TNT: Baseline and final LDL cholesterol levels
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Transcript of TNT: Baseline and final LDL cholesterol levels
LaRosa JC et al. N Engl J Med 2005; available at: http://www.nejm.org.
TNT: Baseline and final LDL cholesterol levels LDL cholesterol level
Atorvastatin 10 mg (n=5006)
Atorvastatin 80 mg (n=4995)
Mean baseline LDL cholesterol levels (mg/dL)
98 97
Final LDL cholesterol levels (mg/dL)
101 77
TNT: Primary efficacy outcomes
LaRosa JC et al. N Engl J Med 2005; available at: http://www.nejm.org.
Outcome Atorvastatin 10 mg (n=5006)
Atorvastatin 80 mg (n=4995)
Hazard ratio(95% CI)
p
Total major cardiovascular events (%)
10.9 8.7 0.78(0.69-0.89)
<0.001
•Death from coronary heart disease (%)
2.5 2.0 0.80(0.61-1.03)
0.09
•Nonfatal MI (%) 6.2 4.9 0.78(0.66-0.93)
0.004
•Resuscitation after cardiac arrest (%)
0.5 0.5 0.96(0.56-1.67)
0.89
•Fatal or nonfatal stroke (%)
3.1 2.3 0.75(0.59-0.96)
0.02