VACCINOLOGY (BIO-301) Credit Hrs 3(2-1)

Dr. Aneela javed

The aim of the course is to

•Introduce students to the various disciplines associated with

vaccinology including

•vaccine development

•The relevant basic sciences such as immunology, microbiology and

molecular biology

•clinical trials

•vaccine safety, ethics

•vaccine-economics

•vaccination strategies and evaluation of vaccines.

Objectives

•An introduction to Vaccinology

•Vaccine history and types

•Epidemiologic basis of Vaccinology

•Role of combination vs. single vaccines

•The immune responses to the pathogen & vaccine

development

•Immunology of Vaccines

•Antigen and Vaccine Delivery Strategies

•Determinants of Vaccine Availability

•Vaccine development strategies: New approaches

•Live versus attenuated vaccines

•Role of multinational companies in vaccines production

•DNA as vaccine

•Peptide & Subunits vaccine

•Adjuvants in vaccines

•Population Genetic analysis: immunity

to vaccine

•Recombinant vaccine

•Animal models of vaccine testing

•Vaccine Delivery Systems

•Practical issues in relation to trials

•Ethical issues related to clinical

evaluation of vaccines

•Vaccine safety

•Review of vaccines in current use

•Vaccine-economics

•Future of Vaccines/Vaccination

Course Contents

Part 2: Principles of Vaccine Design

Immunologic Memory: T and B Cells memory

• Antigen Processing and Presentation by MHC Class I, II, and Nonclassical Molecules

• Understanding the Mucosal Immune System for Better Mucosal Vaccine Design

PART 1 : INTRODUCTION• Definition• History • Types• Combination vs single vaccine

Course Contents

Part 3: ANIMAL MODELS FOR VACCNE TESTING

• Utility of Mouse Models in Vaccine Design and Development,

• Utility of Nonhuman Primate Models for Vaccines,

Part 4: Delivery Systems•Transcutaneous Immunization via Vaccine Patch Delivery System•Needle-free Jet Injection for Vaccine Administration•Oral Vaccines: An Old Need and Some New Possibilities Adjuvants:

Part 6: Regulatory Considerations•Regulatory Issues•Role of international companies•Vaccine economics

Part 5: Evaluating Vaccine Efficacy

• Trials in human and practical issues

PART 7: Population genetics and vaccines

• Ethical issues

• Vaccine safety

Antigen Engineering Sequence-Based Computational Approaches to Vaccine Discovery and DesignAntigen Discovery for Vaccines Using High-throughput Proteomic Screening Technologies, Phage LibrariesAttenuated Bacterial VaccinesVirus-like Particles as Antigen ScaffoldsRecombinant MVA vaccines: Optimization, Preclinical, and Product DevelopmentRecombinant Adenoviruses for VaccinationRecombinant Avipoxviruses, Intracellular Facultative Bacterial Vectors for Cancer Immunotherapy Nucleic Acid Vaccination,Artificial Antigen-presenting Cells: Large Multivalent Immunogens

Recommended Books:

The Vaccine Controversy: The History, Use, and Safety of Vaccinations by

Kurt Link; Praeger.

Novel Vaccination Strategies by Stefan H. E. Kaufmann.

Vaccinia, Vaccination, Vaccinology - Jenner, Pasteur and Their Successors

by Pasteur, B. Fantini, S.A. Plotkin

Progress in Vaccinology by Richard Moxon.

The Virus and the Vaccine: Contaminated Vaccine, Deadly Cancers, and

Government Neglect by Debbie Bookchin and Jim Schumacher.

BOOKS

Rules

1. 2 OHTs….skip rule…. makeup

2. 6 quiz/surprise test…no makeup

3. Class participation….

4. Assignments/Presentation /project

•Review of vaccines in current used in pakistan

Cell Biology, Microbiology and Virology, Basic Immunonology

PRE- REQUISITE(s)

REVISION

Cell Biology, Microbiology and Virology, Basic Immunonology

HISTORY

1796

TYPES

infectious bovine rhinotracheitis (IBR)

Bovine viral diarrhoea virus (BVDV)

ANTIGENICITYTOXICITY

FORMALIN

ADVANTAGES