The Gazette -- December 7, 2009

111010

our 39th year

Covering Homewood, East Baltimore, Peabody,

SAIS, APL and other campuses throughout the

Baltimore-Washington area and abroad, since 1971.

December 7, 2009 the newspaper of the Johns hopkins university Volume 39 No. 14

Job Opportunities

Notices

Classifieds

NuCLeuS Shaper

Researchers say that a cell’s

‘cap’ of bundled fibers could

yield clues to disease, page 3

arra reSearCh

Johns Hopkins scientists are

exploring schizophrenia at the

molecular level, page 7

I N B r I e f

MSEL changes for exams; Peabody concerts in

East Baltimore; ‘Gazette’ holiday schedule

C a L e N D a r

JHU Press holiday book signing; Homewood

by Candlelight; ‘A Christmas Carol’ reading2 12

A homecoming for historic windows H O M E W O O D

Learning about BaltimoreB y G r e G r i e n z i

The Gazette

This Intersession, Craig Hollander will teach a class titled Mov-ers and Shakers: Baltimore by

Biography. Hollander, a fourth-year doc-toral student in history and a native Baltimorean, will hitch his lessons to

famous city sons and daughters such as H.L. Mencken, Babe Ruth, Billie Holiday, Thurgood Marshall and Josh-ua Barney. Barney may lack instant name rec-ognition, but Hol-lander says that the

naval officer’s impact on the city and American history is nonetheless signifi-cant. Born in Baltimore in 1759, Barney had a long, decorated and eventful naval career. He was captured and imprisoned by enemy forces no fewer than five times, served in both the U.S. and French navies and as a commander helped defend Bal-timore and ships on the Chesapeake Bay during the War of 1812. “Ask anyone on the street 150 years ago, and they would have heard of Barney,” Hollander says. “Barney was a very prestigious Marylander, and I think by studying the trajectory of his life we can learn a good deal about the develop-ment of the modern navy, the War of 1812 and the city during this period.” Hollander has less than one week to make his point. The Movers and Shakers course is one of 15 academic offerings in the third annual B’More: A Common Freshman Experience, a one-week academic and personal enrichment program with the city as its centerpiece. The innova-tive and increasingly popular program, which will run from Saturday, Jan. 16, to Friday, Jan. 22, offers freshmen in the schools of Arts and Sciences and Engi-neering the opportunity to get to know Baltimore better, make new friends and foster school spirit.

freshmen

experience

city in an

innovative

program

Continued on page 9

I N T E R S E S S I O N

23 restored stained-glass treasures are reinstalled in Gilman Hall

B y G r e G r i e n z i

The Gazette

the windows in the hutzler undergraduate reading room display marks used by european printers from the 15th and 16th centuries.

Migraine raises risk of common stroke in women R E S E A R C H

Continued on page 7

B y D a v i D M a r c h

Johns Hopkins Medicine

Pooling results from 21 studies involving 622,381 men and women, research-ers at Johns Hopkins have affirmed

that migraine headaches are associated with more than twofold higher chances of the most common kind of stroke: those occur-ring when blood supply to the brain is sud-denly cut off by the buildup of plaque or a blood clot.

The risk for those with migraines is 2.3 times greater than for those without, accord-ing to calculations from the Johns Hopkins team that were presented Nov. 16 at the American Heart Association’s annual Scien-tific Sessions in Orlando, Fla. For those who experience aura—the sighting of flashing lights, zigzag lines and blurred side vision along with migraines—the risk of so-called ischemic stroke is 2.5 times higher, and in women, 2.9 times as high. Study participants, mostly in North Amer-ica and Europe, were between the ages of 18

and 70, and none had suffered a stroke prior to enrollment. Cardiologist Saman Nazarian, senior study investigator, said that the team’s latest analysis, believed to be the largest study of its kind on the topic, reinforces the rela-tionship between migraine and stroke while correcting some discrepancies in previous analyses. For example, a smaller combina-tion study in 2005 by researchers in Mon-treal that showed a bare doubling of risk had

Continued on page 7

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As the massive renovation of Gilman Hall enters its final nine months, many of its historic glass treasures have returned with a pris-

tine sparkle and luster. The Hutzler Undergraduate Read-ing Room’s 19 stained glass windows and Memorial Hall’s four steel-sash picture windows that feature stained glass were

recently reinstalled in their bays after almost a year’s worth of restoration work. Worcester Eisenbrandt, a local restoration firm that oversaw the project, mended wood and metal frames, sealed cracks, reglazed the windows and re-created lost or damaged art. The work was conducted off site at

2 THE GAZETTE • December 7, 2009

I N B R I E F

e D i t o r Lois Perschetz

W r i t e r Greg Rienzi

Pr o D u c t i o n Lynna Bright

co P y eD i t o r Ann Stiller

Ph o t o G r a P h y Homewood Photography

aD v e rt i s i n G The Gazelle Group

Bu s i n e s s Dianne MacLeod

ci r c u l at i o n Lynette Floyd

We B M a s t e r Tim Windsor

Applied Physics Laboratory Michael Buckley, Paulette CampbellBloomberg School of Public Health Tim Parsons, Natalie Wood-WrightCarey Business School Andrew BlumbergHomewoodLisa De Nike, Amy Lunday, Dennis O’Shea,Tracey A. Reeves, Phil SneidermanJohns Hopkins MedicineChristen Brownlee, Stephanie Desmon, Audrey Huang, John Lazarou, David March, Katerina Pesheva, Vanessa Wasta,Maryalice YakutchikPeabody Institute Richard SeldenSAIS Felisa Neuringer KlubesSchool of Education James Campbell, Theresa NortonSchool of Nursing Kelly Brooks-StaubUniversity Libraries and Museums Brian Shields, Heather Egan Stalfort

c o n t r i B u t i n G W r i t e r s

The Gazette is published weekly Sept-ember through May and biweekly June through August for the Johns Hopkins University community by the Office of Government, Community and Public Affairs, Suite 540, 901 S. Bond St., Baltimore, MD 21231, in cooperation with all university divisions. Subscrip-tions are $26 per year. Deadline for calendar items, notices and classifieds (free to JHU faculty, staff and students) is noon Monday, one week prior to publication date.

Phone: 443-287-9900Fax: 443-287-9920General e-mail: [email protected] e-mail: [email protected] the Web: gazette.jhu.edu

Paid advertising, which does not repre-sent any endorsement by the university, is handled by the Gazelle Group at 410-343-3362 or [email protected].

MSE Library implements changes during exam period

The Homewood campus’s Eisenhower Library experienced unprecedented demand for seating during the fall

2009 semester. To better accommodate Johns Hopkins students during reading period and exams, the library will be open to visitors only from 8 a.m. to 4 p.m. from Friday, Dec. 4, through Friday, Dec. 18. At all other times, a valid JHU ID will be required for entrance. Quiet study zones will be strictly enforced, and students who need to work in groups will be asked to relocate.

Turkish Prime Minister Erdogan will speak today at SAIS

Recep Tayyip Erdogan, prime minis-ter of Turkey, will speak at SAIS at 4 p.m. today, Dec. 7. His topic is

“Turkey in the 21st Century: Building Peace Through Diplomacy.” SAIS Dean Jessica Einhorn will provide welcoming remarks, and Daniel Hamilton, director of the SAIS Center for Transatlan-tic Relations, will moderate the session. The event will be held in the Nitze Build-ing’s Kenney Auditorium. Non-SAIS affiliates should RSVP to the Center for Transatlantic Relations at http://transatlantic.sais-jhu.edu/events/2009/erdogan.htm.

Weekly Peabody chamber music concerts planned for East Balto.

Beginning Jan. 20, a weekly series of chamber music concerts featuring Peabody students, alumni and faculty

will be held during the spring semester at noon on Wednesdays in Turner Auditorium on the East Baltimore campus. Bill Nerenberg, a visiting faculty member and director of Peabody Presents, said that the performances will resume a tradition of concerts held at JHH that was begun by George Udvarhelyi, who is now retired and an adviser to the fine arts staff at the hospital. Each concert will be 45 minutes in length with no intermission. The first scheduled performer is pianist Michael Sheppard, a Peabody alumnus, who will be followed on Jan. 27 by the Vinca String Quartet, a young group being men-tored by renowned violinist Pamela Frank.

Press book signing and Madeira tasting scheduled for Dec. 9

More than a dozen authors will be on hand from 5 to 7 p.m. on Wednes-day, Dec. 9, when the Johns Hop-

kins University Press and Homewood Muse-um host their annual Holiday Book Signing and Madeira Tasting. Among those who will sign their books are Mike Gesker, The Orioles Encyclopedia;

Joseph R.L. Sterne, Combat Correspondents; and David W. Harp and Tom Horton, The Nanticoke. In addition, a display will fea-ture JHU Press books published in 2009 that were written or edited by university colleagues, many of whom will be in atten-dance. The museum will be decorated for the holidays and the shop stocked with gifts and cards.

Peabody Consort collaboration to be broadcast on NPR show

If Music Be the Food of Love, a collabora-tion between the Peabody Consort, led by faculty artist Mark Cudek, and actors

from the Indiana Repertory Theatre, will be broadcast the week of Dec. 7 to 13 on National Public Radio’s nationally syndi-cated program Harmonia. The program, recorded in July at the India-napolis Early Music Festival, will be available the following week on the Web page http://indianapublicmedia.org/harmonia. Cudek, who directs Peabody’s Early Music program, is artistic director of the festival.

Guided Care Nursing online course adds sponsor to expand

The online Guided Care Nursing Course offered by the Institute for Johns Hopkins Nursing is now spon-

sored by SeniorBridge, a professional ser-vices provider for individuals requiring care for chronic health conditions. The $10,000 sponsorship will help support the institute’s marketing and outreach of the course, which is focused on chronic disease man-agement, caregiver education and support, transitional care and geriatric evaluation. The six-week course, launched in June, is designed to improve patients’ quality of life and care while improving the efficiency of treating the sickest and most complex patients. The course brings together faculty and clinical experts from the Johns Hopkins schools of Nursing, Medicine and Public Health, as well as The Johns Hopkins Hos-pital and Health System. It has received sev-eral awards, most recently the 2009 Medi-cal Economics Award for Innovation in Practice Improvement from the American Academy of Family Physicians, the Society of Teachers of Family Medicine and Medical Economics magazine.

Deadlines are today, Dec. 7, for last ‘Gazette’ issue of semester

Because of the midyear vacation, The Gazette will not be published the weeks of Dec. 21 and 28.

Next week’s calendar will include events scheduled from Monday, Dec. 14, through Monday, Jan. 4. The deadline for calendar and classifieds submissions for that issue is noon today, Dec. 7.

B y l i s a D e n i k e

Homewood

Leonard Susskind, the Felix Bloch Professor of Physics at Stanford University, will give the 2009 Fer-

dinand G. Brickwedde Lecture in Physics on Tuesday, Dec. 8. Titled “The World as a Hologram,” Susskind’s lecture will take place at 4 p.m. in the Bloomberg Center for Physics and Astronomy’s Schafler Audi-torium on the university’s Homewood campus. Widely regarded as one of the fathers of string theory, Susskind in 1997 won the J.J. Sakurai Prize for his pioneering contributions to hadronic string models, lattice gauge theories, quantum chro-modynamics and dynamical symmetry breaking. He is known as an engaging and imaginative speaker with a rare ability to explain complex scientific concepts to lay audiences. In fact, Stanford has put a series of Susskind’s lectures on theoretical physics, including those on “Einstein’s Theory of Relativity” and

“Dark Matter vs. Dark Energy,” on You-Tube. The Brickwedde lectures were estab-lished in 1981 and are funded by an endowment provided by Johns Hopkins alumnus Ferdinand G. Brickwedde and his wife, Langhorne Howard Brick-wedde. Ferdinand Brickwedde, who received his bachelor’s degree in 1922 and doctor-ate in 1925, had a distinguished research and academic career. A co-discoverer of deuterium, a heavy isotope of hydrogen, he was long associated with the National Bureau of Standards and from 1956 to 1963 was dean of the College of Chem-istry and Physics at Pennsylvania State University, where he was Evan Pugh Research Professor of Physics Emeritus until his death in 1989. As part of the lecture tradition, at least one outstanding scientist is invited to campus for a three-day period each academic year. During that visit, the sci-entists deliver a public address and the weekly departmental colloquium and, as stipulated by the Brickweddes, are asked to spend generous amounts of time with the students.

‘World as a Hologram’ is topic of 2009 Brickwedde Lecture

B y k a t e r i n a P e s h e v a


A few home visits by a health care specialist to educate children with asthma about basic strategies for

earlier symptom recognition and improving medication use can lead to fewer flare-ups and less-frequent trips to the emergency room, according to research from the Johns Hopkins Children’s Center published in the December issue of Pediatrics. An estimated 6.5 million children in the United States have asthma, which is the leading pediatric chronic illness in this coun-try and disproportionately affects minorities. “We compared several strategies to improve asthma control among children and, much to our delight, we found that taking a few simple steps can go a long way toward doing so,” said senior investigator Kristin Riekert, a pediatric psychologist at Johns Hopkins and co-director of the Johns Hopkins Adherence Research Center. Researchers say the key is providing regu-lar asthma education that includes in-the-home demonstration and training on the proper use of inhalers by an asthma special-ist and a discussion with the family about regular access to a pediatrician, and ensuring they have access to one; an asthma action plan specifically tailored to each child, with a list of must-take daily controller medica-tion to keep inflammation at bay; and a checklist of what to do when symptoms start and when to seek emergency care. Researchers compared the effectiveness of three different strategies in 250 African-American children with asthma who ended up in an emergency room with an asthma attack. One group received a booklet with basic asthma information, the standard and usual care. The other two had educational home visits by asthma educators, with one group receiving education only and the

other education plus feedback on how well the patient was following his or her medica-tion instructions, which researchers deter-mined by a monitoring device on the child’s inhaler to record each use, as well as coach-ing on how to improve adherence. Follow-ups at six, 12 and 18 months showed that: • Children in the two groups that received home visits and whose medication use was monitored had 15 percent fewer trips to the emergency room compared to children who got the standard care. They also had a 52 percent faster rate of refill of inhaled corti-costeroids, a daily controller medication that helps keep inflammation at bay. • Children who got educational home visits reported, on average, fewer symp-toms per month compared to children who received the informational booklet. • Children who got the informational pamphlet—the standard of care—had 12 percent more emergency room visits and 17 percent higher use of oral corticoster-oids, a marker of an asthma flare-up, when compared to children from the other two groups. • There was no added value in provid-ing medication monitoring and feedback beyond providing at-home educational visits alone. • There was no significant difference in the number of hospitalizations among the three groups. The National Heart, Lung and Blood Institute funded the research. Lead author Michiko Otsuki was a Johns Hopkins Behavioral Medicine fellow at the time of the study and is currently at the University of South Florida, St. Petersburg. Other Johns Hopkins investigators in the study were Michelle Eakin, Arlene Butz, Cynthia Rand, Jean Ogrborn and Andrew Bilderback. University of Maryland co-in-vestigators were Van Doren Hsu and Ilene Zuckerman.

Educational home visits can improve asthma in children

Need extra copies of ‘the Gazette’?A limited number of extra copies of The Gazette are available each week in the Office of Government, Community and Public Affairs, Suite 540, 901 South Bond St., in Fells Point. Those who know they will need a large number of newspapers are asked to order them at least a week in advance of publication by calling 443-287-9900.

December 7, 2009 • THE GAZETTE 3

B y M a r y s P i r o

Engineering in Oncology Center

It turns out that wearing a cap is good for you, at least if you are a mammal cell. Researchers from the Johns Hopkins

Engineering in Oncology Center have shown that in healthy cells, a bundled “cap” of filaments holds the cell’s nucleus—its genetic storehouse—in its proper place. Understanding this cap’s influence on cell and nuclear shape, the researchers said, could provide clues to the diagnosis and treatment of diseases such as cancer, mus-cular dystrophy and the age-accelerating condition known as progeria. “Under a microscope, the nucleus of a sick cell appears to bulge toward the top, while the nucleus of a healthy cell appears as a flattened disk that clings to the base,” said principal investigator Denis Wirtz, professor of chemical and biomolecular engineering and director of the Engineering in Oncology Center. “If we can figure out how and why this shape-changing occurs, we may learn how to detect, treat or perhaps even prevent some serious medical disorders.” Scientists have known that misshapen nuclei are an indicator of disease, Wirtz said, but they were not certain how a cell controlled the shape of its nucleus—the structure in mammal cells where genetic material resides. However, in a study pub-lished in the Nov. 10 issue of the Proceed-ings of the National Academy of Sciences, the research team led by Wirtz reported the discovery of a fibrous structure that holds the nucleus in its place. The researchers call this new network structure the peri-nuclear actin cap. “In healthy cells, the perinuclear actin cap is a domed structure of bundled fila-ments that sits above the nucleus, sort of like a net that is tethered all around to the perimeter of the cell membrane,” Wirtz said. This configuration pushes the nucleus down

toward the base of the cell and also creates the distinctive flattened shape of normal cells. Cells with cancer, muscular dystrophy or progeria lack this distinctive cap, allowing the nucleus to float upward toward the top of the cell’s membrane. These diseased cells may appear more rounded and bulbous. “The cap controls the shape of the nucleus by controlling the shape of the cell itself,” Wirtz said. The perinuclear actin cap was discovered while the team was trying to find out if cell shape controls nucleus shape. By growing cells on a surface with alternating sticky and nonsticky stripes, the researchers noticed that as cells grew along a sticky stripe, their nuclei elongated as well. Using a confocal microscope—a special kind of microscope

A cell’s ‘cap’ of bundled fibers could yield clues to disease R E S E A R C H

that can view an object one “slice” at a time—doctoral student Shyam Khatau was able to reconstruct the cell in three dimen-sions. By stacking the confocal microscope images together, Khatau, who is affiliated with the Johns Hopkins Institute for Nano-BioTechnology, was able to produce short movies showing the 3-D structure of the cells, the nucleus and the perinuclear actin cap. (The movies are online at http://inbt .jhu.edu/outreach/media-library/video.) “That’s when we saw the cap,” Khatau said, “and Dr. Wirtz realized we were on to something.” The cap’s role in disease became evident when Khatau tested cells without the gene to produce lamin A/C, a protein found in the membrane of the nucleus of normal cells but absent in the nuclear membrane of cells

from people with muscular dystrophy. Cells without lamin A/C failed to produce the perinuclear actin cap. “We next plan to study how the cap’s effect on the shape of the nucleus affects what genes the cells express,” Wirtz said. Khatau, who is pursuing his doctor-ate in the Department of Chemical and Biomolecular Engineering, is lead author of the journal article. Additional Johns Hopkins authors on this paper are Wirtz; doctoral student Christopher M. Hale and senior Meet Patel, both from the Whiting School of Engineering’s Department of Chemical and Biomolecular Engineering; and Peter C. Searson, a professor in the school’s Department of Materials Science and Engineering. Other co-authors are P.J. Stewart-Hutchinson and Didier Hodzic, both of the School of Medicine at Wash-ington University in St. Louis; and Colin L. Stewart, of the Institute of Medical Biol-ogy, Singapore. This work was funded by the National Institutes of Health and the Muscular Dys-trophy Association.

Related Web sites‘pNaS’ journal article: www.pnas.org/content/106/45/ 19017.full.pdf+html

Johns hopkins engineeringin oncology Center: http://engineering.oncology.jhu .edu

Johns hopkins Institute for NanoBiotechnology: http://inbt.jhu.edu Department of Chemical and Biomolecular engineering: www.jhu.edu/chembe

Shyam Khatau and Denis Wirtz played a key role in finding a bundled ‘cap’ of thread-like fibers that holds a cell’s nucleus in its proper place.

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The Old Farmer’s Almanac is calling for slightly colder weather with below-normal snowfall this winter.

But whenever it does snow, you’ll be able to find out easily whether the university is open. Chances are, it will be. The university’s policy is to remain open on a normal schedule whenever possible, both because minimizing interruptions to teaching and research is a priority and because so many university employees and students are involved in patient care. For instant answers on snow closings and delays, go to the university’s Web page at http://webapps.jhu.edu/emergencynotices or call the weather emergency hotline at 410-516-7781 (800-548-9004 from outside Baltimore). Information about classes and the status of the university on snow days is usually posted to the hotline and Web by 6 a.m., with frequent updates throughout the day in the case of a major storm.

These places are better sources than your local television and radio stations. Although the university notifies Balti-more and Washington media, the stations generally do not post closings or delays as quickly as the university does, often do not have time to get through their notices from hundreds of institutions and do not include details. The university’s hotline and Web page will include information on such specif-ics as outpatient clinics, APL, Peabody Prep, evening classes, shuttle bus opera-tions, and library and recreation center closings. Required-attendance employees should check with their supervisors to deter-mine whether they should follow snow closing and delay information or report to work. The university’s policy on weather-re-lated curtailment of operations is online at htto://hrnt.jhu.edu/elr/pol-man/section .cfm?id=35.

Snow in the forecast?Are we open? Closed?

B y D a v i D M a r c h


Flu experts at The Johns Hopkins Hos-pital have received confirmation from the U.S. Centers for Disease Control

and Prevention and the Maryland Depart-ment of Health and Mental Hygiene that two recently treated patients with 2009 H1N1 flu, both since discharged, had drug-resistant forms of the virus. Laboratory tests performed at the CDC and DHMH showed that both cases had type A strains of the latest influenza virus resistant to the drug oseltamivir, better known as Tamiflu, the initially recom-mended and most widely used drug treat-ment available. These cases are believed to be the first two cases of drug-resistant H1N1 infection reported in Maryland. The World Health Organization has reported at least 57 cases worldwide of oseltamivir resistance in people infected with novel H1N1, with more than 20 in the United States, includ-ing a cluster of four recently reported cases in North Carolina. Trish Perl, senior hospital epidemiologist responsible for infection control at Johns Hopkins, said that the emergence of such mutations is “not surprising” as viruses mutate naturally as they infect more and more people, and even more so when an antiviral is in widespread use. But what she said is “a serious cause for concern” is that a widespread emergence of oseltamivir-resistant strains would severely curtail the number of drugs available to treat the disease, especially if the virus mutates into a more contagious or more virulent form.

Current treatment options, she pointed out, are taking higher doses of oseltamivir, switching to zanamivir (Relenza) or using oseltamivir in combination with rimanta-dine (Flumadine), another antiviral drug. Perl says that vaccination is the best defense against new and potentially more dangerous strains of H1N1. “If you are vac-cinated against H1N1, you are protected against catching the virus. Everyone should get vaccinated,” said Perl, a professor of medicine and pathology at the Johns Hop-kins School of Medicine. As a precaution, the families of both men treated at the hospital have been vac-cinated against H1N1 as well as seasonal flu. According to internist Redonda Miller, vice president for medical affairs and the hospital’s chief patient safety officer, neither of the infected patients, both of whom had weakened immune systems, was at serious risk of transmitting the drug-resistant strain to other people in the hospital as each had a private room and wore a mask when leaving his room. In addition, Miller said, all staff working with such patients were vaccinated against H1N1 and are required to wear masks. Infectious disease expert John Bartlett, a professor in the School of Medicine, said, “The lesson from these drug-resistant cases is that all physicians and health care work-ers in Maryland really need to be vigilant in their monitoring of H1N1 and in getting people who are prioritized as at high risk for infection vaccinated for both seasonal flu and H1N1.” Oseltamivir resistance is still very rare, he said, noting that it occurs in less than 1

First reported cases of Tamiflu-resistant H1N1 treated at JHHpercent of all cases of 2009 H1N1 infection and, in nearly all cases, in people who have previously taken the medication. “In order to minimize widespread resis-tance, physicians also need to focus their use of oseltamivir, as set out in CDC guidelines,

on those patients with H1N1 who are at highest risk of complications from the infec-tion and seriously ill enough to require hos-pitalization,” added Bartlett, who was direc-tor of Infectious Diseases at Johns Hopkins for more than 25 years.


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russell Margolis with Nadine yoritomo, a research nurse who performs most of the biopsies and clinical interviews for his schizophrenia studies.

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Homewood

About 1 percent of the population is affected by schizophrenia, a severe form of mental illness that has prov-

en difficult to study and treat, according to Russell Margolis, director of the Johns Hop-kins Schizophrenia Program. But a recent breakthrough in the ability to transform skin cells into stem cells and then into nerve cells has Margolis and his research partner, Hongjun Song, poised to make progress in exploring schizophrenia at the cellular level, with the help of a two-year $275,000 grant from the National Insti-tutes of Health, underwritten by the federal stimulus package. “The field has been stymied in developing new approaches to treatment,” Margolis said. “Fundamentally, treatments haven’t changed much in 50 years or so. New medicines have come along, but both old and new drugs often have nasty side effects. Both work by similar means and were discovered largely by accident. So the field is in great need of new approaches to finding therapeutic targets that might be treatable by medicines.” Margolis, a professor of psychiatry and neurology at the Johns Hopkins School of Medicine, and Song, an associate professor of neurology at both the Institute of Cellular Engineering and the School of Medicine, plan to use a remarkable new technology in which cells extracted from a pencil eraser–sized skin sample from a patient or a control subject can be converted into induced pluri-potent stem cells by using a few biochemical growth factors. The iPS cells can then be differentiated into neurons, Margolis said. “These cells hold great promise in helping to sort out the pathogenic processes at work in schizophrenia and have the potential to lead to new therapeutic advances,” Margolis said. “One of the goals of our field is to find new ways to approach therapy, and that’s where this work comes into the big picture.

It would be wonderful to study cells from people with schizophrenia to see if those cells are different than the cells of people without schizophrenia, and find ways to intervene and normalize the pathways that

are affected.” Living nerve cells from people with the disease have not been readily available for study, and ani-mal models remain problematic—two

significant limitations for researchers. With-out new research options, patients are left with existing treatments that don’t help everyone and often have severe side effects, Margolis said. “One of the central problems is that it has been difficult to develop good cell or animal models,” Margolis said. “Animals don’t have schizophrenia. We can’t ask if

Exploring schizophrenia at the molecular level A R R A R E S E A R C H

they have hallucinations or delusions, and other symptoms, like loss of motivation and cognitive problems, are difficult to interpret in animals.” Margolis and Song are studying a small, carefully selected group of people who have been extensively examined clinically and cognitively and who have undergone neu-roimaging assessments. The skin biopsy itself is a relatively simple process that is slightly more invasive than drawing blood. Song’s lab has the expertise in the necessary cell conversion, Margolis said. Through Margolis’ ARRA grant, he and Song will be able to hire one or two assis-tants, and he will continue to work with his longtime Johns Hopkins associates Nadine Yoritomo, a research nurse who performs most of the biopsies and clinical interviews, and psychiatrist Sarah Reading, who uses MRI technology to study brain structure and function of individuals with schizophrenia. Christopher Ross, a psychiatrist and direc-

tor of the Division of Neurobiology within the Department of Psychiatry, will also assist with the cell analysis, Margolis said. The stimulus grant made it possible for Margolis and Song to pursue this new line of research. “Without the funds, we do nothing or we do extremely limited, slow work,” Mar-golis said. “This approach to schizophrenia is done by only a handful of laboratories. It’s expensive and technically challenging to grow, develop and analyze iPS cells. We consider our investigation a pilot project, and we expect that the process will become more streamlined over time. So we are starting small, and once we prove that it works, we can seek other funding to expand the project.” Margolis and Song are also working together on a separate NIH grant with related goals, where Song is the lead researcher and Margolis is co-investigator. Margolis’ schizophrenia project is among the more than 300 stimulus-funded research grants totaling $157.4 million that Johns Hopkins has garnered since Congress passed the American Recovery and Revitalization Act of 2009 (informally known by the acro-nym ARRA), bestowing on the National Institutes of Health and the National Science Foundation $12.4 billion in extra money to underwrite research grants by September 2010. The stimulus package—which pro-vided $550 billion in new spending, includ-ing the above grants, and $275 billion in tax relief—is part of President Barack Obama’s plan to revitalize a stagnant economy by doling out dollars for transportation projects, infrastructure building, the development of new energy sources and job creation, and financing research that will benefit human-kind. As of November, Johns Hopkins scien-tists have submitted nearly 1,300 proposals for stimulus-funded investigations.

This is part of an occasional series on Johns Hop-kins research funded by the American Recovery and Revitalization Act of 2009. If you have a study you would like to be considered for inclu-sion, contact Lisa De Nike at [email protected].

Continued from page 1

Windows

Worcester Eisenbrandt’s Baltimore work-shop. The Hut’s stained glass windows—the room’s defining feature—display the marks (logos) used by European printers from the 15th and 16th centuries, the dawn of the industry. Memorial Hall’s picture windows feature stained glass panels with seals of the institutions at which Daniel Coit Gilman, the university’s first president and the build-ing’s namesake, worked during his lifetime (Johns Hopkins, Yale, the University of California, Berkeley and the Carnegie Insti-tution of Washington).

Worcester Eisenbrandt—which also han-dled the restoration of Baltimore’s Patterson Park Pagoda and Hippodrome Theatre—preserved as much of the original windows and frames as possible. Future Memorial Hall and Hut visitors will see “a very noticeable difference” in the windows’ appearance, according to the res-toration’s project manager, Todd Anderson. Sunlight will now shine clearly through the Hut’s windows thanks to new insulated exte-rior windows that feature clear laminated glass, which will also allow people to view the stained glass from the outside. Previ-ously, the exterior windows had a Plexi-glas layer that had weathered and yellowed to the extent that passersby couldn’t see through it. Gilman Hall is scheduled to reopen for the fall 2010 semester. G

a detail of one of the hut’s 19 stained glass windows, which were restored by Worcester eisenbrandt in its Baltimore workshop.

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Stroke

mixed together different mathematical mea-sures of risk, while the Johns Hopkins study pooled together only like measures. Another half-dozen recent and smaller studies from Harvard University yielded mixed results, some showing a link between migraines and ischemic stroke, while one did not show a tie-in. Nazarian said that while nearly 1,800 articles have been written about the rela-tionship between migraine and ischemic stroke, the Johns Hopkins review was more selective, combining only studies with simi-lar designs and similar groups of people, and was more comprehensive, including analysis of unpublished data. “Identifying people at highest risk is cru-cial to preventing disabling strokes,” said Nazarian, an assistant professor at the Johns Hopkins School of Medicine and its Heart and Vascular Institute. “Based on this data, physicians should consider addressing stroke risk factors in patients with a history or signs of light flashes and blurry vision associated with severe headaches.” Prevention and treatment options for migraine, he said, range from smoking cessa-tion to taking anti–blood pressure or blood-thinning medications, such as aspirin. In women with migraines, stopping use of oral contraceptives or hormone replacement therapy may be recommended. Such widespread use of hormone-control-ling drugs is what Nazarian said may explain why women with migraines have such high risk of ischemic stroke. Contraceptives and other estrogen therapies are known to con-tribute to long-term risk factors for cardio-

vascular diseases and stroke, such as high blood pressure and increased reactivity by clot-forming blood platelets. Nazarian said that the researchers’ next steps are to evaluate whether preventive therapies, especially aspirin, offset the risk of ischemic stroke in people with migraines. Funding support for the study, performed entirely at Johns Hopkins, was provided by the National Institutes of Health Clinical Research Scholars Program. Other researchers involved in this study were Susan Kahn, Miranda Jones, Monisha Jayakumar and Deepan Dalal, all of Johns Hopkins. The lead study investigator was June Spector, a former postdoctoral research fellow at Johns Hopkins, who is now in Seattle.

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B y a n D r e W B l u M B e r G

Carey Business School

Philanthropist and social change pio-neer Bill Shore is the featured speaker for the Johns Hopkins Carey Business

School’s annual H. Melvin Brown Lecture, to be held at 5 p.m. on Wednesday, Dec. 9, in Mason Hall on the Homewood campus. Shore is founder and executive director of Share Our Strength, the nation’s lead-ing organization working to end childhood hunger in America. His remarks are titled “Creating Community Wealth to Capitalize Social Change.” Shore founded Share Our Strength in 1984 in response to the Ethiopian fam-ine and subsequent renewed concern about hunger in the United States. He is also the chairman of Community Wealth Ventures, a for-profit subsidiary of Share Our Strength that provides strategic counsel to founda-tions and nonprofit organizations interested in creating community wealth. From 1988 to 1991, Shore served as chief of

staff for Sen. Robert Kerrey of Nebraska. Pre-viously, from 1978 through 1987, he served on the senatorial and presidential campaign staffs of Sen. Gary Hart of Colorado. Shore’s three books, Revolution of the Heart, The Cathedral Within and The Light of Conscience, describe his transition from the political world to one of innovative community ser-vice that encompasses social change, acts of conscience and resourceful leadership. In 2008, Shore received the Gleitsman Citizen Activist Award from the Center for Public Leadership at Harvard’s John F. Ken-nedy School of Government. The biennial award recognizes exceptional citizen-leaders and their work to correct social injustice. In 2005, U.S. News & World Report named Shore one of “America’s Best Leaders.” The H. Melvin Brown Lecture series was founded in 1977 by Henry “Mel” Brown, an alumnus and supporter of business educa-tion at Johns Hopkins, to give students the opportunity to learn from and interact with the great leaders and thinkers of the day. To register for the lecture, go to carey.jhu .edu/h_melvin_brown.

Share Our Strength founder to give Carey School lecture


Baltimore

Freshmen select one of 15 one-credit classes that focus on Baltimore. In addition to Mov-ers and Shakers, this year’s program includes Urban Schools; Before Harborplace: Down-town Baltimore Before and After Urban Renewal; City on Display: Exploring Balti-more Through Its Museums; Junk Food vs. Whole Foods: Access to Food in Baltimore; and The Wire, The Corner: The City? Classes meet all day and are divided into a morning classroom lecture session and an afternoon slate of related activities, which this year include field trips to museums, guest speakers, city tours, a concert night, dinners and more. For his Movers and Shakers course, Hol-lander is looking to take students to such destinations as the Babe Ruth Museum and Birthplace and Westminster Hall and Bury-ing Ground, the final resting place of Edgar Allan Poe. “I want to use the life stories of about 10 famous Baltimoreans to trace the develop-ment of the city and their impact on the country as a whole,” he says. “Billie Holiday, for example, had a huge cultural impact with her music, and Babe Ruth was a phenom-enon that clearly transcended sports.” For Intersession 2010, B’More has been greatly expanded, according to director Jes-sica Madrigal. In addition to courses in humanities and the social sciences, the program now includes courses in the fields of public health and medicine. Students in What Ails You? will receive an introduction to the core concepts of public health and be asked to write about a particular health problem that affects Baltimore. The 2010 program will also feature Divide and Explore trips to 15 Baltimore neighbor-hoods led by city natives—upperclassmen who are Baltimore Scholars, students from Baltimore City Public Schools who were admitted to Johns Hopkins on full-tuition scholarships. Madrigal says that the program has grown significantly in just three years. In the first year, 48 students registered for four courses. Enrollment last year exceeded 100 students

for nine courses. Based on the number of calls and e-mails from students she has received, Madrigal anticipates that 250 or more students will enroll in the 15 being offered this year. “I’ve actually been getting calls from juniors and seniors who wanted to enroll. They feel they have missed out,” Madrigal says. “I hate to turn them away, but this is really for freshmen and building class spirit. It’s about getting new students familiar with the real Baltimore, not just the popular tour-ist destinations.” William Smedick, a co-chair of B’More’s steering committee and director of leader-ship programs and assessment initiatives for the Office of the Dean of Student Life, says that the mission of the program has remained the same: introduce freshmen to their new home. “Some time ago, we conducted in-depth exit interviews with about 200 graduating seniors, and one thing that came up again and again was that they wished they had become more familiar with Baltimore dur-ing their time here,” Smedick says. “We asked ourselves, what we can do about that. We thought, let’s offer a short but intensive program while the students were still settling into Baltimore.” Many B’More classes include an afternoon of course-related community work. Students will also participate in the university’s Mar-tin Luther King Jr. Community Service Day on Jan. 18, which includes such activities as staffing the St. Francis Academy Commu-nity Center Job Fair, building a woodworking shop in the Remington neighborhood and hosting a youth sports camp with JHU ath-letes in the O’Connor Recreation Center.

“We thought these activities would enhance class spirit and get [the students] involved with the community in a meaning-ful way,” Smedick says. This year’s list of B’More guest speakers includes Catherine Rogers Arthur, director and curator of the university’s Homewood Museum, who will talk about the history of Baltimore and Johns Hopkins; Matt Cren-son, a professor emeritus of political science at Johns Hopkins, who will discuss the city’s political history; and Bishop Douglas Miles, a prominent community and civil rights leader and the pastor of Koinonia Baptist Church. Bill Tiefenwerth, director of the Center for Social Concern and a B’More steering committee co-chair, says that Miles has become a fixture of the annual program. “He is a very dynamic speaker and some-one who has clearly made an impact on

students the past two years,” Tiefenwerth says. “I had a group of students come up to me last year and say, ‘We listened to Bishop Miles and participated in the community service activity. We really want to commit to something long term, is there something we can do?’ Some students have been very moved by their B’More experience, and we’d like to see that happen a bit more.” Madrigal says that the entire program is now more integrated into the classroom experience. “Everything we are doing out in the com-munity reinforces what they are learning in the classroom,” she says. “And with the diversity of classes we are offering this year, there is something in there for everyone.” Enrollment for B’More runs from Dec. 7 to Jan. 11. For a full list of courses and activities, go to www.jhu.edu/intersession/bmore.

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This is a partial listing of jobscurrently available. A complete list

with descriptions can be found on the Web at jobs.jhu.edu.

Job OpportunitiesThe Johns Hopkins University does not discriminate on the basis of gender, marital status, pregnancy, race, color, ethnicity, national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status, or other legally protected characteristic in any student program or activity administered by the university or with regard to admission or employment.

S c h o o l s o f p u b l i c h e a l t h a n d N u r s i n g

h o m e w o o d 41651 Research Imaging Assistant41695 Sr. Laboratory Coordinator41053 Academic Program Coordinator41161 Sr. Technical Support Analyst41385 CTY Aide41406 Student Career Counselor41453 Academic Adviser41486 Academic Program Coordinator41503 Director, Multicultural Affairs41585 Financial Manager41782 Recreational Facilities Supervisor41802 Painter41816 Sr. Administrative Manager41817 Financial Manager41856 Electrical Shop Supervisor41859 HVAC Technician41920 Research Specialist41921 Fulfillment Operations Manager

Office of Human Resources: Suite W600, Wyman Bldg., 410-516-8048JoB# poSItIoN

40463 Research Service Analyst40697 Software Engineer41068 Network Security Engineer II41220 Program Manager, Center for Talented Youth41564 Sr. Systems Engineer41663 IT Project Manager41340 Campus Police Lieutenant, Investigative Services41343 IT Manager41467 Instrument Shop Supervisor41497 Programmer Analyst41521 Research Technologist

Office of Human Resources:2021 East Monument St., 410-955-3006JoB# poSItIoN

41848 Sr. Administrative Coordinator41562 IT Service Coordinator41151 Research Assistant41844 Outreach Worker41456 Research Specialist41473 Program Specialist41388 Program Officer40586 Project Director, Research 2 Prevention40189 Laboratory Assistant40889 Program Coordinator41398 Research Data Analyst41841 Research Assistant42043 Research Program Assistant42028 Sr. Academic Program Coordinator40927 E-Learning Coordinator, PEPFAR41380 Strategic Project Coordinator

41197 Sr. Program Officer II/Team Lead42011 Program Specialist40912 Clinic Assistant41561 Sr. Sponsored Project Analyst39308 Software Engineer 41265 Fogarty Program Coordinator39306 Programmer Analyst39296 Data Assistant41414 Research Technologist41785 Sr. Program Officer41724 Program Coordinator40770 Sharepoint Developer40758 Physician Assistant41692 Research Program Assistant 38840 Communications Specialist41877 Health Educator41945 Budget Specialist41204 Assistant Director, MHS Program38886 Research Assistant41387 Deputy Project Director, Advance Family Planning41463 Research and Evaluation Officer40769 Software Engineer39063 Research Assistant41451 Multimedia Systems Specialist

P O S T I N G S

S c h o o l o f M e d i c i n e

Office of Human Resources: 98 N. Broadway, 3rd floor, 410-955-2990JoB# poSItIoN

38035 Assistant Administrator35677 Sr. Financial Analyst30501 Nurse Midwife22150 Physician Assistant38064 Administrative Specialist37442 Sr. Administrative Coordinator37260 Sr. Administrative Coordinator38008 Sponsored Project Specialist36886 Program Administrator

37890 Sr. Research Program Coordinator37901 Casting Technician

Notices B U L L E T I N B O A R D

Winter accessories Drive — SOURCE, the JHSPH Anna Baetjer Society, SoM Interaction and the SoN Student Govern-ment Association are sponsoring a winter accessories drive, continuing through Dec. 11. Clean, gently used or new accessories—hats, gloves, scarves, mittens and earmuffs—will be distributed to local community-based organizations. Drop boxes are located in the SoN lobby; at SoM in the rooms of the Nathans, Sabin, Taussig and Thomas colleges; at SPH in E1002 and the Student Lounge; and at SOURCE, 2017 E. Monument St.

Intersession Courses — Registration has begun for the Intersession 2010 Personal

Enrichment courses, which are open to faculty and staff and their families as well as students. Register online or in the Student Life Office, 102 Levering Hall, through Dec. 18. For specific registration informa-tion and course descriptions, go to www.jhu .edu/intersession or call 410-516-8209.

peabody Spring Semester Classes — Peabody Preparatory Adult and Continuing Education is offering several classes for the spring semester, Jan. 25 through May 22. Courses, which vary in length from eight to 16 weeks, include Ballroom Dancing (levels 1 and 2), Computer Music: ProTools 101, Tai-Chi Chuan, World Music Survey and Beginner Cello and Cello Ensemble for Adults. For more information, e-mail prep@ peabody.jhu.edu or go to www.peabody.jhu .edu/3430.


Calendar D E C . 7 – 1 4

T Cell Responses and Protective Anti-malarial Immunity After Immunization With Radiation Attenuated Plasmodium Parasites,” a Molecular Microbiology and Immunology/Infectious Diseases seminar with John Harty, University of Iowa. W1020 SPH. eB

thurs., Dec. 10, noon. The Randolph Bromery Seminar—“Variability in North Atlantic Bottom Water Nutrients and Carbonate Ion During the Last 467,000 Years BP” with Harunur Rashid, Ohio State University. Sponsored by Earth and Planetary Sciences. Olin Auditorium. hW

thurs., Dec. 10, noon. “Phosphoinosit-ide 4-Kinases at the Crossroad of Cellular Trafficking and Signaling,” a Cell Biol-ogy seminar with Tamas Balla, NICHD/NIH. Suite 2-200, 1830 Bldg. eB

thurs., Dec. 10, 1 p.m. “Neuroimag-ing Approaches to Social Exchange and Its Applications to Psychopathology,” a Neuroscience research seminar with P. Read Montague, Baylor College. West Lecture Hall (ground floor), WBSB. eB

thurs., Dec. 10, 4 p.m. “Optimiza-tion of Retinal Signaling Near Absolute Visual Threshold,” a Biology seminar with Alapakkam Sampath, University of Southern California Keck School of Medicine. 100 Mudd. hW

Mon., Dec. 14, 12:15 p.m. “Identifying the Neural Substratus of a Developmen-tally Critical Behavior in Drosophila,” a Carnegie Institution Embryology seminar with Benjamin White, NIMH. 3520 San Martin Drive. hW

Mon., Dec. 14, 2 p.m. “A Longitu-dinal Study to Assess the Presence of Manganese in Blood and Exhaled Breath Condensate Following Acute Inhala-tion Exposure to Welding Fumes,” an Environmental Health Sciences thesis defense seminar with Julie Richman. W2015 SPH. eB

S p e C I a L e V e N t S

Mon., Dec. 7, 5 to 7 p.m. “Homewood by Candlelight,” the museum’s annual

open house, with rooms lit by candle-light, the sounds of early music, decora-tions of garlands and boxwood, and egg-nog and cookies served in the wine cellar. $6 general admission, free for Homewood Museum members. hW

Wed., Dec. 9, 5 to 7 p.m. JHU Press Holiday Book Signing and Madeira Tast-ing, an opportunity to meet JHU Press authors and purchase books for signing, as well as holiday gifts from the Home-wood Museum Shop. (See “In Brief,” p. 2.) Homewood Museum. hW

thurs., Dec. 10, 10 a.m. to 3 p.m. Student Assembly auction to support the JHSPH Student Conference Fund, featuring both a silent auction from 10 a.m. to 3 p.m., and a live auction from noon to 1:30 p.m. E2030 SPH (Feinstone Hall). eB

Sat., Dec. 12, noon to 4 p.m. “Sil-houettes for the Holidays,” with master cut-paper artist Anne Leslie. Sittings take approximately 15 minutes. $40 for two copies of each portrait silhouette; framing available at additional cost. Advance, pre-paid reservations are required; call 410-516-5589. Homewood Museum. hW

Sat., Dec. 12, 1 to 3 p.m. Holiday card-making workshop with Evergreen curator James Abbott, using colorful papers, ribbons, fabrics and printed illus-trations to create holiday and gift cards. $5 general admission (includes materials and museum admission), free for Ever-green members. Advance registration required; call 410-516-0341 or e-mail [email protected]. Evergreen Museum & Library.

Sat., Dec. 12, 3 p.m. Reading of Charles Dickens’ A Christmas Carol, by actors of the Baltimore Shakespeare Fes-tival. Free admission but reservations required; call 410-516-0341 or e-mail [email protected]. Evergreen Museum & Library.

W o r K S h o p S

fri., Dec. 11, 12:15 p.m. “Career Crash Course,” a Career Services workshop covering relevant career topics including resume/CV, job searching, interviewing and networking. W2015 SPH. eB

With H1N1 influenza vaccine now more plentiful, Lloyd B. Minor, provost and senior vice president

for academic affairs, announced last week that Johns Hopkins has taken another step along the priority tiers described in its vac-cination priority plan. Vaccine against H1N1 flu is now available to anyone in tier 2 of the plan, specifically anyone employed by Johns Hopkins as a health-care provider, even in a general-risk setting, and anyone age 24 and younger who is either a full-time employee of the univer-sity or a part-time employee for whom the university is the primary employer. Also, Minor said that H1N1 vaccine is still being administered to faculty and staff ages 25 to 64 who meet other criteria in the vaccination priority plan. This includes full-time and eligible part-time employees who are pregnant, who are caregivers for children younger than 6 months or who have asthma,

diabetes, an abnormal or suppressed immune system, chronic cardiovascular disease (not high blood pressure) or a neurologic disease (such as a seizure disorder or neuromuscular problems). Locations and times for receiving the vaccine are posted online at www .hopkinsmedicine.org/hse/occupational_health/flu_campaign.html. An announcement will be made when Johns Hopkins goes to tier 3, Minor said. At that point, vaccination will be open to all full-time and eligible part-time employees of any age, even those who meet none of the conditions listed above. The Johns Hopkins vaccination plan is posted online at http://tinyurl.com/ jhuvaxplan and a summary of the tiers at http://tinyurl.com/jhuvaxtiers. (Both docu-ments are accessible only from within the Johns Hopkins network.) Other flu infor-mation is available at http://flu.jhu.edu.

H1N1 flu vaccine now available to employees in tier 2 of plan


ClassifiedsapartMeNtS/houSeS for reNt

Butchers Hill, rm in lg TH, fully furn’d, hdwd flrs, separate BA, short- or long-term rental. $850/mo. 301-455-3303.

Butchers Hill, 3BR, 2BA TH, 2 blks to JHMI, 1,400 sq ft, bamboo flrs, stainless steel appls, fp, jetted shower, W/D. $1,450/mo. 617-272-6140.

Canton, 3BR, 2.5BA waterfront TH, 3 flrs, CAC, granite counters, stainless steel appls, marble BAs, garage. Sonny, 443-955-2040.

Catonsville, spacious, furn’d 2BR, 1.5BA TH, fin’d bsmt, great neighborhood/location (nr 695/Rt 40/Rolling Rd). $1,350/mo. Ally, 443-797-7877.

Charles Village, 3BR, 2.5BA house, jacuzzi tub, W/D, CAC/heat, fin’d bsmt, nr Home-wood campus. [email protected].

Charles Village, furn’d studio avail to sublet, January through March. $375/mo incl utils. 410-689-5777 or [email protected].

Charles Village, corner 2BR, 2BA condo w/balcony, clean, 1,200 sq ft, CAC, 24-hr front desk, steps to Hopkins shuttle, all utils incl’d. 410-466-1698.

Charles Village (2807 Calvert St), lg 3BR, 2BA apt w/sunrm, W/D, hdwd flrs, eat-in kitchen; other units available. 410-383-2876.

Cross Keys Village, 1BR w/hdwd flrs, CAC/heat, free prkng, 24-hr security, swimming pool. $900/mo + utils (water incl’d). 646-284-2279 or [email protected].

East Baltimore, rms in single-family house, cable, WiFi, crpt, walk-in closet, view. $550/mo incl utils. 240-547-0437 or miranda_ [email protected].

Ellicott City, 3BR, 3BA garage TH, W/D, fenced yd, nr routes 40/29/100 and I-70. $1,800/mo + utils + sec dep. 410-465-9595 or [email protected].

Fells Point (Aliceanna and Broadway), 2BR, 2BA apt w/top-of-the-line appliances, granite countertops, 2 blks to water, bike to Hopkins. $1,595/mo. 805-338-2277 or hLkan888@ hotmail.com.

Fells Point (Fleet and Wolfe), 3BR, 2.5BA restored RH, W/D, some furniture, 1 mi to medical campus. 443-629-2264 or aynur [email protected].

Gunpowder Falls Bike Trail, apts in registered historic carriage house, pref faculty/grad stu-dents. $1,100/mo (3BR, 2BA) or $1,000/mo (2BR, 1.5BA). 410-472-4241.

Hampden, 2BR, 1.5BA RH, renov’d, hdwd flrs, stainless steel appls, W/D, prkng, walk to Rotunda, Superfresh, JHU campus. $1,350/mo. 843-991-4014.

Hampden, 3BR, 2BA TH, dw, W/D, fenced yd, nr light rail. $1,100/mo + utils. 410-378-2393.

Hampden (41st St), 3BR apt w/new BA, new paint, living rm, dining rm, kitchen, pantry, dw, W/D, garage. $1,275/mo incl utils. 410-338-4455.

Jefferson Court, 2BR, 2.5BA TH, hdwd flrs, W/D, CAC, rear yd, steps to JHMI/SoM/SoN, quiet w/active community association. $1,000/mo + utils. [email protected].

Mt Vernon, 1BR apt nr Peabody Institute, avail Dec 15 to Jan 17, fully furn’d, nr JHU shuttle,

M A R K E T P L A C E

light rail, Superfresh, 10-min walk to down-town. $150/wk (negotiable). 425-890-1327.

Mt Vernon Square, luxurious, completely furn’d 1BR apt in historic brownstone, rent incls all utils. 410-685-7523.

Mt Washington, 2BR, 2BA house w/lg loft, W/D, dw, fp, hdwd flrs, balcony, elevator, garage, in serene area. $1,450/mo. 301-525-4505.

Patterson Park, 2BR, 1.5BA house, hdwd flrs, crpt upstairs, stainless steel appls, skylight, expos’d brick, 1.25 mi to JHMI. $1,100/mo. 443-286-4883.

Roland Park, bright 1BR apt w/hdwd flrs, shared laundry, porch and patio. $925/mo + utils. 410-591-8740.

Roland Park, 2BR + den condo, all new inside, gorgeous view, 4 mi to Homewood campus. 410-747-5037, [email protected] or http://sites.google.com/site/devonhillrental.

1BR high-rise condo nr JHU/Homewood/Guil-ford, rent incl doorman/security, pool and prkng. [email protected].

Sublet/rent charming 1BR in beautiful 2BR apt nr Homewood campus, fully furn’d, 1BA, full kitchen, living rm, W/D, avail Jan 1, pref students, refs req’d. $525/mo + utils. 617-512-6665.

Great office space, 800 sq ft, 2 offices, lg central space, storage, bath, kitchenette; extra storage, security, prkng and wireless avail for fee; nr Hunt Valley, Glyndon, Owings Mills, Cock-eysville and 795. $700/mo. 443-471-6121.

houSeS for SaLe

Bayview (Bonsal St), 2BR, 1.5BA house, hdwd flrs, new kitchen, great location opposite shut-tle, off-street prkng. $155,000. 410-982-3476 or [email protected].

Charles Village/Guilford, sunny 1BR condo w/den, 24-hr front desk, 1/2 blk to JHU shuttle, MLS#BA7177675. $139,900. 443-534-8664.

Guilford/Charles Village (3601 Greenway #207), very spacious, sunny 1BR condo w/sep dining rm and office, 24-hr front desk, CAC/heat, easy walk to campus/shuttle. $104,000. [email protected].

Hampden (3544 Buena Vista), 2BR, 1.5BA renov’d RH, updated kitchen, hdwd flrs, CAC, deck, deep backyd, blks to the Avenue and Roosevelt Park. $199,900. 410-456-5658.

Loch Raven Village, 3BR, 2BA house, updates incl new kitchen, BA, rec rm, flrs, roof, patio, paint. $249,000/best offer. 443-307-3814 or http://baltimore.craigslist.org/reo/1478040854 .html.

Mt Vernon, huge 3BR beaux arts apt, very elegant, light, quiet, opposite shuttle stop, overlooks square. $549,000. 410-234-2641.

3BR, 2.5BA RH, totally renov’d, w/screened porch, fenced yd, prkng, walk to Homewood/shops/grocer. $278,000. 919-607-5860 or 410-962-5417.

249 S Castle St, excellent, renov’d RH w/gour-met kitchen, walk to JHMI/Fells Point/Can-ton, open house Sundays, noon-2pm. $279,000 ($5,000 closing help). 301-730-0159.

Updated 3BR house in beautiful historic neigh-borhood, new W/D, AC, big yd, garage, easy commute to all Hopkins campuses. $274,900 (or rent $2,000/mo). 410-908-6531.

rooMMateS WaNteD

Prof’ls wanted for 1BR in 3BR, 2.5BA RH, 3

blks to JHH, pref nonsmoker. $500/mo incl utils, high-speed Internet. 703-944-8782.

Share 3BR, 2.5BA Bel Air house, hdwd flrs, W/D, CAC, fridge, microwave, stove, off-street prkng, great neighborhood, 30-min commute to Balto. $550/mo incl utils, cable, Internet. 410-458-1517 or [email protected].

Rm avail in lg, furn’d 5BR Oakenshawe TH, W/D, lg backyd, 5 mins to JHU. $475/mo + share of utils. [email protected].

F wanted for furn’d, spacious (700 sq ft) BR in 3BR Gardenville house, built-in shelves, modern kitchen w/convection oven, gran-ite counters, deck, landscaped yd, sign 1-yr contract, get 1 month free. $550/mo + utils. [email protected].

1BR avail in beautiful 2BR apt in Homewood, renov’d kitchen, bsmt storage, laundry, nr JHMI shuttle. $500/mo (approx) incl utils. 848-459-5043 or [email protected].

Share Bonnie Ridge apt w/JHU grad students, own BR/BA, furn’d common areas, CAC, W/D, w/w crpt. $458/mo + 1/3 utils. 443-854-2303.

F wanted to share 3BR, 2BA house w/F JHMI student and staff, short-term lease OK, 10-min drive to JHH. $500/mo incl wireless, utils, prkng. [email protected].

Quiet prof’l looking for same to share sunny, renov’d house, nr train/shops, 2nd flr apt has 2 lg rms, office, full BA; shared kitchen on 1st flr. $600/mo incl utils, off-street prkng, clean-ing service. Margaret, 617-335-7632.

Roommate wanted for 1BR, 1BA Charles Vil-lage apt, priv entrance, spacious living rm, full kitchen, dining area, patio. $975/mo + elec (negotiable). 443-858-9118.

Share 2BR, 2BA apt at 222 E Saratoga St w/F grad student and dog, W/D, prkng, garage, 4 blks to JHH shuttle. $750/mo + 1/2 utils. [email protected].

Roommate needed for huge 2BR, 3-level house, walk to Federal Hill/UMAB/shuttle to JHU, nice, fenced yd w/patio. $650/mo. 410-499-9179 (after 5pm).

CarS for SaLe

’99 Honda Civic CX, 2-dr hatchback, silver, 1 owner, 117K mi. $4,000. cnmuhoro@hotmail .com.

’00 Alero GLS coupe w/sunroof, rear spoiler, in good cond, 93.5K mi; contact for pics. $4,490. [email protected].

’97 Olds Cutlass Supreme, V6, new tint job, CD player, power seats/windows, new brakes and tires, excel cond, 100K mi. $2,250. Pat, 410-598-0308.

IteMS for SaLe

Red wok w/plug and rack, $5; toddler skate-board, $5; Cybex lat pulldown, commercial, 250lb weight stack, you haul, $500. 410-877-3270 or [email protected].

Ikea “Ektorp” sofabed, 3 yrs old, $400; table 51" x 29" w/4 chairs, $140; also kitchen stuff (plates, pots, etc), complete list on demand. [email protected].

Vintage chair, made in Sweden, 1960s. $260/best offer. Elizabeth, 443-631-0881 or http://bit.ly/5fg6lE (for images).

Danby dishwasher, apartment-sized, $100; baby items—swing, $20; chair, $5; play yd, $10. [email protected].

Classified listings are a free ser-vice for current, full-time Hop-kins faculty, staff and students only. Ads should adhere to these general guidelines:

• Oneadperpersonperweek.A new request must be submitted for each issue. • Adsarelimitedto20words, including phone, fax and e-mail.

• WecannotuseJohnsHopkins business phone numbers or e-mail addresses.• Submissionswillbecondensedat the editor’s discretion. • DeadlineisatnoonMonday, one week prior to the edition in which the ad is to be run.• Realestatelistingsmaybeoffered only by a Hopkins-affiliated seller not by Realtors or Agents.

(Boxed ads in this section are paid advertisements.)Classified ads may be faxed to 443-287-9920; e-mailed in the body of a message (no attach-ments) to [email protected]; or mailed to Gazette Classifieds, Suite 540, 901 S. Bond St., Bal-timore, MD 21231. To purchase a boxed display ad, contact the Gazelle Group at 410-343-3362.

pLaCING aDS

www.brooksmanagementcompany.com

Johns Hopkins / Hampden

WYMAN COURT APTS. (BEECH AVE.) Effic from $570, 1 BD Apt. from $675, 2 BD from $775

HICKORY HEIGHTS APTS. (HICKORY AVE.) 2 BD units from $750

Shown by Appointment 410-764-7776

Chicco high-chair, “sahara style,” folds and reclines, adjustable height, removable tray, safety harness, excel cond. $80/best offer. [email protected].

Dressing table w/shelves, printer, computer, chair, microwave, 3-step ladder, reciprocating saw, tripods, digital piano. 410-455-5858 or [email protected].

Conn alto saxophone, mint condition. $650/best offer. 410-488-1886.

Moving sale: queen size mattress, boxspring, frame and pillows, dining table w/4 chairs, fold-ing chairs (2), Russell Hobbs tea kettle, 4 flower vases, all in very good cond. 443-939-1254.

Christian Dior Norwegian blue fox fur coat, medium size, full-length, great holiday gift. $1,200. 443-824-2198.

Pair of exterior French doors, new, white, 8 ft x 3 ft, made of Auralast wood, 15 double E-glass panels, double locks. $750/both. 443-768-4751.

McClaren infant rocker w/canopy, navy blue, barely used. $20. 410-377-7354.

SerVICeS/IteMS offereD or WaNteD

Studio or 1BR apt wanted for January 2010, furn’d or unfurn’d, must be safe area, nr Carey-JHU DC campus, Dupont Circle, Foggy Bot-tom, Columbia Hts. 561-627-0550.

Child care needed for easy-tempered, imagi-native 5-yr-old, pick up from kindergarten, 3-6pm, must own car, have license, auto insur-ance, flawless driving rec, must demonstrate highest level of responsibility and integrity, experience req’d. [email protected].

Tutor avail: All subjects/levels; remedial, gifted and talented; also college counseling, speech and essay writing, editing, proofreading, data-base design, programming. 410-337-9877 or [email protected].

Horse boarding, 20 mins from JHU, beauti-ful trails from farm. $500/mo (stall board) or $250/mo (field board). 410-812-6716 or argye [email protected].

Affordable landscaper/certified horticulturist avail to maintain existing gardens, also plant-ing, designing, masonry; free consultations. 410-683-7373 or [email protected].

LCSW-C providing psychotherapy, JHU-affili-ated, experience w/treating depression, anxiety, sexual orientation and gender identity concerns, couples. 410-235-9200 (voicemail #6) or shane [email protected].

Guitar lessons w/experienced teacher, begin-ner through advanced, many styles taught; learn songs, technique, theory, improv skills, reading. Joe, 410-215-0693.

Rosie’s green cleaning service, affordable and reliable. 410-960-8578 or [email protected] (for free estimate).

Interior/exterior painting, home/deck power washing, leaf removal, bush trimming, Xmas lights installed, general maintenance, licensed, insured, free estimates, affordable. 410-335-1284 or [email protected].

I can help with your JHU retirement plan investments portfolio! Free, confidential con-sultations. 410-435-5939 or [email protected].

Power washing, no job too small, free estimate. Donnie, 443-683-7049.

Licensed landscaper available for leaf and snow removal, trash hauling, Taylor Landscaping LLC. 410-812-6090 or romilacapers@comcast .net.

QUEST DENTALKATHERINE GRANT COLLIER, DDS

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Calendar

C o L L o Q u I a

fri., Dec. 11, 1 p.m. “The Devel-opment of Modal Reasoning,” an Evolution, Cognition and Culture colloquium with Shaun Nichols, University of Arizona; and Justin Halberda, KSAS. Sponsored by Philosophy. 233 Ames. hW

fri., Dec. 11, 2 p.m. “Interna-tional Opportunities and Chal-lenges for U.S. Space Policy,” an Applied Physics Laboratory col-loquium with Scott Pace, George Washington University. Parsons Auditorium. apL

fri., Dec. 11, 4 p.m. “A (New and Improved) Framework for the Psychology of Norms,” an Evolu-tion, Cognition and Culture col-loquium with Stephen Stich, Rut-gers University. Sponsored by Phi-losophy. 102A Dell House. hW

D a N C e

tues., Dec. 8, 7 p.m. JHU Classical Ballet Company winter showcase. Shriver Hall Audito-rium. hW

D I S C u S S I o N S / t a L K S

Mon., Dec. 7, 3:30 p.m. “Tough Times, Tough Decisions: Strate-gies for Putting Public Health First,” a panel discussion with Stephanie Coursey Bailey, Cen-ters for Disease Control and Pre-vention; Frances Phillips, Mary-land Department of Health and Mental Hygiene; and Aaron Wernham, Pew Charitable Trusts and the Robert Wood Johnson Foundation. Live webcast avail-able at www.jhsph.edu/maphtc/training_events/events_calendar .html. Co-sponsored by the Pfizer Corp., the SPH Office of Public Health Practice and Training, the SPH Department of Health Pol-icy and Management, the Mid-Atlantic Public Health Training Center, the Mid-Atlantic Health Leadership Institute, the Mary-

land Public Health Association and the Maryland Association of County Health Officers. W1214 SPH (Sheldon Hall). eB

Mon., Dec. 7, 4 p.m. “Turkey in the 21st Century: Building Peace Through Diplomacy,” a SAIS Center for Transatlantic Relations discussion with Recep Tayyip Erdogan, prime minister of Tur-key, with introductory remarks by SAIS Dean Jessica Einhorn. (See “In Brief,” p. 2.) Kenney Audito-rium, Nitze Building. SaIS

Mon., Dec. 7, 5 p.m. “Assess-ing the Public Health Risks from Chemicals: Current Challenges and Future Opportunities,” an Environmental Health Sciences panel discussion with Brenda Berry, American Chemistry Coun-cil; Lynn Flowers, U.S. Environ-mental Protection Agency; and Jennifer Sass, Natural Resources Defense Council. W3008 SPH. eB

Mon., Dec. 14, 9:30 a.m. “Energy Information Agency’s (EIA) Updated Energy Forecast to 2035,” a SAIS Global Energy and Environment Initiative dis-cussion with Richard Newell, EIA administrator, U.S. Department of Energy. Kenney Auditorium, Nitze Building. SaIS

I N f o r M a t I o N S e S S I o N S

Wed., Dec. 9, 12:15 p.m. Infor-mation session for PATH (Pro-gram for Appropriate Technology in Health), with representatives of the international nonprofit organization. Sponsored by Career Services. W2030 SPH. eB

L e C t u r e S

tues., Dec. 8, 4 p.m. The 2009 Ferdinand G. Brickwedde Lec-ture in Physics—“The World as a Hologram” by Leonard Susskind, Stanford University. (See story, p. 2.) Sponsored by Physics and

Astronomy. Schafler Auditorium, Bloomberg Center. hW

Wed., Dec. 9, 4 p.m. Dean’s Lecture—“The Keratin Multi-gene Family: Roles in Acute and Chronic Disease” by Pierre Cou-lombe, SPH. Sponsored by the SPH Dean’s Office. W1214 SPH (Sheldon Hall). eB

M u S I C

tues., Dec. 8, 8 p.m. A cappella group Adoremus presents its fall concert. Mudd Hall Auditorium. hW

tues., Dec. 8, 8 p.m. The Pea-body Concert Orchestra, the Peabody-Hopkins Chorus and the Peabody Singers perform works by J.S. Bach and Tchaikovsky. $15 general admission, $10 for senior citizens and $5 for students with ID. Friedberg Hall. peabody

Wed., Dec. 9, 7:30 p.m. Pea-body Wind Ensemble performs music by de Meij (featuring excerpts from his Symphony No. 1, The Lord of the Rings), Theo-fanidis, Meechan, Camphouse and Graham. $15 general admission, $10 for senior citizens and $5 for students with ID. Friedberg Hall. peabody

thurs., Dec. 10, and fri., Dec. 11, 7:30 p.m. The Peabody Renaissance Ensemble performs Cristo e Nato: An Italian Christmas. $15 general admission, $10 for senior citizens and $5 for students with ID. Griswold Hall. pea-body

fri., Dec. 11, 7:30 p.m. Peabody Jazz Orchestra performs a program dedicated to the styles and reper-toire of Count Basie. $15 general admission, $10 for senior citizens and $5 for students with ID. East Hall. peabody

Sat., Dec. 12, 3 p.m. Prepara-tory Young Artists Orchestra and the Peabody String Ensemble per-form. Griswold Hall. peabody

Sat., Dec. 12, 7 p.m. The Pea-body Youth Orchestra performs works by Rimsky-Korsakov, Mass-enet, Lortz and Mendelssohn. Friedberg Hall. peabody

o p e N h o u S e S

tues., Dec. 8, 4:30 to 6:30 p.m. Open house for the Johns Hopkins Engineering for Professionals mas-ter’s degree programs. Kossiakoff Center. apL

r e a D I N G S / B o o K t a L K S

tues., Dec. 8, 4 p.m. Alfred Sommer, dean emeritus of SPH, discusses the subject of his new book, Getting What We Deserve: Health and Medical Care in America. (See photo, this page.) E2014 SPH (Sommer Hall). Reception to fol-low in E2030 SPH (Feinstone), where the book will be available for purchase and signing. eB

Wed., Dec. 9, 7 p.m. Local author and BSO musician Michael Lisicky will discuss and sign copies of his new book, Hutzler’s—Where Baltimore Shops. (See “In Brief,” p. 2.) Barnes & Noble Johns Hop-kins. hW

thurs., Dec. 10, 7 p.m. Author Nawar Shora will discuss and sign copies of The Arab-American Handbook. Barnes & Noble Johns Hopkins. hW

S e M I N a r S

Mon., Dec. 7, 9 a.m. “Consumer Involvement in Care and Its Rela-tionship to Utilization and Cost in Medicare,” a Health Policy and Management thesis defense semi-nar with Joanna Famadas. 688 Hampton House. eB

Mon., Dec. 7, noon. “Screening for Genes: Image-Based Live Cell Screening Reveals New Insights Into Membrane Biogenesis,” a Biochemistry and Molecular Biol-ogy seminar with David Andrews, McMaster University. W1020 SPH. eB

Mon., Dec. 7, 1:30 p.m. “Micro-fluidic Single-Molecule Detection and Quantum Dot Technologies for Genomic Analysis of Diseases,” a Biomedical Engineering seminar with Jeff Wang, WSE. 110 Clark. hW

Mon., Dec. 7, 3 p.m. “The Weak Null Condition, Global Existence and the Asymptotic Behavior of Solutions to Einstein’s Equations,” an Analysis/PDE seminar with Hans Lindblad, University of Cali-fornia, San Diego. Sponsored by Mathematics. 304 Krieger. hW

Mon., Dec. 7, 3:30 p.m. “Recov-ery From Hip Fracture: The Balti-more Hip Studies Experience,” a Center on Aging and Health semi-nar with Jay Magaziner, University of Maryland School of Medicine. Suite 2-700, 2024 E. Monument St. eB

Mon., Dec. 7, 4 p.m. “Eternal Solutions to Lagrangian Brakke Flow,” an Analysis seminar with Yng-Ing Lee, National Taiwan University. Sponsored by Math-ematics. 304 Krieger. hW

Mon., Dec. 7, 4 p.m. “Dynam-ics of Peptide-Membrane Interac-tions,” a Biophysics seminar with Feng Gai, University of Pennsyl-vania. 111 Mergenthaler. hW

D E C . 7 – 1 4 .

Continued on page 10

(Events are free and open to the public except where indicated.)

apL Applied Physics LaboratoryBrB Broadway Research BuildingCrB Cancer Research BuildingCSeB Computational Science and Engineering BuildingeB East BaltimorehW HomewoodKSaS Krieger School of Arts and SciencespCtB Preclinical Teaching BuildingSaIS School of Advanced International StudiesSoM School of MedicineSoN School of NursingSph School of Public HealthWBSB Wood Basic Science BuildingWSe Whiting School of Engineering

CalendarKey

Mon., Dec. 7, 4:30 p.m. “Twist-ed Spin Bordism and Twisted K-Theory,” a Topology seminar with Mehdi Khorami, Wesleyan University. Sponsored by Math-ematics. 308 Krieger. hW

tues., Dec. 8, noon. “A New Look at Notch Signaling in Embryonic Neural Stem Cells and Neurons,” a Biological Chemistry seminar with Nicholas Gaiano, SoM. 612 Physiology. eB

tues., Dec. 8, 12:10 p.m. “An Employer’s Approach to Resolv-ing Domestic Violence Impact-ing the Workplace,” a Graduate Seminar in Injury Research and Policy. Co-sponsored by Health Policy and Management and the Education and Research Cen-ter for Occupational Safety and Health. 250 Hampton House. eB

tues., Dec. 8, 12:30 p.m. “The Impact of Vitamin A Supplemen-tation in utero and in Infancy on the Psychomotor Development of School-Aged Children in Rural Nepal,” an International Health thesis defense seminar with Gil-lian Joan Buckley. W8504 SPH. eB

Wed., Dec. 9, noon. “Imple-menting Mental Health Insur-ance Parity,” a Mental Health seminar with Howard Goldman, University of Maryland. B14B Hampton House. eB

Wed., Dec. 9, noon. “Structure of the Vacuolar ATPase—Anat-omy of a Versatile Proton Pump,” a Physiology seminar with Ste-phen Wilkens, SUNY Upstate Medical Center. 203 Physiology. eB

Wed., Dec. 9, 2 p.m. “Criti-cal Components of Proximal and Distant Regulatory Elements in the Human Genome,” an Insti-tute of Genetic Medicine semi-nar with Ivan Ovcharenko, NIH. G007 Ross. eB

Wed., Dec. 9, 4 p.m. “Target-ed Maximum Likelihood-Based Causal Inference,” a Biostatistics seminar with Mark van der Laan, University of California, Berkeley and founder/CEO of Target Ana-lytics Inc. W2030 SPH. eB

Wed., Dec. 9, 5 p.m. “Manag-ing Prion Disease Risks: An Inter-national Perspective,” a Center for a Livable Future seminar with Daniel Krewski, University of Ottawa. Co-sponsored by Envi-ronmental Health Sciences and Epidemiology. W3008 SPH. eB

thurs., Dec. 10, noon. “CD8

‘Health and Medical Care in America’the Jhu press and Bloomberg School of public health this week co-host a talk by the school’s former dean, alfred Sommer, about his timely and provocative assessment of the state of public health in america as put forth in his new book, ‘Getting What We Deserve: health and Medical Care in america.’ humorous, sometimes acerbic and always well informed, Sommer’s thought-provoking book aims to change the way we look at health care. See readings/Book talks.

alfred Sommer

The Gazette -- December 7, 2009

Documents

Transcript of The Gazette -- December 7, 2009