The Gazette

111010

our 41ST year

Covering Homewood, East Baltimore, Peabody,

SAIS, APL and other campuses throughout the

Baltimore-Washington area and abroad, since 1971.

January 23, 2012 The newspaper of The Johns Hopkins university Volume 41 No. 19

Job Opportunities

Notices

Classifieds

SerIeS DeBuT

Les Violons du Roy brings its

early-music repertoire from

Canada to Shriver Hall, page 12

LeaDerS + LeGeNDS

Kathleen Taylor, CEO of the

Four Seasons, to give Carey

Business School lecture, page 7

I N B r I e f

Lacrosse tix; Biomarker Discovery Center

chosen for consortium; special-ed resources

C a L e N D a r

Woodwinds and live electronics; Black-

board 9.1; Nobelist Adam Riess at APL2 12

N U R S I N G

Continued on page 5

Interprofessional center to focus on innovative care in aging

B y G r e G r i e n z i

The Gazette

Enhancing the golden years

The aging of America is undeni-able. Nearly 10,000 people turn 65 every day, with the total number of senior citizens to soon pass the 40 million mark.

The number will climb only higher, as people reaching age 65 have an average life expectancy of an additional 18.6 years, according to the Administration on Aging,

and those ages 55 to 64 are projected to be the fastest-growing segment of the adult population during the next decade. The impact on the health care system will be profound. “We’re facing an unprecedented demographic shift,” said Sarah L. Szan-

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Bloomberg School of Public Health

A public health initiative launched in four historically violent neigh-borhoods in Baltimore City effec-

tively reduced gun violence in three of those neighborhoods, according to a new study by researchers at the Johns Hopkins Bloomberg School of Public Health. The study is slated for publication in a future

lence. Staff serve as positive role models and direct youth toward services and opportuni-ties to live productive, violence-free lives. In addition, staff work to mobilize neighbor-hoods to promote nonviolence. From July 2007 through December 2010, outreach staff mediated 276 disputes, rang-ing from one to four mediations per month in each of the four neighborhoods where the program was implemented. The vast

Safe Streets Baltimore is reducing gun violence P U B L I C H E A L T H

Creativity fuels ideas for cancer curesB y V A n e S S A W A S t A

Johns Hopkins Medicine

Historic Hurd Hall on Johns Hop-kins’ East Baltimore campus was filled to capacity on Jan. 13

with students, faculty and staff waiting to hear five scientists—all in the early part of their careers—describe their

novel ideas on how to cure metastatic cancer. The five were finalists, cho-sen from among 44 entrants, in a competition on creative thinking named for John Rangos Sr., chair-man of the Rangos

Family Foundation, who funded the awards. Each scientist had 10 minutes to present his or her idea and answer questions from a panel of faculty judges, who would select the winners based on the novelty and scientific merit of their ideas, as well as the feasibility of future clinical applications of their proposals. Donald Coffey, whose theory on kill-ing cancer by weakening its DNA scaf-folding continues to spur innovative research, opened the event, describing it as the “Olympics” of research competi-tions at Johns Hopkins. The finalists were awarded the John G. Rangos Medal of Honor in Creative Thinking, and the top three received cash prizes: $20,000 for top-place win-ner Andrew Sharabi, $5,000 for second-place winner Cheng Ran “Lisa” Huang and $1,000 for third-place winner Diane Heiser. This is the first year of the pro-gram, which has the goal of encouraging young people to look at the problem of metastatic cancer, propose new research strategies and be given a chance to pur-sue their proposals. “Every family knows someone who has suffered from cancer. Some forms of the disease, such as testicular cancer, are curable even after they have spread, but most are not,” Rangos said earlier. “This competition has solicited ideas from the

Continued on page 7

E A S T B A L T I M O R E

Winners

announced

in ‘olympics’

of research

competitions

edition of the Journal of Urban Health. The authors have received permission from the journal to release the findings in advance of publication. Safe Streets Baltimore was launched by the Baltimore City Health Department in 2007 as a replication of Chicago’s CeaseFire program. The evidence-based public health initiative targets high-risk youth ages 14 to 25 and employs and trains outreach profes-sionals to de-escalate and mediate disputes that might otherwise result in serious vio-

Laura N. Gitlin, a sociologist and social psychologist, directs the new Center for Innovative Care in aging at the School of Nursing. at the white board are the SoN’s Marie Nolan and Sarah Szanton, two of the center’s eight inaugural faculty.

Continued on page 3

2 THE GAZETTE • August 15, 20112 THE GAZETTE • January 23, 2012

I N B R I E F

Nobel laureate Adam Riess to give Provost’s Lecture at APL

Nobel laureate Adam Riess, a profes-sor of physics and astronomy at Johns Hopkins and a staff member

of the Space Telescope Science Institute, is the next speaker in the Provost’s Lecture Series, which takes place this week at APL. Riess will discuss “Dark Energy and the Cosmic Expansion History” and review a number of recent experiments, including improvements in the determination of the Hubble constant using a new infrared array on the Hubble Space Telescope and a three-year search for the most distant exploding stars, perhaps among the very first superno-vae in the universe. His talk begins at 2 p.m. on Friday, Jan. 27, in the Kossiakoff Center Auditorium. A Q&A session and reception will follow. Those planning to attend should RSVP to [email protected].

Men’s lacrosse tickets for faculty, staff available Feb. 1

Tickets for the Blue Jays 2012 men’s lacrosse season will be available beginning Wednesday, Feb. 1. To

receive two complimentary season tickets, faculty and staff members should bring a valid university ID to the main office in Homewood’s Athletic Center between 8:30 a.m. and 5 p.m., Monday through Friday, and until 7 p.m. on Feb. 7, 9, 13 and 15. All faculty/staff members are responsible for picking up their own tickets, meaning only one set of tickets will be given out per person. All full-time students are admitted free and must present a valid university ID to pick up their ticket prior to each game. Tick-ets will be available beginning the Monday before each home game in the Athletic Center main office, or on game day in the Athletic Center lobby starting an hour and a half before face-off. Gates to Homewood Field will open 90 minutes before face-off. For a game schedule, go to www .hopkinssports.com.

New Maryland Learning Links offers special-ed resources

Maryland families and educators seeking early intervention services and special education informa-

tion now have a user-friendly resource at their fingertips with a new website cre-ated through a partnership of the Maryland State Department of Education’s Division of Special Education/Early Intervention Ser-vices and the Johns Hopkins University School of Education’s Center for Technol-ogy in Education. MarylandLearningLinks .org provides information about the Indi-

Applied Physics Laboratory Michael Buckley, Paulette CampbellBloomberg School of Public Health Tim Parsons, Natalie Wood-WrightCarey Business School Andrew Blumberg, Patrick ErcolanoHomewoodLisa De Nike, Amy Lunday, Dennis O’Shea,Tracey A. Reeves, Phil SneidermanJohns Hopkins MedicineChristen Brownlee, Stephanie Desmon, Neil A. Grauer, Audrey Huang, John Lazarou, David March, Vanessa McMains, Ekaterina Pesheva, Vanessa Wasta,Maryalice YakutchikPeabody Institute Richard SeldenSAIS Felisa Neuringer KlubesSchool of Education James Campbell, Theresa NortonSchool of Nursing Kelly Brooks-StaubUniversity Libraries and Museums Brian Shields, Heather Egan Stalfort

e d i t o r Lois Perschetz

W r i t e r Greg Rienzi

Pr o d u c t i o n Lynna Bright

co P y ed i t o r Ann Stiller

Ph o t o G r A P h y Homewood Photography

Ad V e rt i S i n G The Gazelle Group

Bu S i n e S S Dianne MacLeod

ci r c u l At i o n Lynette Floyd

We B m A S t e r Lauren Custer

c o n t r i B u t i n G W r i t e r S

The Gazette is published weekly Sept-ember through May and biweekly June through August for the Johns Hopkins University community by the Office of Communications and Public Affairs, Suite 540, 901 S. Bond St., Baltimore, MD 21231, in cooperation with all university divisions. Subscriptions are $26 per year. Deadline for calendar items, notices and classifieds (free to JHU faculty, staff and students) is noon Monday, one week prior to publica-tion date.

Phone: 443-287-9900Fax: 443-287-9920General e-mail: [email protected] e-mail: [email protected] the Web: gazette.jhu.edu

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vidualized Family Services Plan and Indi-vidualized Education Program processes, family involvement and other topics and trends related to special education. The site features a number of interactive tools, blogs and newsletters aimed at administrators, teachers, service providers and parents. Developed through Maryland’s State Improvement Grant, the website offers help-ful information for families and educators working with children with disabilities, from birth through age 21, and provides the ben-efit of an online community. Parents and educators can join, participate and share in an ongoing conversation, all designed to strengthen student learning. “We’re proud that our partnership with MSDE’s Division of Special Education and Early Intervention has produced a premier destination for educational resources,” said Jackie Nunn, director of the Center for Technology in Education. “From its content to design, Maryland Learning Links serves as the bridge between research and practice, linking general and special educators, par-ents and professionals. We look forward to teachers from across the state sharing their resources and advice and for parents to con-nect with professionals to better understand and inform the process and practice of edu-cating their children.” Bernard Sadusky, interim state superin-tendent of schools, said, “We know that students thrive when their support system is equipped with the best information. MarylandLearningLinks.org provides users with critical ideas and resources, all free of charge and available just a click away.”

Biomarker Discovery Center to participate in new consortium

The National Cancer Institute has chosen Johns Hopkins’ Biomarker Discovery Center as one of the

research entities to participate in a new mul-timillion dollar Clinical Proteomic Tumor Analysis Consortium that will undertake a coordinated effort to develop a catalog of proteins created by cancer cells. This infor-mation, which will be made available to other researchers, could be used to develop new ways to detect cancer and treat it. Daniel Chan, professor of pathology, oncology, radiology and urology in the School of Medicine and director of the Biomarker Discovery Center, says that Johns Hopkins’ 10-member research team will focus on ovarian cancer, and that he expects to receive $2 million annually from the NCI for the next five years. In addition to Johns Hopkins, the research consortium includes the Broad Institute and Fred Hutchinson Cancer Research Cen-ter, Pacific Northwest National Laboratory, Vanderbilt University, Washington Univer-sity, the University of North Carolina and Boise State University.

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January 23, 2012 • THE GAZETTE 3

Continued from page 1

Golden years

ton, an assistant professor at the School of Nursing and an expert on geriatric nursing. “We’re on a collision course with this demo-graphic trend.” To better address the needs for the grow-ing senior population, the School of Nursing recently founded the Center for Innova-tive Care in Aging. The interprofessional initiative will seek to develop and advance behavioral interventions that support the well-being of older adults and their families. Specifically, the center seeks to shorten the time from intervention to implementa-tion of clinical trial evidence, and enhance the yield of programs, policies, practices and tools to help older adults and family mem-bers remain healthy, independent and living in their own homes and communities. Center director Laura N. Gitlin, a profes-sor in the Department of Health Systems and Outcomes at the School of Nursing with a joint appointment in Psychiatry at the School of Medicine, said that the center’s focus will be on generating novel interven-tions that enhance quality of life and enable older adults to age in place. “As the nation’s population is aging, peo-ple would rather live in their own homes than move to an assisted living or nursing facility,” Gitlin said. “The center will gen-erate interventions that equip older adults with the behavioral, self-management, phys-ical and environmental tools to live longer, healthier and more-productive lives in their advancing years.” Gitlin said that the center seeks a national and international impact by serving as a think tank to advance intervention and implementation science. The center’s faculty

will engage in research to develop and test innovative interventions; apply evidence-based programs in community and practice settings; provide research training, educa-tion and mentorship to emerging scholars and practitioners; create scholarly forums for meaningful exchanges; and develop useful templates and tools to advance the science of intervention research. The center’s inaugural faculty includes Gitlin, Szanton, Cheryl Dennison-Himmel-farb, Nancy Hodgson, Sharon Kozachik, Marie Nolan, Miyong Kim and Elizabeth “Ibby” Tanner. Areas of expertise currently represented among this group—which will expand to include faculty from other divi-sions—include advancing interventions in chronic disease management, health dispari-ties, depression, dementia care, caregiving, end of life, aging in place, fall prevention and care transitions. Gitlin, for example, is working on a non-pharmacological intervention to reduce agi-tation in people with dementia. The study seeks to identify and exploit the “preserved” capabilities of the person by simplifying activities and training family members to assist. “Our approach seeks to give meaning to people with dementia and re-engage them in their environment,” she said. “Dementia has reached epidemic proportions but has been severely underaddressed.” Szanton will continue her study of older low-income citizens living on their own in Baltimore City through a $325,000 grant from the Robert Wood Johnson Foundation. She will interact with 60 households in her CAPABLE study, a community outreach project that addresses both the environmen-tal and health needs of older adults. The study, which launched in August 2010, has already helped dozens of seniors age safely at home. Through a collaboration with Baltimore City, improvements have

been made to bathrooms, stairways, kitchens and other living spaces to ensure that seniors are able to perform basic tasks without risk of an injury. Szanton said that nursing can and should provide a holistic approach to dealing with issues related to aging. “We will look at the person in his or her environment, not just the diseases or condi-tions,” Szanton said. Tanner, an associate professor of geriatric medicine with joint appointments in the schools of Nursing and Medicine, is currently studying the impact of high-intensity volun-teering on older adults’ health and whether it prevents disability-related decline. She said that the center will be critical to enhancing and supporting interdisciplinary interven-tion research in aging at the School of Nursing, especially at this time when limited federal funding is available. “The center is also crucial in enabling our faculty to organize our efforts, under the direction of Dr. Gitlin, and provide exper-tise and leadership for others in the field of aging, both nationally and internally—and communicate what we are doing so that we can impact others,” she said. “As an orga-nized center, we are very, very strong and will make great contributions to the field of aging research.” The center’s first year will be a busy one, Gitlin says. In early March, the center will launch a monthly series called The Issue Is … , a forum for faculty and students to explore pressing issues related to behavioral inter-vention and implementation science. This spring, the center will start a lec-ture series, beginning with a visit by Mar-tin Prince, a world-renowned scientist in dementia care and president of Alzheimer’s International. From June 14 to 16, the center will host a Summer Research Institute on Behavioral

Intervention in Aging for nationwide inves-tigators in all disciplines. Additionally, the center will convene brainstorming sessions with core faculty to learn about scholarly needs and identify future directions for center activities. Other planned activities include the establishment of a network of practice and community sites to implement evidence-based programs generated by the center’s faculty. Gitlin, who has a background in sociology and social psychology, joined Johns Hop-kins in January 2010. Prior to her arrival in Baltimore, she was the founding director of the Jefferson Center for Applied Research in Aging and Health at Thomas Jefferson University in Philadelphia. She previously served as co-director of the Jefferson Health System’s Senior Health Institute. Gitlin said that the Center for Innovative Care in Aging will actively seek collabora-tions with other university divisions. She has already identified more than 20 faculty members from the schools of Public Health and Medicine who are in various stages of developing behavioral types of interventions related to aging. “We would like to invite faculty with a wide range of expertise and interests to work with us in the design and implementation of novel models of care and interventions for older adults,” she said. “It’s important that we have people from diverse backgrounds representing many areas of expertise as core faculty of the center to advance our mission.” The center plans to bring together experts in trial methodology, basic science, bioeth-ics, health policy, health disparities, com-munity-participatory research, biobehav-ioral measurement, implementation science, epidemiology, health economics, health sys-tems design and geriatrics from throughout Johns Hopkins and elsewhere. For more information on the center, go to nursing.jhu.edu/areas_of_excellence/aging/center.

G

Immunizations are a valuable tool for controlling infectious diseases among populations both in the United States

and globally. Although routine immunizations and sup-plemental activities such as immunization campaigns are designed to provide cover-age to entire populations, current measure-ments used to determine the success and rates of immunization can be flawed and inconsistent. According to a new study led by researchers at the Johns Hopkins Bloom-berg School of Public Health, estimates of vaccination coverage can be significantly improved by combining administrative data with survey data. The results are featured in the October issue of PLoS Medicine. “Reliable estimates of vaccination cover-age are key to managing population immu-nization status,” said Justin Lessler, lead author of the study and an assistant professor

in the Bloomberg School’s Department of Epidemiology. “Currently, the performance of routine and supplemental immunization activities is measured by the administrative method, which leads to coverage estimates that are often inconsistent with the propor-tion reporting vaccination in cross-sectional surveys. Furthermore, administrative cov-erage does not tell you how many people are systematically missed by vaccination activities. We estimated that the size of the population never reached by any activity was high in Sierra Leone and Madagascar, 31 percent and 21 percent respectively, but it was much lower in Ghana, only 7 percent.” The widely used administrative method divides the number of doses distrib-uted by the size of the target population. Lessler, along with colleagues from Johns Hopkins, the University of Oxford, Epicen-tre and Princeton University, developed a

Researchers develop method to better estimate vaccine coveragemethod for estimating the effective coverage of vaccination programs using cross-sec-tional surveys of vaccine coverage combined with administrative data. The method was applied using demographic health survey and administrative coverage data reported to the World Health Organization from mea-sles vaccinations in Sierra Leone, Madagas-car and Ghana. They found that estimates of routine supplemental immunization activi-ties coverage are substantially lower than administrative estimates for Madagascar and Sierra Leone, and only slightly lower for Ghana. In addition, their estimates of rou-tine coverage are, in general, lower than WHO and United Nations Children’s Fund estimates. Derek Cummings, an assistant professor in the Bloomberg School’s Department of Epidemiology, said, “This method not only attempts to correct coverage estimates but

also distinguishes between issues of overall coverage and vaccine within activity inef-ficiencies. For our technique to be useful, countries must have cross-sectional data on vaccine coverage for children across a range of ages, some of an age where they have been exposed to multiple vaccination activities.” Added Lester, “Estimates of the ineffi-ciency of past vaccination activities and the proportion not covered by any activity allow us to more accurately predict the results of future activities and provide insight into the ways in which vaccination programs are fail-ing to meet their goals.” This research was supported by grants from the Vaccine Modeling Initiative of the Bill and Melinda Gates Foundation, the Department of Homeland Security, the National Institutes of Health, the Burroughs Welcome Fund and the Royal Society.

—Natalie Wood-Wright

New research by Johns Hopkins sci-entists suggests that vitamin D, long known to be important for bone

health and in recent years also for heart pro-tection, may stop conferring cardiovascular benefits and could actually cause harm as levels of the vitamin in the blood rise above the low end of what is considered normal. Study leader Muhammad Amer, an assis-tant professor in the Division of General Internal Medicine at the Johns Hopkins University School of Medicine, says his findings show that increasing levels of vita-min D in the blood are linked with lower levels of a popular marker for cardiovascu-lar inflammation: c-reactive protein, also known as CRP. Amer and his colleague Rehan Qayyum examined data from more than 15,000 adult participants in the continuous National Health and Nutrition Examination Survey, a nationally representative sample, from

2001 and 2006. They found an inverse relationship between vitamin D and CRP in adults without cardiovascular symptoms but with relatively low vitamin D levels. Healthier, lower levels of inflammation were found in people with normal or close to normal vitamin D levels. But beyond blood levels of 21 nanograms per milliliter of 25-Hydroxyvitamin D—considered the low end of the normal range for vitamin D—any additional increase in vitamin D was associ-ated with an increase in CRP, a factor linked to stiffening of the blood vessels and an increased risk of cardiovascular problems. “The inflammation that was curtailed by vitamin D does not appear to be curtailed at higher levels of vitamin D,” said Amer, whose newest finding appears in the Jan. 15 issue of the American Journal of Cardiol-ogy. “Clearly vitamin D is important for your heart health, especially if you have low blood levels of vitamin D. It reduces cardio-

When it comes to heart health, how much is too much vitamin D?vascular inflammation and atherosclerosis, and may reduce mortality. But it appears that at some point it can be too much of a good thing.” Amer says that consumers should exer-cise caution before taking supplements, and physicians should know the poten-tial risks. Each 100 international units of vitamin D ingested daily produces about a one nanogram per milliliter increase in 25-Hydroxyvitamin D levels in the blood. “People taking vitamin D supplements need to be sure the supplements are necessary,” Amer said. “Those pills could have unfore-seen consequences to health even if they are not technically toxic.” Amer and Qayyum, also an assistant pro-fessor in General Internal Medicine at Johns Hopkins, say the biological and molecular mechanisms that account for the loss of cardiovascular benefits are unclear. Vitamin D is found in very few foods, though com-

mercially sold milk is usually fortified with it. It is often called the “sunshine vitamin” because its primary source is the sun. As peo-ple spend more and more time indoors and slather their bodies with sunscreen, concern is rising that many are vitamin D–deficient, Amer notes. As a result, Amer says, many doctors prescribe vitamin D supplements, and many consumers, after reading news stories about the vitamin’s benefits, dose themselves. Older women often take large doses to fight and prevent osteoporosis.

—Stephanie Desmon

Related websiteMuhammad amer: www.hopkinsmedicine.org/gim/ faculty/Amer.html


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Thank you Johns Hopkins Medicine & Johns Hopkins University for your outstanding support of the 2011 United Way of Central Maryland campaign. Your pledges of more than $2.2 million will help thousands of people who are struggling to get out of crisis, stay out of crisis and

achieve self-sufficiency in our region.

United Way of Central Maryland would like to offer a special thank youto the following individuals:

Ronald J. Daniels (President, JHU), Jerry Schnydman (Chair, JHU Campaign), Ian Reynolds (Coordinator, JHU), Kathleen Crostic (Coordinator, JHU),

Dr. Edward D. Miller (Dean/CEO, JHM), Dr. Theodore DeWeese (Chair, JHM Campaign), Charles Reuland (Vice Chair, JHM Campaign), Christine White (Coordinator, JHM),

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Thank you to all campaign committee members, coordinators, ambassadors and donors.


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majority of these disputes involved situa-tions where the risk of gun violence was high, such as disputes between armed gang members. Outreach workers in each site were working closely with 35 to 60 high-risk youth at any given time. Safe Streets Baltimore also held monthly events to pro-mote nonviolent alternatives to resolving conflicts. These events typically attracted between 100 and 200 people. The Johns Hopkins researchers also iden-tified specific programmatic factors related to success in reducing violence. “The results suggest that the number of conflicts mediated by the outreach workers was associated with greater program impact on homicides,” said Daniel Webster, lead author of the study and deputy director of the Johns Hopkins Center for the Preven-tion of Youth Violence. Other key findings of the study include: • In all four neighborhoods—McElderry Park, Elwood Park, Madison-Eastend and Cherry Hill—the program was associated with a statistically significant decline in homicides, nonfatal shootings or both. • Overall, researchers estimated that the program prevented at least five homicide incidents and 35 nonfatal shooting inci-dents. Had there not been increases in homicides following program implementa-tion in Madison-Eastend and a neighbor-hood bordering Elwood Park that were likely unrelated to the program, Safe Streets is estimated to have prevented 15 homicides in four of the most violent neighborhoods in Baltimore. • In the South Baltimore neighborhood of Cherry Hill, the program was associated with a 56 percent decline in homicides and a 34 percent decline in nonfatal shootings. • In Elwood Park, the program was asso-ciated with a 34 percent drop in nonfatal shootings.


Safe Streets • Researchers estimated that Safe Streets Baltimore was responsible for a 26 percent reduction in homicides in McElderry Park over the nearly three and a half years the program was in place. This site did not expe-rience a homicide during the first 23 months of program implementation. “Safe Streets is an important component of our citywide strategy to reduce homicides and gun violence, and a key to our plans to grow the city,” Baltimore Mayor Stephanie Rawlings-Blake said. “By expanding this effective initiative, we help people build social capital and empower communities.” Oxiris Barbot, the city’s commissioner of health, said, “This study demonstrates clearly that a public health intervention can be a successful means for reducing youth vio-lence. Thanks to the recent award from the Office of Juvenile Justice and Delinquency Prevention, we are excited to expand this program to other communities and extend our message that gun violence is not accept-able.” The study was funded primarily through a

grant to Johns Hopkins from the Centers for Disease Control and Prevention’s designated Academic Centers of Excellence in the pre-vention of youth violence. Linda C. Degutis, director of CDC’s National Center for Injury Prevention and Control, said, “The CDC has long recog-nized that violence is an important public health problem that can be prevented through the application of evidence-based programs. This type of research evaluating the effectiveness of community-based strat-egies has tremendous potential for inform-ing the efforts of communities across the United States looking to prevent youth violence.” The annual cost of operating a Safe Streets Baltimore site is approximately $375,000. The program is currently located in two communities, McElderry Park and Cherry Hill, but funding for these sites ends in June. The Health Department says it will use these positive evaluation results to seek additional funding for sustaining these sites. G

B y d A V i d m A r c h


TV crime shows such as Bones and CSI are quick to explain each death by showing detailed scans and video

images of victims’ insides. Traditional autop-sies, if shown at all, are, at best, in supporting roles to the high-tech equipment, and usu-ally gloss over the sometimes physically gru-eling tasks of sawing through skin and bone. But according to two autopsy and body imaging experts at The Johns Hopkins Hospital, the notion that “virtopsy,” made popular by such TV dramas, could replace traditional autopsy is simply not ready for scientifically rigorous prime time. The lat-est virtual imaging technologies—including full-body CT scans, MRIs, ultrasound, X-ray and angiography—are helpful, they say, but cannot yet replace a direct physical inspec-tion of the body’s main organs. “The traditional autopsy, though less and less frequently performed, is still the gold standard for determining why and how peo-ple really died,” said pathologist Elizabeth Burton, deputy director of the autopsy ser-vice at Johns Hopkins. In an editorial appearing in the Annals of Internal Medicine online Jan. 17, Burton and Johns Hopkins clinical fellow Mahmud Mossa-Basha offer their own assessment of why the number of conventional autopsies has declined over the past decade and why, despite this drop, the virtopsy is unlikely to replace it anytime soon. Burton, who has performed well over a thousand autopsies, says that current imag-ing technologies can help tremendously when used in combination with autopsies. “It’s not a question of either traditional autopsy or virtopsy,” she says. “It’s a question

of what methods work best in determining cause of death.” The Johns Hopkins experts base their claims on evidence, some of which is pub-lished in the same edition of Annals, that some common diagnoses are routinely missed when imaging results are compared to autopsy findings. There is now no proof, they say, that virtopsy is a more reliable alternative to conventional autopsy. According to Burton, a visiting associate professor in the Johns Hopkins University School of Medicine, hospital autopsy rates in the United States—for patients who die of natural causes in hospitals and whose bod-ies do not have to be examined by the local medical examiner or coroner—have fallen from a high of about 50 percent in the 1960s to about 10 percent today. At The Johns Hopkins Hospital, she says, the rate remains close to a once-required standard for hospital accreditation of 25 percent, set as an appro-priate goal for teaching medical residents and fellows, and for auditing clinical practice. Burton says that many reasons are behind the drop in conventional autopsy rates. Medical overconfidence in diagnostic imag-ing results partly explains the decline but is also to blame for the high number of diag-nostic errors, she says. “If we chose the right test at the right time in the right people, and followed clinical guidelines to the letter, then modern diag-nostic tests would produce optimal results, but we don’t,” Burton says. Burton says that such misinterpretations of images, lab results and physical signs and symptoms help explain the roughly 23 per-cent of new diagnoses that are detected by autopsy. She acknowledges that it also is easier for physicians to rely on existing diagnostic techniques to determine the cause of death

Traditional autopsies—not high-tech ‘virtopsies’—still gold standardthan to go through the often-uncomfort-able task of asking grieving family members for permission to perform a conventional autopsy to confirm the cause of death. Mak-ing the process more difficult is that many physicians simply don’t know what steps to take, including the paperwork and approv-als, to get an autopsy performed. For many families, dissuading factors include the prospect of delaying funeral arrangements and possible disfigurement of a loved one’s body, as well as the stress in cop-ing with their loss and the cost of an autopsy, which can run upward of $3,000 unless the hospital offers to do it at no charge for teach-ing or auditing purposes. While diagnostic overconfidence, chang-ing cultural norms and cost may depress autopsy rates, Burton says that overreliance on technology underscores an inherent flaw in switching to virtopsy. In a German study that accompanies Burton and Mossa-Basha’s editorial, conven-tional autopsy and imaging results, as would be seen in virtopsy, were compared for accu-racy in 162 people who died in a hospital. Some had just virtopsy, while the others had both virtopsy and conventional autopsy. In the 47 who underwent both procedures, 102 new diagnoses were found; in comparison, 47 new diagnoses were found among the 115 who underwent virtopsy alone. Study results also showed that virtual autopsy by CT scan failed to pick up 20.8 percent of the new diagnoses, while conventional autopsy missed only 13.4 percent. Medical problems most commonly missed or not seen by autopsy included air pock-ets in collapsed lungs (which could have impeded breathing) and bone fractures; the most common diagnoses missed by imaging were heart attack, pulmonary emboli and cancer.

Burton says that the study findings are not surprising because, for example, a tumor nodule in the lung could appear on any scan or X-ray image as a small dense white spot or “coin lesion” that could easily be interpreted as a fungal infection, tuberculosis-related granuloma or benign tissue mass. But until the tissue is physically examined in a lab, after biopsy or during traditional autopsy, “there’s no way to know the diagnosis with 100 percent certainty,” she said. In addition to diagnostic weaknesses, Mossa-Basha says that perhaps the big-gest hurdle for proponents of the virtopsy alternative is the high cost of imaging. Modern ultrasounds and MRI scanners cost hundreds of thousands of dollars, with the most advanced CT scanners needed for the most detailed imaging priced well in excess of $1 million. Full-body CT scans, he says, run about $1,500 each, which, when added to device purchasing and maintenance fees, make vitropsy an expensive option. Mossa-Basha says that major advances in scanning devices make some forensic aspects of autopsy easier, when keeping the body closed protects physical evidence from being destroyed, such as tracking bullet trajecto-ries in gun victims. “Steady progress in imaging technology is refining conventional autopsy, making it better and more accurate,” said Mossa-Basha, a clinical fellow in Neuroradiology at Johns Hopkins. “Physicians really need to be selective and proactive—even before a critically injured patient in hospital dies—in deciding whether an autopsy is likely to be needed and, if so, whether to approach the family in advance. Only in this way do we ensure that we are using the latest scanning devices appropriately during autopsy and when it is most effective in producing the most accurate as possible death certificates.”


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Kathleen Taylor, president and chief executive officer of the Four Seasons Hotel and Resorts, is the featured speaker for the Johns Hopkins Carey Business

School’s Leaders + Legends lecture series on Wednesday, Jan. 25. The event will take place at 7:30 a.m. in the Legg Mason Tower in Harbor East. Taylor, who joined Four Seasons in 1989 as corporate counsel, was appointed to her current positions in 2010, and oversees all aspects of the company’s global operations. In her more than two decades with Four Seasons, she has proved a linchpin in its suc-cess, with the company now comprising 85 hotels and resorts in 35 countries, and more than 50 projects in either the planning or development stage. Prior to assuming the role of CEO, Taylor was chief operating officer. She also served for seven years as president of worldwide business operations, overseeing hotel and residential product design, construction and development activities; managing the com-pany’s acquisition and corporate planning;

Head of Four Seasons to give Leaders + Legends lecture

and overseeing corporate finance and legal affairs, human resources and administration. Previously, Taylor practiced corporate securities and competition law at Goodmans LLP, including a secondment to the Ontario Securities Commission. Recognition accorded Taylor during her career includes the Women’s Executive Network: Canada’s Top 100 Most Powerful Women Award, 2011; HOTELS maga-zine Corporate Hotelier of the World, 2011; International Society of Hospitality Consultants Pioneer Award, 2011; Hen-nick Centre for Business and Law Medal for Career Achievement, 2010; Forbes 25 Most Influential Women in Travel, 2008; Canadian General Counsel Award for Busi-ness Achievement, 2006; and Schulich Award for Outstanding Executive Leader-ship, 2001. Taylor holds two degrees from York Uni-versity in Toronto: a law degree from the Osgoode Hall Law School and an MBA from the Schulich School of Business. She is a director of the Royal Bank of Canada, serving as chair of its Human Resources Committee and a member of its Audit Committee. Her community affilia-tions include serving on the boards of The Hospital for Sick Children Foundation in Toronto and the United Way of Toronto, and as benefactor of the Harris-Taylor Read-ing Room at York University’s Osgoode Hall Law Library and of the University of Toronto Jack and Adrienne Taylor Scholar-ship for Undergraduate Students. The Leaders + Legends lecture series, which features today’s most influential busi-ness and public policy leaders addressing topics of global interest and importance, is designed to engage business and community professionals in an examination of the most compelling issues and challenges facing soci-ety today. Admission to the lecture, which includes breakfast, is $35. To register and for more information, go to carey.jhu.edu/ leadersandlegends.

Kathleen Taylor


Creativity

minds of bright young students with creative approaches to solving the dilemma of meta-static cancer, and I am extremely honored to be part of it.” The competition was open to all currently enrolled full-time students and trainees at The Johns Hopkins University, including undergraduate, graduate and medical stu-dents; residents; and fellows. Rangos, who has had a long association with Johns Hopkins Medicine, worked with faculty members in the Department of Urol-ogy, including Coffey and Horst Schirmer, to develop the program. Organizers plan to continue the competi-tion in future years and perhaps open it up to students at other institutions. “Why some metastatic cancers can be cured while most cannot is one of the most provoca-tive questions in medicine,” Coffey said, “and it will take novel, creative approaches to overcome this very difficult challenge.” First up to the podium was medical oncol-ogy fellow and eventual fifth-place winner Kevin Cheung, who proposes turning back the clock on cancer cells by reprogram-ming them into germ cells. He suggests that the reason testicular and other germ cell tumors have high cure rates is because of their undifferentiated state. Just as scientists have created immature pluripotent stem cells from adult cells, Cheung says that the same could be done with cancer cells. By age reversing resistant cancer cells, he proposes to make them sensitive to conventional chemotherapy. Third-place winner Diane Heiser, a doc-

toral candidate in Cellular and Molecular Medicine, proposes that more metastatic cancers can be cured by understanding how cancer cells repair their own DNA. She sug-gests that metastatic cancer cells are able to survive the severe DNA breaks that occur with DNA damaging agents like chemo-therapy, by repairing themselves quickly and efficiently, and says that determining the specific proteins that help metastatic cancer cells repair their DNA could reveal new targets for drugs that sensitize cancer cells to chemo or radiation therapy. Genetics postgraduate student and sec-ond-place winner Huang describes cancer as a “fight between two parasites: cancer vs. transposons.” She notes that nearly half of the human genome is made up of “jump-ing” DNA, short sequences of DNA that

get inserted into the genome at various points; too many transposons can lead to genomic instability and kill the cell. Huang says that germ cell tumors have the highest level of transposon activity, making them more prone to cell death and, thus, more easily killed by chemotherapy drugs. There is potential, she says, of using drugs to target proteins that normally suppress transposon activity in most cell types. Brian Ladle, a pediatric oncology fellow and fourth-place winner, posits that cancer cure rates depend on the cancer cells’ level of uniformity. Low-risk pediatric leukemias are mostly curable, he says, and most of the cells have uniform qualities and certain genetic abnormalities in common. Cancers that are more difficult to cure are less uni-form. Ladle suggests that targeting different

populations of cells within cancers could result in fewer relapses and more cures. The overall prize went to radiation oncol-ogy resident Sharabi for his idea titled “Spe-cific Immune Response Against Testicular Cancer: A Proposed Mechanism for Long-Term Remission.” Sharabi suggests that metastatic testicular cancer is largely curable in most patients because immune cells zero in on testicular cancer cells with far more accuracy than they do in other cancers. He proposes that testicu-lar cells are essentially recognized as foreign to the immune system because the testes are protected by the so-called blood-testis barrier, much like the blood-brain barrier. Testicular cancer cells can spread to the rest of the body and may initially go undetected by immune system cells. However, he says he believes that chemotherapy given to patients causes testicular cancer cells to die, releasing many targets for the immune cells. At that time, the immune system kicks into high gear, gen-erating large numbers of circulating immune cells, whose task is to seek the testicular can-cer cells and destroy them. He also believes that after chemotherapy, testicular cancer cells essentially may be recognized as foreign by the immune cells because the blood-testis barrier had, until then, kept testicular cells hidden from the immune system. He proposes further investigations of how the immune system responds to testicular can-cer cells to identify specific immune system targets common to testicular cancer as well as other types of cancer. The research could lead to the development of vaccines that prime the body to defend against and fight cancers. Just before Sharabi was announced the top winner, Rangos called Johns Hopkins a “beacon of light in the measurement of medicine.” It is here, he said, that we’ll find the next generation of scientific leaders.

John rangos Sr., third from left, and Greek ambassador Vassilis Kaskarelis, fourth from left, with finalists Brian Ladle, Kevin Cheung, andrew Sharabi, Cheng ran “Lisa” Huang and Diane Heiser.

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Black senior citizens who need surgery for the intestinal disorder diverticu-litis are significantly more likely to

die in the hospital than their equally ill white counterparts, even when each racial group carries the same health insurance, new Johns Hopkins research suggests. While all patients in the study required surgery, black patients were 26 percent more likely than white patients to undergo riskier and more expensive emergency diverticulitis surgery rather than “elective” scheduled surgery for their condition, the Johns Hopkins researchers found. The results emerged in a study of data from Medicare, the government health insur-ance for senior citizens. Black seniors also spent more time in the hospital recovering from their opera-tions, and the costs of their stays averaged nearly $30,000 more than those of com-parable white patients. Publishing in the November issue of the medical journal Archives of Surgery, the researchers say that while lack of insurance is often a major driver of racial disparities in health care, their analysis shows that even with equal access to a doctor, race-based differences in outcomes persist. “Even if everyone has coverage, black patients are doing worse, so we need to find out what else is going on,” said study leader Eric B. Schneider, an epidemi-ologist at the Johns Hopkins Center for Surgical Trials and Outcomes Research. “Maybe then we can make a difference.” Schneider and his team analyzed data from more than 50,000 Medicare patients who underwent surgery—removal of part of the colon with or without a colostomy procedure—between 2004 and 2007 in the United States. Adjusting for age, gender and other underlying illnesses, the researchers found that being black was associated with a 28 percent increase in in-hospital mortality, regardless of whether the patient underwent emer-

gency or pre-planned surgery. Diverticular disease is a common gas-trointestinal condition, affecting up to 25 percent of the elderly. In severe cases, it is treated with surgery. Previous research has found higher rates of mortality, complication and readmis-sion among black surgical patients when compared to white patients undergoing similar procedures. Schneider says that the conventional wisdom is that black patients’ poorer outcomes can largely be accounted for by differences in socioeco-nomic status, including health insurance coverage and greater underlying co-mor-bidity. The new research, he says, contra-dicts that hypothesis. Schneider says that past research has shown that even when they have insur-ance, black patients are less likely to go to the doctor than white patients, even for routine preventive services such as vaccination. Black patients also may have more undetected or undiagnosed illnesses than white patients, as research shows that black patients are less likely to undergo diagnostic evaluations than white patients. One study, Schneider says, suggested that underutilization of health care resources by blacks might be related to a higher level of distrust of the medical establishment. If black seniors were encouraged to see doctors more quickly when they are sick, an illness such as diverticulitis could be treated earlier, potentially obviating the need for surgery, or at least allowing for a less risky pre-planned operation. “It may be an access issue. It may be a cultural issue,” he said. “Whites are more likely to have a family practitioner, and that may be a factor.” Other Johns Hopkins researchers in -volved in the study are Adil Haider, Amy J. Sheer, Hali L. Hambridge, Jodi Segal, Albert Wu and Anne O. Lidor.

—Stephanie Desmon

Black elderly more likely than whites to die after intestinal surgery


aCaDeMIC CeNTerS aND affILaTeSLeah ramsay has joined the Johns Hop-kins Berman Institute of Bioethics as a sci-ence writer to manage communications and news media relations. She comes to Johns Hopkins from Washington, D.C., where she most recently handled media and pub-lic relations for the advocacy organization DC Vote. Previously she worked in docu-mentary production for National Geographic, the Smithsonian Channel and Discovery Networks, and as a writer online for DC Style and Metromix.com. A graduate of the Catholic University of America with a degree in media studies, Ramsay also worked with prominent independent filmmakers in Washington, helping to produce Yoo-Hoo, Mrs. Goldberg with Aviva Kempner and interning with Charles Guggenheim on his final film, Berga: Soldiers of Another War.

BayVIeW MeDICaL CeNTerJoseph Carrese , associate professor of medicine and chair of the Bayview Ethics Committee, has received the 2011 Presi-dential Citation Award from the American Society of Bioethics and Humanities. A member of the ASBH’s Clinical Ethics Con-sultation Affairs Committee, Carrese was honored for his dedication to the important work of the committee, whose other mem-bers also received the award. Colleen Christmas , assistant profes-

CheersCheers is a monthly listing of honors and awards received by faculty, staff and students plus recent appoint-ments and promotions. Contributions must be submitted in writing and be accompanied by a phone number.

sor of medicine and director of the Inter-nal Medical Residency Program; Ginette Hinds , assistant professor and director of the Department of Dermatology; and Timo-thy Wang , associate professor and medical director of Dermatology, were named Home-town Heroes by the Chesapeake Gateway Chamber of Commerce. They were hon-ored for their “extraordinary” Christmas Eve 2010 house call to an elderly man’s home to perform surgery on a skin cancer tumor after it was determined that it would be too risky to transport the frail patient to the medical center. Michael Smith , associate professor in Psychiatry and Behavioral Sciences and director of the Behavioral Sleep Program, and Janelle Coughlin , assistant professor of psychology and director of the Obesity Behavioral Medicine Program, have been named to head the new Johns Hopkins Center for Behavior and Health. CBH, based at Bayview, will focus on overcoming one of medicine’s biggest current challenges: changing patients’ dietary choices, sedentary lifestyles, sleeping habits and other behav-iors in order to prevent illness and better manage health. Smith will be director and Coughlin associate director of CBH, a col-laboration of the departments of Psychiatry and Behavioral Sciences, Internal Medicine, and Pediatrics.

BLooMBerG SCHooL of PuBLIC HeaLTHJeff Goldsmith , yang Ning and rus-sell “Taki” Shinohara , all Biostatistics doctoral students, have been recognized with Student Travel Awards for papers to be presented at the 2012 Annual Meeting of the International Biometrics Society/Eastern North American Region, to be held in April in Washington, D.C. The winning papers and their authors were “Corrected Confidence Bands for Functional Data Using Principal Components” (Goldsmith), “Bias Correction and Likelihood Based Inference under Model Misspecification” (Ning) and “Alternating Event Processes During Lifetimes: Population Dynamics and Statistical Inference” (Shinohara).

JoHNS HoPKINS HeaLTH SySTeMronald r. Peterson , president of The Johns Hopkins Hospital and the Johns Hop-kins Health System and executive vice president of Johns Hopkins Medicine, has been named to a new 12-member President’s Advisory Council for Notre Dame of Mary-land University in Baltimore. The executive leadership group will advise the university’s president, Mary Pat Seurkamp, on issues related to Notre Dame’s recent transition from a college to a university and also pro-

F O R T H E R E C O R D

vide counsel for the search and leadership transition for a new president to be named this year.

KrIeGer SCHooL of arTS aND SCIeNCeSandrew Cherlin , the Benjamin H. Gris-wold III Professor of Public Policy and Sociology in the Department of Sociology, has been named a fellow of the National Council on Family Relations, a status that recognizes him as one of the country’s most influential and productive family scholars. In making the announcement, NCFR said, “Dr. Cherlin is considered among the most prominent experts and pioneers in the field of family studies. His work is accessible to family professionals and lay audiences. Dr. Cherlin is a recognized authority on divorce, remarriage, stepfamilies, cohabitation, fam-ily trends, poverty and child well-being.” Cherlin received his bachelor’s degree in engineering and applied science from Yale University and his doctorate in sociology from the University of California, Los Ange-les. He has written many popular books and more than 80 scholarly articles.

SCHooL of MeDICINeadrian Dobs , professor of medicine and of oncology and vice director of the Depart-ment of Medicine for faculty development, has been appointed director of the Johns Hopkins Clinical Research Network. She succeeds Charles Balch, professor of sur-gery and oncology and dermatology, who retired. JHCRN is an integrated network of academic and community-based clinical researchers established within the Johns Hopkins Institute for Clinical and Transla-tional Research. Its purpose is to improve patient care by accelerating the adoption of diagnostic, treatment and disease-preven-tion advances. Todd Dorman , professor and vice chair for critical care in the Department of Anes-thesiology and Critical Care Medicine, has been promoted to senior associate dean for education coordination. He will remain associate dean of continuing medical educa-tion, and an assistant dean and director of CME will be hired to join the leadership team. francis Giardiello , professor of medi-cine, oncology and pathology and director of the Hereditary Colorectal Cancer Program, and anthony Kalloo , professor of medi-cine and chief of the Division of Gastroen-terology and Hepatology, have been named to the Becker’s ASC Review list of the 125 leading gastroenterologists in the United States. Those selected to appear on the list lead their field in clinical and research efforts. Becker’s ASC Review features general

business, legal and clinical guidance on a variety of medical topics. Bruce Leff , professor of medicine, has been elected chair of the American Col-lege of Physicians’ Council of Subspecialty Societies. Leff, a geriatrician, also became a member of the ACP’s board of regents. atul Nakhasi , a first-year medical stu-dent, has received an American Medical Association Foundation Leadership Award. Presented in association with Pfizer Inc., the award recognizes strong nonclinical leadership skills in advocacy, community service and/or education. Nakhasi serves on the AMA’s Committee on Legislation and Advocacy. robert Siliciano , professor of medi-cine and of molecular biology and genetics, has received a Research in Action Award from Treatment Action Group, one of the leading AIDS research advocacy organi-zations. Also a Howard Hughes Medical Institute investigator, Siliciano was honored for his discoveries about HIV, which have changed the way treatment for it is given.

WHITING SCHooL of eNGINeerINGJacob Khurgin , a professor in Electrical and Computer Engineering, has been elected a fellow of the American Physical Society. The fellowship program recognizes members who have made advances in physics through original research and publication, or have made significant innovative contributions in the application of physics to science and technology. According to the APS citation, Khurgin was elected a fellow for his “diverse contributions to understanding the underly-ing physics and improving the performance of numerous electronic and optical devices, such as semiconductor second-order nonlin-ear optical generators, intersubband semi-conductor lasers and Raman oscillators, slow light and plasmonic devices.” Christian Davies-Venn , an instructor in the Engineering for Professionals program, has been elected vice president of the Amer-ican Academy of Environmental Engineers. His term began Jan. 1. He is slated to serve as the academy’s president-elect in 2013 and as its president in 2014. Davies-Venn is vice president and chief engineer of PEER Consultants, based in Washington, D.C. At Johns Hopkins, he teaches courses in prin-ciples of water and wastewater treatment, and water and wastewater treatment plant design, in the Environmental Engineering, Science and Management master’s degree program. He received his bachelor’s degree in civil engineering from the University of Sierra Leone and his master’s and doctor-ate in environmental engineering from the University of Cincinnati and the University of Arkansas, respectively.

B y A m y l u n d A y

Homewood

The Federal Reserve Board has appointed Johns Hopkins Uni-versity faculty member Jon Faust

as special adviser in the Office of Board Members, effective Jan. 17. Faust is the Louis J. Maccini Professor of Economics in the Krieger School of Arts and Sciences and the director of the Cen-ter for Financial Economics at Johns Hop-kins. His appointment is a homecoming of sorts—he served at the Fed before joining the Johns Hopkins faculty in 2006. According to a news release from the Board of Governors of the Federal Reserve System, Faust will become a spe-cial adviser “contributing to the monetary policy process and in staffing the Federal Open Market Committee’s subcommittee on communications.” Faust also will work with Steven Kamin, director of the Divi-sion of International Finance, “in analyz-ing key international issues.”

“Jon has an exceptional breadth of exper-tise in international economics, monetary economics, finance and econometrics, along with nearly two decades of prior experience in the Federal Reserve System,” said Federal Reserve Chairman Ben S. Bernanke in the Fed’s news release. Katherine S. Newman, the James B. Knapp Dean of the Krieger School, said that Faust has been granted a two-year “public service” leave of absence, given only to fac-ulty who have been asked to contribute their expertise to institutions of government. She praised Faust, commenting, “This is a wonderful opportunity for Jon as well as for the Center for Financial Economics. The Federal Reserve calls upon the nation’s most prominent economists for public service, and we are honored that they chose a mem-ber of our faculty for this important role. Their selection illustrates the remarkable quality of our colleagues. When Jon returns to Johns Hopkins in two years, our students will benefit from his even greater breadth of experience.” Faust spent nearly 20 years in the Fed-

Economist Faust named special adviser to Federal Reserve Boarderal Reserve System, rising to the posi-tion of assistant director in the Division of International Finance, where he directed research on both international finance and trade. Faust has held visiting faculty posts at Prince ton University, Georgetown Univer-sity and the Center for Applied Economics and Policy Research at Indiana University. A graduate of the University of Iowa, he earned a master’s degree in economics from the University of Oxford and a doctorate in economics from the University of California, Berkeley. His research spans the broad array of theoretical and applied topics confronted by macroeconomic policymakers, such as econometric measurement of policy effects, political economy of policy and understand-ing macro-financial linkages. In Faust’s absence from Johns Hopkins, two co-directors have been appointed to the Center for Financial Economics: Robert Barbera and Jonathan Wright. Barbera is the chief economist at Mount Lucas Management in New York and a fel-low at the Center for Financial Economics, where he has taught his “economic forecast-

ing” class each spring for the past nine years. A Johns Hopkins alumnus, Barbera earned both his bachelor’s and doctoral degrees from the Department of Geog-raphy and Environmental Engineering in the Whiting School of Engineering, in 1974 and 1978, respectively. Wright is a professor in the Department of Eco-nomics who specializes in econometrics, empirical macroeconomics and finance. Prior to joining the Johns Hopkins faculty in 2008, he worked for nine years at the Federal Reserve Board in Washington. “Jonathan and Bob are an extraordi-nary team to lead the Center for Finan-cial Economics,” said Joseph Harrington, chair of the Department of Economics. “Since the CFE’s creation, they have been central contributors to its intel-lectual life and have been instrumental in bringing research and practice to our students. It is that blended scholar-prac-titioner approach that singularly defines the CFE in the academic landscape, and Jonathan and Bob are sure to be a dynamic duo for developing that vision.”

SAIS hosts release of EIA’s ‘Annual Energy Outlook 2012’

The Johns Hopkins School of Advanced International Studies will host the release of the Annual

Energy Outlook 2012, published by the U.S. Department of Energy’s Energy Information Administration, at 9:30 a.m. today, Jan. 23, in the Nitze Building’s Kenney Auditorium. Howard Gruenspecht, EIA’s acting admin-istrator, will present the agency’s projections of U.S. energy supply, demand and prices to 2035 with the early release of the Reference case projections from the Annual Energy Outlook 2012. A live webcast of the event can be found at www.sais-jhu.edu/pressroom/live.html.


Blunt , Marquise, PathologyBooker , Abigail, UrologyBryant , Mae Linda, GastroenterologyBurgert , Susan, Chemical Dependency

BayviewChahal , Raman, PsychiatryCunningham , Carla, Clinical Practice

AssociationDorer , Janet, Clinical Immunology

(Bayview)Gomez , Juan, Infectious DiseasesGrisbach , Cinda Lynne, SurgeryHarry rucker , Inez, Infectious DiseasesHoward , William, PsychiatryKennan , Anne, Fund for Johns Hopkins

MedicineKnudsen , Yvonne, General

Administration, Chairman’s OfficeLazarou , John, Marketing and

CommunicationsMarkowitz , Sandra, PathologyMcGowan , Felicia, Institute for Basic

Biomedical SciencesMeyerson , David, Cardiology

(Bayview)Nunez , Jeanne, PediatricsPerkins , Audrey, Infectious Diseasesrennert ariev , Jodi, Hospitalists

(Bayview)Skinner , Flavia, PathologyTurnbull , Melissa, Oncologyugarte , Marykate, Administration for

Johns Hopkins MedicineWeaver , Debbie, Psychiatry

5 years of serviceadams , Mary, Cardiologyandrews , Tina, Infectious DiseasesBeyer , Lisa, Human ResourcesBishop , Shannon, Infectious

DiseasesBrandon , Vernell, Clinical Practice

AssociationBurgess , Krystal, Rheumatology

(Bayview)Cassidy , Rachel, Johns Hopkins

TechnologyCohn , Silvia, Infectious DiseasesDaniels , Sheridia, PathologyGorman , Ingrid, SurgeryGrant , Letta, OphthalmologyHines , Angelina, Biological

ChemistryJacobson , Toni, OphthalmologyKodsi , Alejandra, RadiologyLaffoon , Marjorie, PathologyLee , Loza, Cell BiologyLinden , Sheila, OncologyLong , Felicia, OphthalmologyMantegna , Steven, Human ResourcesMariano , Brian, OncologyMarkus , Susan, OncologyMcCann , Laura, OphthalmologyMiles , Leslee, PediatricsMoore , Rickey, SurgeryPatel , Urvi, Anesthesiology and Critical

CarePillai , Jay, Radiologyredd , Marvin, Facilitiesrobinson , Andre, Jr., Infectious

DiseasesSmith , Deborah, Fund for Johns Hopkins

MedicineSzylow , Lucas, Clinical InvestigationsTate , Stuart, OrthopaedicsTubman , Antoinette, Institute of Genetic

MedicineWang , Fengying, PathologyWhite , David Saxton, OphthalmologyWilliams , Crystal, UrologyZhang , Daisy, UrologyZhao , Shan, Cell Biology

SCHooL of NurSING15 years of serviceWisowaty , Amy, Finance and

Administration Office

SHerIDaN LIBrarIeS/ JHu MuSeuMS15 years of servicearthur , Catherine, Homewood HouseMorgan , Daniel, Sheridan Libraries

uNIVerSITy aDMINISTraTIoNRetireesSunderland , Joyce, 46 years of service,

Office of Chief Networking OfficerValentine , Lamona, 35 years of

service, Controller

30 years of servicerandall , Alonza, Supply Chain Shared

ServicesStidham , Brenda, Office of Chief

Networking Officer

25 years of serviceDavis , William, Facilities

20 years of servicePetrovia , Tiffany, Controller

15 years of serviceBorsella , Claudia, ControllerChapman , Deborah, ControllerDemuth , Susan, Development and

Alumni Services

10 years of serviceaugust , Lisa, Johns Hopkins Real

Estatefarrell , Nicholas, Johns Hopkins Real

EstateGalvin , Robert, Johns Hopkins Real

EstateHilseberg , Charles, Johns Hopkins

Real EstateHofferbert , H. Craig, Enterprise

ApplicationsMakowy , William, Johns Hopkins Real

EstateMazzoni , Denise, Johns Hopkins Real

EstateMoreland , Lisa, Human ResourcesMoss , Angela, Office of Chief

Networking OfficerSparwasser , Edward, FacilitiesStrott , Matthew, Johns Hopkins Real

EstateSwartz , Alex, ControllerWarner , Terrence, Johns Hopkins Real

Estate

5 years of serviceCobb , Katrece, Office of Chief

Networking Officerfincher , Melissa, Development and

Alumni Servicesreynolds , Joseph, Office of the Chief

Enterprise TechnologySpence , Roberta, FacilitiesWahl , Noelle, Treasurer

WHITING SCHooL of eNGINeerINGRetireesfry , Ronald, 18 years of service, Center

for Imaging Science

10 years of serviceHabert , Elizabeth, Engineering

for ProfessionalsMcCutcheon , Cathy, Development

and Alumni Relations

5 years of servicearrington , Pamela, Center for

Leadership Education AdministrationBates , Monique, Center for Imaging

ScienceLyskov , Sergey, Chemical and

Biomolecular Engineering

MilestonesThe following staff members are retiring or celebrating an anniversary with the university in January 2012. The informa-tion is compiled by the office of Work, Life and engagement, 443-997-7000.

aCaDeMIC aND CuLTuraL CeNTerS5 years of serviceBrignole , Kathryn, JhpiegoCharurat , Elaine, JhpiegoCockrell , Randolph, Center for

Talented YouthCollins , Howard, Center for Talented

YouthLambert , Valerie, Center for Talented

YouthLinett , Sean, AV SupportMartin , Daniel, Johns Hopkins

University PressTanjung , Marwan, Jhpiego

BLooMBerG SCHooL of PuBLIC HeaLTH45 years of serviceBremer , Peggylee, Academic Program

Areas

25 years of serviceWhitney , Edson, Malaria Project

20 years of serviceanderson , Alfreda, Center for

Immunization Research and Vaccine Sciences

Boyd , Patricia, Center for Accelerated Vaccine Access

frazier , Deborah, Facilities

10 years of serviceJackson , Rhonda, Environmental

Health SciencesMallya , Bonny, Population, Family and

Reproductive Health Services

5 years of serviceButler , Ollie, FacilitiesColson , Vonda, EpidemiologyDukes , Antoinette, FacilitiesGlaser , John, FacilitiesGreen , Jerome, FacilitiesJacob , Martin, Information SystemsKillian , Elizabeth, Information SystemsMazursky , Sara, Center for

Communication ProgramsNorth , Tina, Center for American

Indian HealthScott , Joseph, FacilitiesWilliams , Bernita, Graduate Education

and Research

HoMeWooD STuDeNT affaIrS25 years of serviceSullivan , Michael, Business

Management

5 years of serviceVerrier , David, Preprofessional Advising

KrIeGer SCHooL of arTS aND SCIeNCeSRetireesSpivak , Wendy, 24 years of service,

Office of the Dean

20 years of serviceGaralde , Ofelia, Zanvyl Krieger Mind/

Brain Institute15 years of serviceVitarelli , Kathryn, Communications

5 years of serviceConnolly McCusker , Colleen,

Advanced Academic Programs

SaISRetireesflores , Miquel, 30 years of service,

Facilities

40 years of serviceProphet , Barbara, Business Office

10 years of serviceMaes , Katrien, JHU Foreign Policy

Institute

5 years of servicefung , Paulette, JHU Foreign Policy

Instituteroberts , Michael, Development and

Alumni Affairs

SCHooL of eDuCaTIoN15 years of serviceDanforth , Janis, Center for Social

Organization of Schools

10 years of serviceShaffer , Jennifer, Admissions

SCHooL of MeDICINeRetireesBreeden , Sophia, 35 years of service,

PsychiatryHarris , Susan, 17 years of service, Surgeryo’Neill , Claire, 10 years of service,

Chairman’s Officeo’Neill , Patricia, 32 years of service,

Cell BiologyStarklauf , Barbara, 41 years of service,

Clinical InvestigationsWankel , Loretta, 26 years of service,

Pediatrics

40 years of serviceWadsworth , Stanley, Health, Safety and

Environment

35 years of servicefrado , Sharon, Otolaryngology

30 years of serviceCain , Dennis, OphthalmologyCalini , Mary, EndocrinologyDashiell , Donna, OncologyKalinowski , Joseph, Facilities

25 years of serviceCusic , Ann, PediatricsHeffler , Michele, PediatricsJones , Priscilla, OphthalmologyMeans , Tammy, OncologyMitchell , Linda, Hematologyriley , Carol, Oncologyrogers , Ophelia, Medicine, Hematology

20 years of serviceallen , Bernice, OphthalmologyCavallio , Susan, SurgeryKarpovich , Theo, Graduate CurriculumSatterfield , Robert, Facilitiesushry , Patricia, Gastroenterology

15 years of servicearmour , Brenda, NeurologyBender , Kathryn, OncologyCantone , Theresa, PathologyGilbert , Patrick, Marketing and

CommunicationsJennings , Jo, OrthopaedicsLand , Cassia, PediatricsMangold , Leslie, UrologyNickoles , Jennifer, Infectious DiseasesPhillips , Edward, Jr., Art as Applied to

MedicinePowers , Pendleton, OncologySatterfield , Elnora, SurgeryShepard , Jennifer, Pediatrics

10 years of serviceabell , Robert, Cardiologyamoss , Regina, Rheumatology

(Bayview)


B U L L E T I N B O A R D

Notices

410-243-1216105 West 39th St. • Baltimore, MD 21210

Managed by The Broadview at Roland ParkBroadviewApartments.com

• Large airy rooms• Hardwood Floors• Private balcony or terrace• Beautiful garden setting• Private parking available• University Parkway at West 39th St.

2 & 3 bedroom apartments located in a private park setting. Adjacent to JohnsHopkins University Homewood Campus and minutes from downtown Baltimore.

Woodcliffe Manor ApartmentsSPA C I O U S G A R D E N A PA RT M E N T L I V I N G I N RO L A N D PA R K

H o m e w o o d

Office of Human ResourcesWyman Park Building, Suite W600410-516-7196Critical postings within our Homewood Division include the following; applications are being accepted for these immediate opportunities. For more detailed job descrip-tions and to apply, go to jobs.jhu.edu.

50722 University Disability Services Officer50948 Director, Instructional Resource Center50718 Senior Research Service Analyst50702 Research Programmer Analyst

Office of Human Resources98 N. Broadway, Suite 300410-955-2990The Department of Ophthalmology is seeking experienced technicians and assistants who are team players with outstanding customer service attitudes. For detailed job descriptions and to apply, go to jobs.jhu.edu.

48725 Ophthalmic Technician48755 Ophthalmic Technician49137 Ophthalmic Ultrasound Technician49138 Ophthalmic Ultrasound Specialist49687 Ophthalmic Technician Assistant50401 Ophthalmic Clinical Supervisor

S c h o o l o f M e d i c i n e

Hot JobsListed below are some of the university’s newest openings for in-demand jobs that we most urgently need to fill.

In addition to considering these opportunities, candidates are invited to search a complete listing of openings and apply for positions online at jobs.jhu.edu.

Johns Hopkins University is an equal opportunity employer and does not discriminate on the basis of gender, marital status, pregnancy, race, color, ethnicity, national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status, other legally protected characteristics or any other occupationally irrelevant criteria.

H U M A N R E S O U R C E S

Office of Human Resources2021 E. Monument St.410-955-3006The Bloomberg School of Public Health is seeking skilled and dynamic applicants for part- and full-time positions. For detailed job descriptions and to apply, go to jobs.jhu.edu.

50715 Senior Research Program Supervisor50514 Project Administrator50882 Communications Coordinator50846 Admissions Officer50783 Administrative Manager

S c h o o l s o f P u b l i c H e a l t h a n d N u r s i n g

Peabody Preparatory Cuban Salsa Classes — This 10-week Adult and Con-tinuing Education session has openings for

couples and individuals who want to learn Cuban-style salsa. Classes will take place from 7 to 8 p.m. on Mondays at Peabody’s downtown campus. Tuition is $50, with a special rate for Hopkins and Peabody Con-servatory students. For more information, call 410-234-4630.

B y V A n e S S A W A S t A


Working with human breast cells, researchers at the Johns Hop-kins Kimmel Cancer Center have

shown how the inactivation of a single copy of the breast cancer gene BRCA1 leaves breast cells vulnerable to cancer by reducing their ability to repair DNA damage, causing genetic instability. An inherited mutation in BRCA1 is the leading risk factor for hereditary breast cancer, prompting preventive mastectomies or close monitoring. The new findings may aid devel-opment of drugs to prevent hereditary breast cancer and tools to identify women who ben-efit most from prophylactic treatments. Precisely how BRCA1 inactivation raises cancer risk has remained something of a puzzle. BRCA1 is considered a “tumor sup-pressor” gene, and typically the loss of one copy of such genes is not enough to cause cancer. That’s because humans inherit two copies of each gene (one from each parent), and the second copy works well enough to keep cells healthy—just as a car can safely stop after losing the front brakes since the rear brakes are still intact. Cancer appar-ently develops in such cases only after the second copy is inactivated in a cell, perhaps by some random mutation during cell divi-sion, resulting in the “second hit”—causing uncontrolled cell growth as if the cell had lost its “brakes.” Mouse models of BRCA-related cancers have shown that “hits” to genes such as TP53 occur before the second “hit” to the remaining functional copy of BRCA. “In theory, this process would take a long time, and BRCA-related breast cancers occur at an early age,” said Ben Ho Park, an associate professor of oncology at the Johns Hopkins Kimmel Cancer Center. For the study, reported Oct. 25 in the Pro-ceedings of the National Academy of Sciences, Park and his team at Johns Hopkins took advantage of new technology to introduce a single copy of a typical BRCA1 mutation into normal breast cells. The leading hypothesis has been that the original inactivation of a single copy of BRCA1 causes further DNA mutations to accumulate more quickly than normal, a condition called “genomic instability.” The protein coded by BRCA1 is involved in repairing major DNA breaks, so it would make sense that its inactivation could weaken a cell’s resistance to DNA muta-tions, Park says. But the consequence of losing a single copy of BRCA1 was not easy to model or study, he adds. Previous efforts to create mice with single-copy BRCA1 mutations had uncertain results because the mice failed to show the pattern of human cancers. Researchers also have found it difficult to create human cell lines in which the only flaw is a single mutated copy of BRCA1. To test the idea, Park’s team first selected cell lines derived from noncancerous human breast epithelial cells, where BRCA1 breast cancers originate. They then used an advanced gene-targeting technique to create new cell lines that have a typical cancer-linked BRCA1 mutation in only one copy of the gene. Park’s team then ran tests on the two cell types—the ones that had the BRCA1 mutation and the original cells that had two healthy copies of BRCA1—and com-

pared their DNA repair activity. They were able to show that cells with BRCA1 mutations were less efficient at conducting the type of DNA repair known to involve the BRCA1 protein. The BRCA1-mutated cells were more likely to die when exposed to a DNA-damaging chemotherapy drug or radiation. BRCA1-mutated cells allowed to divide for several weeks also were more likely to lose other genes, including those often mutated in breast tumors. Tests on noncancerous breast cells taken from women with BRCA1 mutations showed similar genetic losses. “What this shows is that having only a single working copy of BRCA1 really does bring about changes in a cell that would be expected to give rise to cancer,” Park said. Park plans additional experiments on the team’s new cell models of BRCA1 mutations. “We hope to use this new system to introduce other known BRCA1 mutations to get a better idea of the rela-tive cancer risk each individual mutation represents because right now there are few good ways to do that,” he said. “In the future, we hope to further define risk so that family members with one type of BRCA1 mutation may be advised to get preventive treatment or surgery, and those with other BRCA1 mutations could rely on careful screening.” The new cell models also may be useful in determining the susceptibility of various BRCA1 mutations to drugs, he adds. Anti-cancer drugs known as PARP inhibitors are currently in clinical trials against tumors with BRCA1 mutations. Women born with a mutated copy of BRCA1 have been shown to have lifetime risks of breast cancer between 50 and 90 per-cent, a wide range. They also have high, but variable, risks of ovarian and other cancers. The research was funded by the V Foun-dation; National Institutes of Health; Susan G. Komen for the Cure; Avon Founda-tion; Mary Kay Ash Charitable Founda-tion; Stewart Trust Fund; Flight Attendant Medical Research Institute; Breast Cancer Research Foundation; Grants-in-Aid for Scientific Research from the Japanese Min-istry of Education, Culture, Sports, Science and Technology, known as MEXT; Strategic Research Foundation Grant-aided Project for Private Universities from MEXT; Aichi Cancer Research Foundation; and Osaka Cancer Research Foundation. Other contributors to the research include Hiroyuki Konishi, a member of the Park lab; Johns Hopkins colleagues Morassa Mohseni, Akina Tamaki, Joseph P. Garay, Sarah Croessmann, Hong Yuen Wong, Yuko Konishi, Bedri Karakas, Abde M. Abukhdeir, John P. Gustin, Justin Cidado, Grace M. Wang, David Cosgrove, Rory Cochran, Danijela Jelovac, Michaela J. Higgins, Sabrina Arena, Lauren Hawkins, Josh Lauring, Amy L. Gross, Christopher M. Heaphy, Edward Gabrielson, Alan K. Meeker, Kala Visvanathan and Pedram Argani; Sivasundaram Karnan, Akinobu Ota and Yositaka Hosokawa, all of the Aichi Medical University School of Medi-cine, Japan; and Khola Tahir and Kurtis E. Bachman, both of the University of Mary-land School of Medicine. Under a license agreement between Hori-zon Discovery Inc. and The Johns Hopkins University, Park is entitled to a share of roy-alties received by the university. He also is a paid member of the scientific advisory board of Horizon.

Scientists show how BRCA1 gene mutations harm breast cells


Classifieds M A R K E T P L A C E

Classified listings are a free ser-vice for current, full-time Hop-kins faculty, staff and students only. Ads should adhere to these general guidelines:

• Oneadperpersonperweek.A new request must be submitted for each issue. • Adsarelimitedto20words, including phone, fax and e-mail.

• WecannotuseJohnsHopkins business phone numbers or e-mail addresses.• Submissionswillbecondensedat the editor’s discretion. • DeadlineisatnoonMonday, one week prior to the edition in which the ad is to be run.• Realestatelistingsmaybeoffered only by a Hopkins-affiliated seller not by Realtors or Agents.

(Boxed ads in this section are paid advertisements.)Classified ads may be faxed to 443-287-9920; e-mailed in the body of a message (no attach-ments) to [email protected]; or mailed to Gazette Classifieds, Suite 540, 901 S. Bond St., Bal-timore, MD 21231. To purchase a boxed display ad, contact the Gazelle Group at 443-275-2687.

PLaCINGaDS

aParTMeNTS/HouSeS for reNT

Brewers Hill, rehabbed 2BR, 2.5BA TH, gourmet kitchen, fin’d bsmt, deck, no pets, avail Feb 1. $1,850/mo. 410-303-1214 or [email protected].

Canton/Fells Point (603 S Patterson Park Ave), 2BR, 2.5BA renov’d RH, 1,500 sq ft, CAC, hdwd flrs, expos’d brick, extra rms, laun-dry, rooftop deck, walk to park. $1,650/mo. [email protected].

Ednor Gardens, 3BR, 2BA charmer in his-toric neighborhood nr JHU/JHMI, inlaid hdwds, sunrm, new appls, no smoking/no pets. $1,350/mo. [email protected].

Essex, 2BR, 1BA condo in secure bldg, water view, laundry in unit, rent or rent to own. $875/mo (unfurn’d) or $925/mo (furn’d). 410-322-2168 or [email protected].

Federal Hill, architect-renovated 2BR, 1.5BA TH, roof deck w/harbor view, hdwd flrs, pets OK. $2,300/mo. 410-472-4702 or [email protected].

Fells Point, spacious 2BR, 1BA condo in PS25 building in the heart of the city, 14' ceilings, hdwd flrs, granite counters, stainless steel appls, mins to Hopkins shuttle stop, pets welcome. $1,698/mo. 410-952-8045.

Glen Burnie, studio apt, BA, kitchenette, W/D, 12 mi to campus, must be car owner. 443-799-7530.

Hamilton Ave (at Walther), 2BR, 1BA apt, 1st flr. $750/mo. 301-538-3819.

Harbor East, lg, luxury 1BR, walking dis-tance to Carey Business School, 3-month lease, avail March 1. $2,136/mo incl prkng. 917-951-1440.

Inner Harbor, beautiful, new 1BR condo in luxury apt bldg, hdwd flrs, stainless steel appls, W/D in unit, balcony, reserved garage prkng spot, 24-hr doorman, pool, gym, mins to JHH. 305-469-4663 or absrini@gmail .com.

Mt Washington, sublet 2BR apt in beautiful wooded area nr campus, conv to downtown, avail end of Jan to May, meditative energy, lots of light, W/D, dw, microwave, DSL, WiFi, Netflix, community fitness center, rent discounted in exchange for cat care. $850/mo + utils. 410-764-3494.

Ocean City (137th St), 3BR, 2BA condo, steps from the beach, lg pool, 2 prkng spaces, short walk to entertainment and restaurants. 410-544-2814.

Owings Mills Newtown, 2BR, 2BA condo, 3rd flr. $1,300/mo. 609-647-9386 or [email protected].

Patterson Park/Highlandtown, 3BR, 1.5BA RH, huge kitchen w/new stainless steel appls, hdwd flrs, updated master BA, backyd w/privacy fence, CAC, blks to shuttle stop, no pets allowed, refs req’d. $1,400/mo. 410-218-4708 or [email protected].

Remington (29th St), 2BR, 1BA TH w/kitchen, living rm, bsmt, fenced yd, no pets/no smokers, 5-min walk to Homewood campus. $800/mo + utils. 443-783-5666 or [email protected].

Remington, 2BR and 1 full BA, located off 28th St at Miles Ave. $800/mo + utils. 443-449-4883.

Villages of Homeland, 1BR apt in gated community, CAC, laundry rm on same flr, walk-in closets, patio, pool, exercise rm, prkng, avail Feb 1. $850/mo incl heat. 410-532-9492.

Fabulous 5BR executive home avail, furn’d or unfurn’d, rent or rent to own, convenient to Baltimore. 410-259-8879.

Beautiful 1BR apt across from park, 2nd flr of TH, priv entry, 10-min drive to JHH/Homewood campus, unfurn’d, 1-yr lease. $550/mo incl heat. Paula, 410-868-2815 or [email protected].

2BR, 1.5BA avail in 3BR house, kitchen, living rm, dining rm, fin’d bsmt, lg yd w/big grill. $1,400/mo. 410-800-8141.

HouSeS for SaLe

Fells Point (300 blk S Durham St), 3 sto-ries, new front/rear masonry work, nice yd, nr JHH. $175,000. Dorothy, 410-419-3902.

Gardenville, 3BR, 1.25BA RH, new kitchen and BA, CAC, hdwd flrs, fenced, mainte-nance-free yd w/carport, club bsmt w/cedar closet, quiet neighborhood, 15 mins to JHH. $120,000. 443-610-0236 or [email protected].

Owings Mills New Town, 2BR condo nr metro station. $74,900. www .4409silverbrook.info.

rooMMaTeS WaNTeD

Mature F wanted to share 2BR, 1BA apt w/married prof’l from Delaware. $575/mo incl utils, cable, Internet. 302-724-0044.

Sublet: 1BR w/priv BA in 2BR Butchers Hill apt, hdwd flrs, roof deck, prkng, furn’d/unfurn’d, now through June, timing flexible. $850/mo. 781-249-5269.

F nonsmoker bedspacer wanted to share condo in Washington Hill (98 N Broadway) w/grad student, adjacent to Church Profes-sional Building, walk to JHH/shuttle. $450/mo + utils. [email protected].

Nonsmoker wanted for furn’d 700 sq ft BR in 3BR house in Cedonia owned by young F prof’l, bright, modern kitchen w/convection oven, walk-in closet, landscaped yd, lg deck, free prkng, public transportation to JHU, wireless Internet incl’d. $550/mo + utils. 410-493-2435 or [email protected].

F nonsmoker wanted for 1BR in 2BR W University Pkwy apt, share w/Hopkins alumna, AC, heat, hot water, 5 mins to cam-pus, no pets. $540/mo + 1/2 elec. [email protected].

M nonsmoker wanted for 2BR apt in Towson (695 at exit 28), quiet and safe, 1BR/1BA avail. $535/mo incl water (elec, Internet not incl’d). [email protected].

Lg BR avail in Fells Point 3BR apt (918 S Wolfe St), good windows, great neigh-borhood, historic house next to Red Star restaurant. $800/mo + share of utils, cable,

Alfred Dunner pull-on pants, size 10 regu-lar, color black, new. $20. 410-522-7546.

Upright piano, Kohler and Campbell. $750/best offer. Kiani, 443-722-9807.

Motorcycle gear: Women’s lined leather jacket, size XS, $125; women’s Milwaukee boots, #7, $85; 12-volt battery charger, $55; all in excel cond. [email protected].

Ethan Allen sofa, forest green upholstery, dk wood trim, in excel cond. $300 (negotiable). John, 410-256-0369 or tinydancer133@ verizon.net.

SerVICeS/ITeMS offereD or WaNTeD

Seeking experienced, long-term nanny to care for 2 young children nr Homewood campus. 773-396-4852 (cell) or [email protected].

Stage your home or office for quick sale, your style, our stage. Amelia, 410-499-6156.

Help send cookies to troops. 443-710-2320 (leave message) or donnamacklea@hotmail .com.

St Thomas Aquinas grade school in Hamp-den is accepting enrollment for fall 2012, walking distance to JHU. 410-880-4618.

Looking for a tutor for 10-yr-old focusing on spelling and reading. Tracy, [email protected].

Live-in nanny avail, caring, responsible former teacher, years of experience, refs avail. Olya, 443-831-7807 or [email protected].

Need someone to edit your biomedical journal article or grant application? Jones Biomediting can help. [email protected].

French tutor w/MAT available. 443-691-1412.

Certified personal and career coach com-mitted to helping young professionals achieve their potential. 410-375-4042 or [email protected].

Tutor available: all subjects/levels; remedial, gifted; help w/college counseling, speech and essay writing, editing, proofread-ing. 410-337-9877 (after 8pm) or i1__@ hotmail.com.

Licensed landscaper avail for fall/winter lawn maintenance, yard cleanup, leaf/snow removal, trash hauling. Taylor Landscap-ing LLC. 410-812-6090 or [email protected].

Transmission repairs, rebuilt or used, 20% discount for all JHU faculty, staff, students and employees, free estimate. Bob, 410-574-8822.

Piano lessons offered by Peabody doctorate, great teaching experience, all levels/ages welcome. 410-662-7951.

Friday Night Swing Dance Club, open to public, great bands, no partners necessary. 410-663-0010 or www.fridaynightswing .com.

wireless. 917-647-7779 or mari.grotz@gmail .com.

Share 2BR, 1BA waterfront apt in Balti-more County, W/D, 12 mi to E Baltimore campus. $900/mo ($450/ea) + sec dep + heat and AC. [email protected].

F wanted to share lg apt in Towson area, priv BR w/full BA, use of W/D, com-mon areas, pool, Dish TV/Internet, quiet, upscale area. $725/mo incl utils. 443-465-7011 or [email protected].

CarS for SaLe

’07 VW Passat, black, leather, DVD, Navi, CD, MP3, clean, up-to-date on mainte-nance, 115K mi (highway). $9,500. 804-504-1202 or [email protected].

’03 Jeep Liberty Sport, 3.7L, 4WD, Md insp’d, in great cond, 114K mi. $6,500. 443-791-1799 or [email protected].

’06 Toyota 4Runner SR5, V8, white, sun-roof, tow hitch, roof racks, orig owner, new tires/brakes, scheduled service done at the dealer, in excel cond, 68K mi. $19,000. [email protected].

’05 Mazda 6 sedan, just serviced, new tires, in excel shape, 48K mi. $8,850. 410-948-0789.

’89 Chevy Silverado pickup, 4x4, rebuilt motor, new tires. $2,400. John, 443-750-7750.

ITeMS for SaLe

Dell Inspiron 8100 and 8200, w/dock sta-tions, $130 and $150; Toshiba Satellite L25, $100; eMachine 330 w/monitor, $70; HP ScanJet 4570c scanner, $50; 13" and 21" Sony TVs w/HDTV antenna and digital converters, $60 and $120; NuWave cooker, $60; bread maker, $30; rice cooker, $25; Belgian waffle maker, $15. 410-812-9267 or [email protected].

Singer sewing machines (2), in cabinets, both in working order, $100/ea; Fender acoustic guitar, $150; oak entertainment center, $350. Chris, 443-326-7717.

Hotpoint refrigerator/freezer, white, 18 cu ft, w/automatic icemaker and defrost, 4 yrs old, buyer picks up. $225. 443-803-7401 or [email protected].

TI-83 Plus graphing calculator, $25; TI-89 titanium graphing calculator, $50; long-track speed skates, men’s size 36, Dark Star blades, $75; Panasonic 20" color TV (not a flat screen), $20; Sony Trinitron 13" TV (not flat screeen), $25. 410-542-0409 or [email protected].

Oil-filled heaters (3), inkjet printer, por-table canvas chair, sand beach chairs (2), keyboard case, 100W amplifier. 410-455-5858 or [email protected].

iPod nano 8G, 6th generation, black, brand new, never used, w/clip, shake shuffle, FM transmitter, touch display, many other fea-tures. Best offer. grogan.family@hotmail .com.

30+ professional male seeking male to share 3BD, 2BA, 3-lvl ths in Ednor Gardens/

Orig.l Northwood, hwd fls, W/D, priv.BA w/tub, 3.1 mi, 7 mins. to Homewood. 3.4 mi, 13 mins to JHMI, Avail-3/10/12, $750 mo.+ sec.dep. cable,

internet/utili. incl., 6 mo. or 1 year lease, no pets. More info./or set up visit, 410-961-4048 or

[email protected].

WYMANCOURTJustRenovated!

HICKORYHEIGHTSA lovely hilltop setting

on Hickory Avenue in Hampden!

2 BD units from $760 w/Balcony - $790!

Shown by appointment 410.764.7776www.BrooksManagementCompany.com

Beech Ave. adj. to JHU!Studios - $595 - $630 1 BD Apts. - $710-740

2 BD from $795

12 THE GAZETTE • January 23, 2012

J A N . 2 3 – 3 0

Calendar D I S C u S S I o N /

T a L K S

Wed., Jan. 25, 5:30 p.m. “U.S. Interests in Central Asia and Its Strategy for Advancing Them,” a Central Asia-Caucasus Institute at SAIS discussion with Robert Blake Jr., U.S. assistant secretary of state for South and Central Asian Affairs. A live webcast will be accessible at www.sais-jhu.edu/pressroom/live .html. Non-SAIS affiliates should RSVP to CACI at [email protected]. Kenney Auditorium, Nitze Bldg. SaIS

Mon., Jan. 30, 4 p.m. Johns Hopkins Medicine Distinguished Speaker Series—“Trading Risks: The Impact of Resident Work Hour Regulations on Patients, Providers and the Future of Health Care” with Charles Bosk, Univer-sity of Pennsylvania. Address fol-lowed by patient/provider panel and audience Q&A. Hurd Hall. eB

L e C T u r e S

Wed., Jan. 25, 7:30 to 9 a.m. Leaders & Legends Lecture by Kathleen Taylor, president and CEO of Four Seasons Hotels and Resorts. (See story, p. 7.) Speaker’s remarks will be followed by ques-tions from the audience. Business attire required. 100 International Drive, Harbor East.

M u S I C

Tues., Jan. 24, 8 p.m. Syl-via Adalman Peabody Chamber Series presents music by Men-delssohn, Rose and Faure. $15 general admission, $10 for senior citizens and $5 for students with ID. Friedberg Hall. Peabody

Sun., Jan. 29, 3 p.m. Prepa-ratory Honors Recital. Griswold Hall. Peabody

Sun., Jan. 29, 3 p.m. “Digital Embrace,” a concert featuring works for wind ensemble and live electronics. Friedberg Hall. Pea-body

Sun., Jan. 29, 5:30 p.m. The Shriver Hall Concert Series pres-ents Les Violons du Roy, with Ber-nard Labadie, director, and Mau-rice Steger, recorder. (See story, this page.) $38 general admission, $19 for non-JHU students; free for JHU students. Shriver Audi-torium. HW

S e M I N a r S

Mon., Jan. 23, 12:15 p.m. “A Neural Mechanism for Learning Temporal Expectancies,” a Carn-egie Institution Embryology semi-nar with Marshall Shuler, SoM. Rose Auditorium, 3520 San Mar-tin Drive. HW

Mon., Jan. 23, 12:15 p.m. “Mixed Messages: The Intersec-tion of Prenatal Genetic Testing and Abortion,” a Berman Insti-

tute of Bioethics seminar with Rachel Rebouche, Levin College of Law, University of Florida. W3008 SPH. eB

Mon., Jan. 23, 1 p.m. “Can-cer Inflammation and Immune Responses in Pancreatic Carci-noma in Mice and Humans,” an Immunology Training Program seminar with Robert Vonderhe-ide, University of Pennsylvania School of Medicine. Tilghman Auditorium, Turner Concourse. eB

Mon., Jan. 23, 4 p.m. “Opti-mal Sparse Signal Identifica-tion With Applications in Copy Number Variation Analysis,” a Biostatistics seminar with Jessie Jeng, University of Pennsylva-nia School of Medicine. W2030 SPH. eB

Tues., Jan. 24, noon. “Roles for Phosphorylation and Acidi-fication in the Copper-Depen-

dent Trafficking of the Membrane ATPase, ATP7B,” a Gastroenter-ology seminar with Lelita Braiter-man, SoM. 903 Ross. eB

Tues., Jan. 24, noon. “Auto-mating the Contextualization of Population-Based CDSS in Tethered EHR/PHRs,” a Health Policy and Management seminar with Hadi Kharrazi, Indiana Uni-versity. 688 Hampton House. eB

Tues., Jan. 24, noon. “When Ion Channel Meets Transporter: Structure and Mechanism of a Eukaryotic CLC Transporter,” a Biological Chemistry seminar with Liang Feng, Rockefeller University/HHMI. Mountcastle Auditorium, PCTB. eB

Tues., Jan. 24, 12:10 p.m. “Falling Through the Cracks: Designs That Kill,” a Graduate Seminar in Injury Research and Policy seminar with Susan Baker, SPH. Sponsored by the Center

for Injury Research and Policy. W2008 SPH. eB

Tues., Jan. 24, 4 p.m. “Mecha-nism of miRNA-Mediated Trans-lational Repression,” a Biology special seminar with Sergej Djura-novic, SoM. 100 Mudd. HW

Wed., Jan. 25, noon. “Immune Privilege and Autoimmunity,” a Molecular Pathology seminar with Rachel Caspi, National Eye Insti-tute/NIH. Sponsored by Pathol-ogy. 490 Rangos. eB

Wed., Jan. 25, 12:15 p.m. Mental Health Wednesday Noon Seminar—“Risk Reduction for Juvenile Drug Court–Involved Youth” with Elizabeth Letourneau, SPH. B14B Hampton House. eB

Wed., Jan. 25, 1:30 p.m. “The Cellular RNA Soup: Add Salt(s) and Spice to Taste,” a Biophysics and Biophysical Chemistry semi-nar with David Draper, KSAS. 701 WBSB. eB

Wed., Jan. 25, 4 p.m. Special Bodian Seminar—“Explaining Visual Search With the Selective Attention for Identification Model (VS-SAIM): Competitive Interac-tions Between/Within Selection and Object Identification” with Dietmar Heinke, University of Birmingham, UK. Sponsored by the Krieger Mind/Brain Institute. 338 Krieger. HW

Wed., Jan. 25, 4 p.m. “Ster-oidogenic Enzyme Inhibitors and Hormone Dependent Cancer,” a Pharmacology and Molecular Sciences seminar with Angela Brodie, University of Maryland School of Medicine. West Lecture Hall (ground floor), WBSB. eB

Thurs., Jan. 26, noon. “Fat Cad-herins in Regulation of Planar Cell Polarity and Mitochondrial Biology,” a Cell Biology seminar with Helen McNeill, University of Toronto. Suite 2-200, 1830 Bldg. eB

Thurs., Jan. 26, noon. “Why Mycobacterium tuberculosis Re -mains Such an Enduring Patho-gen,” a Molecular Microbiology and Immunology/Infectious Dis-eases seminar with David Russell, Cornell University. W1020 SPH. eB

Thurs., Jan. 26, noon. “Next Steps in Reducing Maryland’s Cancer Burden: Maryland’s Can-cer Control Plan,” a LunchLearn-Link seminar with Diane Dwyer and Sarah Hokenmaier, Maryland Department of Health and Men-tal Hygiene. Sponsored by Health Policy and Management. W1214 SPH. eB

Thurs., Jan. 26, 1 p.m. “Molec-ular Mechanisms of Neuronal Morphogenesis,” a Neuroscience research seminar with Wesley Grueber, Columbia University. West Lecture Hall (ground floor), WBSB. eB

Thurs., Jan. 26, 4 p.m. “The Roles of the Nuclear Pore Com-plex in Chromatin Organization, Transcription and Development,” a Biology seminar with Maya Capelson, Salk Institute for Bio-logical Studies. 100 Mudd. HW

fri., Jan. 27, noon. “Introduc-ing Learning Features in Intelli-gent Patient Safety Reporting and Management Systems,” a Health Informatics/Information Science faculty candidate seminar with

(Events are free and open to the public except where indicated.)

aPL Applied Physics LaboratoryBrB Broadway Research BuildingCrB Cancer Research BuildingeB East BaltimoreHW HomewoodJHoC Johns Hopkins Outpatient CenterKSaS Krieger School of Arts and SciencesNeB New Engineering BuildingPCTB Preclinical Teaching BuildingSaIS School of Advanced International StudiesSoM School of MedicineSoN School of NursingSPH School of Public HealthWBSB Wood Basic Science BuildingWSe Whiting School of Engineering

CalendarKey

Les Violons du Roy to make SHCS debut

Shriver Hall Concert Series begins 2012 by presenting its annual Paul and Barbara Krieger Early Music Concert, with the Canadian ensemble Les Violons du Roy. The acclaimed group will perform works by Handel, Telemann, Sammartini and Geminiani at 5:30 pm. on Sunday, Jan. 29, in Home-

wood’s Shriver Hall Auditorium. Borrowing its name from the renowned string orchestra of the court of the French kings, Les Violons du Roy is widely hailed for the excep-tional energy, brilliance and vitality of its performances. The orchestra, with a core membership of 15 players, makes its series debut with founding artistic and music director Bernard Labadie and recorder virtuoso Maurice Steger. Since its founding in 1984, the group has specialized in the vast repertoire of music for chamber orchestra performed in the stylistic manner most appropriate to each era. Though the ensemble plays mod-ern instruments, its approach to the works of the baroque and classical periods has been strongly influenced by research into 17th- and 18th-century performance practice; in this repertoire, Les Violons uses copies of period bows. In recent seasons, the orchestra has begun to explore 19th- and 20th-century repertoire. Les Violons du Roy is at the heart of the music scene in Quebec City, where it has been in residence at the Palais Montcalm since 2007. The group first performed in Europe in 1988 and has given dozens of concerts in France, Germany, England, Spain and the Netherlands. Since its first U.S. performance, in 1995 in Washington, D.C., the group has made regular stops in New York, Chicago and Los Angeles. For ticket information, go to www.shriverconcerts.org or call 410-516-7164.

Yang Gong, University of Mis-souri. Brown bag lunch provided. 688 Hampton House. eB

fri., Jan. 27, 12:15 p.m. “Mul-timorbidity, Inflammation and Physical Performance Among HIV-Infected and Uninfected Current and Former Injection Drug Users,” an Epidemiol-ogy thesis defense seminar with Megan Salter. W1214 SPH. eB

Mon., Jan. 30, 8 a.m. “Manage-ment of Colorectal Liver Metas-tasis: Understanding Shifting Treatment Strategies,” a Gradu-ate Training Program in Clinical Investigation thesis defense semi-nar with Timothy Pawlik. E2527 SPH. eB

Mon., Jan. 30, noon. “IL-18 and IL-18BP in Autoimmune Diseases and Poxvirus Infection,” a Biochemistry and Molecular Biology seminar with Junpeng Deng, Oklahoma State Univer-sity. W1020 SPH. eB

S P e C I a L e V e N T S

fri., Jan. 27, 2 to 4 p.m. Provost’s Lecture Series—“Dark Energy and the Cosmic Expan-sion History” by Nobel Prize winner Adam Riess. (See In Brief, p. 2.) Q&A session and reception follow Riess’ talk. Co-sponsored by Biology, Conversa-tions in Medicine, Homewood Student Affairs and Pre-Profes-sional Advising. Kossiakoff Cen-ter Auditorium. aPL

W o r K S H o P S

The Center for educational resources sponsors a series of workshops on the Blackboard 9.1 interface. The training is open to all faculty, staff and TAs in full-time KSAS or WSE programs who have administrative respon-sibilities in a Blackboard course. To register, go to www.bb.cer.jhu .edu. Garrett Room, MSE Library. HW

• Mon., Jan. 23, 10 a.m. to noon; Thurs., Jan. 26, 2 to 4 p.m.; and Mon., Jan. 30, 10 a.m. to noon. “Getting Started With Blackboard.”

• Tues., Jan. 24, 10 a.m. to noon. “Blackboard Com-munication and Collabora-tion.”

• Wed., Jan. 25, and fri., Jan. 27, 10 a.m. to noon. “Assessing Student Knowl-edge and Managing Grades in Blackboard.”

The Gazette

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