Valvular Heart DISEASE
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Transcript of Valvular Heart DISEASE
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Valvular Heart DISEASE
Toni Mustahsani Aprami,
Department of Cardiology and Vascular Medicine
Division of Cardiovascular, Department of Internal Medicine
Padjadjaran University School of Medicine/Hasan Sadikin Hospital , Bandung
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• Etiology• Pathophysiology• Physical Exam• Natural History
• Testing• Treatment
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What Are the Types of Valve Disease?• There are several types of valvular heart disease,
include:
• 1) Valvular stenosis: When a valve opening is smaller than normal
• 2) Valvular Insufficiency/REGURGITATION: occurs when a valve does not close tightly, thus allowing blood to leak backwards.
• Both valvular diseases can involve all four valves.
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Types • Mitral Stenosis
• Mitral Regurgitation
• Aortic Stenosis
• Aortic regurgitation
• Tricuspid valve is affected infrequently
– Tricuspid stenosis
– Tricuspid regurgitation
• Pulmonary valve disease
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• Congenital : mostly affect the aortic or pulmonic valve
• Acquired :• Rheumatic fever • Infective endocarditis • Coronary artery disease• Heart attack• Cardiomyopathy (heart muscle disease)• Syphilis .• Hypertension . • Aortic aneurysms .• Connective tissue diseases
What Causes Valvular Disease?
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Rheumatic Heart Disease
• Inflammatory process that may affect the myocardium, pericardium and or endocardium
• Usually results in distortion and scarring of the valves
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Infective endocarditis • Infection of heart valves • Commonly bacterial • Results in damage to valve structure
giving rise to stenosis or regurgitation
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MITRAL STENOSIS (MS)
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• Usually results from rheumatic carditis• Is a thickening by fibrosis or calcification• Can be caused by tumors, calcium and thrombus • Valve leaflets fuse• These narrows the opening and prevents normal
blood flow from the LA to the LV• LA pressure increases Left Atrium dilates
PV pressure increases PA pressure
increases and the RV hypertrophies• Pulmonary congestion and right sided heart failure
occurs• Hemoptysis : due to rupture bronchial vessels due
to elevated pulmonary pressure• Followed by decreased Preload and CO decreases
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Natural History of MS• Disease of plateaus:
– Mild MS: 10 years after initial RHD insult– Moderate: 10 years later– Severe: 10 years later
• Mortality: Due to progressive pulmonary congestion, infection, and thromboembolism.
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Physical Exam Findings of MS
• Prominent "a" wave in jugular venous pulsations: Due to pulmonary hypertension and right ventricular hypertrophy
• Signs of right-sided heart failure: In advanced disease
• Mitral facies: When MS is severe and the cardiac output is diminished, there is vasoconstriction, resulting in pinkish-purple patches on the cheeks
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• Diastolic murmur: – Low-pitched diastolic rumble most prominent at
the apex. – Heard best with the patient lying on the left side
in held expiration – Intensity of the diastolic murmur does not
correlate with the severity of the stenosis
Heart Sounds in MS
Grading of severity of MSSeverity of MS Mild Moderate Severe
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Evaluation of MS
• ECG: may show atrial fibrillation and LA enlargement
• CXR: LA enlargement and pulmonary congestion. Occasionally calcified MV
• ECHO: The GOLD STANDARD for diagnosis. Asses mitral valve mobility, gradient and mitral valve area
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Echocardiography
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Echocardiography
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Management of MSSerial echocardiography:
– Mild: 3-5 years– Moderate:1-2 years– Severe: yearly
• Medications: MS like AS is a mechanical problem and medical therapy does not prevent progression– -blockers, CCBs, Digoxin which control heart
rate and hence prolong diastole for improved diastolic filling
– Duiretics for fluid overload
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Management of MS
• Identify patient early who might benefit from percutaneous mitral balloon valvotomy.
• IE prophylaxis: Patients with prosthetic valves or a Hx of IE for dental procedures.
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Baloon valvuloplasty
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Chronic Mitral Regurgitation : Occurs when the mitral valve does not close properly while the heart pumps out blood Backflow of blood from the LV to the LA during systole
Mild (physiological) MR is seen in 80% of normal individuals
Most common cause is mitral valve prolapse (MVP)
Mitral Regurgitation
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Acute MR
• Endocarditis• Acute MI• Malfunction or disruption of prosthetic valve
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• Myxomatous degeneration (MVP)• Ischemic MR• Rheumatic heart disease• Infective Endocarditis
Etiologies of Chronic Mitral Regurgitation
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Pathophysiology of MR• Pure Volume Overload
• Compensatory Mechanisms:
Left atrial enlargement, LVH and increased contractility– Progressive left atrial dilation and right
ventricular dysfunction due to pulmonary hypertension.
– Progressive left ventricular volume overload leads to dilatation and progressive heart failure.
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Physical Exam findings in MR
• Auscultation: soft S1 and a holosystolic murmur at the apex radiating to the axilla– S3 (CHF/LA overload)– In chronic MR, the intensity of the murmur
does correlate with the severity.• Exertion Dyspnea: ( exercise intolerance)• Heart Failure: May coincide with increased
hemodynamic burden e.g., pregnancy, infection or atrial fibrillation
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The Natural History of MR
• Compensatory phase: 10-15 years• Patients with asymptomatic severe MR
have a 5%/year mortality rate• Once the patient’s EF becomes <60%
and/or becomes symptomatic, mortality rises sharply
• Mortality: From progressive dyspnea and heart failure
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Imaging studies in MR
• ECG: May show, LA enlargement, atrial fibrillation and LV hypertrophy with severe MR
• CXR: LA enlargement, central pulmonary artery enlargement.
• ECHO: Estimation of LA, LV size and function. Valve structure assessment– TEE if transthoracic echo is inconclusive
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Grading of severity of MRSeverity of MR Mild Moderate Severe
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Management of MR (1)• Medications
a) Vasodilator such as hydralazine
b) Rate control for atrial fibrillation with -blockers, CCB, digoxin
c) Anticoagulation in atrial fibrillation and flutter
d) Diuretics for fluid overload
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Management of MR (2)
• Serial Echocardiography: – Mild: 2-3 years– Moderate: 1-2 years– Severe: 6-12 months
• IE prophylaxis: Patients with prosthetic valves or a Hx of IE for dental procedures.
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Aortic Stenosis• characterized by an abnormal
narrowing of the aortic valve opening.
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• Normal Aortic Valve Area:
3-4 cm2
• Symptoms:
Occur when valve area is 1/4th of normal area.
• Types: – Supravalvular– Subvalvular– Valvular
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Etiology of Aortic Stenosis
• Congenital• Rheumatic• Degenerative/Calcific : Most commonly,
aortic stenosis is due to age-related progressive calcification
Patients under 70: >50% have a congenital cause
Patients over 70: 50% due to degenerative
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Etiology of AS
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Pathophysiology of Aortic Stenosis• A pressure gradient develops between
the left ventricle and the aorta. (increased afterload)
• LV function initially maintained by compensatory pressure hypertrophy
• When compensatory mechanisms exhausted, LV function declines.
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Presentation of Aortic Stenosis
- Syncope: (exertional)
- Angina: (increased myocardial oxygen demand; demand/supply mismatch)
- Dyspnea: on exertion due to heart failure (systolic and diastolic)
- Sudden death
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Physical Findings in Aortic Stenosis• Slow rising carotid pulse (pulsus tardus)
& decreased pulse amplitude (pulsus parvus)
• Heart sounds- soft and split second heart sound, S4 gallop due to LVH.
• Systolic ejection murmur- cresendo-decrescendo character. This peaks later as the severity of the stenosis increases.– Loudness does NOT tell you anything
about severity
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Natural History
• Mild AS to Severe AS:– 8% in 10 years– 22% in 22 years– 38% in 25 years
• The onset of symptoms is a poor prognostic indicator.
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Evaluation of AS
• Echocardiography is the most valuable test for diagnosis, quantification and follow-up of patients with AS.
• Two measurements obtained are:
a) Left ventricular size and function: LVH, Dilation, and EF
b) Doppler derived gradient and valve area (AVA)
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Evaluation of AS
Grading of severity of AS
Severity of AS AVA Velocity
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Management of AS• General- IE prophylaxis in dental procedures
with a prosthetic AV or history of endocarditis. • Medical - limited role since AS is a mechanical
problem. Vasodilators are relatively contraindicated in severe AS
• Aortic Balloon Valvotomy- shows little benefit.
• Surgical Replacement: Definitive treatment
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Aortic RegurgitationLeakage of blood into LV during diastole due to ineffective coaptation of the aortic cusps
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Etiology of Acute AR
• Endocarditis• Aortic Dissection
• Physical Findings:– Wide pulse pressure– Diastolic murmur– Florid pulmonary edema
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Treatment of Acute AR
• True Surgical Emergency:• Positive inotrope: (eg, dopamine,
dobutamine) • Vasodilators: (eg, nitroprusside)• Avoid beta-blockers• Do not even consider a balloon
pump
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Etiology of Chronic AR
• Bicuspid aortic valve
• Rheumatic • Infective endocarditis
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Pathophysiology of AR
• Combined pressure AND volume overload
• Compensatory Mechanisms: LV dilation, LVH. Progressive dilatation leads to heart failure
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Natural History of AR• Asymptomatic until 4th or 5th decade• Rate of Progression: 4-6% per year• Progressive Symptoms include:
- Dyspnea: exertional, orthopnea, and paroxsymal nocturnal dyspnea
- Nocturnal angina: due to slowing of heart rate and reduction of diastolic blood pressure
- Palpitations: due to increased force of contraction
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Physical Exam findings of AR• Wide pulse pressure: most sensitive
• Hyperdynamic and displaced apical impulse
• Auscultation- – Diastolic blowing murmur at the left sternal
border– Austin flint murmur (apex): Regurgitant jet
impinges on anterior MVL causing it to vibrate – Systolic ejection murmur: due to increased
flow across the aortic valve
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Auscultatory and peripheral findings in severe AR :A glossary of eponyms
Sign Description
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The Evaluation of AR
• CXR: enlarged cardiac silhouette and aortic root enlargement
• ECHO: Evaluation of the AV and aortic root with measurements of LV dimensions and function (cornerstone for decision making and follow up evaluation)
• Aortography: Used to confirm the severity of disease
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Grading of severity of AR
Severity of AR Mild Moderate Severe
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Management of AR• General: IE prophylaxis in dental
procedures with a prosthetic AV or history of endocarditis.
• Medical: Vasodilators (ACEI’s), Nifedipine improve stroke volume and reduce regurgitation only if pt symptomatic or HTN.
• Serial Echocardiograms: to monitor progression.
• Surgical Treatment: Definitive Tx
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Treatment of valvular heart disease
• Drugs to facilitate myocardial functioning
• Surgical-valve replacement/valve repair
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Mechanical Valve
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Mechanical Valve
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Tissue Valve
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Thank you
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Simplified Indications for Surgical Treatment of AR
• ANY Symptoms at rest or exercise• Asymptomatic treatment if:
– EF drops below 50% or LV becomes dilated
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Clinical presentation
• Congestive heart failure • Syncope• Angina
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Aortic Regurgitation• is the leaking of the aortic valve of the heart
that causes blood to flow in the reverse direction during ventricular diastole, from the aorta into the left ventricle.
• Causes:• Infective endocarditic• Rheumatic disease• Trauma• Aortic dilatation like in Marfan’s Syndrome,
syphilis
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Mitral Stenosis• Usually results from rheumatic carditis• Is a thickening by fibrosis or calcification• Can be caused by tumors, calcium and thrombus • Valve leaflets fuse• These narrows the opening and prevents normal blood flow
from the LA to the LV• LA pressure increases, left atrium dilates, PAP increases, and
the RV hypertrophies• Pulmonary congestion and right sided heart failure occurs• Followed by decreased preload and CO decreases
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Mitral Stenosis, cont.
• Mild – asymptomatic• With progression – dyspnea, orthopneas, dry cough,
hemoptysis, and pulmonary edema may appear• Right sided heart failure symptoms occur later • Signs
– Atrial fibrillation – Apical diastolic murmur is heard
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diagnostic tests
• Echocardiography .• Transesophageal
echocardiography . • Cardiac catheterization .
(also called an angiogram) • MRI
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Medial Treatment
• Nonsurgical management focuses on drug therapy and rest
• Diuretic, beta blockers, digoxin, O2, vasodilators, prophylactic antibiotic therapy
• Manage atrial fibrillation , if develops, with conversion if possible, and use of anticoagulation
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Surgical Management of Valve Disease
• Mitral Valve– Mitral Valve Replacement– Balloon Valvuloplasty
• Aortic Valve Replacement
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Advantages of surgical repair
• Reducing progression into heart faliure• better functional outcome
Disadvantages • Valve failure• Some valves warrant life long anticoagulatioln
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Thank you….