The Nanomedicine Delivery Challenge. You have learned that some sunscreen products contain nanoscale...
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Transcript of The Nanomedicine Delivery Challenge. You have learned that some sunscreen products contain nanoscale...
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The Nanomedicine Delivery The Nanomedicine Delivery ChallengeChallenge
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You have learned that some sunscreen You have learned that some sunscreen products contain nanoscale structuresproducts contain nanoscale structures..
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Nanoscale structures in sunscreen include clusters Nanoscale structures in sunscreen include clusters of zinc oxide and/or titanium oxideof zinc oxide and/or titanium oxide
Different number of ions can cluster together.Different number of ions can cluster together.• ZnO always has equal numbers of Zn and O ionsZnO always has equal numbers of Zn and O ions
• TiOTiO2 2 always has twice as many O ions as Ti ionsalways has twice as many O ions as Ti ions
~100 nm TiO2 particle ~200 nm TiO2 particle
Source: Images adapted from http://www.cse.clrc.ac.uk/msi/projects/ropa.shtml
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The unbalanced chemical equation below The unbalanced chemical equation below describes the formation of iron oxide describes the formation of iron oxide
structures commonly called magnetite.structures commonly called magnetite.
FeClFeCl33 + FeCl + FeCl22 + NH + NH44++ + OH + OH−− → Fe→ Fe33OO44 + NH + NH44ClCl
Water is used to rinse off the ammonium chloride.Water is used to rinse off the ammonium chloride.
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A surfactant is then mixed with the iron oxide so A surfactant is then mixed with the iron oxide so that nanoscale clusters of iron oxide form.that nanoscale clusters of iron oxide form.
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The magnetite clusters can be put into a demonstration The magnetite clusters can be put into a demonstration cell that contains an organic liquid. cell that contains an organic liquid.
The clusters can be manipulated in a magnetic field and The clusters can be manipulated in a magnetic field and behave like a fluidbehave like a fluid. .
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Ferrofluids as a model of a Ferrofluids as a model of a nanoscale medicinenanoscale medicine
The goal for your group is to use the materials in the plastic containers to propose methods for delivering a nanoscale medicine to a specific location in the human body.
The activity has been adapted from the November 2006 Science Scope Journal article “Nanomedicine: Problem Solving to Treat Cancer” co-authored by Melissa A. Hemling, Lauren M Samuel, Greta Zenner, Amy C. Payne, and Wendy C. Crone.
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There are Three Data TablesThere are Three Data Tables
• In Data Table #1 you need to describe the effectiveness of medicine delivery devices.
• In Data Table #2 you need to compare the behaviors of nanoscale and larger than nanoscale particles in a magnetic field.
• In Data Table #3 you need to describe the possible advantages and disadvantages of a medicine that responds to a magnetic field.
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CreditsCredits
Slide 1: A manipulated nanoscale structure:
Nanomedicine: Problem solving to treat cancer
by Melissa A. Hemling, Lauren M. Samuel, Greta Zenner, Amy C. Payne, and Wendy C. Cron
Science Scope Journal; November 2006
Slide 5 : FerroFluid Structure;
Page 944 Journal of Chemical Education • Vol. 76 No. 7 July 1999 • JChemEd.chem.wisc.edu
Slide 6: A FerroFluid display cell available from Educational Innovations Inc . At:
http://www.teachersource.com/ElectricityAndMagnetism/Ferrofluid/FerrofluidPreformDisplayCell.aspx
YouTube video at: http://www.youtube.com/watch?v=9SKVHv63SlM&feature=related