Use of Animals in Research: IACUC's, Animal Care Requirements

and More

Panel members:

William Ray Stricklin, PhD IACUC ChairDouglas Powell, DVM, ACLAM Attending VeterinarianAmanda Underwood, B.S., CPIA IACUC Manager

University of Maryland, College Park

Use of Animals in Research: IACUC's,

Animal Care Requirements and More

Panel members:

William Ray Stricklin, PhD IACUC ChairDouglas Powell, DVM, ACLAM Attending VeterinarianAmanda Underwood, B.S., CPIA IACUC Manager

University of Maryland, College Park

Regulatory Background

Animal Welfare Act created in 1966 - primarily to protect ‘pet’ type animals- 4 major amendments

PHS Policy on the Humane Care and Use of Laboratory Animals – created in 1971

- expanded with Health Research and Extension Act in 1985

Guidelines

AVMA Guidelines on Euthanasia

Guide for the Care and Use of Agricultural Animals in Research and Teaching

Guide for the Care and Use of Laboratory Animals, 8th edition

The Principles of Humane Experimental Technique

Biosafety in Microbiological and Biosafety Laboratories

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

AAALAC Accreditation

Gold standard

Independent verification of program strength

Ensures adequate veterinary care

Ensures appropriate oversight

Ensures clear lines of authority

Ensures strong institutional commitment to the Animal Care and Use Program

Oversight

USDA Yearly visit by USDA Inspector Reviews only USDA species

OLAW PHS Assurance Covers all vertebrate species Self-report all non-compliance

AAALAC Reviews program description Every 3 years undergo site visit and reaccreditation

IACUC Semi-annual review of program Semi-annual inspection of all facilities and labs Annual review of protocols

The IACUC – a brief overview

Campus responsibilities Committee membership meets regulatory requirements Stand-alone committee Communication and support from IO

Committee responsibilities Scientific justification 3 R’s Minimize pain and distress Appropriate care of animals Appropriate method of euthanasia Investigate all animal abuse issues

Veterinary Oversight

Procurement and trackingTransportationPhysical Environment - SOPsMonitoring/treatment of health issuesAssist PI with revising care and proceduresMonitor all survival surgeries

Training Program

PI/Animal User Course

In Facility Training

Lab-specific Training

Procedure-specific Training

Post-approval Monitoring

Are they trained?Are they trained well?Do they do what they are supposed to?

Good PAM Protects Animals Institution PI Facility Staff

Basil © Disney

It’s not Just the Animals

Occupational Health and Safety

Department of Environmental Safety

Facilities Management

Regulatory Considerations

Protocol-grant congruency

MOUs

Sub-awards

Suspension of Protocols Effects on Funding

Questions?