TOXICOLOGY - Food and Agriculture Organization...GD\ IRU IHPDOHV UHVSHFWLYHO\ WKH 12$(/ ZDV SSP...
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Transcript of TOXICOLOGY - Food and Agriculture Organization...GD\ IRU IHPDOHV UHVSHFWLYHO\ WKH 12$(/ ZDV SSP...
TOXICOLOGY
Biochemical aspects
Toxicological data
Biochemical and toxicological data on metabolites and/or degradates
Human data
Toxicological evaluation
Levels relevant to risk assessment of acetochlor
Critical end-points for setting guidance values for exposure to acetochlor
Summary
RESIDUE AND ANALYTICAL ASPECTS
NCl
O
O
NH2 NH2OH
CO2HHN
O
OH
HN
OS
O O
OR
R=glucose sulfate
CO2HN
OO
HOHN
OSO
CO2H
OGluc
HN
OSO3H
N
OS
CO2H
NH2
O
NOH
O
O
N
OS
NH
CO2H
O
OCO2H
N
OS
NH
CO2H
O
OCO2H
O
N
O
OS
O O
CO2HN
O
O
OH
HNOH
O
HN
OS
O O
CO2HHN
O
NH2
OH
Plant metabolism
CO2HN
O
OHN
OS
CO2H
OHO
N
O
OSO
CO2HN
O
OSO
CO2H
OH
N
O
OSO3H
Animal metabolism
Environmental fate
Methods of Analysis
Stability of pesticide residues in stored analytical samples
Definition of the residue
NCl
O
O
ONNHHO
O
metolachlor
CGA-37913 CGA-49751
6N HCl
N ClO
O NCl
OO
N ClO
O
Results of supervised residue trials on crops
Animal feeds
Fate of residues during processing
Residues in animal commodities
DIETARY RISK ASSESSMENT
Long-term intake
Short-term intake
