THESIS Presentation10
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Transcript of THESIS Presentation10
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DETERMINATION OF LOW DENSITYLIPOPROTEIN (LDL) LOWERING
ACTIVITY OF FORMULATED
CAPSULE FROM RED YEAST(Monascus purpureus) RICE INHYPERLIPIDEMIC RABBITS
Alcarde,Gerallene Mae F.
Sinoy,Alejli Anne C.
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CHAPTER 1
INTRODUCTION
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The Problem and Its setting
WHO STATISTICS
30 % of all global deaths is due to
CARDIOVASCULAR
DISEASES
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DEPARTMENT OF HEALTH
TOP LEADING CAUSE OF MORTALITY
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Monacolin K
LACTONE FORM HYDROXY ACID
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Dr. Dulce Florespresented a studyabout red yeastrice
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STATEMENT OF THE PROBLEM
1. What is the Approximate Effective Dose (AED)of the Red Yeast Rice formulated capsule inrabbits?
2. What is the Effective Dose (ED50) of the RedYeast Rice formulated capsules inhyperlipidemic rabbits?
3. Is there a significant difference in the LDL levelof rabbits when treated with formulatedcapsule of Red yeast rice, Lovastatin Tablet andPlacebo capsule?
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NULL HYPOTHESIS
There is no significant difference on the LDLlevels of the hyperlipidemic rabbits treatedwith formulated capsule of Red yeast ricecompared with Lovastatin tablet and Placebocapsule .
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THEORETICAL FRAMEWORK
Red Yeast rice may lower totalcholesterol by 13-26% and LDL by 21-
33%-Wang et al (1997), Heber et al
(1999), Qin et al (1999), Rippe et al (1999) , Keithley et al (2002)
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RYR and therapeutic lifestyle change decreaseLDL cholesterol level without increasing CPK in
pain levels and may be a treatment option fordyslipidemic patients who cannot toleratestatin-theraphy
(Becker , D., Gordon , R., Halbert, S., French , B.,Morris, P., & Rader , D. (2009, June 16). Redyeast rice for dyslipidemia in statin-intolerant
patients: a randomized trial. . US National Library of Medicine )
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RYRsignificantly reduces totalcholesterol, LDL cholesterol andtotal triacylglycerols concentrationscompared with placebo (Heber etal)
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CONCEPTUAL FRAMEWORK
INDEPENDENTVARIABLEFormulated Capsule of
Red Yeast RiceLovastatin Tablet(positive control)
Placebo( negative control)
DEPENDENTVARIABLE
LDL level (mmol/L)in hyperlipidemicrabbits
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To theResearchers
Prove that red yeast rice can
lower the LDL in hyperlipidemicrabbits
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Mortalitycases of CVDS
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Emphasize the effortsmade by the Food andTechnology Department toprovide cost-effectiveproducts for poorhyperlipidemic Filipinos
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To the Philippine Pharmaceutical Society
Help in the production andmarketing of cost-effective drug for hyperlipidemic patients especiallythe poor .
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SCOPE AND DELIMITATION
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The coverage of the study will focus on the
determination of LDL lowering activity levels of theRed Yeast rice and determination of its AED and
ED50 in treating hyperlipidemic rabbits
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Red Yeast Rice : UP Mindanao Food Tech Dept. Lovastatin : commercially available
Experimentation : University of the ImmaculateConception Test Animals (Rabbits) : Rabbit Breeding Farm
in Tugbok District
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PARAMETERS IN MEASURING LDL
Monitoring of :1. Mortality2. body weight
3. food consumption4. water intake5. measurement of LDL levels
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Definition of Terms
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APPROXIMATE EFFECTIVE DOSE.
Approximate Effective Dose is the
estimated dose of a drug to produce adesired response.
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CHOLESTEROL Cholesterol is a sterol and a lipid found in
the cell membranes of all body tissues.
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Effective Dose (ED50) Effective dose is the dose of a drug
predicted to produce a characteristic effectin 50 % of the subjects to whom the doseis given.
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Hyperlipidemia Hyperlipidemia is an increase in the
amount of fat (such as cholesterol andtriglycerides) in the blood. Theseincreases can lead to heart disease andpancreatitis.
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Lipid Profile Lipid Profile is a group of test that
indicates your risk of heart disease. Thelipid profile tests levels of cholesterol, HDLcholesterol, LDL cholesterol andtriglycerides .
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Lovastatin Lovastatin is a widely used statin drug, a
cholesterol lowering agent; anindependent variable used as a positivecontrol in the study.
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LDL (Low Density Lipoprotein)
Low Density Lipoprotein refers to a classand range of lipoprotein particles, varyingin their size (18-25 nm in diameter) andcontents, which carry cholesterol in theblood and around the body, for use bycells.
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Placebo Placebo is an independent variable which
serves as negative control.