The Skin

Cutaneous membrane Accessory structure

DermisEpidermis

Papillary layer Reticular layer

nailsHair follicle

Exocrine gland

Epidermis composed of cells

Keratinocytes

Melanocytes

Langerhan’s cell

Merkel cells

DERMIS

It is a soft connective tissue, composed of

• Collagen fiber : Type I until VII

• Elastic fiber

• Ground substance: proteoglycans and fibronectins

• Nerve

• Blood vessel

• Lymphaticts

• Epermal appendages

• Free cells : macrophage, leucocyte, fibroblast,

Recent study has described “ Dermal perivascular dendritic macrophage” expressing MHC class II antigens

Physical protection from environmental hazards

Thermoregulator Excretion

Sensory information Synthesis of vitamin D 3

Coordination of immune response to pathogens

and cancer in skin

Integumantary System