THE PERSONAL GENETIC STORY OF LESLIE EDMUNDS

THE PERSONAL GENETIC STORY OF

L E S L I E E D M U N D S

Blueprint version 2.1

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INTRODUCTION

There is a lot of information in your 3X4 Blueprint and it can beoverwhelming. To help you focus on the areas where you will seethe biggest benefit, we have used a language of color. Eachpathway is color-coded from a dark purple (highest impact on yourhealth) to light green (lowest impact on your health) to help youand your healthcare practitioner know where to focus yourattention. We recommend you start with your summary plan thathas been created based on your unique genetic profile to highlightthe areas where you can make the biggest positive impact on yourhealth.

Why this genet ic test?

Your genes are the basic instructions for how you build, regulate, and maintain your body. These instructions determinehow your body responds to food, exercise, stress, and toxins.

3X4 makes complex science simple. Our approach is different from conventional genetic tests. Instead of looking at everygene individually, we use a patented machine learning model to understand the interactions between your genes in manybiological processes in your body. We call these processes your metabolic pathways or pathways for short.

We use all of this information to help you make simple and meaningful changes to your quality of life, by identifying the 3pathways where you can make the biggest impact on your long term health. For each of these pathways we provide:

- 3x diet recommendations, - 3x lifestyle or behavior interventions, - and 3x possible supplements or behavior suggestions.

Through this journey, we hope that you will come to understand three things:

- You are unique and have your own health story, - Thanks to your DNA you now know where to make the biggest difference in your health, - Your DNA does not define you, the small daily choices you make from today can have a profound impact on your DNA.

The Language of Color

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CONTENTS

1 Your Plan Pages 4-5

Having a plan means you and your practitioner can finally start to put things into action! We provide you with apersonalized summary based on your unique genetic profile, that indentifies the 3 pathways along with simple to followrecommendations that will have the biggest positive impact on your life long health. Using these insights along withyour current diet, lifestyle and medical history, your practitioner will work with you to develop a personalized andtargeted plan to get you started on your journey to a longer, better and healthier life.

2 Your Results Pages 6-8

This is where it gets a bit technical, but this is a genetic test, so bear with us. In this section, we show you the results ofevery individual gene variant we tested and show you how these work within 36 pathways that determine your overallexpression of health. Although complex, your results start to give you a sense of how unique you are and how unlikely itis that anybody will have the same genetic makeup as you do. Awesome, right?

3 Your Story Pages 9 to 15

Genetics can be a complicated subject, but a critical one in your journey towards optimal health. Getting to optimalhealth requires making sustainable changes, but if you don't understand why you need to make a change, it's unlikelyyou ever will.

This is where 3X4 believes that the power of storytelling helps bring you closer to getting a deeper level ofunderstanding whats happening in your body at a genetic level. So, grab your blanket, sit back and let your practitionertell you the story of you.

4 Glossary & Detailed Results Pages 17 to 32

This is where we nerd out. Some of you will be, like 'Just tell me what I need to do', others will want to know what thisgenetic thing is all about. What are these pathway things of which you speak? For those of you with a deep curiosity inthis subject, this section is for you!

All 36 metabolic processes are broken down, defined and explained in the glossary, in a simple, easy-to-understandlanguage.

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YOUR 3X4 SUMMARY PLAN Leslie Edmunds

Welcome to your own personalized 3X4 plan. We have identified the top 3 pathways based on your unique genetic profile whereyou will see the biggest impact to your health. For each pathway, we provide three recommended diet and lifestyle interventionsand three supplement suggestions. Your health practitioner will use these recommendations in combination with your currentdiet, lifestyle, medical history, family history, and environmental exposures to build a complete picture of whom you are, resultingin practical and personalized recommendations that guide you on your journey to making health a daily choice.

Genetics can have an impact on many areas of yourhealth, which can be overwhelming. At 3X4 webelieve it is important to keep it simple by introducingsmall incremental changes to your lifestyle that areeasy to implement and become habits.

Our philosophy is that given a small number oflifestyle changes built around a personalized story ofyou helps you understand why theserecommendations are important for your health andensures that these interventions are more likely tobecome sustainable habits in your daily life.

Oxidative stress is the human equivalent of rusting. The impact of all exposures over time results in damage to ourcells. Unmanaged, oxidation can impact on our energy levels, memory, premature aging and sometimes cancer risk. Ina healthy functioning cell, enzymes that counteract oxidative damage, a 'rust block' so to speak, are made. The abilityto make those enzymes is determined by certain genes. However, a good diet and lifestyle can aid towards a loweroxidative burden and help maintain the health of your cells.

1. Consume at least 1-2 cups of whole plant foods (pomegranate, berries, dark leafy greens, chilli peppers, beetroot, olives andolive oil).

2. Optimize foods rich in Zinc, Copper, Selenium and Manganese (seeds, nuts, leafy greens and legumes).3. Implement an anti-inflammatory diet plan with foods high in polyphenols, omega-3 rich foods, curcumin, black pepper,

cardamom and cumin seeds.

1. Extensive endurance and high intensity training increases superoxide molecules which can cause oxidative stress. Managetraining regime, ensure recovery with rest and proper nutrition.

2. Limit contact with strong pro-oxidants (heavy metals, pesticides, mold, radiation), avoid excessive intake of Iron, Copper,vitamin C and E as single nutrients.

3. Regulate circadian rhythm by sleeping in a dark environment for at least 7-8 hours per night. Limit exposure to blue lightbefore bed.

1. Coenzyme Q10 (Ubiquinone or Ubiquinol)2. Alpha Lipoic Acid, Methylsulfonylmethane (MSM), and GliSODin (Cantaloupe Melon extract rich in SOD)3. Manganese, Zinc and Selenium

OXIDATIVE STRESS VERY HIGH

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Leslie Edmunds

Inflammation is a normal automatic immune response to injury, irritation or infection. When you bump your toe and itbecomes swollen, that's the inflammatory response working to speed up healing. Sometimes injuries or irritations areinternal (in places like our gut, muscles, joints, or blood vessels). Inflammation is protective by design, but can becomedestructive if left unchecked. Long term, chronic inflammation can eventually lead to conditions like arthritis, eczema,IBS, autoimmune conditions, and several diseases.

1. Include organic, non-GMO polyphenol-rich foods (berries, cocoa, olives, hazelnuts, dark chocolate), and anti-inflammatoryspices (curcumin, black pepper, cardamom, cumin seeds).

2. Aim for unsaturated fats (salmon, sardines, cold-pressed olive and avocado oil), fermented foods (kimchi, miso, yogurt),prebiotic fibers (garlic, onions, leeks), and beta-glucans (whole grains, shiitake mushrooms).

3. Limit intake of pro-inflammatory fats rich in omega-6s and saturated fats. Consider elimination trial of proinflammatory diettriggers (gluten, dairy, saturated fats, sugar, processed foods), then reintroduce. Eliminate trans fats completely.

1. Limit exposure to environmental inflammatory triggers: pollen, mold, pesticides, non-organic cleaning products, perfumes,cosmetics, air fresheners.

2. Intermittent fasting reduces inflammation. Avoid eating 3 hours before bedtime and eat a late breakfast to ensure an overnightfast.

3. Ensure enough sleep, meditate, practice yoga, and other relaxation techniques to reduce stress hormones.

1. Omega-3s (EPA & DHA daily) 1000-3000mg2. 30mg Zinc, 200mcg Selenium, Quercetin and Luteolin to block mast cell activation.3. Fat soluble vitamins A, D3 and E

Detoxification is the body's way of getting rid of toxins that could otherwise build up and interfere with health. Signsof poor detox include lethargy, fatigue, difficulty concentrating and unexplained aches and pains in the body. The liveris the main site of whole-body detox but every cell has its own toxin-eliminating processes to keep it clean, healthyand working well. Detoxification can be optimized by making the right diet and lifestyle changes to support goodcellular cleaning processes.

1. Consume at least 1-2 cups of organic plant foods that support liver enzymes (berries, pomegranate, cruciferous vegetables,green tea and walnuts).

2. Include foods that support phase 2 detox (garlic, radishes, asparagus, onion, apples, nuts, sesame, pumpkin, mustard seeds,ginger). Avoid GMO foods, farmed fish, non-organic meats and poultry, and dirty dozen produce.

3. Aim for 25-40g of fiber daily (whole grains, sweet potatoes, celery and apples). These foods also contain toxin bindingproperties.

1. Lower your 'toxic burden' by avoiding harmful micro-plastics, non-organic cleaning and personal products, pesticides, paintand glue.

2. Intermittent fasting activates detoxification. Ensure enough time between meals and overnight.3. Sweat for at least 30 minutes 3-4 times a week with steam, infrared sauna, and exercise.

1. Active sulforaphane (whole broccoli sprouts) as recommended by healthcare practitioner.2. Vitamin B6, B2, Magnesium, Selenium to support liver health.3. Zeolite/Bentonite clay to support toxin excretion.

INFLAMMATION HIGH

DETOXIFICATION MEDIUM

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GENE SUMMARY Leslie Edmunds

Gene Variant Result

CETP Taq1B G>A AA

CYP2C19 *1/*2/*17 *1/*17

FOXO3 G>T GG

TIMP4 –55 T>C CC

UCP2 –866 G>A GA

ADIPOQ –395 G>A GG

ADRB3 Trp64Arg T>C TT

AKT1 G1172+23A T>C TT

ALDH2 Glu504Lys G>A GG

ANK3 318473 C>T CC

ANK3 A>G AA

APOA2 –492 T>C TC

APOA5 C>A CC

BDNF Val66Met G>A GG

BHMT Arg239Glu G>A GG

CACNA1C G>A GG

CBS 699 C>T CC

CETP 279 G>A AA

COL1A1 1546 G>T GG

CYP1A1 Ile462Val A>G AA

CYP1B1 Leu432Val C>G CC

CYP1B1 Asn453Ser A>G AA

CYP2C9 Ile359Leu A>C AA

CYP2C9 Arg144Cys C>T CC

CYP2D6 *1/*3/*10 *1/*1

CYP3A4 –392 A>G AA

DRD1 –48 G>A AA

DRD1 –94 G>A GG

DRD2 TaqIA C>T CC

DRD3 Ser9Gly T>C TT

EPHX1 Tyr113His T>C TT

F2 20210 G>A GG

F5 Arg506Gln G>A GG

Gene Variant Result

FAAH Pro129Thr C>A CC

FABP2 Ala54Thr G>A GG

FOXO1 A>G AG

FTO 87653 T>A TT

FUT2 Trp153Ter G>A GA

GSTP1 Ala114Val C>T CC

HFE C282Y/H63D CC/HD

HNMT Thr105Ile C>T CC

HTR1A –1019 C>G CC

MMP1 –1607 1G/2G 1G/1G

MMP2 Gly226Gly G>C GG

MNSOD Val16Ala T>C CC

MTHFD1 1958 G>A GG

MTHFR 1298 A>C AA

MTHFR 677 C>T CC

MTR 2756 A>G AA

NAT1 Arg187Gln G>A GG

NQO1 Pro187Ser C>T CC

NRF2 A>G AA

OGG1 Ser326Cys C>G CG

OPRMI Asn40Asp A>G AA

OXTR A>G GG

PAI 4G/5G 5G/5G

PPARD 294 T>C TT

SLC23A1 790 G>A GG

SLC2A2 Thr110Ile C>T CC

SLCO1B1 Val174Ala T>C TT

TCN2 776 C>G CC

TNFA –238 G>A GG

UCP1 –3826 A>G AA

UCP3 –55 C>T CC

VDR Taq1 T>C TC

You will notice that some of the genes have a star ★ next to them. Based on your individual results, these genes have beenidentified as having a bigger impact on your pathways and individual health. It’s important that you and your practitioner areaware of them, as they need to be considered along with your existing diet, lifestyle and medical history in creating yourpersonalized 3X4 plan.

BENEFICIALBENEFICIAL

NO IMPACTNO IMPACT

NO IMPACTNO IMPACT

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GENE SUMMARY Leslie Edmunds

Gene Variant Result

ACE2 7132 T>C TC

ACE2 A>G AG

ACSL1 T>C TC

ACTN3 577 R/X RX

AGT Met235Thr A>G AG

AMPD1 133 C>T CT

APOA5 –1131 T>C TC

APOC3 3175 C>G CG

CAT –262 C>T CT

CHRNA5 Asp398Asn G>A GA

CHRNA5 C>T CT

CKM Ncol T>C TC

CYP2R1 A>G AG

DAO C>T CT

DIO2 Thr92Ala T>C TC

DRD4 –521 C>T CT

GDF5 5'UTR C>T CT

GSTP1 Ile105Val A>G AG

HNMT 939 A>G AG

IL-6 –174 G>C GC

IL-6R Asp358Ala A>C AC

IRS1 C>T CT

LEPR Lys109Arg A>G AG

LEPR Gln223Arg A>G AG

MTRR 66 A>G AG

NAT2 R/I/S Intermediate

PEMT –744 G>C GC

PLIN 11482 G>A GA

TCF7L2 IVS3 C>T CT

TNFA –308 G>A GA

VDR Bsm1 G>A GA

VEGF –634 G>C GC

ACE Ins/Del ID

CRP 2147 G>A GA

DAO His645Asp C>G CG

FADS1 592 G>T GG

HLA DQ 2.2/2.5/8 DQ2.5/DQ8X

MC4R T>C TC

Gene Variant Result

NBPF3 T>C CC

PON1 Gln192Arg A>G GG

PPARA 89204 G>C GG

SIRT1 994 T>C TT

TAS2R38 Ala262Val C>T TT

ACVR1B A>G AA

ADIPOQ –11391 G>A GG

ADRB2 Arg16Gly A>G GG

ADRB2 Gln27Glu C>G GG

CLOCK 3111 T>C CC

COL5A1 BstUI C>T TT

CYP17A1 34 T>C CC

FUT2 Gly258Ser G>A GA

GABRA2 Lys132Lys A>G AG

HIF1A Pro582Ser C>T CC

HO-1 –413 A>T TT

LEPR Lys656Asn G>C GG

LPL Ser474Ter C>G CC

PPARG Pro12Ala C>G CC

★ APOE E2/E3/E4 E3/E4

★ COMT Val158Met G>A AA

CYP1A2 –163 A>C CC

GC A>C CC

GPX1 Pro198Leu C>T TT

★ GSTM1 INS/DEL DEL

GSTO2 Asn142Asp A>G GG

IL-1 +/– +

NOS3 –786 T>C TT

PPARGC1A Gly482Ser G>A GG

LOWLOW

MEDIUMMEDIUM

MEDIUMMEDIUM

HIGHHIGH

VERY HIGHVERY HIGH

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PATHWAY-BASED RESULTS Leslie Edmunds

PATHWAY IMPACT

CE

LL

UL

AR Oxidative stress VERY HIGH

Inflammation HIGH

Detoxification MEDIUM

Methylation LOW

SY

ST

EM

S

Female hormone balance MEDIUM

Collagen & joints MEDIUM

Histamine overload MEDIUM

Bone health MEDIUM

Mood & behavior LOW

Memory & brain health LOW

Glucose & insulin LOW

CA

RD

IOV

AS

CU

LA

RH

EA

LTH

Vascular health MEDIUM

Cholesterol MEDIUM

Blood pressure MEDIUM

Blood clotting LOW

EN

ER

GY

Pro-inflammatory fat VERY HIGH

Exercise response HIGH

Energy expenditure HIGH

Weight gain & weight loss resistance HIGH

Adipogenesis MEDIUM

Appetite/Satiety/Intake MEDIUM

AC

TIV

ITY

Power HIGH

Recovery HIGH

Injury HIGH

Training response MEDIUM

Endurance MEDIUM

NU

TR

IEN

TS

Caffeine VERY HIGH

Vitamin D HIGH

Vitamin C HIGH

Vitamin B12 MEDIUM

Gluten MEDIUM

Salt MEDIUM

Choline LOW

Fatty acids LOW

Folate LOW

Iron overload LOW

CELLULAR OVERVIEWWe are the sum of our cells, and we are only as healthy as they are. Every cell in your body functions independently - like a smallapartment or office space inside a high-rise building - each unit takes care of its own day-to-day maintenance, but ultimatelycontributes to the overall success and functionality of the building as a whole. Similarly, every cell in your body has its ownmechanisms in place to clean and protect it, to maintain health for the whole body and all its organs.

INFLAMMATIONHIGH

A daily intake of polyphenols, avoidance of processedfoods, and including lifestyle behaviors likeintermittent fasting, can assist in the management ofyour elevated inflammatory potential, as suggested byyour genes.

2

OXIDATIVE STRESSVERY HIGH

Your gene results suggest a significantly reducedability to balance oxidative stress, caused by toxinbyproducts from normal biologic function and aging.Eat a variety of plant foods that supply antioxidantsand minerals, avoid pollutants.

1

DETOXIFICATIONMEDIUM

Your genetic results indicate that you have a mildlyreduced ability to neutralize and remove toxins.Support detoxification processes using food,supplements & lifestyle interventions. Reduce toxinexposure from your diet and environment.

GSTM1 DEL★COMT AA★

3

METHYLATIONLOW

Methylation is a biochemical process involved in theproduction, repair and behavior of genes and othermetabolic processes. Your genetic results show thatthese processes are likely working optimally.

4

SYSTEMS & CARDIOVASCULAR OVERVIEWInside your body at any given moment are several highly-sophisticated systems operating at the same time to keep you alive,healthy and running smoothly. Think of the network inside you as being similar to a complex underground railroad system below abig city, where multiple separate but interconnected parts are meticulously being organized to keep everything on track, onschedule, and safe. If these orderly systems stopped working properly and began rail-crossing, there’d quickly be widespreadchaos, delays, and eventually a complete stand-still.

MOOD & BEHAVIORLOW

Genes influence the creation and balance of chemicals inthe brain necessary to manage mood, anxiety, depressionand related behaviors. Genetically, you may not besusceptible to an imbalance in these brain chemicals.

5

MEMORY & BRAINHEALTHLOW

Your genetic results show that you are less likely to loseflexibility in the brain; important for learning, processing,remembering and storing information, as long as youmaintain a healthy diet and lifestyle.

6APOE E3/E4★

HISTAMINEOVERLOADMEDIUM

Histamine is produced during immune processes, allergenremoval, and in response to injury and toxins. Your generesults indicate that you may be mildly prone to histamineoverload. Limit high histamine foods if symptoms aretriggered.

3

FEMALE HORMONEBALANCEMEDIUM

Genetically, you may be less efficient at balancing thehormones required for hormone-related processes.Reduce exposure to environmental toxins and includeregular servings of cruciferous vegetables (broccoli,cauliflower etc.).

1COMT AA★

GLUCOSE & INSULINLOW

Glucose and insulin production need to be in balance toprevent damage to cells, systems and organs. Genetically,you should be able to regulate your blood sugar providedyou eat a balanced healthy diet and exercise regularly.

7

BLOOD CLOTTINGLOW

CARDIOVASCULAR HEALTH

Blood clotting is a survival tactic to prevent uncontrolledbleeding, but may be harmful if not constrained. Yourgenetics may not contribute to inappropriate clotformation and breakdown.

4CHOLESTEROLMEDIUM


Genetics influences how we process various fats and theirimpact on cholesterol formation and vascular health. Yourresults show that you may be genetically prone toelevated cholesterol. Choose plant-based fats and a high-fiber diet.

2

APOE E3/E4★

VASCULAR HEALTHMEDIUM


Genes impact the integrity of arteries and veins, affectingblood flow. Your results show that injury to your bloodvessels may be partly due to genetics. A diet rich inpolyphenols, stress management and exercise is advised.

1

BLOOD PRESSUREMEDIUM


High blood pressure is associated with damage to theartery wall and fluid retention within the blood vessel.Your genes may contribute to the development of highblood pressure. Diet and stress factors should beaddressed.

3

BONE HEALTHMEDIUM

Bone health refers to maintaining the balance betweenbuild-up and breakdown of bone tissue. Genetically, yourbone turnover is mildly impacted. It is important to includesunlight, minerals, vitamins D and K, and exerciseregularly.

4

COLLAGEN & JOINTSMEDIUM

Connective tissue degeneration and injury occur whenbreakdown in joints, ligaments, collagen, cartilage andskin exceeds repair. Genetically, you may be prone tocollagen damage. Eat quality protein and micronutrientsnecessary for repair.

2

ENERGY OVERVIEWGlucose is our main fuel source and what we make energy from. How we extract, absorb, burn, distribute, store and waste thiscurrency varies between individuals, partly because of genetic variation. People respond very differently to calories, exercise,fasting, fatigue, etc. Hunger is also experienced very personally and with great variability. Knowing how you’re hard-wired tohandle fat, food, and fitness can save you a lot of frustration and, well… energy. These insights can be a powerful tool that enablesyou to work with your body, not against it, to finally reach your health goals.

APPETITE/ SATIETY/ INTAKEMEDIUM

We all experience appetite, hunger, and fullnessdifferently. Your genetics may have a moderate influenceon your eating patterns and food choices. Structure mealsand eat adequate quality protein and fiber regularly.

6

ADIPOGENESISMEDIUM

The process by which you store fat and releaseenergy impacts your fat loss ability. Your geneticresults suggest that you may be mildly resistantin releasing fat from stores. A healthy diet andregular exercise will support this process.

5

PRO-INFLAMMATORY FATVERY HIGH

Fat cells have the potential to become inflamed, inhibitingthe release of energy from fat stores. Your genes willcertainly contribute to inflammation. Include anti-inflammatory foods and avoid toxins, stress, and foodadditives.

1

ENERGY EXPENDITUREHIGH

Energy is needed for important functions such asbreathing, digestion and activity. Your results indicate thatyour genes will likely reduce the efficiency of yourmetabolism. Choose nutrient-dense, low-energy foodsand regular, intensive exercise.

3EXERCISE RESPONSEHIGH

The ability to mobilize and release stored energy duringexercise varies. Genetically, you may be inefficient atreleasing energy in response to activity. A nutrient-richdiet, regular exercise, and quality sleep will help manageweight.

2

WEIGHT GAIN & WEIGHT LOSSRESISTANCEHIGH

The ability to maintain a healthy body weight varies by person. Yourresults indicate that your genes will likely impact your ability tomanage your weight. Set realistic goals, use cognitive behavioraltherapy and mindfulness to assist.

4

ACTIVITY OVERVIEWYour activity infographic provides insights into how your body responds to training. Understanding the best training strategy foryour body, helps you train optimally while avoiding injury. Your potential for endurance and power-based sports performanceprovides insights to optimize and personalize your training program. Finally, knowing how your body recovers helps you trainoptimally and achieve your fitness goals in a sustainable way.

TRAINING RESPONSEMEDIUM

Your gene resultssuggest you are likely tohave a medium trainingresponse after exercise.You will likely have anaverage fitness to start,but will see positive gainsin VO2 max, leading tobetter sportsperformance.

4

INJURYHIGH

Your gene results suggest your risk for softtissue injury is high. You can minimize yourinjury risk by regularly incorporatingmovements that increase range of motion,and improve strength and balance.

3

ENDURANCEMEDIUM

Your gene results suggest moderate endurancepotential. Your endurance levels and overall healthwill improve with regular aerobic exercise. Graduallyincrease both frequency and duration of your aerobictraining sessions.

5POWERHIGH

Your results suggest that with the righttraining program you can achieve highperformance levels in power-based sports.Regularly include high intensity intervalsessions requiring muscular force andspeed, and increase load gradually.

1

RECOVERYHIGH

Your results suggest you may needdaily support to achieve adequaterecovery between exercise sessions.Allow for a day of rest between intenseexercise sessions, quality sleep, andnutrient-dense foods to enhancerecovery times.

2

NUTRIENTS OVERVIEWThe vitamins, minerals and compounds we find in food are integral to keeping our body’s processes working optimally. They keepour cells robust, efficient and healthy, they support the work of our genes, and they help transport oxygen to the tissues. Makingthe best choices means understanding how much we need of these nutrients and which foods we should choose, it also gives usinsights into how we respond to certain nutrients.

CAFFEINEVERY HIGH

The efficiency with which we process caffeine varies byperson; affecting our sleep, detoxification, alertness andsports performance. As a very slow metabolizer, limit andplan your caffeine intake in order to ensure the best effect.

1

IRON OVERLOADLOW

Excessive iron accumulation in the body can damageorgans and precipitate disease conditions such as cancer,irregular heartbeat, and liver cirrhosis. Genetic variantsassociated with iron overload were not detected.

10

FATTY ACIDSLOW

Fatty acids, the building blocks of dietary fat, playmany important roles in the body including cellmembrane structure and function. Your geneticresults indicate that you are able to optimize fattyacid processes.

8

CHOLINELOW

Choline regulates memory, mood, and DNAbuilding; and plays a valuable role in pregnancy.Your results indicate that synthesis andavailability of choline is not affected by yourgenes. Adequate dietary intake is still advised.

7

FOLATELOW

Genetically, you are able to optimally use dietary folate.Folate works with other B vitamins to build tissues,maintain brain chemicals and blood cells, and ensure DNAhealth.

9

GLUTENMEDIUM

Your genetic results indicate that you have a mild potentialfor the development of celiac disease, a gastrointestinalinflammatory condition associated with gluten. Investigatefurther to confirm if gluten avoidance is necessary.

5

VITAMIN DHIGH

Vitamin D is a vital nutrient involved in manybiochemical pathways, essential for heart,bone and neurological health. Your resultsshow that you need to ensure sufficientvitamin D intake and sun/light exposure tofunction optimally.

2

SALTMEDIUM

Salt has the potential to raise blood pressure, but geneticsinfluences the extent to which this may happen. Yourgenetic results show you may benefit from moderate saltrestriction to manage or prevent high blood pressure.

6

VITAMIN CHIGH

Vitamin C activity is affected by your genes. Sinceit is important for connective tissue maintenance,immune health and removing toxins, ensure dailyintake of foods rich in vitamin C.

3

VITAMIN B12MEDIUM

Vitamin B12 is an essential nutrient for both brain andblood cells, as well as for the making of DNA. Genetically,you may have a mildly reduced ability to transport B12 tocells, making animal protein foods or a B12 supplementnecessary.

4

CLOSING

Pract i t ioner-Driven Personal izat ion

The f i rst steps towards the future you

Whether you want to focus on personal well-being, manage your weight, prevent chronic illness, or up yourathletic abilities, your 3X4 Blueprint will help you get there. But no passage to greatness was ever really donealone, which is why your practitioner will walk the journey with you.

Your full story has yet to be unlocked. Placing the answers that lie within your 3X4 Blueprint into context, yourpractitioner will use these rich genetic insights to build a complete picture of who you are, resulting in practical andpersonalized recommendations that guide you towards incremental and sustainable health.

Having read your personalized 3X4 story, we hope you’ve been able to uncover exciting insights about yourself orfind the answer to questions you’ve often wondered about but were never quite sure how to resolve.

But this is only the beginning of your journey.

By choosing 3X4, we’re confident that you’ve made the right choice and investment into the future of your health.We encourage you to enjoy and embrace these first steps as you embark on your journey towards making health adaily choice.

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THE GLOSSARY

The formation, storage, and release of fat cells are affected by variability in our genes. These gene variations may bepartly responsible for why some people find it easy to gain or lose weight compared to others, even though their dietand lifestyles are similar. How our fat cells release energy is determined by certain genes and their variations.Knowing how your fat cells are predisposed to store and release energy can empower you to make the right diet andlifestyle choices to suit your unique genotype.

Some people are very sensitive to the sensation of satiety (fullness), while others often overeat and take longer toregister that they are full. We all experience hunger and fullness differently. While many people believe that servingsizes and other eating behaviors should be equal for all, variations in our genes determine our appetite level andsatiety to some degree, and consequently, may affect our eating patterns (snacking, binge eating, servings, frequencyof meals, etc.) in a very real, biological way.

Blood clotting is a survival mechanism designed to prevent uncontrolled bleeding. On the other hand, excess bloodclotting, which may be linked to genetic variants coupled with diet and lifestyle factors also needs to be addressed.When clotting occurs, the clot travels to a small blood vessel or vein in either the heart, brain or extremities and mayresult in a stroke, heart attack or deep vein thrombosis. There are numerous preventative actions that can be taken.

Blood pressure indicates how hard the heart is working in order to pump blood around the circulatory system, and isused as a measure for confirming good health. High blood pressure can cause damage to blood vessels, delicatetissues in organs and systems in the body. Genetic variance impacts the ability to contract and relax blood vesselsand balance fluid volume within them.

Bones offer important structural support and protective roles within our body. Bone is made up of minerals such ascalcium and phosphorus, which is also used elsewhere in the body. The turnover of these minerals in the breakdownor build-up of new bone cells is important for bone health. Gene variants may impact these processes and affect thebalance of breakdown and build-up. Diet and lifestyle choices also contribute a great deal to these processes.

Caffeine is a central nervous system stimulant. In small amounts, caffeine's effects include mild euphoria, alertness,and enhanced cognitive performance; but in higher quantities, it can trigger anxiety, restlessness, irritability, nausea,and insomnia. The clearance of caffeine can vary to up to 40-fold between individuals, a genetically-determinedability. Certain gene variants confer a higher sensitivity to caffeine and are associated with slower metabolism ofcaffeine.

ADIPOGENESIS | MEDIUM ENERGY

APPETITE/SATIETY/INTAKE | MEDIUM ENERGY

BLOOD CLOTTING | LOW CARDIOVASCULAR HEALTH

BLOOD PRESSURE | MEDIUM CARDIOVASCULAR HEALTH

BONE HEALTH | MEDIUM SYSTEMS

CAFFEINE | VERY HIGH NUTRIENTS

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THE GLOSSARY

Cholesterol metabolism refers to processes that determine the distribution of lipids in the body. Fats bind to proteinsthat transport them in the bloodstream between organs. Different forms of fat particles have important roles to playas part of cell membrane structures and as precursors for hormones. Suboptimal cholesterol processes may result inan imbalance in the accumulation and breakdown of fats in the bloodstream, which most commonly leads tocardiovascular diseases like heart disease and stroke.

Choline is a vitamin that plays an important role in the building of cell membranes. It is a key nutrient for a healthypregnancy, mood regulation, memory and making new DNA. It is also involved in fat transport and supportsmethylation. Certain genes may affect the availability of choline, increasing dietary choline requirements.

All our cells are continuously being renewed by being broken down and replaced by new ones. Collagen is the majorstructural protein and the foundation of all our soft-tissue (skin, hair, nails, joints, and organs). Variations in collagengenes might affect the structure and function of these areas. Causing excessive breakdown of cells without acomparable formation of new cells will result in degeneration. Genes play a large part in the process of collagenformation and breakdown, as does lifestyle factors such as diet and exercise.

Detoxification is the body's way of getting rid of toxins that could otherwise build up and interfere with health. Signsof poor detox include lethargy, fatigue, difficulty concentrating and unexplained aches and pains in the body. The liveris the main site of whole-body detox but every cell has its own toxin-eliminating processes to keep it clean, healthyand working well. Detoxification can be optimized by making the right diet and lifestyle changes to support goodcellular cleaning processes.

Endurance refers to activities where muscles are exercised at lower intensities for prolonged periods of time. Yourgenes play a role in determining how well you will respond to endurance-based activities, and can be used as a guideto optimize your exercise program to get the best results. Endurance levels will improve when you follow a programthat gradually increases your training load (duration, frequency and intensity). Numerous health benefits can beachieved at lower intensities of exercise.

Energy expenditure is the amount of energy (kilojoules or calories) that is needed to carry out important functionssuch as breathing, digesting food, circulating blood, regulating temperature, and exercising. The more commonly usedterm when referring to how we burn calories is to say we have a 'fast' or 'slow' metabolism. The rate at which we useand manage calories for energy is largely determined by our genes, our activity, what and how much we eat,resulting in significant individual differences between how we burn energy.

CHOLESTEROL | MEDIUM CARDIOVASCULAR HEALTH

CHOLINE | LOW NUTRIENTS

COLLAGEN & JOINTS | MEDIUM SYSTEMS

DETOXIFICATION | MEDIUM CELLULAR

ENDURANCE | MEDIUM ACTIVITY

ENERGY EXPENDITURE | HIGH ENERGY

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THE GLOSSARY

Research has confirmed that people’s response to exercise varies considerably. Some respond quickly to exercise(e.g. they get fit fast and their body composition changes favorably), while others are less sensitive to exercise'seffects. A significant contributor to these differences in exercise response is genetics. An individual's ability tomobilize stored body fat and burn it for exercise fuel is partly predisposed by certain genes. It is useful to understandthe extent exercise may help weight loss and how to balance these factors out.

Fatty acids are the building blocks of fats and perform many important functions in the body. They are the base forcell membranes, help make hormones, are involved in inflammation, brain function and the immune system. Differentdietary fats impact the body in different ways and our genes impact how these fats are metabolized and processed.Good quality dietary fat intake may correct these imbalances driven by genes.

Estrogen is the major female hormone involved in reproduction. Estrogen-like molecules are also found externally inour environment, in the foods we eat, the packaging and products we are exposed to, as well as in artificial hormonemedications such as the contraceptive pill and hormone replacement therapy (HRT). Cumulative lifetime exposure toestrogens can increase our cancer risk, so keeping a favorable estrogen metabolism is important. Certain genes aswell as diet and lifestyle choices impact how these hormones are metabolized.

Folate is an essential vitamin that works together with all B vitamins and plays a vital role in methylation. Folate alsohelps maintain brain, nerve, blood cells, and DNA health. Natural occurring folate is found in numerous foodsincluding leafy greens, legumes and asparagus. The synthetic form is called folic acid, commonly used in supplementsand fortified foods, but is less beneficial compared to folate. Genetic variation affects the availability and therequirement for folate.

Our cells run on glucose, a simple sugar obtained from the food we eat. Our bodies work hard to ensure the amountof glucose in the blood is kept at just the right level. High blood glucose is often associated with weight issues anddiabetes, but chronically elevated blood sugar also has other effects such as accelerated aging and chronicinflammation, which underlie every major chronic disease. The way insulin and glucose do their job is determined bycertain genes as well as by our weight, diet, and lifestyle choices.

Celiac disease occurs when there is an immune reaction to gluten which is the protein found in wheat, barley and rye.In these cases, gluten can causes inflammation in the gut which damages the gut wall and leads to complicationsresulting in deficiency conditions like anemia, osteoporosis and thyroid problems. If certain genes variants are present,gluten may need to be removed from the diet completely.

EXERCISE RESPONSE | HIGH ENERGY

FATTY ACIDS | LOW NUTRIENTS

FEMALE HORMONE BALANCE | MEDIUM SYSTEMS

FOLATE | LOW NUTRIENTS

GLUCOSE & INSULIN | LOW SYSTEMS

GLUTEN | MEDIUM NUTRIENTS

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THE GLOSSARY

Histamine is a chemical produced by mast cells, that is involved in immunity and the removal of allergens from thebody. It also helps with digestion and is released in response to injury and toxins. Histamine can be made by bacteriain the gut but is also present in certain foods. Genes regulate enzymes that are responsible for histamine breakdown.Inefficient breakdown may result in a histamine overload and cause symptoms like migraines, flushing, dizziness, skinrashes and hives.

Inflammation is a normal automatic immune response to injury, irritation or infection. When you bump your toe and itbecomes swollen, that's the inflammatory response working to speed up healing. Sometimes injuries or irritations areinternal (in places like our gut, muscles, joints, or blood vessels). Inflammation is protective by design, but can becomedestructive if left unchecked. Long term, chronic inflammation can eventually lead to conditions like arthritis, eczema,IBS, autoimmune conditions, and several diseases.

Injuries are caused by many internal and external factors. A torn tissue or chronic overuse of muscles, tendons orligaments does not affect everyone in the same way, or necessarily result in injury. The combination of your body'smake-up and genetics contribute to the development of injuries. Knowing your genetically determined risk for injurycan help to manage and avoid these risks, and help you adjust exercise, lifestyle, diet, and recovery routinesaccordingly.

Certain genes affect the body's ability to transport iron from the tissues to the blood, so that excess iron can beexcreted. Excessive iron accumulation within the tissues, known as hemochromatosis, is a condition that can result inthe damage of organs which can precipitate disease conditions such as diabetes, cancer, irregular heart beat and livercirrhosis.

The brain is the control center of the body, and keeping it healthy is crucial for overall mental and physical health.Apart from regulating all hormones and other biological processes, the brain is also responsible for cognitive function,including attention, focus, learning capacity, and memory. Brain health and function tend to decline with age but at afaster rate in individuals with unfavorable diet and lifestyle behaviors. Certain genetic variations may be anotherreason why our brain health and cognitive function might not be optimal.

Methylation is the biochemical process of repairing and making new DNA, making sure every cell is functioningoptimally. Methylation is not just responsible for how we repair DNA, but also how we make energy, respond tostress, handle inflammation, how well our cells detoxify, and how our brain chemistry works. Methylation is thebiochemical process involved in actually turning genes on or off. We may be able to reduce our risk of developingcertain diseases and some types of cancers by optimizing methylation.

HISTAMINE OVERLOAD | MEDIUM SYSTEMS

INFLAMMATION | HIGH CELLULAR

INJURY | HIGH ACTIVITY

IRON OVERLOAD | LOW NUTRIENTS

MEMORY & BRAIN HEALTH | LOW SYSTEMS

METHYLATION | LOW CELLULAR

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THE GLOSSARY

It is normal for our moods to change depending on the situation, but when a person's emotional state leads tochanges in behavior that affect their ability to deal with daily routines, support should be sought. Genetics affects ourability to manufacture and balance chemicals in the brain that are necessary to manage mood, anxiety, depression,addiction and related behaviors. In addition, diet and lifestyle choices impact brain chemicals and may requireadjustment.

Oxidative stress is the human equivalent of rusting. The impact of all exposures over time results in damage to ourcells. Unmanaged, oxidation can impact on our energy levels, memory, premature aging and sometimes cancer risk. Ina healthy functioning cell, enzymes that counteract oxidative damage, a 'rust block' so to speak, are made. The abilityto make those enzymes is determined by certain genes. However, a good diet and lifestyle can aid towards a loweroxidative burden and help maintain the health of your cells.

Power refers to activities where muscles are exercised at higher intensities for shorter periods of time. It is theproduct of force and the speed at which the action is performed. Power is important for athletic performance, andgenetics play a significant role in how a person's power capacity can improve following a strength and power-basedtraining program. Many daily activities are enhanced by adequate power capacity. It becomes even more important tocontinue with strength and power-based exercises as you age and muscle mass decreases.

Fat cells are not just inactive storage compartments for excess weight - they are metabolically active messengers thatcontrol our energy levels. These messenger molecules found in fat tissue are called adipokines. Fat tissue secretesvarious pro- and anti-inflammatory adipokines to manage inflammation. If there is excess adipose tissue in the body,the inflammatory response can become disrupted, and these proinflammatory molecules increase. Obesity-inducedinflammation can be managed by losing excess weight, which reduces adipokines.

Because exercise is a type of ‘stress’ on the body (the good kind of stress), some level of wear and tear inevitablyoccurs in muscles and tissues during and directly after a workout (this is how muscles grow). Given the right recoveryresources and building blocks, the body quickly repairs and rebuilds muscles and tissues back to a healthy, normalstate, ready for the next exertion. Without enough recovery time or resources, inflammation and oxidative stress canarise in the body and the risk for tissue break-down, injury, and pain increases.

Salt sensitivity is estimated to be present in 51% of individuals with high blood pressure and 26% with normal bloodpressure. In individuals with salt sensitivity, blood pressure may increase when excess sodium is consumed. Althoughthe mechanisms underlying salt sensitivity are complex, your genes can help determine and predict your response tosalt.

MOOD & BEHAVIOR | LOW SYSTEMS

OXIDATIVE STRESS | VERY HIGH CELLULAR

POWER | HIGH ACTIVITY

PRO-INFLAMMATORY FAT | VERY HIGH ENERGY

RECOVERY | HIGH ACTIVITY

SALT | MEDIUM NUTRIENTS

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THE GLOSSARY

Your genetics plays a significant role in influencing your baseline fitness level, as well as your response to aerobictraining. Your fitness levels and training response can be measured as VO2 max, which is the maximum amount ofoxygen you can use during intense exercise. The higher your VO2 max, the fitter you are. Being fitter reduces yourrisk of cardiovascular disease and improves quality of life. High VO2 max levels are associated with performance inendurance-based sports.

Veins and arteries make up a network in the body responsible for transporting oxygen and nutrients to our organsand systems, and for removing waste. Having healthy blood vessels means maintaining their strength and flexibility.Loss of function makes them vulnerable to damage and disease. Certain genes, and diet and lifestyle factors influencehow these vessels are maintained and kept healthy.

Vitamin B12 is an essential vitamin that works together with folate and other B vitamins . It's a major player inmaintaining the health of both brain and blood cells, as well as the synthesis of DNA. Vitamin B12 is exclusivelyavailable from animal products, but may be made in the gut by bacteria. Genes may affect the availability, metabolismand requirement for Vitamin B12.

Vitamin C is capable of excreting or neutralizing substances such as toxins and biproducts of normal cellular functionthat may cause rust-like damage within our cells. It is also a key nutrient in the health of our collagen and bloodvessels and assists in iron absorption, and wound healing. Certain genes show us how effective we are at activatingvitamin C for use in these functions.

Vitamin D is made in the skin when exposed to sunlight. It is then activated in the liver and kidneys to produce vitaminD3. Vitamin D3 is able to switch multiple genes on, genes that are responsible for the maintenance of bone health andimmunity, as well as the health of the hormone, glucose and cardiovascular systems. Variants in the VDR gene impactabsorption, metabolism, and utilization of Vitamin D, therefore dietary intervention and increased sun exposure maybe required.

There is considerable inter-individual variability in our physical ability to lose, gain, or maintain a healthy weight.Certain gene variations affect how we regulate energy and make us more genetically- prone to weight gain and slowweight loss. A one-size-fits-all model does not exist when it comes to how much or how frequently we should eat, orwhat type of exercise we should do and for how long. Genetic variations can explain, at least in part, how peoplerespond to overeating, exercise, and diet.

TRAINING RESPONSE | MEDIUM ACTIVITY

VASCULAR HEALTH | MEDIUM CARDIOVASCULAR HEALTH

VITAMIN B12 | MEDIUM NUTRIENTS

VITAMIN C | HIGH NUTRIENTS

VITAMIN D | HIGH NUTRIENTS

WEIGHT GAIN & WEIGHT LOSS RESISTANCE | HIGH ENERGY

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GENES BY PATHWAY Leslie Edmunds

OXIDATIVE STRESSOXIDATIVE STRESS 1 INFLAMMATIONINFLAMMATION 2 DETOXIFICATIONDETOXIFICATION 3 METHYLATIONMETHYLATION 4

You will notice that some of the genes have a star ★ next to them. Based on your individual results, these genes have beenidentified as having a bigger impact on your pathways and individual health. It’s important that you and your practitioner areaware of them, as they need to be considered along with your existing diet, lifestyle and medical history in creating yourpersonalized 3X4 plan.

CELLULAR

APOE E3/E4E2/E3/E4

GPX1 TTPro198Leu C>T

GSTM1 DELINS/DEL

GSTO2 GGAsn142Asp A>G

HO-1 TT–413 A>T

PON1 GGGln192Arg A>G

PPARG CCPro12Ala C>G

GSTP1 AGIle105Val A>G

TNFA GA–308 G>A

UCP2 GA–866 G>A

ALDH2 GGGlu504Lys G>A

CAT CT–262 C>T

HFE CC/HDC282Y/H63D

MNSOD CCVal16Ala T>C

NQO1 CCPro187Ser C>T

OGG1 CGSer326Cys C>G

PPARGC1A GGGly482Ser G>A

UCP1 AA–3826 A>G

UCP3 CC–55 C>T

APOE E3/E4E2/E3/E4

IL-1 ++/–

HO-1 TT–413 A>T

CRP GA2147 G>A

DAO CGHis645Asp C>G

FADS1 GG592 G>T

FUT2 GAGly258Ser G>A

SIRT1 TT994 T>C

HLA DQ2.5/DQ8XDQ 2.2/2.5/8

IL-6 GC–174 G>C

IL-6R ACAsp358Ala A>C

TNFA GA–308 G>A

CYP1A1 AAIle462Val A>G

CYP1B1 CCLeu432Val C>G

FOXO3 GGG>T

FUT2 GATrp153Ter G>A

HNMT CCThr105Ile C>T


PAI 5G/5G4G/5G

PPARA GG89204 G>C

TIMP4 CC–55 T>C

TNFA GG–238 G>A

★ COMT AAVal158Met G>A

★ GSTM1 DELINS/DEL


CYP17A1 CC34 T>C

CYP1A2 CC–163 A>C

PON1 GGGln192Arg A>G


NAT2 IntermediateR/I/S

CYP2C19 *1/*17*1/*2/*17



CYP1B1 AAAsn453Ser A>G


CYP2C9 CCArg144Cys C>T

CYP2C9 AAIle359Leu A>C

CYP2D6 *1/*1*1/*3/*10

CYP3A4 AA–392 A>G

EPHX1 TTTyr113His T>C

GSTP1 CCAla114Val C>T


MTHFR CC677 C>T

NAT1 GGArg187Gln G>A


SLCO1B1 TTVal174Ala T>C

COMT AAVal158Met G>A

NBPF3 CCT>C

MTRR AG66 A>G

PEMT GC–744 G>C

CBS CC699 C>T

MTHFD1 GG1958 G>A

MTHFR AA1298 A>C

MTHFR CC677 C>T

MTR AA2756 A>G



TCN2 CC776 C>G

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FEMALE HORMONEFEMALE HORMONEBALANCEBALANCE

1 COLLAGEN & JOINTSCOLLAGEN & JOINTS 2 HISTAMINE OVERLOADHISTAMINE OVERLOAD 3 BONE HEALTHBONE HEALTH 4

SYSTEMS

★ COMT AAVal158Met G>A

CYP17A1 CC34 T>C

GSTM1 DELINS/DEL


CYP2C19 *1/*17*1/*2/*17


CYP1B1 AAAsn453Ser A>G


CYP3A4 AA–392 A>G

EPHX1 TTTyr113His T>C


MTHFR CC677 C>T


COL5A1 TTBstUI C>T

GDF5 CT5'UTR C>T

COL1A1 GG1546 G>T

MMP1 1G/1G–1607 1G/2G

DAO CGHis645Asp C>G

DAO CTC>T

HNMT AG939 A>G

HNMT CCThr105Ile C>T

CYP2R1 AGA>G

DIO2 TCThr92Ala T>C

GDF5 CT5'UTR C>T

VDR GABsm1 G>A

TIMP4 CC–55 T>C

COL1A1 GG1546 G>T

VDR TCTaq1 T>C

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MOOD & BEHAVIORMOOD & BEHAVIOR 5 MEMORY & BRAIN HEALTHMEMORY & BRAIN HEALTH 6 GLUCOSE & INSULINGLUCOSE & INSULIN 7

SYSTEMS


GABRA2 AGLys132Lys A>G

CHRNA5 GAAsp398Asn G>A

CHRNA5 CTC>T

DRD4 CT–521 C>T

AKT1 TTG1172+23A T>C

ANK3 CC318473 C>T

ANK3 AAA>G

BDNF GGVal66Met G>A

CACNA1C GGG>A

DRD1 AA–48 G>A

DRD1 GG–94 G>A

DRD2 CCTaqIA C>T

DRD3 TTSer9Gly T>C

FAAH CCPro129Thr C>A

HTR1A CC–1019 C>G

MTHFR AA1298 A>C

MTHFR CC677 C>T

MTR AA2756 A>G

OPRMI AAAsn40Asp A>G

OXTR GGA>G

★ APOE E3/E4E2/E3/E4


BDNF GGVal66Met G>A



MTHFR AA1298 A>C

MTHFR CC677 C>T

MTR AA2756 A>G



ADIPOQ GG–11391 G>A

ADRB2 GGArg16Gly A>G

ADRB2 GGGln27Glu C>G

DIO2 TCThr92Ala T>C

IRS1 CTC>T

TCF7L2 CTIVS3 C>T

TNFA GA–308 G>A

FOXO3 GGG>T

UCP2 GA–866 G>A

ADIPOQ GG–395 G>A

APOA2 TC–492 T>C

CETP AATaq1B G>A

FABP2 GGAla54Thr G>A

FOXO1 AGA>G

FTO TT87653 T>A

PPARA GG89204 G>C


SLC2A2 CCThr110Ile C>T

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VASCULAR HEALTHVASCULAR HEALTH 1 CHOLESTEROLCHOLESTEROL 2 BLOOD PRESSUREBLOOD PRESSURE 3 BLOOD CLOTTINGBLOOD CLOTTING 4


APOE E3/E4E2/E3/E4

LPL CCSer474Ter C>G

HO-1 TT–413 A>T

AGT AGMet235Thr A>G

APOA5 TC–1131 T>C

CRP GA2147 G>A

IL-6 GC–174 G>C

VEGF GC–634 G>C

CETP AATaq1B G>A

ACE IDIns/Del


F2 GG20210 G>A

F5 GGArg506Gln G>A

MTHFR AA1298 A>C

MTHFR CC677 C>T


PAI 5G/5G4G/5G

PPARA GG89204 G>C

★ APOE E3/E4E2/E3/E4

LPL CCSer474Ter C>G

APOA5 TC–1131 T>C

APOC3 CG3175 C>G

IL-6 GC–174 G>C

CETP AATaq1B G>A

APOA5 CCC>A

CETP AA279 G>A


TNFA GG–238 G>A

ACE2 TC7132 T>C

ACE2 AGA>G

AGT AGMet235Thr A>G

ACE IDIns/Del


F2 GG20210 G>A

F5 GGArg506Gln G>A

PAI 5G/5G4G/5G

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PRO-INFLAMMATORY FATPRO-INFLAMMATORY FAT 1 EXERCISE RESPONSEEXERCISE RESPONSE 2 ENERGY EXPENDITUREENERGY EXPENDITURE 3

ENERGY

IL-1 ++/–


CRP GA2147 G>A

IL-6 GC–174 G>C


TNFA GA–308 G>A

ADIPOQ GG–395 G>A

TNFA GG–238 G>A



LEPR GGLys656Asn G>C

LEPR AGGln223Arg A>G

MC4R TCT>C

CLOCK CC3111 T>C

ADRB3 TTTrp64Arg T>C

FTO TT87653 T>A

LEPR AGLys109Arg A>G



CLOCK CC3111 T>C



MC4R TCT>C

UCP2 GA–866 G>A


FTO TT87653 T>A



UCP1 AA–3826 A>G

UCP3 CC–55 C>T

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WEIGHT GAIN & WEIGHT LOSSWEIGHT GAIN & WEIGHT LOSSRESISTANCERESISTANCE

4 ADIPOGENESISADIPOGENESIS 5 APPETITE/SATIETY/INTAKEAPPETITE/SATIETY/INTAKE 6

ENERGY




CLOCK CC3111 T>C

MC4R TCT>C

APOA5 TC–1131 T>C



PLIN GA11482 G>A

TCF7L2 CTIVS3 C>T


UCP2 GA–866 G>A

ADIPOQ GG–395 G>A


APOA2 TC–492 T>C


FTO TT87653 T>A

MMP2 GGGly226Gly G>C


UCP1 AA–3826 A>G

UCP3 CC–55 C>T



PLIN GA11482 G>A



MMP2 GGGly226Gly G>C



CLOCK CC3111 T>C

TAS2R38 TTAla262Val C>T



MC4R TCT>C

APOA2 TC–492 T>C

DRD2 CCTaqIA C>T

FAAH CCPro129Thr C>A

FTO TT87653 T>A


SLC2A2 CCThr110Ile C>T

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POWERPOWER 1 RECOVERYRECOVERY 2 INJURYINJURY 3

TRAINING RESPONSETRAINING RESPONSE 4 ENDURANCEENDURANCE 5

ACTIVITY

NOS3 TT–786 T>C

ACVR1B AAA>G



ACE IDIns/Del

ACTN3 RX577 R/X

AGT AGMet235Thr A>G

AMPD1 CT133 C>T

CKM TCNcol T>C

IL-6 GC–174 G>C

HIF1A CCPro582Ser C>T


VDR GABsm1 G>A

VDR TCTaq1 T>C

CRP GA2147 G>A

GPX1 TTPro198Leu C>T

IL-6 GC–174 G>C


IL-1 ++/–

CAT CT–262 C>T


TNFA GA–308 G>A

COL5A1 TTBstUI C>T

GDF5 CT5'UTR C>T

TNFA GA–308 G>A

COL1A1 GG1546 G>T

HIF1A CCPro582Ser C>T

ACSL1 TCT>C

AMPD1 CT133 C>T

CAT CT–262 C>T

CKM TCNcol T>C

VEGF GC–634 G>C

ACE IDIns/Del


PPARA GG89204 G>C

ACE IDIns/Del

CKM TCNcol T>C

VEGF GC–634 G>C



NRF2 AAA>G

PPARD TT294 T>C

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CAFFEINECAFFEINE 1 VITAMIN DVITAMIN D 2 VITAMIN CVITAMIN C 3 VITAMIN B12VITAMIN B12 4

GLUTENGLUTEN 5 SALTSALT 6 CHOLINECHOLINE 7

FATTY ACIDSFATTY ACIDS 8 FOLATEFOLATE 9 IRON OVERLOADIRON OVERLOAD 10

NUTRIENTS

CYP1A2 CC–163 A>C


NAT2 IntermediateR/I/S

GC CCA>C

CYP2R1 AGA>G

VDR GABsm1 G>A

VDR TCTaq1 T>C


SLC23A1 GG790 G>A

FUT2 GAGly258Ser G>A

TCN2 CC776 C>G

HLA DQ2.5/DQ8XDQ 2.2/2.5/8

ACE IDIns/Del

AGT AGMet235Thr A>G

PEMT GC–744 G>C

BHMT GGArg239Glu G>A

MTHFD1 GG1958 G>A

APOA2 TC–492 T>C

FADS1 GG592 G>T

MTHFD1 GG1958 G>A

MTHFR AA1298 A>C

MTHFR CC677 C>T

TCN2 CC776 C>G

HFE CC/HDC282Y/H63D

THE PERSONAL GENETIC STORY OF LESLIE EDMUNDS

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