The Secrets of Zone Pasta, Pizza, and Pastries:

Secret Weapons in the War Against Diabetes

Diabetes:

The Dark Future of Medicine

Why Health Care Costs Will Be Increasing

Costs ($) = % Older than 65 x % Diabetic

Both are increasing worldwide

Diabetes Is The Wild Card

• Number of diabetics will increase by 200% in next 25 years

• Costs will increase by 300% in next 25 years

• Increases the risk of both CHD and Alzheimer’s by 2-4 times

Diabetes in the U.S.

86M are pre-diabetic– 25% of entire U.S. population

29M diabetics – 9% of entire U.S. population

26% of Americans over 65 are diabetic

The Problem is Epidemic

Zone Diet (1995)

40% low-glycemic load carbs

30% low-fat protein

30% monounsaturated fat, but low in omega-6 and saturated fats

1,200 to 1,500 calories per day

Joslin Diabetes Research Center (2007)

40% low glycemic load carbs

20-30% low-fat protein

30-40% monounsaturated fat

1,200 to 1,500 calories per day

The Secrets of Satiety:

Calorie Restriction Without Hunger or Fatigue

The Gut Is Your Second Brain

The Importance Of L-cells In The Ileum

Release satiety hormones in response to nutrients

Protein: PYY

Carbohydrate: GLP-1

PYY

Primary satiety hormone

Released if adequate levels of protein reach the L-cells in lower part of the gut

Low PYY Output May Be First Defect Leading to Diabetes

Low levels of PYY appear to earliest indicator of future development of obesity and type 2 diabetes

– Boey et al Neuropeptides 40: 317 (2006)– Viadort et al Int J Obesity 32:943 (2008)

GLP-1

Secreted from L-cells in response to carbohydrates

Increases insulin output in diabetics

Increases satiety in non-diabetics

Hunger Hormones

Insulin (blood)

Ghrelin (gut)

Endocannabinoids (brain)

NPY (brain)

AgRP (brain)

Satiety Hormones PYY (gut)

GLP-1 (gut)

Melacortin (brain)

Leptin (brain)

Insulin (brain)

How Do They Work?

Hunger NeuronsNPY/AgRP

PPY, GLP‐1 Ghrelin

Leptin Insulin

Melacortin

PVN

Satiety Neurons

Why Hormonal Balance Matters

If satiety > hunger: Calorie restriction is possible

If hunger > satiety: Calorie restriction is impossible

Why Weight Gain Is So Common After Weight Loss

One year after dietary weight loss– Ghrelin increases– PYY decreases– Hunger increases

– Sumithran et al NEJM 365:1597 (2011)

After Gastric Bypass Surgery– Ghrelin decreases– PYY increases– Hunger decreases

Why Diets Fail

Constant hunger and fatigue

Restrict your favorite foods

Too much thinking involved

Changing Diet Is Hard Must be more desirable than

current diet

Must be more convenient than current diet

Must induce satiety

Must increase energy

Can the Hormonal Benefits of Gastric Bypass Surgery Be

Achieved With Molecular Baking?

Molecular Baking

Patented technology to make unique food products to control hunger

Enhance the gut, blood, brain hormonal connections

Healthy “junk foods”

Stealth Nutrition

Understanding how gastric bypass surgery works to treat diabetes

Replication in food products that diabetics love to eat– Pizza– Pasta– Pastries

Zone Pasta Meals

Chinese Orzo Tofu Rice Bowl

Zone Pasta Meals

Shrimp Veggie Pasta American Casserole

Zone Pasta MealsAsparagus Tomato

PastaRoasted Vegetable

Fusilli

Zone Pizza

Home Made Pizzeria Made

Zone Breakfast

Zone Croissants Zone Croissants

Cooking Vegetables is Easy With Technology

Zone Pastries

Zone Pastries

Zone Pastries

Zone Mexico Prototype Is Already Operating

And There Is More

Does It Work?

Body Composition Changes

Parameter Active Placebo Significance

Weight -7.0 lbs. -5.9 lbs. p = 0.8

Lean body mass +3.1 lbs. -1.3 lbs. p < 0.05

Fat mass -10.1 lbs. -6.2 lbs. p < 0.05

Changes In Insulin Resistance

Parameter Active Placebo Significance

Insulin (uU/ml) -26% -4% p < 0.05

Insulin Resistance (HOMA)

-26% -1% p < 0.05

Powerful New Concept

The more Zone Pasta you eat, the more fat you lose

The more Zone Pasta you eat, the more lean body mass you gain

The more Zone Pasta you eat, the more your reduce insulin resistance

Benefits of Molecular Baked Foods Sustainable source of protein

Convenient and desireable

Excellent patient compliance

Reduces insulin resistance

Unlimited Number of Recipes Pasta-based meals

Rice-based meals

Pizza meals

Condiments to any meal– Desserts– Side dish

You Can’t Live On Molecular Baked Foods Alone

Super Zone Diet for Dummies

Add unlimited amounts of vegetables to any meal– 2 pound rule– T-Fal makes it easy

Take your fish oil and polyphenols

Molecular Baking Makes Reaching the Zone Easy

Why Reducing Insulin Resistance Is Important

Insulin Resistance

Obesity

Diabetes

Alzheimer’s