“THE WAR ON PANCREATIC CANCER REQUIRES DEDICATION”

SINJAN BOSEAPRIL 23 , 2012

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Training to Improve Survival Initiative

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Facts about Pancreatic Cancer

4th leading cause of deathOnly one with a 5 year survival rate of 6%Survival rate has not improved since passage

of National Cancer Act of 1971In 2012, 43,920 Americans will be diagnosed

and 37,390 will die75% of patients die within the first 12 months

of diagnosisOnly 2% of NCI’s annual budget allocated

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2012 Relative Five Year Survival Rates

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NCI Annual Funding 2001-2010

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Issues

Lack of funding towards researchPhysician and public awareness of the

diseaseFuture supply of scientists in serious

jeopardy

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Pancreatic Research and Education Act

Develop a Strategic Plan for ResearchCancer Research Incubator Pilot for the

Deadly CancersStrengthening and Expanding SPORE for

Pancreatic CenterPromoting Physician and Public Awareness

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Strategic Plan for Research

Amend Part B of title III of Public Health Service Act (42 U.S.C. 243 et. seq.) § 320B(a). Pancreatic Cancer Initiative. “The

Secretary shall establish and implement a Pancreatic Cancer Initiative to assist in coordinating activities to address the high mortality rate associated with pancreatic cancer. Such initiative shall focus on: (A) advancing research on the causes, diagnosis, and

treatment of pancreatic cancer with the goal of increasing 5-year survival”

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Strategic Plan for Research

Amend Part B of title III of Public Health Service Act (42 U.S.C. 243 et. seq.) § 320B(b). Interdisciplinary Pancreatic Cancer

Coordinating Committee. (1) Establishment (2) Membership (3) Responsibilities (4) Strategic Plan

“(A) Development – The Committee shall develop not later than 6 months of the Committee’s establishment and update not less than every 5 years thereafter a strategic plan for the conduct and support of pancreatic cancer research and awareness for the upcoming fiscal 5-year period”

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Strategic Plan for Research

Amend Part B of title III of Public Health Service Act (42 U.S.C. 243 et. seq.) § 320B(b). Interdisciplinary Pancreatic Cancer

Coordinating Committee. (1) Establishment (2) Membership (3) Responsibilities (4) Strategic Plan (5) Prioritization and Award of NIH Research Grants

In General. – The Committee shall conduct evaluations and make recommendations as needed to the Secretary, the Director of National Institutes of Health, and the Director of the National Cancer Institute regarding prioritization and award of NIH research grants relating to pancreatic cancer

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Cancer Research Incubator Pilot for the Deadly Cancers

Amend Part B of title IV of Public Health Service Act (42 U.S.C. 284 et. seq.) § 409K. Cancer Research

(a) Cancer Research Incubator Pilot Project – (1) Grants –

• (A) In General – The Secretary may award grants to research institutions for use in developing innovative compounds or technologies for the prevention, early detection, or treatment of those cancers with 5-year survival rates of less than 50%

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Strengthening and Expanding of Excellence for Pancreatic Center

Amend Part B of title IV of Public Health Service Act (42 U.S.C. 284 et. seq.) § 409K. Cancer Research

(b) Centers of Excellence – (1) Designation – The Secretary may designate two

additional Specialized Programs of Research Excellence (SPOREs) focusing solely on pancreatic cancer research. In carrying out this paragraph, the Secretary may choose to designate 1 or more satellite centers that augment the work of a previously designated Specialized Program of Research Excellence

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Promoting Physician and Public Awareness

Amend Part B of title III of Public Health Service Act (42 U.S.C. 243 et. seq.) § 320B(c). Physician Awareness

(1) Program. – The Secretary, in consultation with the Director of the National Institutes of Health, the Director of the Centers for Disease Control and Prevention, and relevant patient advocate and physician organizations, shall develop a primary care provider education program on pancreatic cancer. The Secretary may include in such program accredited continuing medical education and such other activities as the Secretary determines appropriate

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The NCI and Pancreatic Cancer

Allocates budget through grant mechanisms – R grants

From 2008 to 2009 number of R grants increased from 216 to 231 but amount of grants decreased from $49.1 million to $48 million

Fellowship, Career, and Training Awards (FKT) decreased by 15% from 2008 to 2009

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The NCI and Pancreatic Cancer

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Training to Improve Survival Initiative

Amend § 320B. Pancreatic Cancer Initiative Add (a)(4)(C)(iv).

“The grant will develop education and training resources for investigators and health care providers about pancreatic cancer risk assessment, evaluation protocols, and sample collection.”

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Policy Paramours

U.S. Senate Sheldon Whitehouse (D-RI) Tom Harkin (D-IA)

U.S. House of Representatives Anna Eshoo (D-CA) Leonard Lance (R-NJ) Dave Reichert (R-WA) Tim Murphy (R-PA)

Republican Physician’s Caucus Co

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Opposition

U.S. House of Representatives Fred Upton (R-MI) Ed Whitefield (R-KY) Steve Scalise (R-LA)

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Stakeholders

Governmental Center for Medicare and Medicaid Services Center for Disease Control and Prevention Department of Health and Human Services National Institutes for Health

National Cancer Institute Food and Drug Administration

Non-governmental Pancreatic Cancer Action Network (PANCAN) Cancer Leadership Council American Association of Cancer Research (AACR) American Pancreatic Association Doctors, Caregivers, Scientists Major Hospitals

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References

American Cancer Society. Cancer Facts & Figures 2012. Atlanta: American Cancer Society; 2012

Surveillance, Epidemiology, and End Results (SEER) Program, National Cancer Institute. “Age-Adjusted U.S. Death Rates and Trends for the Top 15 Cancer Sitesa by Race/Ethnicity, Both Sexes”

Smith BD, Smith GL, Hurria A, Hortobagyi GN, Buchholz TA. Future of Cancer Incidence in the United States: Burdens Upon an Aging, Changing Nation. J Clin Oncol. 2009

Li D, Xie K, Wolff R, Abbruzzese JL. Pancreatic Cancer. Lancet.2004; 363:1049 – 1057

Oettle H, Post S, Neuhaus P, et al. Adjuvant Chemotherapy With Gemcitabine vs Observation in Patients Undergoing Curative-Intent Resection of Pancreatic Cancer: A Randomized Controlled Trial. JAMA. 2007;297:267-277.

American Cancer Society. www.pancan.org