Iron deficiency anemia (IDA), the most common nutritional deficiency in the world, is a major cause of reduced work capacity in adults and impaired mental function

1in children and adolescents . IDA during pregnancy significantly increases the risk 2for low birth-weight infants .

Contains the nutrients most commonly lacking in anemic individuals and provides them

in forms that are both well-absorbed and biologically active.*

Prolonged release iron tablets are easy to swallow and easy on your stomach

An unique formulation rich in iron (in the form of bis-glycinate ) in prolonged release form combines

with bioactive form l-methylfolate, physiologically active vitamin B12 and Zinc.

- 1. Killip S, Bennett JM, Chambers MD. Am Fam Physician 2007;75:671-678. 2. Haider BA, Olofin I, Wang M, et al. BMJ 2013;346:f3443

TabletsPROLONGED RELEASE

well-absorbed and biologically active

blood-building formula

LACTO OVA R

For healthcare practitioners only*

Non constipating Iron

Maximum iron absorption

Helps restore your energy significantly reducing fatigue & pallor

Low dose iron form for maximum benefit

Provides a unique prolonged release formula significantly more bioavailable and better tolerated

For pre & post surgical anaemia

Higher bioavailability through

Iron bisglycinate

Well-absorbed, non-constipating iron bisglycinate in prolonged release form

Prevents oxidation of ferrous ion to insoluble ferric form

Absorption 2 to 4 times better than other ferrous form’s that are commonly prescribed for iron.

First, by inhibiting oxidation of ferrous ion.

Second, by forming a soluble complex even in the alkaline PH of the small intestine.

Ferrous bisglycinate has 2 fold effect on

enhancing the bioavailability of iron.

Complete hematinic formula with prolonged release iron for better absorption

L-Methyl Folate in

Ferrous bisglycinate in

- Andres E, Serraj K. J Blood Med 2012;3:97-103. - Imbard A, Benoist JF, Blom HJ. Int J Environ Res Public Health 2013;10:4352-4389. Centers for Disease Control and Prevention. Folic acid. CDC Web site - 2009;Available at http://www.cdc.gov/ncbddd/ folicacid/about.html Accessed April 2009.

Bioactive form of folic acid, imparting enhanced absorption and bioavailability.

Sufficient consumption of l-methyl folate before conception and during pregnancy can prevent up to 70% of neural tube defects.

According to the CDC, most women in India do not get enough folic acid in their diets to help prevent birth defects.

Not affected by inhibitors

Maximum absorption

Enhanced iron absorption & strengthen’s overall immunity

- Killip S, Bennett JM, Chambers MD. Am Fam Physician 2007;75:671-678. - Haider BA, Olofin I, Wang M, et al. BMJ 2013;346:f3443.

PROLONGED RELEASE

Excellent before,

during and after

pregnancy

Precautions and Warnings: Accidental overdosage of

iron-containing products is a leading cause of fatal

poisoning in children under age of 6. Keep this product out

of reach of children. In case of accidental overdose, call a

doctor or poison control center immediately.

Pyridoxal 5 Phosphate in

Bioactive form of vitamin B6

Higher absorption and bioavailability

Zinc bisglycinate in

It is a highly absorbed zinc form

Corrects zinc deficiency during pregnancy

Helps to strengthen overall immunity

Adenosylcobalamin in

Methylcobalamin and

Active, coenzyme forms of vitamin B12 for immediate utilization Prevents pernicious anemia

Superior blood-building effect

- Fernández-Bañares F, Monzón H, Forné M. World J Gastroenterol 2009;15:4644-4652.- Kulnigg S, Gasche C. Aliment PharmacolTher 2006;24:1507-1523

PROLONGED RELEASE

Indications And Clinical Uses: Iron (Ferrous bisglycinate)Adenosylcobalamin, Methylcobalamin, L-methylfolate calcium, Pyridoxal 5 phosphate, Zinc bisglycinate indicated in the supportive treatment of nutrient deficiency during and after pregnancy.

Contra-Indications: Hemosiderosis, Hemochromatosis, Hemolytic anemia.

Precautions: Oral multinutrient iron preparations may aggravate existing peptic ulcer, regional enteritis and ulcerative colitis. Iron compounds taken orally can impair the absorption of tetracycline antibiotics. Antacids given concomitantly with iron compounds decrease iron absorption.

Case Study of Adverse Reactions oral supplementation of Iron : In a neurotic patients supplementation of iron was interrupted because of nausea and regurgitation. In pregnant women, the incidence of pyrosis and chronic constipation is slightly increased. In children, a clinical investigator reported 3 cases of slight diarrhea which disappeared within a few days. In 1 case, slightly curdled stools were observed, although this could not be definitely attributed to the product. In the final case studies, clay colored stools were noted.

Symptoms And Supplementation Of Overdose: Iron poisoning is rare in adults but serious acute poisoning in children can result from ingestion of doses in excess of 1g. Doses of 1g should be considered as toxic in children and therapy instituted as soon as possible. Serum iron levels above 500 µg/100 mL can be taken as presumptive evidence of poisoning; severe poisoning is usually associated with levels well above 1000µg /100 mL. Symptoms: May occur within 30 minutes or may be delayed several hours. They are largely those of gastrointestinal irritation and necrosis with vomiting, diarrhea, tarry stools, hematemesis, fast and weak pulse, lethargy, low blood pressure, coma and signs of peripheral circulatory collapse. There may be a transient period of apparent recovery after 4 to 6 hours followed by a second crisis characterized by cyanosis, pulmonary edema, circulatory collapse, convulsion, and coma may then occur followed by death in 12 to 48 hours.

Treatment: Milk should be given immediately and vomiting induced. Eggs and milk should be fed (to form iron-protein complexes) until it is possible to perform gastric lavage with 1% sodium bicarbonate solution (to convert the iron to a less soluble form). Gastric lavage should not be performed after the first hour of iron ingestion because of the danger of perforation due to gastric necrosis. If an iron-chelating agent such as deferoxamine mesylate is available, it should be utilized. BAL (dimercaprol) should not be used because it may form a toxic complex. Measures to combat shock, dehydration, blood loss and respiratory failure may be necessary.

Dosage And Administration: Adults and children over 12: 1 Tablet with meals for the supplementation of mild to serve iron deficiency anemia.

Availability And Storage: 10x10 blister pack in a box. Store in a cool, dry & dark place.

Prescribing info:

Supplement Facts

Each prolonged release tablet contains (approx):

Ferrous bisglycinate Equivalent to Elemental Iron 60mgAdenosylcobalamin 150 mcg Methylcobalamin 150 mcgL-methylfolate calcium 400 mcgPyridoxal 5 phosphate 2.5 mgZinc bisglycinate 15mg

R

Hyderabad, Telangana, INDIAwww.lactonova.com

PROLONGED RELEASE

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