Why is Stem Cell donation important
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Little Anthony died at age 7 only because his mother could not find a matching donor to save his life. The
mother’s unstoppable efforts to enroll donors for Anthony lead to the formation of the well known Donor
Registry of England known as the Anthony Nolan Trust.
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Rashmi is a Thalassaemia Major.
She needs lifelong blood transfusions – on an average every 15 days
Her life is one of great challenge
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Shivendra suffers from Aplastic Anaemia.
His blood cells get destroyed
His chances of survival are bleak
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Gaurav has Acute Myeloid Leukemia
His Leukemic cells do not allow production of normal blood cells
His days are numbered
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Rashmi, Gaurav, Shivendra and many many others have only one hope -
A Stem Cell TransplantFrom a Stem Cell Donor
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What are their chances of finding a stem cell donor?
There was no functional Stem Cell Registry in India till now
Very little
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How do we build a Stem Cell Registry in India?
By enrolling oneself on the Registry
By taking responsibility.
By understanding that you can make a difference.
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How does one enroll oneself on the Registry?
By realizing that you can be a life giver
By reading the Questionnaire. By understanding the risks involved.By giving a blood sample
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What happens to your blood sample?
You will be called if your HLA matches that of the patient
Your HLA (Human Leukocyte Antigen) factors are typed. The factors are listed on the Registry.The Registry will be integrated with Global Registries soon.
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How do you donate your stem cells?
In most cases stem cells will be taken from the blood stream
Previously it was taken from the Bone Marrow (usually the Hip Bone). BUT NOWFrom peripheral blood just like a blood donation i.e. the blood stream in the body
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How do you donate stem cells from Peripheral Blood?
This is the same procedure as in the case of Platelet Donation (its easy..)
The donor is given Growth Factor injections for 4-5 days. Stem cells are extracted by ‘apheresis’.The apheresis procedure can take 3-4 hours
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What are the chances of your HLA matching with that of the patient?
A very large Registry is, therefore, the need of the hour
1 in 4 : if the patient is a sibling
1 in 20,000 : if the patient is unrelated
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International Marrow Donor Registries
Worldwide >14,000,000 donors
USA >8,000,000 donors
Donors ofIndian origin in Foreign registries <30,000 ????
Extreme paucity of donors of Indian origin
in established western registries
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BMDWBMDW
France Greffe de Moelle
183,454183,454 Austrian Bone Marrow Donors
60,860 60,860
National Marrow Donor
Program(USA) 8,000,0008,000,000
Anthony Nolan Research
Center(UK) 411,912 411,912
AustralianBone Marrow Donor
Registry
182,367 182,367
German Registry of
Bone Marrow Donors
3,939,5383,939,538
Bone Marrow Donors WorldwideBone Marrow Donors Worldwide
44 countries44 countries September 2010 September 2010 14,000,000 Donors14,000,000 Donors
64 Registries64 Registries
Marrow Donor Registry (India)
6,500
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Who all Can Register
• All individuals ranging from the age of 18 to 50 years.
• Males and Females.• Should not have any major illness related to
heart and blood.• Minor factors like low Hb, fever, medication,
minor operations don’t matter. • Individual should have the constant urge to
save lives.
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Let’s
Build an Indian Registry
Enroll ourselves
Show that we care
Make a difference
Give life to someone
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What after I register?
• Registration includes the filling of a form and a small blood sample collection.
• The blood will be HLA typed and kept in our confidential database.
• It will be constantly checked to see it matches any patient.
• Only if it matches you will be called for a Stem cell donation. It does not mean that everybody will be called for a donation. Very few will have the privilege to donate once in his lifetime.
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Please Register and Save Lives
All you have to do is Fill the Registration Form Give your blood sample
THAT’S IT.
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How important is your Commitment ?
• Once Registered the donor has the full right to back out anytime he wants. It would be nice if he informs it to us.
• If a donor is chosen as a match for a dying patient, he is the only one who can save his life then.
• Finding a match itself is difficult, but if a matched donor backs out, the hopes of the patient and relatives is shattered.
• Hence register with a long-term commitment.
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Let’s build the MDRI
It’s a challenge to India
It’s the only hope for many Indians.
It’s a way of showing that we care.
Rashmi, Shivendra and Gaurav are waiting for it.
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THANK YOU
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Marrow and the man
Being Human Foundation