Translation and InnovationMark Chance, PhDVice Dean for ResearchSchool of Medicine

October 19, 2015

Translation and Innovation at CWRUSchool of Medicine Leading the Way

• School of Medicine boasts a vibrant pipeline of highly innovative translational programs– Expert guidance is provided through chief translational

officers and the Technology Transfer Office

• Disciplined vetting processes in place to select high potential programs to invest in

• Council to Advance Human Health (CAHH) promotes translation by funding key proof of concept studies focused on preclinical development of drugs

DiscoveryPreclinical

Development

Lead Optimization

Taiwan Medical U./CTSC FundCAHH Innovation FundTTO Innovation Fund

CTSC and CCCC Pilot GrantsHarrington Scholar

NCAI GrantsCoulter Translation Program

NIH fundingHTS Pilots

Ohio Third FrontierNIH SBIR/STTR

ONE FundCTO Road Show

BioMotiv

New Company

Private Investment

License

Industry Partner

Preclinical Optimization

HTS = high throughput screeningCAHH = Council to Advance Human HealthNCAI = National Centers for Accelerated InnovationsCTUHV = Case Technologies and University Hospitals Venture FundCTO = Chief Translational Officers

Medical Innovation Pipeline

Hundreds of SOM research

programs

50

15

3

Vetting Technologies: CAHH

Investigators meet with our experts regularly

Programs marketed to major pharma and biotech annually

Programs presented to CAHH annually (11 funded since 2012)

More than 70 eligible inventions at various stages

26

Case Coulter Translational Funding Pipeline

Letters of Intent received (2012-2015) - 1 round annually

Full proposals submitted

Funded proposals ($100K each)

Presentations to review committee

115

72

44

212

51

12

National Center for Accelerated Innovation Translational Funding Pipeline

Totals CWRU/UHCMC

57

19

4

Letters of Intent received (2-3 rounds/yr)

Full proposals submittedFunded proposals ($100K-$125K each)* *first 3 rounds, 4th round pending

TranslationMarketing

Totaling over $10M in new investments

Commercialization Program: Culture and Product

• New funding• New companies• Culture change• Industry licenses

• Proposed for-profit fund outside the university• Interested in early look at

vetted discoveries across the University

Opportunities for New Exits: ONE Fund

The ONE Fund will provide critical funding needed to develop CWRU opportunities

Translational Research Program Collaboration

CAHH

NCAI

GLEI

Weatherhead

Diligence EnginesReview and Analysis

Modest funding or in-kind supportPeer review

Mentorship and advice

FundingPrograms

Product Value Creation

$300M/year

$2M/year

$6M/year

+100

10-15

2-3

non-profitfor profit

Thank you.