The Obesity Cure

Roadmap to Metabolic Health and Sustained Weight Control with

Power Amino Acids®

Dr. Scheele’s New Book:

George A. Scheele, M.D.

Dr. George A. Scheele, Creator of Factor4 Weight Control®, which combats obesity and metabolic disease.

• Board Certified in Internal Medicine• Princeton BA & John Hopkins MD• Professor at Rockefeller University, Yale University School of Medicine and Harvard Medical School. • Two time Nobel Associate• First to figure out how to separate all the proteins in the human body (est. 20,000) by inventing 2D gel electrophoresis

“As a medical doctor with over 30 years of research, my personal mission is to reduce worldwide obesity and metabolic disease. That is why I created Factor4 Weight Control®.”

– George A. Scheele, MD

Meet Dr. Scheele

Nobel Prize: 1974

Intracellular Compartments:

•Rough Endoplasmic Reticulum (RER)

•Golgi Apparatus

•Condensing Vacuoles

•Secretory Granules

Secretory Pathway Defined:

Protein Secretion Defined in the Cell

Laureates: Albert Claude, Christian DeDuve, George PaladeAssociate: George Scheele

Nobel Prize: 1999

Signal Peptides Target Proteins to:

•The Secretory Pathway

•Mitochondria

•Lysosomes

•Nucleus

Zip Codes for Protein Targeting:

Intracellular Compartments Have Unique Functions in the Cell

Laureate: Gunter BlobelAssociate: George Scheele

Biological Adaptation

Pancreatic digestive enzymes adapt to changes in the diet:

•Proteases increase with dietary protein

•Amylases increase with dietary carbs

•Lipases increase with dietary fats

Pavlov to Scheele:

Mechanisms of Biological Adaptation Defined

Complexity of the Proteome

• Dr. Scheele was the first scientist to figure out how to separate all the proteins in the human body, now estimated at 20,000

• Invention of 2D Gel Electrophoresis

How Many Proteins in the Human Body?

Enabled Biological Adaptation Studies Throughout the Body

Proteome in Obesity

• Fattening diets contained high carbs and low protein in experimental subjects

• Protein deficiency caused an increase in food intake and showed a selective loss in positive-charged proteins

• Correction of protein deficiency normalized food-intake and body-weight

Biological Adaptation to Obesity

Protein Deficiency Syndrome Defined & Correlated with Obesity

The Obesity Cure

Resolve the Long-Standing Diet Wars•High protein/fat diets of Atkins•Low fat diets of national policy

AIM: To Resolve the Obesity Epidemic

Call Attention to The Obesity Epidemic•Overweight disorders have doubled since 1980•2 out of 3 Americans now overweight•1 out of 3 Americans now obese•Childhood obesity is increasing for the first time

Provide a New Approach to Weight-Loss Health

Book Purpose:

Bottom Line

Exploit nature’s feedback mechanisms to:

• Suppress appetite to avoid food cravings• Burn fat to reduce excess body weight• Build muscle to improve body definition• Boost energy to tackle life

Power Amino Acids®

Scientific Research Reveals a New & Better Approach to Weight Control and Metabolic Health:

Power Amino Acids® Essential for Weight Control!

The Lesson

• Excess calories in a sedentary society

• Excess refined sugars & carbohydrates

• Excess saturated & trans fat

• Protein Deficiency Syndrome – New!

Dietary Causes Defined

Dietary Causes of Obesity:

The Solution

• Correct deficiencies in positive-charged amino acids, proteins & metabolic pathways

• Curb appetite for refined sugars, processed carbs, and fat

• Satisfy hunger with minimal calories

Power Amino Acids® Correct All Dietary Causes of Obesity:

Your Weight-Loss Goals Achieved

Multiple Benefits

Exploit nature’s feedback mechanisms to enable:

• Healthy Lifestyles• Weight Control• Metabolic Health• Anti-Aging Health

Power Amino Acids®

Achieve Normal Body Weight, Metabolic Health, & Anti-Aging Health with:

Power Amino Acids® Essential for Weight Control & Metabolic Health!

The Conclusion

Bon Voyage to Normal Body Weight, Metabolic Health, and Anti-Aging Health

with

Power Shakes & SmoothiesContaining Power Amino Acids®

Look Younger, Live Longer & Feel BetterWith Power Amino Acids®

Protein Deficiency Syndrome

2-Dimensional Gel Analysis:

A: Health Normal Protein Pattern Normal body weight

B: Protein Deficiency Syndrome Positive Charged Proteins Reduced by 90% within 12 days (gain in body weight)

C: CORRECTION with Factor4 Weight Control® Power Amino Acids® correct protein deficiency (Body weight returns to normal)

Amino Acids & Core Body Health

Amino Acids serve as:• Building blocks for proteins, the working units (enzymes)

throughout the body (lifespan of proteins measured in hours to days)

• Used to rebuild the body every minute that we breathe• Protein health means a balance between positive-charged

and negative-charged proteins• Balanced protein health is essential for core body health &

body repair

Monumental Task: 20,000 Proteins in the Body

Amino Acids -> Proteins -> Core Body Health

Problem: The Food Chain Gap• 20 amino acids are required to make proteins

– Humans can only produce 11 of these amino acids– Humans cannot produce the other 9 amino acids, which

therefore must be obtained from the food chain

• During poor nutrition and/or aging the food chain falls short on providing the 9 essential and the 3 positive-charged amino acids (Power Amino Acids®).

• These amino acid deficiencies may lead to 95% disappearance of positive-charged proteins

• Balance is lost between positive-charged and negative-charged proteins (Protein Deficiency Syndrome)

• As a result metabolic pathways are disrupted that burn fat

Power Amino Acids® Rebalance Metabolic Pathways

Solution: Power Amino Acids®

• Essential amino acids (Leu, Ile, Val, Met, Thr, Phe, Trp, Lys, His)

• Branched chain amino acids (Leu, Ile, Val)• Positive-charged amino acids (Arg, Lys,

His)• Satiety amino acids (5-hydroxytryptophan,

DL-Phe, Leu, EAA)• NOS stimulating amino acid (Arg)

Power Amino Acids® include:

Except Where Mentioned, Amino Acids are L-Forms

Solution: Power Amino Acids®Power Amino Acids®:• Correct the deficiency in essential and positive-

charged amino acids• Close the food chain gap (suppress appetite)• Rebalance protein health between positive-

charged and negative-charged proteins (protein deficiency syndrome corrected)

• Supercharge core body health (metabolism)• Reset metabolic pathways to burn fat• Suppress appetite

Power Amino Acids® Stimulate Weight Loss and Sustained Weight Control

Appetite Suppression

Power Amino Acids® suppress appetite centers in the brain and gut providing satiety feelings of “comfort, satisfaction & well-being”

*Absorption times from Protient Technologies

Nutrient Absorption times*

Appetite suppression

Power Amino Acids®

(Factor4 Weight Control®)

5 minutes ++++

Whey protein 2 hours* +/-

Soy protein 4 hours* +/-

Casein protein 8 hours* +/-

Satiety Amino Acids

Power Amino Acids® include Satiety Amino Acids:•Essential Amino Acids•Branched-chain amino acids, particularly Leucine•DL-Phenylalanine: Blocks enzymes that destroy endorphins & enkephalins•5 Hydroxytryptophan: Immediate Precursor to Serotonin

Satiety Amino Acids Act on the Appetite Centers in the Brain Stem (Arcuate Nucleus) and in the Stomach

Appetite Suppression(Comfort, Satisfaction & Well-Being)

Achieved in Minutes, Lasts for Hours

Weight Loss Study

• History: 25 subjects with Chronic overweight disorders for 20-30 yrs. (historical controls)

• Within 3 months 96% of subjects lost weight• Average weight loss: 8.4, 16.2, and 33.4 pounds in

3, 6, and 12 months• Percent body weight reduced by 4.5%, 8.2%, and

16.2% in 3, 6, and 12 months

Weight Loss Significance:FDA Requires a 5% Loss in Body Weight in 12 Months

Conducted in 2007:

Weight Loss PerformanceFactor4™ Outperforms Popular Diet Plans:

112 month resultsNovaLife

312 month results JAMA, March, 2007

Diet Plan Weight Loss

Factor4 Weight Control™1

33 lbs

Factor4 Weight Control™2

16 lbs

Atkins3 10 lbs

National Guidelines3

6 lbs

Dean Ornish3 5 lbs

Zone3 3.5 lbs

26 month resultsNovaLife

Conclusion #1:Factor4 Weight Control® is the most

important dietary supplement for weight loss & sustained weight control

Because Power Amino Acids®:• Suppress Appetite• Burn Fat• Build Muscle• Boost energy

Without stimulants, caffeine or sugar

Good Health: The #1 Priority in Life

Obesity & Metabolic Syndrome

• Overweight disorders & obesity are not isolated in our society

• They are part of the spectrum of metabolic diseases associated with Metabolic Syndrome

• Metabolic Syndrome is associated with chronic degenerative diseases that are responsible for accelerated aging and early death

• Obesity is the most obvious manifestation of Metabolic Syndrome

Overweight Disorders are Part of the Metabolic Syndrome:

Two Epidemics: Obesity & Metabolic Disease

Epidemic of Metabolic DiseaseNumber of Cases in the US alone:

Disease IncidenceOverweight disorders 150 million

Obesity 75 million

High blood pressure 34 million

High cholesterol & TGL 30 million

High blood sugar 90 million

Type 2 Diabetes 30 million

Cardiovascular disease 57 million

Cancer 18 million

Osteoarthritis 20 million

Gallstones 19 million

America Challenged with Chronic Degenerative Disease!

Cost of Type 2 DiabetesComplications:• Blindness• Kidney disease/dialysis/Kidney transplants• Nerve damage/neuropathies/falls/trauma/chronic-infections/amputations• Cardiovascular-disease/heat-attacks/stents/coronary-bypass-surgery/stroke• Obesity/surgery/lap-band/gastric-bypass/corrections/cosmetic-surgery• Depression/anxiety/rage/aggression• Emergency-care/nursing-homes/assisted-living/extended-care• Medications/hypoglycemic-attacks/hospitalization• Increased incidence of cancer, Alzheimer’s disease, and lung disease• Loss of function & productivity• Accelerated aging

Cost of Disease & Complications:• $200,000 to $300,000 added cost per patient• Total cost: $6-9 trillion over a lifetime for pool of type 2 diabetics

Status Quo: US Sovereign Debt Soars to 300% GDP

National Health-Care Crisis

Absolute Costs in 2010: CDC•$2.3 trillion Total health-care costs•$1.7 trillion Preventable chronic disease•$1.0 trillion Diet-related chronic disease (Metabolic)

Costs as Percent of GDP:•2010: 17.4%•2025: 25.0% (est.)•2050: 35.0% (est.)

Tidal Wave of Metabolic Disease:

National Budget Deficit in USA: Health-Care Costs Uncontrolled!

National Budget Deficit in 2011:•$14 Trillion

America’s ChoiceHealth Insurance the Way It Was:•Rules against pre-existing conditions•Rejecting patients when they become sick•Lifetime caps on coverage

Health Insurance the Way it Is:•Pay for expensive treatments rather than prevention•Insolvent government budget by 2025

Health Insurance the Way it Could Be… With Effective Prevention & Treatment Programs:•Regulations that foster healthy foods low in sugar, fat & salt•Power Amino Acids® that can tame appetite, obesity, chronic degenerative disease, and the Metabolic Syndrome

Good Health, The #1 Priority in Life

Conclusion #2:

Appetite Suppression with Power Amino Acids® combats both obesity & metabolic disorders

Because Power Amino Acids® promote:• Healthy Lifestyles • Weight Control• Metabolic Health• Anti-Aging Health

Good Health: The #1 Priority in Life

Intellectual PropertySupplementation with Power Amino Acids®

to correct deficiencies in positive-charged amino acids & proteins for the benefit of obesity, chronic degenerative disease, and the metabolic syndrome:

• Provisional patent application filed in December, 2005

• Regular patent application filed in December, 2006

• Continuation in part (CIP) filed in 2008

• Use patent: Notice of Allowance

• Composition patent: Filed

Patent Protection:Factor4 Weight Control® as a Medical Food

The Product