TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected...
Transcript of TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected...
![Page 1: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/1.jpg)
![Page 2: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/2.jpg)
![Page 3: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/3.jpg)
TOPICAL THERAPY
ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may be greasy or messy - may have different preparations for different sites leading to confusion.
![Page 4: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/4.jpg)
ABSORBTION THROUGH SKIN AFFECTED BY:
• Skin thickness
• Skin barrier function
• Skin hydration
• Molecule size
• Whether lipophilic or not
• Concentration
• Base may be altered to affect absorpti
![Page 5: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/5.jpg)
VEHICLES
VERY IMPORTANT
![Page 6: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/6.jpg)
SOLUTION – usually water containing a dissolved powder
• Normal saline
• Potassium permanganate solution
• drying
![Page 7: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/7.jpg)
LOTION – thicker may contain oil as well as water or alcohol
• Corticosteroid scalp lotion e.g. Locoid Scalp lotion (alcohol based)
• Corticosteroid lotion e.g Betnovate lotion (water based with some oil)
• May have some moisturising ability
![Page 8: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/8.jpg)
CREAM – an emulsion of water and oil phases
• Oil in water emulsion e.g. Aqueous Cream BP
• Water in oil emulsion e.g. healthE Fatty Cream, Oily Cream BP
• Require preservatives
• Variable moisturising ability
![Page 9: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/9.jpg)
OINTMENTS – totally oil or grease.
• Don’t contain preservatives
• More occlusive - better penetration of active ingredient in to skin
• - better emollients
![Page 10: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/10.jpg)
OTHERS
• GEL
• PASTE
• POWDER
• FOAM
• (TRANSDERMAL PATCH)
![Page 11: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/11.jpg)
![Page 12: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/12.jpg)
![Page 13: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/13.jpg)
QUANTITY
• 30 gm required to cover an adult
• Fingertip unit (0.5 gm)
![Page 14: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/14.jpg)
SPECIAL CIRCUMSTANCES
• Premature babies – barrier function impaired
• New born babies – barrier function virtually same as adults
• Babies and infants – surface area to body mass ratio much higher than in adults and therefore much more systemic absorption
• Pregnancy and lactation
![Page 15: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/15.jpg)
![Page 16: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/16.jpg)
TOPICAL CORTICOSTEROIDS
BENEFITS AND PITFALLS
![Page 17: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/17.jpg)
TOPICAL CORTICOSTEROIDS
• Based on naturally occurring hydrocortisone produced by the adrenal gland and necessary for life.
• Excess production causes Cushing’s disease
• Lack of production causes Addison’s disease
![Page 18: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/18.jpg)
TOPICAL CORTICOSTEROIDS
• Hydrocortisone first medically commercially available in the 1950’s.
• Subsequently the molecule has been altered to produce multiple topical corticosteroids, all varying in their degree of potency.
• Large selection available now
![Page 19: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/19.jpg)
TOPICAL CORTICOSTEROIDS
• Class 1Very potent or superpotent (up to 600 times as potent as hydrocortisone)
• Clobetasol propionate (Dermol™ cream/ointment/scalp lotion)
• Betamethasone dipropionate (Diprosone™ OV cream/ointment)
![Page 20: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/20.jpg)
TOPICAL CORTICOSTEROIDS
• Class 2 Potent (100-150 times as potent as hydrocortisone)
• Betamethasone valerate (Beta™ cream/ointment/scalp solution, Betnovate™ lotion/C cream/C ointment, Fucicort™ cream)
• Betamethasone dipropionate (Diprosone™ cream/ointment, Daivobet® 50/500 ointment/gel)
• Diflucortolone valerate (Nerisone™ cream/fatty ointment)
• Hydrocortisone 17-butyrate (Locoid™ lipocream/ointment/scalp lotion/Crelo topical emulsion/)
• Mometasone furoate (m-mometasone™ cream/ointment Elocon™ cream/lotion/ointment)
• Methylprednisolone aceponate (Advantan™ cream/ointment)
![Page 21: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/21.jpg)
TOPICAL CORTICOSTEROIDS
• Class 3Moderate (2-25 times as potent as hydrocortisone)
• Clobetasone butyrate (Eumovate™ cream)
• Triamcinolone acetonide (Aristocort™ cream/ointment, Viaderm KC™ cream/ointment, Kenacomb™ ear drops)
![Page 22: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/22.jpg)
TOPICAL CORTICOSTEROIDS
• Class 4 Mild
• Hydrocortisone (DermAid™ cream/soft cream, DP™ lotion-HC 1%, Skincalm™, Lemnis™ Fatty Cream HC, Colifoam™ rectal foam 10%), Pimafucort™ cream/ointment, Daktacort™ cream, Micreme™ H cream, Resolve Plus™ 0.5%, 1% cream
![Page 23: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/23.jpg)
USES OF TOPICAL CORTICOSTEROIDS
• Have revolutionised the treatment of eczema/dermatitis
• Helpful in psoriasis
• Used in a wide variety of inflammatory dermatoses.
![Page 24: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/24.jpg)
INTERNAL SIDE EFFECTS
• Adrenal gland suppression – Topical steroids can suppress the production of natural steroids, which are essential for healthy living. Stopping the steroids suddenly may then result in illness.
• Cushing syndrome – If large amounts of steroid are absorbed through the skin, fluid retention, raised blood pressure, diabetes and many other side effects may result.
![Page 25: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/25.jpg)
LOCAL SIDE EFFECTS
• Skin thinning (atrophy) and stretch marks (striae).
• Easy bruising and tearing of the skin.
• Perioral dermatitis (rash around the mouth).
• Enlarged blood vessels (telangiectasia).
• Susceptibility to skin infections, eg impetigo, herpes simplex, malassezia folliculitis and molluscum contagiosum.
• Disguising skin infection, eg tinea incognito.
![Page 26: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/26.jpg)
LOCAL SIDE EFFECTS
• Allergy to the steroid cream.
• Delaying diagnosis and treatment of skin cancer, because of the anti-inflammatory action of topical steroid. Topical steroids do not have an anti-tumour effect.
• Aggravating certain inflammatory skin conditions, particularly pustular psoriasis, steroid acne and steroid rosacea.
![Page 27: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/27.jpg)
BASES/VEHICLES
• Lotions are easy to apply.
• Creams rub in well.
• Ointments may be most effective for dry lesions.
• Gels and solutions are useful in hairy areas or for a drying effect.
![Page 28: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/28.jpg)
Skin thinning (atrophy) and stretch marks (striae)
![Page 29: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/29.jpg)
Easy bruising and tearing of the skin
![Page 32: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/32.jpg)
Disguising skin infection, eg tinea incognito.
![Page 33: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/33.jpg)
PRINCIPLES OF TREATMENT
• Use potent ones to get the condition under control. (Best used short term)
• Use milder ones for ongoing treatment
• Swap between the two depending on progress.
![Page 34: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/34.jpg)
PRINCIPLES OF TREATMENT
• Don’t be afraid to use them
• Appropriate use provides great relief
• Be aware of, but don’t be ‘overawed’ by potential side effects.
• Can be used in secondarily bacterially infected dermatitis as long as antibiotics given
![Page 35: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/35.jpg)
![Page 36: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/36.jpg)
EMOLLIENTS
(Moisturisers)
![Page 37: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/37.jpg)
SOFTEN SKIN/ADD MOISTURE
• Used to correct dryness and scaling
• Help fine lines and wrinkles
• Help mild irritant contact dermatitis
![Page 38: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/38.jpg)
![Page 39: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/39.jpg)
CAUSES OF DRY SCALY SKIN
• Dry air e.g. low winter humidity • Exposure to the wind • Over-washing • Reduction in production of natural moisturisers
(sebum) in old age • Diuretic medications • Underactive thyroid gland • Inherited factors • A skin condition such as atopic dermatitis (eczema),
psoriasis or ichthyosis • Any combination of these
![Page 40: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/40.jpg)
TYPES OF MOISTURISERS/EMOLLIEN
TS OCCLUSIVES
• provide a layer of oil on the surface of the skin to slow water loss and thus increase the moisture content of the stratum corneum.
HUMECTANTS
• are substances introduced into the stratum corneum to increase its water holding capacity.
![Page 41: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/41.jpg)
OCCLUSIVE MOISTURISERS
• Bath oils
• Lotions
• Creams
• Ointments
![Page 42: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/42.jpg)
HUMECTANTS
• Glycerine
• Urea
• Alpha hydroxyl acids
![Page 43: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/43.jpg)
EMOLLIENTS
• Alpha Keri, BK, DP, Hydroderm lotions
• Glyc. 10% in Aqueous or sorbolene cream
• (Urea 10% creams)
• QV, Cetaphil, Aveeno, etc. creams
• Lipobase, healthE Fatty Cream
• Lipobase Repair
• WSP, Emuls. Oint
• Bath oils
![Page 44: TOPICAL THERAPY - NZWCS · TOPICAL THERAPY ADVANTAGES - increased dose of medication to affected area. - reduced systemic side effects and toxicity DISADVANTAGES - takes time - may](https://reader033.fdocuments.us/reader033/viewer/2022041419/5e1e1cb2f237b42c1f3d0537/html5/thumbnails/44.jpg)