Responsible Pain Management

Theramine®

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How Does Chronic Pain Affect the Body?

Chronic pain is a disease of the nervous system and can change the way the brain communicates with the body. Chronic pain can:

• Change Amino Acid Levels• Change in Nutrient Levels• Affect Neurotransmitter Levels• Create Miscommunication Between

Cells

Over time, chronic pain can prolong and amplify pain, rendering many treatments ineffective.

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How Can Theramine Improve Pain Management?

Theramine® Provides the “fuel” required to

manage the increased metabolic demands of pain.

Improve concentrations of the key amino acids and nutrients required to make the neurotransmitters responsible for dampening pain signals and reducing inflammation

Restore homeostasis to the central and peripheral nervous systems

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Pain Management Reinvented

Drugs are designed to treat the symptoms of pain, Theramine addresses the increased nutritional requirements of pain.

Pain alters metabolic rates, accelerating the rate that amino acids and neurotransmitters are consumed by the body to manage the pain process.

Nutritional deficiencies that develop over time can prolong and amplify pain and inflammation.

Theramine improves the amino acid levels required to restore nervous system balance and improve pain management.*

* Shell, et al. American Journal of Therapeutics; 2012 108-114 ; Theramine vs. ibuprofen double-blind trial . Publication Pending.

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Theramine as a Frontline Therapy

• Effective Standalone

Therapy

• Effective Adjunct Therapy

• No Severe Side Effects

• No Drug Half Life

• Amino Acid Based

• Rapid Uptake and

Utilization

• Multiple Double Blind

Studies

• No Known

Contraindications

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Improve Pain Management

Theramine® is intended for the dietarymanagement of pain syndromes that include: • Acute Pain• Chronic Pain• Fibromyalgia• Neuropathic Pain• Inflammatory Pain

Recommended Dosing:2 capsules b.i.d.

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In a 28 day double-blind, randomized, controlled, multicenter trial of 127 subjects with chronicestablished back pain, Theramine proved more effective than naproxen at reducing pain. Subjects taking Theramine as an adjunct to low dose naproxen, experienced a statistically significant reduction in pain compared to once daily naproxen (250mg)1 .

1. Shell, et al.,“A Double-Blind Controlled Trial of a Single Dose Naproxen and an Amino Acid Medical Food Theramine for the Treatment of Low Back Pain”; American Journal of Therapeutics; 2012 108-114

Pain Management: Theramine® vs. Naproxen

-70

-60

-50

-40

-30

-20

-10

0

102.95

-44

-65

Reduction of Pain - Roland Morris Index

Percent Reduction of Roland-Morris Pain Index

Perc

ent

(%)

p<0.05n=126

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In a 28 day double-blind, randomized, controlled, multicenter trial of 127 subjects, Theramine proved more effective than ibuprofen at reducing pain in patients with back pain. Subjects taking Theramine as an adjunct to low dose ibuprofen, experienced a statistically significant reduction in pain compared to once daily ibuprofen (400mg) .

Pain Management: Theramine® vs. Ibuprofen

-70

-60

-50

-40

-30

-20

-10

0

10

0.730000000000001

-50.3

-63.1

Reduction of Pain - Roland-Morris Index

Roland-Morris Pain Scale

Perc

ent

(%)

p<0.01

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1. Shell, et al.,“A Double-Blind Controlled Trial of a Single Dose Naproxen and an Amino Acid Medical Food Theramine for the Treatment of Low Back Pain”; American Journal of Therapeutics; 2012 108-114

In this double-blind multicenter trial examining the efficacy of Theramine for pain management, a marked decrease in CRP was measured among subjects taking Theramine compared to subjects taking naproxen (250mg) once daily.1

Theramine® vs. Naproxen: Inflammation Reduction

-100

-50

0

50

100

150

200 184.5

-16.7

-78.6

Change in CRP Levels

Percent Change in CRP

Perc

ent

(%)

p<0.01

n=127

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In this double-blind multicenter trial of 127 subjects with chronic established back pain, a marked decrease in CRP was measured among subjects taking Theramine compared to subjects taking ibuprofen (400mg) once daily.

Theramine® vs. Ibuprofen: Inflammation Reduction

-60

-40

-20

0

20

40

60

80

60.1

-47.05

-35.99

Change in CRP Levls

C-reactive protein

Perc

ent (

%)

p<0.01

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Why is Theramine® a Good Choice?• No reported side effects in over 45 million administrations*

• No reported GI bleeds• No reported adverse CV effects• Non-addictive

• Effective Pain Medication• Reduces chronic back pain**

• Reduces inflammation**

* administrations is defined as number of pills sold since 2004**Shell, et al. American Journal of Therapeutics; 2012 108-114 ; Theramine vs. ibuprofen double-blind trial . Publication Pending.

• Replace or Augment NSAID Therapies• NSAIDs contraindicated in high risk patients

• Replace or Reduce Narcotic Pain Meds• Dose titration • Dose replacement

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1. Safe and effective for pain management

2. Reduce or eliminate high dose narcotics and NSAIDs

3. Effective as a standalone medication or in conjunction with the lowest FDA approved dose of a drug

4. No reported severe side effects

5. Improve the underlying pathology of a pain

6. FDA regulated and inspected

7. Manufactured in the United States at a cGMP certified facility

8. Ingredients are Generally Recognized as Safe (GRAS)

Why Prescribe Theramine?

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For More Information

Visit www.tmedpharma.com