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Transcript of The University of SydneyPage 1 Translational Research Closing the Gap Between Practice and Research...
The University of Sydney Page 1
Translational Research
Closing the Gap Between Practice and
Research
Professor Tim ShawDirector Research in Implementation Science and eHealth (RISe)Faculty, Health Sciences
What is Translational Research?
2
Applied research
Basic research
Why Translational Research?
• Consistent evidence of failure to translate research findings into clinical practice
• 30-40% patients do not get treatments of proven effectiveness
• 20–25% patients get care that is not needed or potentially harmful
(Runciman 2012; Grimshaw 2012; Schuster, McGlynn, Brook, 1998; Grol 2001)
Clinical & Translational Research: Valleys of Death
Basic Biomedical and HSR Research
Clinical Science& Knowledge
Clinical Practice& Health Decision
Making
Translational Continuum – 17 years
Valley 1 Valley 2
Copyright University of Pittsburgh 2006Reis et al. Clin Transl Sci 2008
14% enter into standard clinical practice; 1% lead to important health impacts
Thanks to Eva Grunfeld
Translation
Discovery Trials
Implementation
Improved Patient Outcomes
T1 T2
T3
Purposeful intent around an identified issue/priority
What’s so special?
Isn’t that what we have all being doing anyway?
Barriers
SilosAcadem
ia
Hosp
itals
Discip
lines
Geog
rap
hy
QI
Capacity and understanding
Eg TimelinesLanguageEnd points
MethodologiesRewards
Different planets?Academia/IS QI/Practice
Lack of access to data
Enablers
Building capacity
New Partnerships and FundingAdvanced Health Research and Translation Centres
Translational Cancer Research Centres
Academic Health Units
A systematic approach to identifying and closing evidence-practice gaps
Longitudinal Programs
Tim Shaw, Nicole Rankin, Sarah York, Phyllis Butow, Jane Phillips, Kate White, Jane Young, Puma Sundaresan, Sally Pearson, John Symes
Engaging MDTs in Translational Research
High Performing Tumour Program
Paul Harnett, Lynleigh Evans, Henry Pleass, Guy Eslick, Arthur Richardson, Kim Hill, Kylie Museth, Anna Janssen, Tracy Robinson, Tim Shaw
High Performing Tumour Program
Impact on clinical practice
+Impact on
professional development
+Impact on quality
improvement+
Generation of research questions
WS-LHD staff, Tim Shaw, Paul Harnett, Anna Janssen, Kylie Museth
Data Innovation Lab
High Performing Tumour Program
Disruptive technology
18