology• Dermatology • Pediatrics• ENT • Pulmonology• Gastroenterology • Family Practice

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What-to-Know DRESSDress for the Conference is business casual.

EVENTSThe WAO International Scientific Conference (WISC) 2016 invites delegates to participate in the following special events. Events have been created to give delegates the opportunity to network.

WISC OPENING CEREMONY*6 December 201618:00 – 19:30Ussishkin Auditorium, Main Level, ICC Jerusalem*Conference Badge Required

Join fellow delegates, faculty and the WAO Leadership in the Ussishkin Auditorium at the ICC Jerusalem for the Opening Ceremony to launch the Conference.

WISC 2016 WELCOME RECEPTION*6 December 201619:30 – 21:00Agam Foyer, ICC Jerusalem*Conference Badge Required

EVENT TICKETS FOR GUESTSIf you would like to bring a guest to the Opening Ceremony and Welcome Reception, please visit the WISC 2016 Registration site to purchase tickets: www.worldallergy.org/wisc2016/registration.

EXHIBIT HALL A commercial exhibition will take place during the Conference on the following dates and times*

6 December 2016: 14:30 - 21:007 December 2016: 10:30 - 17:008 December 2016: 10:30 – 15:30*Times are subject to change

GUESTS AND CHILDREN Guests and children will not be allowed to attend any portion of the Scientific Program or Exhibition of WISC 2016.

INSURANCE/LIABILITIES AND DISCLAIMER WAO will not be held liable for personal injuries or for loss of or damage to property incurred by participants or guests at WISC 2016, including those participating in tours and related events. Participants and guests are encouraged to purchase insurance to cover loss incurred in the event of cancellation, medical expenses or damage to or loss of personal effects when traveling.

WAO cannot be held liable for any hindrance or disruption of WISC 2016 proceedings arising from natural, political, social or economic events or other unforeseen incidents beyond its control. Registration of a participant implies acceptance of this condition.

The materials presented at this continuing medical education activity are made available for educational purposes only. The materials are not intended to represent the only, nor

necessarily best, methods or procedures appropriate for the medical situations discussed, but rather are intended to present an approach, view, statement, or opinion of the faculty that may be helpful to others who face similar situations.

LANGUAGEThe official language of the Conference is English. All sessions will be conducted in English.

NO SMOKING POLICY Smoking is not permitted during any meeting activity or event.

PHOTOGRAPHY By registering to attend WISC 2016, you acknowledge and agree that official photographs taken during the Conference may be used for future WAO meeting promotional purposes and may be shared in the Conference Photo Gallery and post event news updates. Please contact the WAO Secretariat if you have any concerns with this policy. Personal photography is allowed, but please refrain from flash photography during the sessions.

SOCIAL MEDIAWAO’s social media allows you to interact and stay connected with WAO and other attendees before, during and after the meeting.

Use the hashtag #WISC2016 for your comments, questions, photos or to see what everyone else is talking about.

Twitter: @worldallergyFacebook: facebook.com/worldallergyorgLinkedIn: linkedin.com/company/world-allergy-organization Instagram: @worldallergyorg

VENUEThe venue of WISC 2016 is:

ICC Jerusalem - International Convention CenterPO 6001 Jerusalem 9106001

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Abstract Submission Deadline: 31 July 2016

WISC 2016 invites you to submit an abstract to be considered for inclusion in the WISC 2016 Scientific Program. Accepted abstracts will be presented in thematic Poster Sessions on 6-8 December 2016.

Online submission is now open. Please visit www.worldallergy.org/wisc2016 to view submission guidelines and to submit an abstract.

NOTIFICATION OF ACCEPTANCENotification of acceptance/rejection will be emailed September 2016. The Presenting Author will receive all correspondence regarding the abstract status, presentation type, date and time, via the email that is provided in the abstract submission.

REGISTRATIONThe Presenting Author must register for WISC 2016 on/by 31 August 2016. Registration may be done online at www.worldallergy.org/wisc2016/registration

TRAVELAbstract presenters are responsible for arranging and paying for their own registration, travel and hotel accommodations. Accommodations can be made at www.worldallergy.org/wisc2016/accommodation

Abstract Submission – Now Open!TRAVEL GRANTSWAO would like to recognize our Junior Members, by extending the opportunity to apply for a Travel Grant to attend WISC 2016. In order to receive a Travel Grant the individual must:

• Be within five (5) years of your latest degree

• Or be 35 years of age or younger

• Submit and have accepted an abstract presented at the Conference

Please visit www.worldallergy.org/wisc2016/scientific-program/abstracts to submit your abstract and to review the Travel Grant application, guidelines and instructions.

Travel Grant Awardees will receive:

• Up to three (3) nights’ accommodations at the Conference appointed hotel

• Complimentary registration

• WAO Certificate of Award as a Travel Grant recipient

If you have any questions in regards to the abstract or travel grant please email [email protected]. Travel grant recipients will be notified in September 2016. We look forward to your participation at WISC 2016.

Go Global with theWAO Junior Members Group

JOIN TODAY!www.worldallergy.org/juniormembers

The WAO Junior Members Group is a network of young allergists / clinical immunologists and scientists who interact with WAO to identify the key issues affecting the world’s up-and-coming allergy practitioners and to advise on ways to help meet their educational and training needs.

Help shape the future of WAO through global advocacy and

leadership as a Junior Member

Who Qualifies to Be a WAO Junior Member?• Working in the field of allergy/clinical immunology

• Under 35 years of age or within 5 years of a training program in allergy, asthma, clinical immunology or related field

• A current member of a WAO Member Society

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TUESDAY, 6 DECEMBER 20168:30 Keynote Lecture

The Mucosal Leukotriene E4 Receptor CysLT3R Regulates Secretion and Responds to the Mast Cell8:45

9:00

PlenaryMechanisms of Allergenicity

9:15

9:30

9:45

10:00

10:15

10:30Coffee Break

10:45

11:00

SymposiumMast Cell Diseases

SymposiumUpdate on Aeroallergens

SymposiumDevelopment of Allergen

Immunotherapy (AIT)

SymposiumThe Microbiome and Its Role in Health and

Disease

SLaai Sister Society Symposium:

Latin American Peculiarities on Allergic

Diseases

WorkshopCan Monoclonal Antibodies Really

be Useful Weapons in Treating Allergic

Diseases as They are In Cancer and Autoimmune

Diseases?

11:15

11:30

11:45

12:00

12:15

12:30

Poster Sessions12:45

13:00

13:15

13:30

SymposiumEmerging Cells in Allergy

SymposiumChronic Urticaria

SymposiumAerobiology and Climate

Change

Junior Member Practical Course

Diagnostic Work-Up of Respiratory Allergies:

From Skin Test to Functional Assessment

ACAAI Sister Society Symposium:

Expanding the Role of the Allergist

WorkshopFood Allergy II

13:45

14:00

14:15

14:30

14:45

15:00Coffee Break

15:15

15:30

SymposiumMast Cell ICON: Mast

Cells in Health and Diseases

SymposiumHereditary Angioedema

SymposiumThe Microbiome and

Airway Diseases

Company Sponsored Symposium

Sister Society Symposium

WorkshopA New Frontier for the

Allergist

15:45

16:00

16:15

16:30

16:45

17:00

17:15

17:30

17:45

18:00

OPENING CEREMONY(Welcome Reception to immediately follow)

18:15

18:30

18:45

19:00

Program At-A-Glance

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WEDNESDAY, 7 DECEMBER 20168:30 Keynote Lecture

Eosinophilic Esophagitis: A Rising Concern8:45

9:00

PlenaryClinical Aspects of Immunotherapy

9:15

9:30

9:45

10:00

10:15

10:30Coffee Break

10:45

11:00

SymposiumAdvances in Pollen

Forecasting to Predict Clinical Symptoms

SymposiumPractical Approaches

for the Management of Chronic Urticaria

SymposiumUsefulness of

Inflammatory Markers in the Treatment of

Asthma

Company Sponsored Symposium

AAAAI Sister Society Symposium:

New Concepts in the Immunopathogenesis

and Management of Primary

Immunodeficiencies

WorkshopIntegrative Allergy:

Complementary Approaches within an

Allergy Asthma Practice: The USA Experience

11:15

11:30

11:45

12:00

12:15

12:30

Poster Sessions12:45

13:00

13:15

13:30

SymposiumNew and Old Hyper- IgE

Syndromes

SymposiumNavigating the Landscape of

Angioedema Conditions: Recognition and Management of

Angioedema Subtypes

SymposiumMold Allergy: Is it Real and What Do We Do

About It?

SymposiumWhat Really Happens during Food-Triggered

Anaphylaxis

Junior Member Practical Course

Challenge Tests and Desensitization in Food

and Drug Allergy

WorkshopImmune Deficiency

13:45

14:00

14:15

14:30

14:45

15:00Coffee Break

15:15

15:30

SymposiumImmuno dysregulatory

Disorders

SymposiumDrug Allergy

SymposiumBeyond

Pharmacotherapy: Role of Lifestyle Modification in Managing Asthma as a Human Condition in the Age of Technology

and Outcomes

Company Sponsored Symposium

KAAACI Sister Society Symposium:

Environment and Respiratory Allergies

WorkshopWhen Allergy and

Immune Deficiency Meet

15:45

16:00

16:15

16:30

16:45

17:00

Program At-A-Glance

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THURSDAY, 8 DECEMBER 20168:30 Keynote Lecture

The Ubiquitin System in Health and Disease8:45

9:00

PlenaryAtopic Dermatitis

9:15

9:30

9:45

10:00

10:15

10:30Coffee Break

10:45

11:00

SymposiumOtitis Media with

Effusion

SymposiumPrimary Prevention of Atopy and Childhood

Asthma

SymposiumSevere Asthma (COSA

Session)

Junior Member Practical Course

Practical Management of Anaphylaxis

TNSACI Sister Society Symposium:

Specific Immunotherapy: Bench to Bedside

WorkshopNon-Allergic Rhinitis

(NAR), Cough and Asthma Practice

11:15

11:30

11:45

12:00

12:15

12:30

Poster Sessions12:45

13:00

13:15

13:30

SymposiumUpdate on Eosinophilic Gastrointestinal Disease

SymposiumDesensitization to Drugs

& Anaphylaxis

SymposiumAsthma in the Elderly

Today

Company Sponsored Symposium

CSACI Sister Society Symposium:

Anaphylaxis, Birth Cohorts, Development and Eosinophils: The

ABC’s of Canadian Allergy Research

WorkshopAnaphylaxis

13:45

14:00

14:15

14:30

14:45

15:00Coffee Break

15:15

15:30

SymposiumTreatment and

Management Advances in Ocular Allergy and

Other Surface Diseases

SymposiumChronic Rhinosinusitis:

From Endotypes to Personalized Treatment

SymposiumAsthma and Poverty: What Can Be Done?

SymposiumAberrant Inflammation and Aberrant Immune Programming in Early

Life

Junior Member Symposium

What’s Going on in Allergy and Clinical Immunology: Junior

Members at the Front Line

Sister Society Symposium

15:45

16:00

16:15

16:30

16:45

17:00

Program At-A-Glance

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FRIDAY, 9 DECEMBER 20168:30 Keynote Lecture

Perturbing Early Life Microbiota Development and Its Immunologic Consequences8:45

9:00

PlenaryThe Next Frontier for Food Desensitization: Alternatives to Oral Immunotherapy

9:15

9:30

9:45

10:00

10:15

10:30Coffee

10:45

11:00

SymposiumUse of Environmental

Control to Treat Allergic Disorders

SymposiumPhenotypes in Chronic

Rhinosinusitis

SymposiumSevere Asthma in

Children

SymposiumFood Allergy

Junior Member Practical Course

Allergy Immunotherapy: What, When and How

Sister Society Symposium

11:15

11:30

11:45

12:00

12:15

12:30

Program At-A-Glance

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TUESDAY, 6 DECEMBERThe Mucosal Leukotriene E4 Receptor CysLT3R Regulates Secretion and Responds to the Mast Cell | Frank Austen (United States)

K. Frank Austen attended Amherst College and Harvard Medical School and served his house staff training years at the Massachusetts General Hospital (MGH). He established an independent laboratory at the MGH in 1962 and moved to the Robert B. Brigham in 1966 to establish a Department of Rheumatology and Immunology which evolved into a department of the Brigham and Women’s Hospital (BWH). After chairing this Department for 25 years, he shifted to the AstraZeneca Professorship of Respiratory and Inflammatory Diseases. Austen has pioneered many aspects of innate immunity/inflammation through an in depth focus on the functions and regulation of arachidonic acid metabolism to the cysteinyl leukotrienes (cysLTs), the pathways for the development and phenotypic diversity of mast cells, and the pattern recognition path for activation of the alternative complement activating pathway which also serves to amplify the classical

complement pathway.

Austen was elected to the National Academy of Sciences and to the American Academy of Arts and Sciences in 1974 and as a foreign member of the Royal Society (UK) in 2004. He has served as President of the American Association of Immunologists, the American Academy of Allergy, Asthma and Immunology, and the American Association of Physicians.

WEDNESDAY, 7 DECEMBEREosinophilic Esophagitis: A Rising Concern | Marc Rothenberg (United States)

Marc Rothenberg is the Director of the Division of Allergy and Immunology at Cincinnati Children’s Hospital Medical Center (Cincinnati Children’s), a tenured Professor of Pediatrics at Cincinnati Children’s and the University of Cincinnati College of Medicine (UCCOM), the Founder and Director of the Cincinnati Center for Eosinophilic Disorders (CCED), and the Founder and Director of the NIH---sponsored, national Consortium of Eosinophilic Disease Researchers (CEGIR). He graduated summa cum laude with Highest Honors in Chemistry and Biochemistry from Brandeis University. At Harvard Medical School (HMS), he completed the combined MD/PhD program. His PhD under the mentorship of Dr. Frank Austen included seminal studies on eosinophil hematopoiesis, identifying and characterizing the original biology of eosinophilopoeitins, which led to the development of a new class of drugs (humanized anti---IL---5). After completing a residency in pediatrics at Children’s Hospital in Boston, Dr. Rothenberg did a combined fellowship in Allergy/Immunology and

Hematology at Children’s Hospital in Boston. Rothenberg did post---doctorate training in the genetics laboratory of Dr. Philip Leder at HMS, where he cloned the eotaxin chemokine, which opened up a new direction in allergy research. He came to the UCCOM and Cincinnati Children’s in 1996 and has helped build a top program in pediatric research; his division is a leader in pediatric allergy and immunology. His research is focused on molecular analysis of allergic inflammation, primarily on the pathogenesis of eosinophilic gastrointestinal disorders (EGIDs). His laboratory takes multi---disciplinary approaches including the development of preclinical murine models of allergic disease, genetics, genomics, molecular immunology, cellular biology, and biochemistry.

Dr. Rothenberg’s awards include the 2007 E. Mead Johnson Award from the Society of Pediatric Research, an NIH MERIT Award in 2010 and he is a member of the Hewlett--- Woodmere Alumni Hall of Fame. He is an elected member of the ASCI, AAP, AAAS and SPR. His publications number over 325. He has served on various review panels for journals and grant agencies including the NIH, Burroughs Trust, the MRC of the UK and the ISF of Israel. He is an Associate Editor of the Journal of Allergy and Clinical Immunology, and Mucosal Immunology, and co---Section Head of the Allergy and Hypersensitivity Section of Faculty 1000. He has served a four---year term on the Advisory Council of the NIAID. His research has been supported by numerous sources including the NIH, Human Frontier Science Program Organization, the Burroughs Wellcome Fund, the Dana Foundation, the US Department of Defense, US---Israel Binational Fund, and PCORI. He has trained a myriad of clinical and research investigators in his own laboratory and also as Program Director and/or Co---Principal Investigator of several NIH training grants including the NIH CTSA KL2, NICHD CHRCDA K12, and NIAID T32.

WISC 2016 Keynote Speakers

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THURSDAY, 8 DECEMBERThe Ubiquitin System in Health and Disease | Avram Hershko (Israel)

Nobel Laureate in Chemistry (2004)

Avram Hershko was born in 1937 in Hungary and emigrated with his family to Israel in 1950. He gained his MD (1965) and PhD (1969) from the Hebrew University - Hadassah Medical School of Jerusalem. After a post-doctoral fellowship at the University of California of San Francisco (1969-72), he joined the faculty of the Haifa Technion becoming professor in 1980. He is now Distinguished Professor in the Unit of Biochemistry in the B. Rappaport Faculty of Medicine of the Technion. His main research interests concern the mechanisms by which cellular proteins are degraded, a formerly neglected field of study. Hershko and his colleagues showed that cellular proteins are degraded by a highly selective system. This system tags proteins for destruction by linkage of a protein called ubiquitin, which had previously been identified in many tissues, as the name suggests, but whose function was previously unknown. Subsequent work in Hershko’s and many other laboratories has shown that the ubiquitin system has a vital role in controlling a wide range of cellular processes, such as the regulation of cell division, signal transduction and DNA repair. Abnormalities in the

ubiquitin system result in diseases such as certain types of cancer. The full range of functions of the ubiquitin system in health and disease has still to be elucidated.

Hershko was awarded the Nobel Prize in Chemistry (2004) jointly with his former PhD student Aaron Ciechanover and his colleague Irwin Rose. His many other honors include the Israel Prize for Biochemistry (1994), the Gairdner Award (1999), The Alfred P. Sloan Prize of the General Motors Cancer Research Foundation (2000), the Lasker Prize for Basic Medical Research (2000), the Wolf Prize for Medicine (2001) and the Louisa Gross Horwitz Award (2001). Hershko is a member of the Israel Academy of Sciences (2000) and a Foreign Associate of the US Academy of Sciences (2003).

FRIDAY, 9 DECEMBERPerturbing Early Life Microbiota Development and Its Immunologic Consequences | Martin J. Blaser (United States)

Martin J. Blaser is the Muriel and George Singer Professor of Medicine, Professor of Microbiology, and Director of the Human Microbiome Program at the NYU School of Medicine. He served as Chair of the Department of Medicine at NYU from 2000-2012. A physician and microbiologist, Dr. Blaser is interested in understanding the relationships we have with our persistently colonizing bacteria. His work over 30 years focused on particular organisms, including Campylobacter species and Helicobacter pylori, which also are model systems for understanding the interactions of residential bacteria with their human hosts. Over the last 15 years, he has been actively studying the relationship of the human microbiome with health and with such important diseases as asthma, obesity, diabetes, and allergies.

Over the course of his career, Dr. Blaser has served as the advisor for a large number of students, post-doctoral fellows, and junior faculty. He served as President of the Infectious Diseases Society of America, Chair of the Board of Scientific Counselors of the National Cancer Institute, Chair of the Advisory Board for Clinical Research of the National Institutes of Health, and on the Scientific Advisory Board of the Doris Duke Charitable Foundation. He was elected to the National Academy of Medicine and the American Academy for Arts and Sciences. He holds 25 U.S. patents relating to his research, and has authored over 540 original articles. Recently, he wrote “Missing Microbes”, a book targeted to general audiences. He now is serving as the Chair of the Presidential Advisory Council for Combating Antibiotic-Resistant Bacteria.

WISC 2016 Keynote Speakers

WISC 2016 6-9 December 2016 Jerusalem, Israel 11

KEYNOTE 08.30 – 09.00 The Mucosal Leukotriene E4 Receptor CysLT3R Regulates Secretion and Responds to the Mast Cell | Frank Austen (United States)

PLENARY 09.00 – 10.30

Mechanisms of AllergenicityThe Evolutionary Roots of Allergenicity | Kathleen Barnes (United States)Recent Discoveries on Molecular Intrinsic Allergenic Properties | Rudolf Valenta (Austria)IgG4 to Environmental Antigens in Healthy and Allergic Children | Paolo Maria Matricardi (Germany)

COFFEE BREAK 10.30 – 11.00

SYMPOSIA 11.00 – 12.30

Mast Cell DiseasesThe Many Faces of Mast Cell Clonal Diseases | Dean Metcalfe (United States)Mast Cell Activation Syndrome | Alon Hershko (Israel)Prognosis and Management of Diseases of Mast Cell Activation and Proliferation | Mariana Castells (United States)

Development of Allergen Immunotherapy (AIT)Mechanisms of Early Desensitization: Histamine Receptors and More | Natalija Novak (Germany)Role of B Reg Cells in Allergen Tolerance during Allergen Immunotherapy (AIT) | Mübeccel Akdis (Switzerland)Rapid Suppression of IgE-Mediated Allergy | Fred Finkelman (United States)

Update in AeroallergensPollen and Fungal Allergens | Jay Portnoy (United States)Mite and Cockroach Allergens | Luis Caraballo (Colombia)Regulatory Aspects of Immunotherapy | Sergio Bonini (United Kingdom)

The Microbiome and Its Role in Health DiseaseBarrier Function and Microbiotic Dysbiosis in Atopic Dermatitis | Michael Levin (South Africa)Early Life Microbiome Dysbiosis and Development of Allergy | Christine Johnson (United States)Late Onset Airway Disease: Role of Viruses and Bacteria | Peter Le Souëf (Australia)

WORKSHOP 11.00 – 12.30

Can Monoclonal Antibodies Really be Useful Weapons in Treating Allergic Diseases as they are in Cancer and Autoimmune Diseases?Cancer and Monoclonal Antibodies | Erika Jensen-Jarolim (Austria)Autoimmune Diseases and Monoclonal Antibodies | TBCAllergic Diseases and Monoclonal Antibodies | Francesca Levi-Schaffer (Israel)

SISTER SOCIETY SYMPOSIUM 11.00 – 12.30

Latin American Society of Allergy, Asthma and Immunology (SLaai) — Latin American Peculiarities on Allergic DiseasesCharacteristics of Anaphylaxis Detection and Management | TBCLessons Learnt from Drug Allergy Registries | TBCAllergic Rhinitis and Its Impact on Asthma (ARIA) Achievements and Future Needs | TBC

POSTER SESSIONS 12.30 – 13.30

Preliminary Scientific Program—Tuesday, 6 December

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SYMPOSIA 13.30 – 15.00

Emerging Cells in AllergyRole of Mast Cells in Innate Inflammation | Hideaki Morita (Japan)Lymphoid Cells, Effector Cells and Immune Responses | Judah Denburg (Canada)Macrophages & Neutrophils | Lorenzo Moretta (Italy)

Aerobiology and Climate ChangeMeteorological Conditions, Climate Change, New Emerging Factors, and Asthma and Related Allergic Disorders: A Statement of the World Allergy Organization | Menachem Rottem (Israel)Climate Change and Allergic Respiratory Diseases: An Update for the Allergist | Gennaro D’Amato (Italy)The Role of Aerobiology in 2016 | Jay Portnoy (United States)

Chronic UrticariaClassification of Chronic Urticaria: New Aspects | David Lang (United States)Angioedema—Histamine or Bradykinin? | Avner Reshef (Israel)Treatment of Patients with Severe Chronic Urticaria | Mario Sánchez Borges (Venezuela)

JUNIOR MEMBER PRACTICAL COURSE 13.30 – 15.00

Diagnostic Work-up of Respiratory Allergies: From Skin Test to Functional Assessment Senior Moderator | TBCJunior Member | Shira Benor (Israel)Junior Member | Mariana Couto (Portugal)

WORKSHOP 13.30 – 15.00

Food Allergy IIDiagnosis of Food Allergy | Yael Levy (Israel)Food Oral Immunotherapy | Yitzhak Katz (Israel)Baked Milk Immunotherapy | Ilan Dalal (Israel)

SISTER SOCIETY SYMPOSIUM 13.30 – 15.00

American College of Allergy, Asthma and Immunology (ACAAI) Symposium - Expanding the Role of the AllergistOcular Allergy ICON: The Eyes Have It | Leonard Bielory (United States)Asthma COPD Overlap Syndrome (ACOS) | Bryan Martin (United States)Provocative Challenges | Stephen Tilles (United States)

COFFEE BREAK 15.00 – 15.30

SYMPOSIA 15.30 – 17.00

Mast Cell ICON: Mast Cells in Health & DiseasesNon-IgE Mediated Mast Cell Activation in Disease | Dean Metcalfe (United States)Mast Cells Beyond Allergy: T Cell-Mast Cell Interaction in Inflammatory Processes | Yoseph Mekori (Israel)Mast Cells in Allergic Airway Inflammation | Ruby Pawankar (Japan)

Hereditary Angioedema (HAE)HAE in the Pediatric Population | Aharon Kessel (Israel)HAE during Pregnancy | Elias Toubi (Israel)Treatment of HAE in 2016 | Michael Frank (United States)

The Microbiome and Airway DiseasesThe Airway Microbiome: Status and Future | Peter Howarth (United Kingdom)Allergens and Superallergens: The Immune Proteome of Staphylococcus Aureus | Claus Bachert (Belgium)Microbial Exposures Influence the Risk for Wheezing and Asthma in Urban Children | James Gern (United States)

WORKSHOP 15.30 – 17.00

A New Frontier for the AllergistClinical Pearls for Diagnosing Allergic Contact Dermatitis | David Bernstein (United States)Skin Tests and Other Provocation Tests in Chronic Urticaria | Marcus Maurer (Germany)Metal Hypersensitivity and Prosthetic Devices | Karin Pacheco (United States)

Preliminary Scientific Program—Tuesday, 6 December

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KEYNOTE 08.30 – 09.00Eosinophilic Esophagitis: A Rising Concern | Marc Rothenberg (United States)

PLENARY 09.00 – 10.30

Clinical Aspects in ImmunotherapyThe Future Directions in Immunotherapy | Giovanni Passalacqua (Italy)The New Routes of Administration: Where Do We Stand? | Gabriela Senti (Switzerland)Advances in Mechanisms and Clinical Implications | Cezmi Akdis (Switzerland)

COFFEE BREAK 10.30 – 11.00

SYMPOSIA 11.00 – 12.30

Advances in Pollen Forecasting to Predict Clinical SymptomsThe Relationship between Pollen Concentration and Clinical Symptom Thresholds | Carmi Geller-Bernstein (United States)Validation of Pollen Collection and Monitoring Techniques and Clinical Symptom Instruments for Assessing the Impact of Pollen Exposure on Patient Health | Santiago Martinez (United States)Modeling and Forecasting Pollen for Allergy Prevention | Carsten Skjøth (United Kingdom)

Usefulness of Inflammatory Markers in the Treatment of AsthmaNovel Aspects of Inflammation in Asthma: Future Approaches | Fernan Caballero-Fonseca (Venezuela)Inflammatory Markers for Asthma Diagnosis and Follow-up | Nelson Rosário Filho (Brazil)Targeted Therapies for Asthma: State of the Art | Walter Canonica (Italy)

Practical Approaches for the Management of Chronic Urticaria Mechanisms of Chronic Urticaria: Do We Understand the Whole Landscape? | Jonathan Bernstein (United States)Diagnostic, Quality of Life and Control Tools in Chronic Urticaria | Torsten Zuberbier (Germany)Treatment of Chronic Urticaria, Guidelines and Beyond | Allen Kaplan (United States)

WORKSHOP 11.00 – 12.30

Integrative Allergy: Complementary Approaches within an Allergy Asthma PracticeWhat is Integrative Allergy, Integrative Medicine and Complementary and Integrative Medicine (CAM) | William Silvers (United States)Evidence Basis for Integrative Modalities | Leonard Bielory (United States)Stress and Immune System | TBC

SISTER SOCIETY SYMPOSIUM 11.00 – 12.30

American Academy of Allergy Asthma & Immulology Symposium - New Concepts in the Immunopathogenesis and Management of Primary ImmunodeficienciesImmune Deficiencies Associated with Early Onset Inflammatory Bowel Disease | Kathleen Sullivan (United States)Severe Combined Immune Deficiency: from Newborn Screening to Cellular and Molecular Therapy | Luigi Notarangelo (United States)The Complex Veiled Among the Common Variables - Addressing the Challenges of the new “CVID-like” Disorders | Klaus Warnatz (Germany)

POSTER SESSIONS 12.30 – 13.30

SYMPOSIA 13.30 – 15.00

New and Old Hyper-IgE SyndromesAutosomal Dominant Hyper IgE Syndromes (AD-HIES), Phosphoglucomutase 3 (PGM 3) and Dedicator of Cytokinesis 8 (DOCK8) Deficiency | Thomas Fleisher (United States)A Common Monogenic Cause for the Mast Cell Activation Syndrome | Joshua Milner (United States)Hypereosinophilic Syndrome (HES) and Eosinophilic Granulomatosis with Polyangiitis (EGPA) | Michael Wechsler (United States)

Mold Allergy: Is It Real and What Do We Do About It? Fungi: What Are They and What Types of Exposure Do We Have to Them? | Estelle Levetin (United States)Health Effects of Fungal Exposure: What is Known | John Cohn (United States)Interventions to Reduce Fungal Exposure and Improve Health | James Sublett (United States)

Preliminary Scientific Program—Wednesday, 7 December

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Navigating the Landscape of Angioedema Conditions: Recognition and Management of Angioedema Subtypes Idiopathic Angioedema: Histaminergic and Kinin-Mediated | Konrad Bork (Germany)C1INH Deficiency: Acquired and Hereditary | TBCBradykinin Mediated Angioedema with Normal C1INH–ACE-I and Associated and HAE with Normal C1INH | Bruce Zuraw (United States)

What Really Happens during Food Triggered AnaphylaxisWho Is at Risk of Food-Triggered Anaphylaxis? | Margitta Worm (Germany)What Drives Symptoms during Acute Allergic Reactions to Food? | Stanley Fineman (United States)Cardiovascular Changes during Acute Allergic Reactions to Food | Paul Turner (United Kingdom)

JUNIOR MEMBER PRACTICAL COURSE 13.30 – 15.00

Challenge Tests and Desensitization in Food and Drug Allergy Senior Moderator | TBCJunior Member | TBCJunior Member | TBC

WORKSHOP 13:30 – 15.00

Immune DeficiencyFive Decades of Immune Deficiency: A Story to be Told | Amos Etzioni (Israel)Primary Immunodeficiency | José Antonio Ortega Martell (Mexico)Newborn Screening for Severe Combined Immunodeficiency (SCID): State of the Art | Raz Somech (Israel)

COFFEE BREAK 15.00 – 15.30

SYMPOSIA 15.30 – 17.00

Immunodysregulatory DisordersInflammasome Related Disorders | Hal Hoffman (United States)Hereditary Periodic Fever Syndromes | Yackov Berkun (Israel)Blockers for the Therapy of Auto Inflammatory Diseases | Lanny J. Rosenwasser (United States)

Beyond Pharmacotherapy: Role of Lifestyle Modification in Managing Asthma as Human Condition in the Age of Technology and OutcomesThe Role of Lifestyles on the Immunology, Physiology, and Quality of Life of Asthma Patients: Is It Time for Artificial Intelligence and Mobile Health? | Mark Lazarovich (United States)The Effect of Activity and Weight Modification on Asthma Management | Louis-Philippe Boulet (Canada)Genetics and Epigenetics of Stress and Asthma | Juan C. Celedon (United States)

Drug AllergyBeta-Lactam Allergy Evaluation: Do We Have Alternatives? | Luis Felipe Chiaverini Ensina (Brazil)Desensitization of Biological Drugs | Nancy Agmon-Levin (Israel)Practical Approach to NSAID Hypersensitivity | Pedro Giavina Bianchi (Brazil)

WORKSHOP 15.30 – 17.00

When Allergy and Immune Deficiency MeetEczema and Asthma in Immune Deficiencies | Kathleen Sullivan (United States)Food Allergies in Immune Deficiencies | Sara Anvari (United States)The Peculiar Atopy in Hyper IgE Syndromes | Ricardo Sorensen (United States)

SISTER SOCIETY SYMPOSIUM 15.30 – 17.00

Korean Academy of Asthma, Allergy, and Clinical Immunology Symposium (KAAACI) - Environment and Respiratory Allergies The Impact of Air Pollutants on Cell Barriers in Asthma| An-Soo Jang (Korea)Major Environmental Factors in Children with Allergic Rhinitis - The Korean Experience| Dae Hyun Lim (Korea)Early Life Origins of Respiratory Disease: Lessons from a Birth Cohort | Allan Becker (Canada)

Preliminary Scientific Program—Wednesday, 7 December

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KEYNOTE 08.30 – 09.00The Ubiquitin System in Health and Disease | Avram Hershko (Israel)

PLENARY 09.00 – 10.30

Atopic DermatitisAtopic Dermatitis: Epidemiology and Mechanisms State of the Art | TBCDifferences between Atopic Dermatitis (AD) Disease Phenotypes and the Need for Personalized Medicine in Atopic Dermatitis | Emma Guttman (United States)Therapy of Atopic Dermatitis | Torsten Zuberbier (Germany)

COFFEE BREAK 10.30 – 11.00

SYMPOSIA 11.00 – 12.30

Otitis Media with Effusion Effusion in the Middle Ear: A Hidden Enemy in School Children (Epidemiological Aspects and Impact on Learning) | Yi Li (China)Otitis Media with Effusion (OME) and Atopy: Cause or Myth? (Phsiopathogenic Mechanisms and Relationship) | Nelson Rosário Filho (Brazil)Eosinophlic Otitis Media (Diagnostic and Approach Treatment) | Mario Zernotti (Argentina)

Severe Asthma: COSA SessionSevere Asthma Phenotypes and Fungal Allergic Respiratory Disease | Paul Greenberger (United States)Aspirin Exacerbated Respiratory Disease | Shmuel Kivity (Israel)Novel Therapies for Severe - Unresponsive Asthma | Elliot Israel (United States)

Primary Prevention of Atopy and Childhood AsthmaModulation of Early Life Allergic Sensitization for the Prevention of Childhood Asthma | Robert Wood (United States)New Insights on the Diagnosis and Treatment of Asthma Exacerbation in Infants under the Age of One Year | Benjamin Volovitz (Israel)Vitamins and/or Probiotics Supplementation for Asthma Prevention | Avraham Biegelman (United States)

JUNIOR MEMBER PRACTICAL COURSE 11.00 – 12.30

Practical Management of Anaphylaxis Senior Moderator | TBCJunior Member | Vered Schichter-Konfino (Israel)Junior Member | Manuel Rial Prado (Spain)

WORKSHOP 11.00 – 12.30

Non-Allergic Rhinitis (NAR), Cough and Asthma PracticeUpper and Lower Airways Relationship and Treatment | Eli Meltzer (United States)How Do We Manage Recalcitrant Sinusitis Patients | Michael Kaliner (United States)Impact of Sinonasal Disease on the Lower Airways | Larry Borish (United States)

SISTER SOCIETY SYMPOSIUM 11.00 – 12.30

Turkish National Society of Allergy and Clinical Immunology Symposium (TNSACI) - Specific Immunotherapy: Bench to BedsideSkin Prick Testing: Optimizing the Practice | Bülent Şekerel (Turkey)SCIT vs. SLIT: Translation to the Practice in the Real World | Dilşad Mungan (Turkey)Modifying the Immune Response: Specific Immunotherapy | Mübeccel Akdis (Switzerland)

POSTER SESSIONS 12.30 – 13.30

Preliminary Scientific Program—Thursday, 8 December

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SYMPOSIA 13.30 – 15.00

Update on Eosinophilic Gastrointestinal DiseaseEpidemiology of EGIDS | Carina Venter (United States)Pathogenesis of EGIDS | Jonathan Spergel (United States)Treatment of EGIDS | Ignacio J. Ansotegui (Spain)

Asthma in the Elderly TodayClinical Features Differentiating Elderly Asthma from Non-Elderly Asthma | Anahi Yañez (Argentina)Asthma in the Elderly: Role of Comormidities | Arzu Yorgancioglu (Turkey)What Are the Challengers in Asthma Elderly Treatment? | Sang Heon Cho (Korea)

Desensitization to Drugs & Anaphylaxis Desensitization to NSAIDS | Pedro Giavina Bianchi (Brazil)Desensitization to Beta-Lactams | Edgardo Jares (Argentina)Desensitization to Chemotherapy and Monoclonal Antibodies | Mariana Castells (United States)

WORKSHOP 13:30 – 15.00

AnaphylaxisAnaphylaxis: Epidemiology and Etiological Factors | Alessandro Fiocchi (Italy)Food Induced Exercise-Related Anaphylaxis | Stephen Tilles (United States)The Epipen Device: The Doctor vs. Patient Perspective | Aharon Kessel (Israel)

SISTER SOCIETY SYMPOSIUM 13.30 – 15.00

Canadian Society of Allergy and Clinical Immunology (CSACI) - Anaphylaxis, Birth Cohorts, Development and Eosinophils: The ABC’s of Canadian Allergy ResearchCross Canada Anaphylaxis Registry (CCARE): Lessons in Anaphylaxis from Montreal and Beyond | Ben Shoshan (Canada)The CHILD study: Lessons from a Birth Cohort | Allan Becker (Canada)Allergy is in the Blood at Birth: Cord Blood Eosinophil Progenitors Predict the Development of Allergy and Asthma | Judah Denburg (Canada)

COFFEE BREAK 15.00 – 15.30

SYMPOSIA 15.30 – 17.00

Treatment and Management Advances in Ocular Allergy and Other Surface DiseasesOcular Overview | Paul Greenberger (United States)Intranasal Steroids and the Eye: Pros and Cons | Leonard Bielory (United States)Inflammatory Mediators of the Ocular Surface: Implications in Management | Dana Wallace (United States)

Asthma and Poverty: What Can Be Done?Epidemiology and Clinical Features of Asthma in the Developing World | Alvaro Cruz (Brazil)Are GINA Guidelines Useful in Underdeveloped Countries | Arnaldo Caprles-Hulett (Venezuela)Asthma in the Inner Cities of Developed Countries | Wanda Phipatanakul (United States)

Chronic Rhinosinusitis: From Endotypes to Personalized TreatmentChronic Rhinosinusitis in Children: Relationship to Adenotonsillar Hypertrophy, Sleep Disordered Breathing and Behavioral Disorders: Role of the Allergist | Bernard Silverman (United States)Aspirin Sensitivity (AERD) in Chronic Rhinosinusitis (CRS) | Larry Borish (United States)Personalized Treatment Approaches: Biologics in CRS | Robert Schleimer (United States)

Aberrant Inflammation and Aberrant Immune Programming in Early LifeImmune-Microbiota Interactions in Early Life: Dysbiosis as a Global Health Issue | Susan Prescott (Australia)The Microbiome and Allergic Disease | Mimi Tang (Australia)Feeding Modalities: Long-Term Influence on the Immune Responses to Food and Environmental Allergens | Ricardo Sorensen (United States)

JUNIOR MEMBER SYMPOSIUM 15.30 – 17.00

What’s Going on in Allergy and Clinical Immunology: Junior Members at the Front Line Patch Testing Procedures: A Consensus Document | Razvigor Darlenski (Bulgaria)The Joint Junior Members Survey for Better Formation and Education | Marco Caminati (Italy)New International Classification of Disease (ICD) and Its Clinical Relevance | Luciana Kase Tanno (France)

Preliminary Scientific Program—Thursday, 8 December

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KEYNOTE 08.30 – 09.00Perturbing Early Life Microbiota Development and Its Immunologic Consequences | Martin J. Blaser (United States)

PLENARY 09.00 – 10.30

The Next Frontier for Food Desensitization: Alternatives to Oral ImmunotherapyOral Immunotherapy with Adjuvants | Wesley Burks (United States)Epicutaneous Desensitization | Hugh Sampson (United States)Multiple Food Desensitization | Motohiro Ebisawa (Japan)

COFFEE BREAK 10.30 – 11.00

SYMPOSIA 11.00 – 12.30

Use of Environmental Control to Treat Allergic DisordersTaking on Environmental Health History | Wanda Phipatanakul (United States)Potentially Fatal Occupational Lung Disease | Chester Zeiss (United States)Communicating Findings and Recommending Interventions: What Works? | Adnan Custovic (United Kingdom)

Severe Asthma in ChildrenThe Definition of Severe Asthma | Bruce Mazer (Canada)Asthma Phenotypes | Leonard Bacharier (United States)When Off-Label Medications could be Prescribed | Peter Le Souëf (Australia)

Phenotypes in Chronic RhinosinusitisChronic Rhinosinusitis with Nasal Polyps | Robert Schleimer (United States)Chronic Rhinosinusitis without Nasal Polyps | Phillippe Gevaert (Belgium)Chronic Rhinosinusitis Phenotypes: How to Apply in Clinical Practice | Lou Zhang (China)

Food AllergyEarly Intervention of Peanut Allergy | Gideon Lack (United Kingdom)Component Resolved Diagnosis in Food Allergy | Motohiro Ebisawa (Japan)Microbiome and Food Allergy | David Fleischer (United States)

JUNIOR MEMBER PRACTICAL COURSE 11.00 – 12.30

Allergy Immunotherapy: What, When and How Senior Moderator | TBCJunior Member | Orly Ben-Or (Israel)Junior Member | Nana Fenny (United States)

Preliminary Scientific Program—Friday, 9 December

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WISC 2016 REGISTRATION INCLUDES:• Admission to all Scientific Sessions

• Admission to Exhibit Hall

• Admission to Poster Hall

• Certificate of Attendance

• Opening Ceremony and Welcome Reception*

*Delegates who choose not to attend the Opening Ceremony and Welcome Reception will receive a reduced registration fee

CANCELLATION AND REFUND POLICY:• Before/on 31 July 2016: Full refund less $85 USD

administrative fee

• 01 August – 30 September 2016: 50% refund

• On/after 01 October 2016: No refund

RegistrationREGISTRATION – NOW OPEN!Register online at www.worldallergy.org/wisc2016/registration

Registration Fees - USD

Registration Category On or Before 31 July 2016

01 August - 30 September 2016

01 October - 9 December 2016

Delegate $675.00 $775.00 $875.00 Delegate - Low Income Economy* $400.00 $500.00 $600.00 Fellow-In-Training/Student/Allied Health** $350.00 $450.00 $550.00 All registration payments are charged in USD

*Low-Income Economy Status If you have questions regarding your country’s income status please email: [email protected]

**Fellow-In-Training, Student and Allied Health Please note your credentials will need to be verified by the WAO Secretariat before your registration is considered complete. Acceptable verification can either be a letter on department letterhead confirming your status or a copy of your valid University/Hospital identification card.

SUBSTITUTION POLICYNo substitutions are allowed. Individuals will have to cancel their original registration and the new person will have to create a new registration. Within groups; however, you will be able to do substitutions up until the regular registration deadline (30 September 2016). After this date you will be charged an $85 USD administrative fee per substitution/name change.

For more information on the registration rates and requirements please visit the WISC 2016 registration website: www.worldallergy.org/wisc2016/registration.

VISA POLICYWAO will not be held liable if you are unable to receive your visa before WISC 2016. Registration refunds will not be provided if you are unable to attend the Conference due to not obtaining a visa. Please allow a minimum of 45 days to complete the visa application process. For visa questions please email: [email protected].

WISC 2016 6-9 December 2016 Jerusalem, Israel 19

To book your hotel accommodations* for WISC 2016, please visit our website: www.worldallergy.org/wisc2016/accommodations *The cut-off date for delegates to make hotel reservations online is Friday, 25 November 2016; published rates are subject to availability.

Below is the list of hotels which are being offered at a reduced price for WISC 2016 attendees. All accommodations are being handled by WAO’s appointed Professional Conference Organizer – ORTRA, Ltd. – the official PCO for WISC 2016

Hotels Category Single Rate – USD Breakfast included

Double Rate – USD Breakfast included

Distance to ICC Jerusalem

Crowne Plaza JerusalemStandard $163 USD $179 USD

650 mDeluxe $189 USD $204 USD

Dan Jerusalem Hotel Standard $143 USD $164 USD 4.2 kmDan Panorama Superior $168 USD $189 USD

3.0 kmDavid Citadel Hotel

Deluxe $197 USD $217 USDSuperior $311 USD $332 USD 3.2 km

Hotel Yehuda Standard $143 ISD $143 USD 6.9 kmInbal Jerusalem Hotel Superior New City $235 USD $250 USD 3.3 kmMamilla Hotel Studio Room $291 USD $311 USD 3.1 kmPrima Park Standard $128 USD $140 USD 1.0 kmRamada Jerusalem Deluxe $179 UD $189 USD 950 m

Waldorf Astoria JerusalemSuperior $357 USD $377 USD

3.3 kmDeluxe $367 USD $388 USD

CANCELLATION POLICY• Cancellations must be requested in writing: [email protected]

• Cancellation Policy: Refund will be made if written notification of cancellation is received by Ortra Ltd. as follows:

- Cancellation received until 5 October, 2016 – Full refund less $100 handling fee

- Cancellation received between 6 October, 2016 – 14 November, 2016 - 50% refund

- Cancellation received from 15 November, 2016 - No refund

*Published rates are subject to hotel availability and are not guaranteed. Published rates shall be offered 3 days pre- and post official Conference dates (6-9 December 2016) and based on hotel availability only and not guaranteed.

*Dates are subject to change.

Accommodations

20 WISC 2016 6-9 December 2016 Jerusalem, Israel

DeDicateD to Reaching alleRgists eveRywheReaccess these FRee resources online:Evidence-Based Allergy Literature Searches

Allergic Diseases Resource Center (Disease Summaries)

Ask the World Experts

Interactive Learning Modules

Online Lecture Series

WAO News & Notes Monthly Electronic Newsletters

Clinical Allergy Tips

Medical Journal Article Summaries

Medical Book Reviews

Interactive Case Reports

Allergy Meetings Worldwide Calendar

Scientific Interviews with Experts

WAO Junior Members Group

World Allergy Organization Journal

visit wao’s website:

www.worldallergy.org

@worldallergy www.facebook.com/worldallergyorg www.linkedin.com/company/world-allergy-organization

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We’re proud to announce that we’ve chosen SkyTeam as our Official Alliance Network for air travel. We would like to offer you seamless air travel via SkyTeam Global Meetings to our event. Our registered Global Meetings event offers you attractive airfares. By booking and buying your airline ticket via the dedicated link below, you will benefit from:

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WAO World Allergy Forum: Emerging Anti-Cytokine Therapies in Severe AsthmaTuesday, 14 June 2016 • 10:30 – 12:00 • Stolz 2, Reed Messe Wien Congress Center Chairpersons: Mario Sánchez-Borges (Venezuela), Antonella Muraro (Italy)

Cytokine Families and Receptors as Targets for Treatment in Severe Asthma Thomas B Casale University of South Florida Tampa, FL, United States

Cytokine Disruptive Therapies in Severe Asthma Sally E. Wenzel University of Pittsburgh Pittsburgh, PA, United States

Eosinophilic Directed Therapies in Severe Asthma William W. Busse University of Wisconsin Madison, WI, United States

This World Allergy Forum is an activity of the WAO Collaborative on Severe Asthma (COSA) – www.worldallergy.org/severe-asthma.

Speakers and Topics:

Production and distribution sponsored through an independent education grant from Teva Pharmaceuticals

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Notes

24 WISC 2016 6-9 December 2016 Jerusalem, Israel

WAO Symposium

ROME/VATICAN CITY27-29 April, 2017 - Rome, Italy/Vatican City

WAO Symposium

Fall, 2017 - Cartagena, Colombia

MEETINGS OF THE WORLD ALLERGY ORGANIZATION

CARTAGENA, COLOMBIA

JERUSALEM – AN IDEAL LOCATIONJerusalem is the capital of Israel and its largest city in terms of both geographic area and population size. Jerusalem is a city that has become home to people from many different faiths, traditions and ethnic groups; therefore, the city’s culinary culture offers something for everyone.

GETTING THERE IS EASY!Some 70 international airlines operate scheduled flights to Tel Aviv’s Ben Gurion International Airport; located only 35 minutes from the heart of Jerusalem. Ben Gurion is not only one of the world’s most efficient and passenger-friendly airports, but also one of its most architecturally beautiful.

VISASAll visitors to Israel must hold a passport that is valid for at least six months from the date they are departing the country. Visitors from some foreign countries will require a visa. Please refer to the Israel Ministry of Foreign Affairs website (http://mfa.gov.il) for more information.

IMPORTANT DATES9 June 2016 Registration and Abstracts Open31 July 2016 Early Registration & Abstract

Submission Deadline 30 September 2016 Regular Registration Rate Deadline 5 December 2016 On-site Registration Begins 6 - 9 December 2016 WAO International Scientific

Conference (WISC 2016)

www.facebookcom/worldallergyorg @worldallergy

www.worldallergy.org/wisc2016 Join the Conversation: #WISC2016

FOR INFORMATION AND UPDATES ON THE CONFERENCE, FOLLOW US AT:

Conference Secretariat

World Allergy Organization555 E. Wells St., Suite 1100 • Milwaukee, WI 53202 United States

Phone: +1 414 276 1791 • Fax: +1 414 276 3349Email: [email protected]

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We look forward to welcoming you toJerusalem, Israel

Local Professional Conference Organizer

1 Nirim Street, Canada House, POB 9352 • Tel Aviv, Israel 6109202Email: [email protected]