The NanoAssemblr Benchtop - ATA Scientific€¦ · 1, 3, 5, 10 ml BD Luer-Lok™ or Slip-Tip...

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www.precisionnanosystems.com • 1.888.618.0031 • [email protected] Develop novel nanomedicines faster using precise formulation conditions Precision NanoSystems’ NanoAssemblr Benchtop system is designed for rapid prototyping of novel nanoparticles, that would be difficult to make with alternative manufacturing methods. The system uses proprietary microfluidics for the quick and precise mixing of nanoparticle components. Users can tune size (~20 to 120+nm) by changing process and composition – tweakening parameters such as mixing ratios and flow rate to achieve desired and repeatable results. The system is fast, enabling 30+ formulations in a day and is easy-to-use. Software controlled mixing as- sures repeatable and precise results. Precise protocols recorded by the software allow for the transfer of manufacturing conditions between sites and users, which accelerates development, reduces waste and ultimately saves time. Accelerate your research and nanomedicine development. Produce nanoparticles in one minute on a standard system and move the discovery and development of your formulations ahead more easily than ever before. Applications and types of formulations Include: • Protein delivery and screening • Nucleic acid delivery and screening • Nanoparticle design • Targeted drug delivery • Lipid nanoparticles • Liposomes • Polymeric nanoparticles The NanoAssemblr ™ Benchtop

Transcript of The NanoAssemblr Benchtop - ATA Scientific€¦ · 1, 3, 5, 10 ml BD Luer-Lok™ or Slip-Tip...

Page 1: The NanoAssemblr Benchtop - ATA Scientific€¦ · 1, 3, 5, 10 ml BD Luer-Lok™ or Slip-Tip Disposable Syringes Max Volume per Run 15 mL Min Recommended Volume per Run 1 mL Fluid

www.precisionnanosystems.com • 1.888.618.0031 • [email protected]

Develop novel nanomedicines faster using precise formulation conditions

Precision NanoSystems’ NanoAssemblr Benchtop

system is designed for rapid prototyping of novel

nanoparticles, that would be difficult to make with

alternative manufacturing methods.

The system uses proprietary microfluidics for the quick

and precise mixing of nanoparticle components. Users

can tune size (~20 to 120+nm) by changing process and

composition – tweakening parameters such as mixing

ratios and flow rate to achieve desired and repeatable

results.

The system is fast, enabling 30+ formulations in a

day and is easy-to-use. Software controlled mixing as-

sures repeatable and precise results.

Precise protocols recorded by the software allow for

the transfer of manufacturing conditions between sites

and users, which accelerates development, reduces

waste and ultimately saves time.

Accelerate your research and nanomedicine

development. Produce nanoparticles in one minute

on a standard system and move the discovery and

development of your formulations ahead more

easily than ever before.

Applications and types of

formulations Include:

• Protein delivery and screening

• Nucleic acid delivery and screening

• Nanoparticle design

• Targeted drug delivery

• Lipid nanoparticles

• Liposomes

• Polymeric nanoparticles

The NanoAssemblr™ Benchtop

Page 2: The NanoAssemblr Benchtop - ATA Scientific€¦ · 1, 3, 5, 10 ml BD Luer-Lok™ or Slip-Tip Disposable Syringes Max Volume per Run 15 mL Min Recommended Volume per Run 1 mL Fluid

www.precisionnanosystems.com • 1.888.618.0031 • [email protected]

NanoAssemblr Microfluidic CartridgePrecision control of the chemical and physical environment is required for nanoparticle self-assembly.

PNI’s highly engineered cartridges provide the perfect solution for formulation development.

Benefits of the Microfluidic Cartridge include:• Isolated fluid path prevents cross-contamination

• Laminar flow and time-invariant mixing

• Rapid mixing (<3 ms)

• Nanoliter reaction volumes (<20 nL)

• <2 min per formulation, 30+ formulations per day

To find out more or to schedule a demo of the benchtop instrument, visit www.precisionnanosystems.com.

Cryo-TEM micrograph of siRNA LNP PDI < 0.09

“Limit size” Liposomes are dictated by the Flow Rate Ratio

Dictating Size by Process and Composition

Monodisperse Lipid Nanoparticles

1 2 3 40

20

40

60

80

100

Flow Rate Ratio (Aqueous:Organic)

Z-A

ve

(nm

)

Post-Dialysis DataAll PDI < 0.09

POPC:Chol:DSPE-PEG (55:42:3)

DSPC:Chol:DSPE-PEG (55:42:3)

System SpecificationsDimensions (width x depth x height) 31 x 23 x 38 cm (12”x9”x15”)

Flow Rates 2 to 12 mL/min

Temperature Control 20 – 70 C (with heating block)

Syringe Compatibility1, 3, 5, 10 ml BD Luer-Lok™ or Slip-Tip Disposable Syringes

Max Volume per Run 15 mL

Min Recommended Volume per Run 1 mL

Fluid Mixing Time <3 ms

Fluid Mixing Properties Laminar

Waste and Sample Collection 15 mL Falcon Conical Tubes

Electrical Instrument 100 – 240 VAC, 1.2 A (Max.)

Heating Controller (accessory)

100 – 240 VAC, 0.58 A (Max.)

Accessories Name Description

Heating block accessory

The block is used to heat precursor solutions prior to injection into the instrument.

Heating controller package

Heating block temperatures can be set up to 75ºC using the digital temperature controller.

Cartridge (5 pack)The cartridge uses microfluidic channels to enable the self-assembly of components into nanoparticles.

Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems Alex K. K. Leung, Yuen Yi C. Tam, Sam Chen, Ismail M. Hafez, and Pieter R. Cullis J. Phys. Chem. B, 2015, 119 (28), pp 8698–8706. DOI: 10.1021/acs.jpcb.5b02891

Microfluidic-Controlled Manufacture of Liposomes for the Solubilisation of a Poorly Water Soluble Drug. Elisabeth Kastner, Varun Verma, Deborah Lowry, Yvonne Perrie. International Journal of Pharmaceutics, Volume 485, Issues 1–2, 15 May 2015, Pages 122-130. DOI:10.1016/j.ijpharm.2014.10.030

Bottom-Up Design and Synthesis of Limit Size Lipid Nanoparticle Systems with Aqueous and Triglyceride Cores Using Millisecond Microfluidic Mixing. Igor V. Zhigaltsev, Nathan Belliveau, Ismail Hafez, Alex K. K. Leung, Jens Huft, Carl Hansen, Pieter R. Cullis. Langmuir, 2012, 28 (7), pp 3633–3640. DOI: 10.1021/la204833h

About Precision NanoSystems, Inc.Precision NanoSystems, Inc. (PNI) creates innovative solutions for the discovery, development and manufacture of novel nanoparticles for use as medicines and in medical research. PNI provides instruments, reagents and services to life sciences researchers, including pharmaceutical companies, and builds strategic collaborations to revolutionize healthcare through nanotechnology.


Dual Data Acquisition · Flow: 1.5 ml/min GC run time ca. 36 min Injektor SSL, 1 µl splitless injection Column MXT-500 (60m, 0.25 mm ID, 0.15 µm film) Flow: 1.5 ml/min GC run time

Dual Data Acquisition · Flow: 1.5 ml/min GC run time ca. 36 min Injektor SSL, 1 µl splitless injection Column MXT-500 (60m, 0.25 mm ID, 0.15 µm film) Flow: 1.5 ml/min GC run time

ML Princess, ML Solo, ML Flex Air humidification

ML Princess, ML Solo, ML Flex Air humidification

NanoAssemblr - Precision NanoSystems

NanoAssemblr - Precision NanoSystems

User s Guide - GilsonP1000L 0.01 mL mL 0.002 mL P5000L 0.01 mL mL 0.002 mL P10mL L mL 0.1 mL 0.02 mL Lock System For additional safety, the volume selected is lockable. With the left

User s Guide - GilsonP1000L 0.01 mL mL 0.002 mL P5000L 0.01 mL mL 0.002 mL P10mL L mL 0.1 mL 0.02 mL Lock System For additional safety, the volume selected is lockable. With the left

Bluetooth-connected Touch Screen Sample Pump Connect to … · 7.4 V, 2.6 Ah, 19.2 Wh or AC using cradle • 40+ hours at 2000 ml/min,* 15+ hours at 5000 ml/min,* indefinite run from

Bluetooth-connected Touch Screen Sample Pump Connect to … · 7.4 V, 2.6 Ah, 19.2 Wh or AC using cradle • 40+ hours at 2000 ml/min,* 15+ hours at 5000 ml/min,* indefinite run from

NanoAssemblr BlazeTM N Gen Technology

NanoAssemblr BlazeTM N Gen Technology

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Accelerating your process optimization: sampling from ... · 4 Run Design: • Start material: 20 mL 50 mg/mL trans-Cinnamic acid in 2-MeTHF solution • Catalyst: 5 mg 5% Pd/C •

Accelerating your process optimization: sampling from ... · 4 Run Design: • Start material: 20 mL 50 mg/mL trans-Cinnamic acid in 2-MeTHF solution • Catalyst: 5 mg 5% Pd/C •

ML- MIDD LE- ML-COMPANY-NAME ML-DIVISION ML-MAIL-STOP …

ML- MIDD LE- ML-COMPANY-NAME ML-DIVISION ML-MAIL-STOP …

Run Hands-Off and Hassle-Free Production Operations · RUN HANDS-OFF AND HASSLE-FREE PRODUCTION OPERATIONS 2 Software Drives Business Outcomes ... analytics with AI/ML intelligence

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Kleargene plant spin plate DNA extraction kits user manualIsopropanol 7.5 mL 30 mL 125 mL 2 x 250 mL Ethanol 7.5 mL 30 mL 125 mL 2 x 250 mL Buffer W1 Ethanol 10.5 mL 42 mL 175 mL 700

Kleargene plant spin plate DNA extraction kits user manualIsopropanol 7.5 mL 30 mL 125 mL 2 x 250 mL Ethanol 7.5 mL 30 mL 125 mL 2 x 250 mL Buffer W1 Ethanol 10.5 mL 42 mL 175 mL 700

Frontier 5000 Series - Hogentogler & Co., Inc.€¦ · Frontier™ 5000 Series Multi Pro Centrifuges FC5718/FC5718R 0.2/ 0.4 ml 0.5 ml 1.5/ 2.0 ml 4.5 ml 5 ml 7 ml 10 ml 15 ml 16

Frontier 5000 Series - Hogentogler & Co., Inc.€¦ · Frontier™ 5000 Series Multi Pro Centrifuges FC5718/FC5718R 0.2/ 0.4 ml 0.5 ml 1.5/ 2.0 ml 4.5 ml 5 ml 7 ml 10 ml 15 ml 16

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La Casa Gallega · 2020. 10. 14. · ml ml ml ml ml ml ml ml ml ml ml ml ml $ $ $ $ $ $ $ $ $ $ $ $ $ $ $ $ $ $ s $ $ $ s $ $ 190. 348. 190. 340. 205. 385. 170. 195. 280. 190. 58.

Manual de Recarga Samsung ML 2251N | ML 2251NP | ML 2251W | ML 2250

Manual de Recarga Samsung ML 2251N | ML 2251NP | ML 2251W | ML 2250

ml-1640, ml-2240, ml-2241, ml-2245 general

ml-1640, ml-2240, ml-2241, ml-2245 general

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