The Gazette

111010

our 40th year

Covering Homewood, East Baltimore, Peabody,

SAIS, APL and other campuses throughout the

Baltimore-Washington area and abroad, since 1971.

September 13, 2010 the newspaper of the Johns hopkins university Volume 40 No. 3

Job Opportunities

Notices

Classifieds

CoNStItutIoN Day

Harvard Law School professor

presents ‘A Skeptical View of

Constitution Worship,’ page 7

LeaDerS + LeGeNDS

Robert L. Johnson, founder

of BET and RLJ Cos., to give

Carey School lecture, page 12

I N B r I e f

Arts Innovation Grants; test of Homewood

emergency system; Swim Across America

C a L e N D a r

Community Involvement Fair; ‘Mark

Twain’s America’; Yom Kippur services2 12

Serving up dinner and discourseTwo programs bring Homewood undergrads, profs together at dean’s

B y A m y L u n d A y

Homewood

Guess who’s coming to dinner? If you’re Kath-erine Newman, the answer is 800 under-graduates.

That’s the number of students the new James B. Knapp Dean of the Krieger School of Arts and Sciences expects to welcome to her home throughout the 2010–2011 academic year, thanks to two informal dinner-and-discussion programs pairing dis-tinguished Krieger School faculty and Homewood students. The first 75 undergraduates will visit Newman’s North Charles Street home this week through the Four-Course Dinners program, now in its third year of bringing together faculty and stu-dents from both the Krieger and Whit-ing schools for casual conversation about a variety of topics in the human-ities. Monday, Tuesday and Wednesday will mark the first dinnertime sessions of the noncredit four-week courses on the Bible, Yiddish humor and Euro-pean film. tonight, KSaS Dean Katharine Newman opens the doors of her new home to the

first of 800 homewood undergraduates she expects to entertain at two series of informal dinner-and-discussion programs this year.Continued on page 5

E V E N T

A new home for IPS in Public HealthB y G r e G r i e n z i

The Gazette

The Johns Hopkins Institute for Policy Studies, a longtime free-standing organization of the

university, has a new academic home: the Department of Health Policy and Management at the Bloomberg School

of Public Health. The move, effec-tive immediately, is intended to maxi-mize IPS’s potential as a resource for the university. Current plans are for the institute to remain on the Homewood campus.

The IPS director previously reported to the Provost’s Office, which announced the move earlier this month in an inter-nal letter. In the message, Provost Lloyd Minor said that the move would best position the institute going forward. “As plans for identifying a new per-manent director [for the institute] were discussed, it became increasingly clear that aligning IPS more closely with the Bloomberg School and HPM would benefit both organizations. In particular, a school affiliation enhances the poten-tial to recruit new faculty to IPS,” Minor said. Ellen MacKenzie, the Fred and Julie Soper Professor of Health Policy and Management and chair of the Depart-ment of Health Policy and Manage-ment, said that she believes the move will raise the profile of the institute and directly fuel work going on in the uni-versity. “We’re very excited about this,” MacKenzie said. “We see IPS as bring-ing expertise in the area of policy that we don’t necessarily have. We see public health researchers and those focused on social policies working very closely together. This brings a lot to the table.” MacKenzie said that two main goals are to foster IPS as a resource that devel-ops and applies policy analysis to a broad array of social issues, and to provide an

Policy

institute will

remain on

homewood

campus

Continued on page 4

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Cloud computing method improves gene analysis T E C H N O L O G Y

Researchers develop free software that cuts both processing time and cost

B y T i m P A r s o n s

Bloomberg School of Public Health

Researchers at the Johns Hopkins Bloomberg School of Public Health have developed software that greatly

improves the speed at which scientists can analyze RNA sequencing data. Known as

Myrna, the new software—which is available for free download at http://bowtie-bio.sf.net/myrna—uses “cloud computing,” an Internet-based method of sharing computer resources. RNA sequencing is used to compare differ-ences in gene expression to identify those genes that switch on or off when, for instance, a par-ticular disease is present. However, sequencing instruments can produce each day billions of sequences, which can be time-consuming and costly to analyze. Faster cost-effective analysis of gene expression could be a valuable tool in understanding the genetic causes of disease. The findings are published in the current edition of the journal Genome Biology.

Cloud computing bundles together the processing power of individual computers using the Internet. A number of firms with large computing centers, including Amazon and Microsoft, rent time on their unused computers over the Internet. “Cloud computing makes economic sense because cloud vendors are very efficient at running and maintaining huge collec-tions of computers. Researchers struggling to keep pace with their sequencing instru-ments can use the cloud to scale up their analyses while avoiding the headaches

2 THE GAZETTE • September 13, 2010

I N B R I E F

Applied Physics Laboratory Michael Buckley, Paulette CampbellBloomberg School of Public Health Tim Parsons, Natalie Wood-WrightCarey Business School Andrew Blumberg, Patrick ErcolanoHomewoodLisa De Nike, Amy Lunday, Dennis O’Shea,Tracey A. Reeves, Phil SneidermanJohns Hopkins MedicineChristen Brownlee, Stephanie Desmon, Neil A. Grauer, Audrey Huang, John Lazarou, David March, Vanessa McMains, Katerina Pesheva, Vanessa Wasta,Maryalice YakutchikPeabody Institute Richard SeldenSAIS Felisa Neuringer KlubesSchool of Education James Campbell, Theresa NortonSchool of Nursing Kelly Brooks-StaubUniversity Libraries and Museums Brian Shields, Heather Egan Stalfort

e d i T o r Lois Perschetz

W r i T e r Greg Rienzi

Pr o d u c T i o n Lynna Bright

co P y ed i T o r Ann Stiller

Ph o T o G r A P h y Homewood Photography

Ad v e rT i s i n G The Gazelle Group

Bu s i n e s s Dianne MacLeod

ci r c u L AT i o n Lynette Floyd

We B m A s T e r Tim Windsor

c o n T r i B u T i n G W r i T e r s

The Gazette is published weekly Sept-ember through May and biweekly June through August for the Johns Hopkins University community by the Office of Government, Community and Public Affairs, Suite 540, 901 S. Bond St., Baltimore, MD 21231, in cooperation with all university divisions. Subscrip-tions are $26 per year. Deadline for calendar items, notices and classifieds (free to JHU faculty, staff and students) is noon Monday, one week prior to publication date.

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MICHAEL J. KLARMANKirkland and Ellis Professor Harvard Law School

“ A SKEPTICAL VIEW OF

CONSTITUTION WORSHIP”

THE 2010 CONSTITUTIONAL FORUM

September 16, 20108 P.M.

110 Hodson Hall Homewood Campus

For more information email: [email protected]

SPONSORED BY The Department of Political Science and the Office of Government, Community and Public Affairs

SUPPORTED BY The George Huntington Williams Memorial Lectureship

sequentially broadcast the voice message, announcing, “This is a test of the Homewood campus emergency warning system.” Those who have subscribed to the text message alert system will receive a brief mes-sage that reads, “This is a test of the Johns Hopkins Homewood Emergency Alert text message system. There is NO emergency at this time.” Shortly after the public address broadcast, an all-clear alert tone will sound, followed by a message saying, in part, “This has been a test of the Homewood campus emergency warning system. Had there been an actual emergency, you would have been given spe-cific instructions on what to do.” Because the public address system incor-porates a silent self-test feature that exer-cises each module on a weekly basis, Cam-pus Safety and Security schedules “live” tests only three times a year. The main purpose of the exercise is to familiarize the Homewood community with the sound of the system. Except for these periodic tests, the system will be used only in the event of a confirmed incident that presents an immediate danger to the Homewood campus. To subscribe to text message alerts, go to http://my.johnshopkins.edu and sign in using your JHED ID and password. Click on the “myProfile” icon in the upper left-hand side of the page, then click on the “Emer-gency Alerts” link on the right.

Esther Brimmer of State Dept. to give lecture at SAIS

Esther Brimmer, assistant secretary of state for international organization affairs, will speak at SAIS at 12:30

p.m. on Wednesday, Sept. 15. Brimmer, a former SAIS faculty member, will speak about “The United States at the U.N. and Beyond: A World of Transnational Challenges.” A live webcast will be acces-sible at www.sais-jhu.edu. The event will be held in the Nitze Building’s Kenney Auditorium. Non-SAIS affiliates should RSVP to the International Development Program at [email protected].

‘Sculpture at Evergreen’ is site of Sunday block party

Sunday, Sept. 19, is the day to explore Evergreen Museum & Library’s largest gallery—its 26-acre park, which is now

featuring the biennial exhibition Sculpture at Evergreen 6: Simultaneous Presence. Visitors are invited to bring a picnic, enjoy performance art by David Page and Shannon Young, and meet the artist team of Eric Leshinsky, C. Ryan Patterson and Fred Scharmen, who will host chalk drawing, a community photo wall and a lemonade stand at its urban-park installation. Outdoor activities are free; regular admis-sion policies apply to museum tours.

Arts Innovation Grants available for Homewood faculty, students

Proposals for Arts Innovation Grants for intersession and the spring and fall 2011 semesters are now being accepted

from Homewood faculty and staff. The initiative is designed to help faculty develop for-credit interdisciplinary courses in the arts—across departments, divisions or institutions—for Homewood undergradu-ates, and to help undergraduates create new co-curricular activities in the arts or significantly increase the impact of existing ones within both the university and greater Baltimore communities. The deadline for submissions is Friday, Oct. 1. For more information, go to www .library.jhu.edu/about/news/announcements/artsinnovationgrants.html.

Swim Across America to benefit JH Kimmel Cancer Center

Swim Across America, the national nonprofit organization dedicated to raising money and awareness for

cancer research, prevention and treatment through swimming-related events, will hold its first swims in the Baltimore area on Sun-day, Sept. 19. Pledges collected by the swimmers, corpo-rate sponsors and online donations will sup-port a lab directed by Luis Diaz at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Among those signed up to swim are Cancer Center director Bill Nelson, Nobel laureates Peter Agre and Carol Greider and a 19-member team rallied by John Burton of Bayview. Olympian Michael Phelps will serve as the official starter for the one- and three-mile open water swims, which will be held in Gibson Island Harbor, starting at 8 a.m. from the Waltjen Shedlick Farm in Pasadena. A one-mile pool swim begins at the same time at the Meadowbrook Aquatic and Fitness Center in Baltimore. The races are open to swimmers of all ages and skill levels. For more information, go to www.swimacrossamerica.org/Baltimore.

Homewood emergency alert system to be tested Tuesday

Homewood Campus Safety and Secu-rity will conduct a test of the cam-pus siren/public address system and

the Johns Hopkins Emergency Alerts text messaging system at 1 p.m. on Tuesday, Sept. 14. The test will be a full-scale simultaneous activation of both systems. The siren/PA system, which is activated by radio signal from the Homewood Com-munication Center, is composed of speakers on Garland Hall, Whitehead Hall and the O’Connor Recreation Center. The sirens will simultaneously sound the alert tone and then

September 13, 2010 • THE GAZETTE 3

B y P h i L s n e i d e r m A n

Homewood

Dexter G. Smith has been appointed the Whiting School of Engineering’s associate dean for Engineer-ing for Professionals, which

offers part-time education for working engineers and scientists. The appoint-ment is effective Oct. 1. Smith, who has been affiliated with Johns Hopkins since 1995, currently serves as a member of the principal pro-fessional staff of the university’s Applied Physics Laboratory and as the EP pro-gram’s chair of Electrical and Computer Engineering.

In announcing the appointment, Nick Jones, the Benjamin T. Rome Dean of the Whiting School, said that Dexter brings to EP a combination of skills and experiences that makes him uniquely qualified for his new leadership role. EP offers master’s degrees in 15 disci-plines. Currently more than 3,000 students are enrolled in EP courses at eight education centers in the Baltimore-Washington, D.C. region, through partnerships with industry and locations nationwide, and online. In directing this program, Smith will suc-ceed Allan Bjerkaas, who in 2001 became the associate dean for what was then called Part-time Programs in Engineering and Applied Science. Bjerkaas recently announced his retirement. “Thanks to Allan, EP is thriving and

WSE names Dexter G. Smith associate dean for EP programsis now positioned to achieve tremendous growth in areas that include corporate part-nerships and partnerships with APL, dis-tance learning, opportunities presented by the BRAC initiative and new academic programs,” Jones said. “This is a terrifically exciting time for EP, and I know that Dex-ter will provide the leadership necessary to bring these possibilities to fruition and to build upon them.” At APL, Smith is a member of the execu-tive management team and is the biomedi-cine business area executive. He played a key role in organizing, staffing and writing the largest Defense Advanced Research Projects Agency contract ever awarded to the Labo-ratory, for a project called Revolutionizing Prosthetics 2009. Previously, he served as the branch supervisor for APL’s Homeland

Protection, specializing in unique facili-ties characterization and chemo/bio sen-sor development. Before joining APL, Smith worked at Gould Electronics, Allied Signal and Noise Cancellation Technologies. He holds bachelor’s and master’s degrees in biomedical engineering, and a second master’s degree and a doctorate in elec-trical engineering, all from Rensselaer Polytechnic Institute. He also holds numerous U.S. patents and is a senior member of the Institute of Electrical and Electronics Engineers, a full member of the scientific research society Sigma XI and a licensed professional engineer in Maryland. In addition, he is a certi-fied flight instructor and an instrument-rated commercial pilot.

A P P O I N T M E N T

B y L i s A d e n i k e

Homewood

We run our modern lives largely by the clock, from the alarms that startle us out of our slumbers and

herald each new workday to the watches and clocks that remind us when it’s time for meals, after-school pickup and the like. In addition to those ubiquitous timekeep-ers, though, we have internal “clocks” that are part of our biological machinery and help set our circadian rhythms, regulating everything from our sleep-wake cycles to our appetites and hormone levels. Light coming into our brains by way of our eyes sets those clocks, though no one is sure exactly how this happens. A Johns Hopkins biologist, however, in collaboration with scientists at the Uni-versity of Southern California and Cornell University, has unlocked part of that mys-

tery recently in a study that found that rod cells—one of three kinds of exquisitely photosensitive cells found in the retina of the eye—are the only ones responsible for “setting” those clocks in low light condi-tions. What’s more, the study found that rods—which take their name from their cylindrical shape—also contribute (along with cones and other retinal cells) to setting internal clocks in bright light conditions. The study appeared in a recent issue of Nature Neuroscience. These findings are surprising for several reasons, according to study leader Samer Hattar, an assistant professor of biology in the Krieger School of Arts and Sciences. “One is that it had previously been thought that circadian rhythms could only be set at relatively bright light intensities, and that didn’t turn out to be the case,” he said. “And two, we knew going in that rods ‘bleach’ or become ineffective when exposed to very bright light, so it was thought that

Tick-Tock: Rods help set internal clocks, Hopkins biologist says rods couldn’t be involved in setting our clocks at all in intense light. But they are.” In the study, Hattar’s team used a group of mice that were genetically modified to have only rod photoreceptors, meaning that their cones and intrinsically photosensitive retinal ganglion cells—both of them light-sensitive cells in the animals’ retinas—were not functional. The team then exposed the rodents to varying intensities of light, measuring the animals’ responding level of activity by how often they ran on hamster wheels. The study results are important because they indicate that prolonged exposure to dim or low light at night (such as that in homes and office buildings) can influence mammals’ biological clocks and “throw off” their sleep-wake cycles. Hattar suggested that one way people can mitigate this effect is by making sure to get some exposure to bright daylight every day. In addition, the study has possible impli-

cations for older people being cared for in nursing homes and hospitals, he said. “Older adults often lose their rod cells to age, which means that their caretak-ers would be well-advised to regularly and deliberately expose them to bright natural daylight in order to make sure that their natural biological rhythms remain in sync so their sleep-wake cycles remain accurately set,” Hattar said. “Otherwise, they could have sleep disturbances, such as intermit-tent waking or difficulty falling asleep, not to mention the impact on their appetite and other bodily functions.” Hattar’s study was funded by the National Institute of General Medical Sciences.

B y k A T e r i n A P e s h e v A

Johns Hopkins Medicine

Obese women have a well-known risk for infertility, but a new Johns Hopkins Children’s Center study

has unraveled what investigators here believe is the mechanism that accounts for the risk. The research, conducted in mice and published online Sept. 8 in the journal Cell Metabolism, shows that the pituitary gland actively responds to chronically high insu-lin levels, triggering a cascade of hormonal changes that disrupt ovarian function and impair fertility. The findings challenge the widely held belief that infertility is a result of insulin resistance—a body’s insensitivity to chroni-cally elevated insulin levels and a hall-mark of obesity—and suggest a new culprit: heightened sensitivity to insulin’s effects on the pituitary gland. “What we propose is a fundamentally new model showing that different tissues respond to obesity differently, and that while cells in the liver and muscle do become insulin-resistant, cells in the pituitary remain sensi-tive to insulin,” said principal investigator Andrew Wolfe, an assistant professor of pediatrics and endocrinology in the School of Medicine. Scientists traditionally have focused on treating infertility by lowering insulin lev-els as a way to treat insulin resistance. However, the new model suggests that decreasing the pituitary’s sensitivity to

insulin could be an important new target for treatment instead. Insulin resistance, marked by persistently elevated insulin, abnormal regulation of blood sugar and insensitivity to insulin in the liver and muscle cells, occurs in type 2 diabetes; metabolic syndrome; and poly-cystic ovary syndrome, or PCOS, the most common cause of infertility, affecting up to one in 10 women. Because ovarian function and fertility are mostly regulated by the pituitary, the body’s master gland, the Johns Hopkins team set out to find out exactly how elevated insulin levels affect the pituitaries of obese women to render them infertile. The investigators focused on a class of pituitary cells called gonadotrophs, which secrete luteinizing hor-mone, or LH, which is critical for ovulation and fertility. The researchers suspected that when awash with too much circulating insulin, the gonadotrophs of obese mice start pumping out large amounts of LH, thus disrupting ovulation. To test their hypothesis, the scientists engineered mice with missing insulin recep-tors in their pituitary glands and compared them to mice with intact insulin receptors. After three months on a high-fat diet, the obese mice with intact insulin recep-tors developed all the classic symptoms of PCOS: elevated LH levels, high testoster-one, irregular reproductive cycles and fewer ovulations. The mice with missing insulin receptors, however, maintained near-normal LH levels, regular cycles and normal ovula-tion despite their obesity. To further clarify the effect of insulin

JHM researchers unravel clues to infertility in obese womenon the pituitary, the researchers compared the gonadotrophs of obese mice to those of lean mice by injecting the animals with gonadotropin-releasing hormone, which stimulates LH and is critical for ovulation and fertility. Lean mice, with and with-out pituitary insulin receptors, had normal elevations of LH. Obese mice with intact insulin receptors experienced increases of LH twice as high. Yet the obese mice with missing insulin receptors in their pituitaries had near-normal LH elevations. These results, the researchers say, show that the high levels of insulin seen in obe-sity make the pituitary more sensitive to gonadotropin-releasing hormone and help initiate a hormonal chain reaction that dis-rupts fertility. To demonstrate insulin’s direct effects on the pituitary, the scientists injected mice with insulin. Mice with intact insulin recep-tors, lean or obese, had mild LH elevations, while mice with deleted insulin receptors, lean or obese, experienced none. To determine whether these hormonal differences would carry over into actual dif-ferences in fertility, the researchers allowed the mice to mate. The pregnancy outcomes mirrored the hormonal findings. Lean mice, with or without pituitary insulin recep-tors, had six times the number of successful pregnancies as obese mice. However, obese mice with missing pituitary insulin receptors had near-normal pregnancy outcomes, with five times more successful pregnancies than obese mice whose pituitary insulin receptors were intact. By deleting the insulin receptors in the

pituitary cells of mice, the researchers man-aged to restore normal LH levels, maintain ovulation and near-intact fertility even in obese mice with elevated insulin levels. Despite normal hormonal levels and ovula-tion, the obese mice with missing insulin receptors were not as fertile as lean mice with normal insulin levels. The finding suggests that since the ovaries share partial control of ovulation and fertility with the pituitary, they, too, may be affected by high insulin levels. Ronald Kahn, of the Joslin Diabetes Cen-ter at the Harvard School of Medicine, was co-investigator on the research. Johns Hopkins co-authors on the study were Kathryn J. Brothers, Sheng Wu, Sara DiVall, Marcus R. Messmer, Ryan S. Miller, Sally Radovick and Fredric E. Wondisford. The study was funded by the National Institutes of Health.

Related websitesJohns hopkins Children’s Center: www.hopkinschildrens.org andrew Wolfe: www.hopkinschildrens.org/ Andrew-Wolfe-PhD.aspx Baltimore Diabetes research and training Center: www.hopkinsmedicine.org/drtc/ index.html

Read The Gazette online http://gazette.jhu.edu


outstanding graduate program in policy studies. “I foresee IPS as being the go-to place in the university for a range of social issues,” she said. IPS is the primary social science policy research and teaching arm of the univer-sity, providing undergraduate and master’s degree programs in public policy and policy administration. The institute’s mission is to strengthen public policy through rigorous analysis of the most pressing social issues. The institute’s interdisciplinary staff of faculty and scientists historically informs policies related to poverty, social welfare, urban housing and an effective workforce. The institute, founded in 1987, offers a Masters of Arts in Public Policy through the Krieger School of Arts and Sciences to 35

Continued from page 1

IPS or more students each year. There are more than 80 students currently enrolled in the program. Michael J. Klag, dean of the Bloomberg School, said that the move will strengthen an already robust relationship. “IPS has a stellar reputation, and we have long admired the work of the faculty there both on the research and education fronts,” Klag said. “The institute has focused on health in the past, and I fully expect it will increasingly do more on urban health issues and extend its mission into health policy. This move will certainly create new syner-gies.” Klag said the move will also strengthen the Bloomberg School’s ties with the Home-wood campus and facilitate even greater col-laboration and scholarly interactions with Homewood faculty and students. School of Public Health faculty currently teach courses in the School of Arts and Science’s Public Health Studies program, which is one of the most popular undergraduate majors. “This gives us an exciting new bridge to

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Homewood as we’ve never had a physical location there,” he said. The institute will transition to its new home in the Department of Health Policy and Management in the current academic year. Since July 2009, Donald Steinwachs, a professor in the Department of Health Pol-icy and Management, has served as interim director of the Institute for Policy Studies. Steinwachs, who succeded longtime director Sandra Newman, will continue in his role until a permanent replacement is found. A search is expected to commence later this year. Steinwachs said he is very excited about the future of the institute and lauded the investment in its work. “This is a great opportunity to strengthen the IPS faculty and become involved very broadly across the university, through both education and research, as we continue to make significant contributions to the sci-ence of policy development, implementa-tion and evaluation,” he said. G

Trauma center care not only saves lives, it is a cost-effective way of treating major trauma, according

to a new report from the Johns Hopkins Bloomberg School of Public Health’s Center for Injury Research and Policy. Although treatment at a trauma center is more expensive, the authors say, the benefits of this approach in terms of lives saved and quality of life-years gained outweigh the costs. The study found that the added cost of treatment at a trauma center versus non-trauma center care is $36,319 for every life-year gained, or $790,931 per life saved; this is despite the fact that initial care in trauma centers is 71 percent higher than in non-trauma centers. While previous studies have found trauma center care decreases one’s likelihood of dying following injury, this is the most comprehensive study to date to also measure cost-effectiveness. The results are published in the July issue of The Journal of Trauma Injury, Infection and Critical Care. “In today’s economic and health care cli-mates, it is critical to determine whether the benefits of expensive therapies warrant their higher costs,” said Ellen MacKenzie, the Fred and Julie Soper Professor and chair of the Department of Health Policy and Man-agement at the Bloomberg School. “Taken together with our previous work demon-strating the effectiveness of trauma centers in saving lives, the results unequivocally support the need for continued efforts and funding for regionalized systems of trauma care in the United States.” The report found that while trauma cen-ter care is cost-effective for all patients taken together, it is of particular value for people younger than 55 years and for those with very severe injuries. The costs per life-year gained are higher for patients with less severe injuries. These results underscore the importance of designing trauma systems that assure that patients are taken to the level of care appropriate to their needs. Taking

the less severely injured to a lower level of trauma care will yield lower overall costs and increased efficiency in the system. Richard Hunt, director of the Division of Injury Response in the National Center for Injury Prevention and Control at the Centers for Disease Control and Preven-tion, said, “Each year in the United States, more than 2 million people are hospitalized for treatment of a traumatic injury. Because injuries often happen in children and young adults, the years of potential life lost are significant. We know that getting the most critically injured patients the right care, at the right place, at the right time can help save lives,” he said. To determine cost-effectiveness, the researchers used three metrics: cost per life

Public health: Trauma center care found to be cost-effectivesaved, cost per life-year gained and cost per quality-adjusted life-year gained. A total of 5,043 patients contributed to the cost-effectiveness analysis from 69 participating hospitals (18 trauma centers and 51 non-trauma centers) across 14 states. In addi-tion to care received in the hospital, costs associated with hospital transport, treatment at transferring hospital, rehospitalizations for acute care, inpatient rehabilitation, stays in long-term facilities, outpatient care and infor-mal care from friends or family members were accounted for when estimating cost. Lifetime costs were modeled using age-specific estimates of per capita personal health expen-ditures for the general U.S. population and limited data on the impact of specific types of injuries on lifetime health care expenditures.

While the value of a year of life is the subject of considerable debate, MacKenzie noted that the cost per life-year saved at a trauma center ($36,319, or $790,931 per life) are “well within an acceptable range of other cost-effective life-saving interventions reported in the literature.” For example, a threshold of $50,000–$100,000 per year is often justified based on the cost-effective-ness of renal dialysis. Additional authors of the study include Daniel O. Scharfstein of the Bloomberg School. The research was funded by the Johns Hopkins Center for Injury Research and Prevention, the Centers for Disease Control and Prevention and the National Institute on Aging. —Tim Parsons


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Dinners

Next week, 40 more undergraduates will visit Newman’s house through the Zelicof Family Dinners with the Dean, a new pro-gram offering students and their professors who are in for-credit Krieger School courses a chance to get together outside the class-room. “My feeling about these programs is that they do some of what we are try-ing to encourage more of at Hopkins, to have informal fun meetings with profes-sors, especially in the humanities, where professors can speak passionately about something that they know about,” said Steven David, vice dean for undergraduate education. “In the case of the Four-Course Din-ners,” he said, “it’s often with students who are not majoring in that area to expose them to something new, to expose a biol-ogy or biophysics major to film or political science or Jewish humor. It’s all about good food and good conversation in an informal setting.” The Monday sessions of the Four-Course Dinners are full with 25 students, and the other two nights are nearly at capacity, said Jaclyn Cohen, program coordinator for the Four-Course Dinners. Students can e-mail Cohen at [email protected] to sign up for the remaining spots. Cohen said they are capping the events to ensure they are conducive to interaction. “The students really want to discuss and learn together, not simply listen to lectures,” said Cohen, a graduate student in Spanish in the Department of German and Romance Languages and Literatures. “The goal is to reach out to any undergraduate at Hopkins. The main point of the program is to spark an interest in the humanities, so I have adver-

tised it to the Whiting School as well. Last semester, we did have a lot of engineering students attend, and they loved it.” The schedule for the Zelicof Family Din-ners with the Dean is still being finalized, but the first group—students of David’s, a political science professor—will call on Tuesday, Sept. 21. Both the Four-Course Dinners and the Zeli cof Family Dinners with the Dean are funded by Caren Zelicof, who earned her bachelor’s degree from the Krieger School in 1986, currently serves on the Alumni Coun-cil and is a national chair emeritus of the Second Decade Society, the school’s alumni leadership development organization. When Zelicof marked the end of her tenure as chair of the society with a donation to the univer-sity, Paula Burger, then dean of undergradu-ate education, suggested using the funds to experiment with initiatives to create a more robust sense of community on campus, and the Four-Course Dinners program was born, said Monica Butta, director of the Second Decade Society. Recently, when Zelicof made a new dona-tion to mark her 25th anniversary as a Johns Hopkins alumna, Newman, who is such a big fan of the Four-Course Dinners that she wanted to host some of the gatherings in her home, suggested the creation of the Zelicof Family Dinners with the Dean. Newman said that both dinner programs give undergraduates something they crave: more one-on-one time with their professors, and a greater sense of community. The same factors motivated the dean to want to live in a nearby neighborhood. “I chose this home because it’s so close to campus, and it’s huge,” Newman said. “I moved into it because what I was looking for was an opportunity to open up my home to students and faculty to increase the interac-tion between the two populations. I want everyone to think of my home as a people’s house.” The homecoming begins tonight with

Four-Course Dinners’ Chewing on Faith and Criticism: The Academic Study of the Bible, with Theodore Lewis, the Blum-Iwry Professor in Near Eastern Studies. On Tuesday, it’s Four Questions about Yid-dish Humor, with Marc Caplan, the Zelda and Myer Tandetnik Professor in Yiddish Language, Literature and Culture in the Department of German and Romance Lan-

guages and Literatures; and on Wednesday, it’s Four European Film Movements, with Bernadette Wegenstein, a research professor in the Department of German and Romance Languages and Literatures. The remaining three weekly 90-minute meetings of all Four-Course Dinners will take place in Charles Commons, in Nolan’s private dining hall.

B y k A r e n B L u m


Scientists at the Johns Hopkins Kimmel Cancer Center have identified two genes whose muta-tions appear to be linked to ovar-ian clear cell carcinoma, one of

the most aggressive forms of ovarian cancer. Clear cell carcinoma is generally resistant to standard therapy. In an article published online in the Sept. 8 issue of Science Express, the researchers report that they found an average of 20 mutated genes per each ovarian clear cell cancer incidence studied. Two of the genes were more commonly mutated among the samples: ARID1A, a gene whose product normally suppresses tumors, and PPP2R1A, an oncogene that, when altered, helps turn normal cells into tumor cells. ARID1A mutations were identified in more than half the tumors studied, and, according to Sian Jones, a research associate at the Johns Hopkins Kimmel Cancer Center, “this gene may play a significant role in this type of cancer.”

The researchers say that ARID1A and PPP2R1A had not previously been linked to ovarian cancer, and “they may provide opportunities for developing new biomark-ers and therapies that target those genes,” said Nickolas Papadopoulos, an associate professor of oncology and director of Trans-lational Genetics at the Ludwig Center for Cancer Genetics and Therapeutics at the Johns Hopkins Kimmel Cancer Center. For the study, the scientists evaluated mutations in 18,000 protein-encoding genes in ovarian clear cell tumors from eight patients at Johns Hopkins and at institu-tions in Taiwan and Japan. They purified the cancer cells and analyzed genes from those cells and from normal cells obtained from the blood or uninvolved tissues of the same patients. Researchers identified 268 mutations in 253 genes among the eight tumors, with an average of 20 mutations per tumor. Next, they determined the amino acid makeup, or sequences, of four genes with the most prevalent mutations, including ARID1A, in the tumor and normal tissues of an additional 34 ovarian clear cell cancer patients. Altogether, ARID1A mutations

Researchers identify genes tied to deadliest ovarian cancerswere identified in 57 percent of the 42 tumors. PPP2R1A mutations were found in 7.1 percent of the tumors. The landscape of cancer-related genes can be likened to a few “mountains” (highly prevalent mutations) among many “hills” (genes with less prevalence), said Papado-poulos, and “ARID1A is one of the biggest mountains found in recent years.” The protein encoded by ARID1A is a component of a cellular structure called a chromatin remodeling complex. Chromatin compresses DNA to make it fit inside cells and shields it from any other chemical sig-nals, providing a means for controlling how and when the DNA is read. When chro-matin gets remodeled, the components are shuffled and certain areas of DNA become exposed, allowing genes to be switched on or off. When the ARID1A gene is mutated, the chromatin remodeling complex is altered, allowing genes to be incorrectly switched on or off. The Johns Hopkins scientists say that mutated ARID1A can now be linked to so-called “epigenetic” changes—alterations to DNA occurring outside the genome; in this case, in the chromatin.

“The mutations in ARID1A provide an important new link between genetic and epigenetic mechanisms in human cancer and may help identify epigenetic changes which can be targeted with therapies,” said Victor Velculescu, an associate professor of oncology at the Johns Hopkins Kimmel Cancer Center. The researchers next plan to search for genes whose chromatin is specifically affected by ARID1A inactivation. Ovarian clear cell carcinoma accounts for about 10 percent of cancers that start in the cells on the surface of the ovaries. It mainly affects women ages 40 to 80 and is resistant to chemotherapy. Funding for this study was provided by the Dr. Miriam and Sheldon G. Adelson Medi-cal Research Foundation, AACR Stand Up to Cancer–Dream Team Translational Cancer Research Grant, Virginia and D.K. Ludwig Fund for Cancer Research, Depart-ment of Defense and National Institutes of Health. Additional study authors from Johns Hop-kins are Tian-Li Wang, Ie-Ming Shih, Rich-ard Roden, Luis A. Diaz Jr., Bert Vogelstein and Kenneth Kinzler.

Homewood Museum toasts the new academic year with the exhibition Cheers! The Culture of Drink in Early

Maryland and three Friday evenings of tra-ditional tastings. The opening reception is from 5 to 7 p.m. on Thursday, Sept. 16. Presenting more than 50 objects drawn from local private and public collections and the museum’s own holdings, the exhi-bition explores the visual and material culture of wine, spirits, beer and “cyder” in early Maryland’s finest homes, with an emphasis on Baltimore and Homewood’s Carroll family.

Homewood Museum opens exhibit on drink in early Md. Wine bottles, decanters, coasters, glass-ware, corkscrews, cellarettes and other related equipage, all created between 1790 and 1840, have been gathered to illustrate the vast array of tools used to heighten the delight of imbibing. The exhibition, open through Nov. 28, is on view as part of the museum’s regular guided tours. The tastings, from 5:30 to 7 p.m., are titled “Mad About Madeira” (Sept. 24), “The Wines of Maryland’s First Families” (Oct. 1) and “Historic Home Brews” (Oct. 8). For ticket information, go to http://museums .jhu.edu/calendar.php?type=special.

Need extra copies of ‘the Gazette’?A limited number of extra copies of The Gazette are available each week in the Office of Government, Community and Public Affairs, Suite 540, 901 South Bond St., in Fells Point. Those who know they will need a large number of newspapers are asked to order them at least a week in advance of publication by calling 443-287-9900.

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B y A m y L u n d A y

Homewood

Harvard Law School professor Michael J. Klarman will dis-cuss civil rights and civil lib-erties at The Johns Hopkins University’s 2010 Constitu-

tional Forum, a discussion of important legal issues held in conjunction with the annual observance of Constitution Day. During his talk, “A Skeptical View of Constitution Worship,” Klarman will dis-cuss how our civil rights and civil liberties depend a lot less on the Constitution and courts than one might think. The forum will take place at 8 p.m. on Thursday, Sept. 16, in Hodson Hall Audito-rium on the Homewood campus. An expert in constitutional law and his-tory with a particular focus on race, Klar-man is the Kirkland and Ellis Professor at Harvard Law School, where he joined the faculty in 2008. He received his bachelor’s and master’s degrees from the University of Pennsylvania, his doctorate from the Uni-versity of Oxford, where he was a Marshall Scholar, and his law degree from Stanford University. After law school, Klarman clerked for Ruth Bader Ginsburg on the U.S. Court of Appeals for the District of Columbia Cir-cuit. He joined the faculty at the University of Virginia School of Law in 1987 and served there until 2008 as the James Monroe Dis-tinguished Professor of Law and professor of history. Klarman has won numerous awards for his teaching and scholarship, which are primarily in the areas of constitutional law

and constitutional history. Klarman has also served as the Ralph S. Tyler Jr. Visiting Pro-fessor at Harvard Law School, Distinguished Visiting Lee Professor of Law at the Marshall Wythe School of Law at the College of Wil-liam and Mary, visiting professor at Stanford Law School and visiting professor at Yale Law School. His first book, From Jim Crow to Civil Rights: The Supreme Court and the Struggle for Racial Equality, was published by Oxford University Press in 2004 and received the 2005 Bancroft Prize in History. He pub-lished two books in the summer of 2007, also with Oxford University Press: Brown v. Board of Education and the Civil Rights

Law prof presents ‘A Skeptical View of Constitution Worship’

Michael J. Klarman

Movement and Unfinished Business: Racial Equality in American History, which is part of Oxford’s Inalienable Rights series. In 2009, Klarman was inducted into the American Academy of Arts and Sciences. The 2010 Constitutional Forum is sup-ported by the George Huntington Wil-liams Memorial Lectureship, which honors Johns Hopkins’ first professor of petrology. A pioneer in the microscopic study of rocks and minerals, Williams in the late 1880s founded what was then called the Depart-ment of Geology (now Earth and Planetary Sciences). In 1917, his family created an endowment in his memory for lectures by

distinguished public figures on topics of widespread contemporary interest. Speakers have included Archbishop Desmond Tutu and Russian President Boris Yeltsin. Klarman’s talk celebrates Constitution Day, Sept. 17, the day in 1787 when del-egates convened in Philadelphia to sign the U.S. Constitution. Additional informa-tion about Constitution Day may be found by searching the website of the National Archives, www.archives.gov. The 2010 Constitutional Forum at Johns Hopkins is sponsored by the Department of Political Science and the Office of Govern-ment, Community and Public Affairs.

Lab taps creativity of NASA/APL interns as well as experts

B y m i c h A e L B u c k L e y

Applied Physics Laboratory

Ten years ago, NASA’s Near Earth Asteroid Rendezvous mission made history as the first spacecraft to orbit

and land on an asteroid. Now the team behind that successful mission proposes a sequel that could pave the way for astronauts to explore an asteroid for the first time. Engineers and scientists at Johns Hopkins’ Applied Physics Laboratory have teamed up with NASA’s Goddard and Johnson space flight centers to devise Next Gen NEAR, a concept of a robotic precursor for a human visit to a near-Earth asteroid. In April, President Barack Obama announced a new direction for the nation’s space program, including plans for NASA to send the first human mission to an asteroid by 2025. This requires building a capability to live and work in deep space, beyond the Earth-moon system. Beyond our moon, asteroids near Earth—called near-Earth objects, or NEOs—are our closest and most accessible planetary neighbors, making them a practical stepping stone for expanded human space exploration. Only two missions—NEAR and Japan’s Hayabusa—have ever visited and touched the surface of a near-Earth object, and sci-entists say we need more insight into these objects before we can safely send humans. “We’ve learned a lot about NEOs using telescopes, Earth-based radar and two robotic missions, but we’d have to get up close and personal with a specific asteroid again, and learn much more about its environment, before we could send human explorers,” said James Garvin, chief scientist at Goddard Space Flight Center. “But there is nothing

intuitive about operating at an asteroid. In fact, sending humans to an asteroid would be one of the most challenging space missions ever. So to make sure we really understand that challenge, we’ve paired NASA experts in small-body robotic and human spaceflight with the only team in the U.S. to design, build and operate an asteroid-orbiter mission.” Planners say that the mission could be ready to launch as soon as 2014 and begin to return data from a target asteroid the fol-lowing year. The mission’s goal is to collect data on the asteroid’s surface and interior, and to scope out potential resources, as well as hazards to human visitors. “We can’t make these measurements by telescopic remote sensing from Earth or even by spacecraft flyby encounters or distant rendezvous,” said Andrew Cheng, chief scientist in APL’s Space Department, who also served as NEAR’s lead scientist and is on the Hayabusa team. Experts say that landing on a small body,

APL shapes ‘precursor’ mission for exploration of an asteroid

without an atmosphere or gravity, is com-pletely different from landing on a planet like Mars. Rob Landis, a NASA mission opera-tions specialist, said, “We’ve worked together to design the Next Gen NEAR concept of operations to parallel, to the extent possible, operations of a future human mission.” Added Paul Abell, of the Johnson Space Center and also a member of the NEAR and Hayabusa science teams, “A mission like this requires extensive science operations from close-in orbit, including contact with the surface.” The Next Gen NEAR spacecraft would run on commercially available subsystems and carry lightweight scientific instruments (such as a camera, composition-measuring spectrometers and even a surface-interac-tion experiment) with flight heritage. It would be fitted with solar power, propul-sion and communications systems that are compatible with launch on a medium-class

rocket toward any one of several targets. It would also have payload capacity to spare for a co-manifested mission, as was done with NASA’s Lunar Reconnaissance Orbiter/LCROSS spacecraft. “This is a simple, straightforward work-horse of a mission that can launch quickly in 2014, stay within tight cost and schedule constraints, and return the necessary data for less than the cost of a low-risk Discovery-class mission,” Cheng said. “It can provide the critical capability NASA needs for the Exploration Systems Mission Directorate’s new robotic-precursor exploration program even when budgets for such missions are being severely cut.” The project has captured the spirit of NASA’s Summer of Innovation, with interns at APL playing a key role in the Next Gen NEAR study. Challenged to design an aster-oid mission on a capped budget and tight schedule, 15 college interns worked in the APL concurrent engineering design center with senior engineers and scientists from APL, Goddard and the Johnson Space Cen-ter. Their innovative mission and spacecraft concepts contributed to Next Gen NEAR. “The experience and results of this study are a win-win for all stakeholders,” said Robert Gold, APL Space Department chief technol-ogist and NEAR mission payload manager. Daniel Kelly, the systems engineer on the intern team and an aerospace engineer-ing graduate student at the University of Michigan, said, “Everybody was fired up to work on this project. This joint team really clicked.” NEAR was the first mission to orbit an asteroid and—after a comprehensive year-long study that yielded more than 160,000 images and measurements of the geology, composition and geophysics of asteroid 433 Eros—the first mission to land on an aster-oid’s surface. Designed and built in just 26 months, the car-sized, solar-powered NEAR Shoemaker was one of 64 spacecraft APL has designed, built or operated over the past half-century.

an artist’s illustration shows the Next Gen Near spacecraft approaching a near-earth object. a concept based on the successful Near earth asteroid rendezvous mission, Next Gen Near could serve as a robotic ‘precursor’ for a human visit to a near-earth asteroid.

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Cloud

associated with building and running their own computer center,” said lead author Ben Langmead, a research associate in the Bloomberg School’s Department of Biosta-tistics. “With Myrna, we tried to make it easy for researchers doing RNA sequencing to reap these benefits.” To test Myrna, Langmead and colleagues Kasper Hansen, a postdoctoral fellow, and Jeffrey T. Leek, senior author of the study and an assistant professor in the Department of Biostatistics, used the software to process a large collection of publicly available RNA sequencing data. Processing time and stor-age space were rented from Amazon Web Services. According to the study, Myrna

calculated differential expression from 1.1 billion RNA sequencing reads in less than two hours at a cost of about $66. “Biological data in many experiments—from brain images to genomic sequences—can now be generated so quickly that it often takes many computers working simultaneously to perform statistical analyses,” Leeks said. “The cloud computing approach we devel-oped for Myrna is one way that statisticians can quickly build different models to find the relevant patterns in sequencing data and connect them to different diseases. Although Myrna is designed to analyze next-generation sequencing reads, the idea of combining cloud computing with statistical modeling may also be useful for other experiments that generate massive amounts of data.” The researchers were supported by grants from Amazon Web Services, the National Institutes of Health and the Johns Hopkins Bloomberg School of Public Health. G


Calendar

S E P T . 1 3 – 2 0


Computational Genomics seminar with Sarah Wheelan, SoM. 517 PCTB. hW

Mon., Sept. 13, 4 p.m. “The America of Luther Brooks: A Case of Slums, Paternalism and the Profits of Segregation,” a History seminar with Nathan Connolly, KSAS. 308 Gilman. hW

Mon., Sept. 13, 4 p.m. “Nodal Sets and Ergodic Eigenfunctions,” an Analysis/PCD seminar with Steve Zelditch, Northwestern University. Sponsored by Math-ematics. 304 Krieger. hW

Mon., Sept. 13, 4:30 p.m. “An Equivariant Main Conjecture and Applications,” a joint Topol-ogy/Algebraic Geometry/Number Theory seminar with Cristian Popescu, University of California, San Diego. Sponsored by Math-ematics. 300 Krieger. hW

tues., Sept. 14, noon. “Effects of Cross-Link Structure on Rep-lication-Independent DNA Inter-strand Cross-Link Repair in Mam-malian Cells,” a Biochemistry and Molecular Biology thesis defense

seminar with Erica Hlavin Bell. W1214 SPH. eB

tues., Sept. 14, 1 p.m. “Force, Cell-Cell Adhesion and the Regu-lation of Collective Cell Migra-tion,” a Center for Cell Dynamics seminar with Douglas DeSimone, University of Virginia. 490 Ran-gos. eB

tues., Sept. 14, 4:30 p.m. “Lin-ear-Time Dynamic Programming for Incremental Parsing,” a Center for Language and Speech Process-ing seminar with Liang Huang, University of Southern California. B17 CSEB. hW

tues., Sept. 14, 4:30 p.m. “Motives Over Symmetric Monoidal Categories,” an Alge-braic Complex Geometry/Number Theory seminar with Abhishek Banerjee, Ohio State University. 205 Krieger. hW

Wed., Sept. 15, noon. “Bed Bugs: Why They’re Back, and the Public Health Response,” a Mid-Atlantic Public Health Training Center seminar with Madeleine Shea, Baltimore City Health Dept., and Susan Jennings, Envi-ronmental Protection Agency. E2014 SPH. eB

Wed., Sept. 15, 12:15 p.m. “Three Generations of School-based Prevention Intervention Trials,” a Mental Health semi-nar with Nicholas Ialongo, SPH. B14B Hampton House. eB

Wed., Sept. 15, 3 p.m. M. Gordon Wolman Seminar—“UV Disinfectant of Drinking Water Treatment: Repair of Bacteria, Lamp Effect and Pilot-Testing” with Jiangyong Hu, National Uni-versity of Singapore. Sponsored by Geography and Environmental Engineering. 212 Dunning. hW

Wed., Sept. 15, 3 p.m. “Prob-ing Plasmonic-Photonic Interac-tions in Large-Area Nanoparticle Arrays for Improved SERS Sen-sors,” a Materials Science and Engineering seminar with Joshua Caldwell, Naval Research Labora-tory. 110 Maryland. hW

thurs., Sept. 16, noon. “Struc-tural Biology and Tropical Dis-eases,” a Molecular Microbiology and Immunology/Infectious Dis-eases seminar with Wim G.J. Hol, University of Washington. W1020 SPH. eB

thurs., Sept. 16, 1 p.m. “Syn-apse Discrimination and Classifi-cation by Array Tomography: The Synaptome Meets the Connec-tome,” a Neuroscience research seminar with Stephen Smith, Stanford University. West Lecture Hall (ground floor), WBSB. eB

thurs., Sept. 16, 4 p.m. “Sin-gle-Molecule Tracking to Map

ing seminar with Alan Russell, University of Pittsburgh. 709 Tray-lor. eB

Mon., Sept. 20, 4 p.m. The David Bodian Seminar—“Visual Search Gets Real: From the Lab to the Airport to the Radiology Suite” with Jeremy Wolfe, Harvard School of Medicine. Sponsored by the Krieger Mind/Brain Institute. 338 Krieger. hW

Mon., Sept. 20, 4 p.m. “Bleached Bones and Unclaimed Corpses: Burying the Dead in 19th-Century Jiangnan,” a History seminar with Toby Meyer-Fong, KSAS. 308 Gil-man. hW

Mon., Sept. 20, 4:30 p.m. “Manifolds of Trees, With Possible Applications to Biology,” a Topol-ogy seminar with Jack Morava, KSAS. Sponsored by Mathemat-ics. 300 Krieger. hW

S P e C I a L e V e N t S

Wed., Sept. 15, noon to 3 p.m. Community Involvement Fair, sponsored by SOURCE, with representatives from community-based organizations discussing ways to become involved. Free ice cream and prizes. E2030 SPH. eB

thurs., Sept. 16, 5 to 7 p.m. Opening reception for Cheers! The Culture of Drink in Early Mary-land. (See story, p. 5.) Homewood Museum. hW

the Dynamic Interior of Dendritic Spines,” a Biology seminar with Thomas Blanpied, University of Maryland School of Medicine. 100 Mudd. hW

thurs., Sept. 16, 4 p.m. “The Effects of the ‘Great Recession’ on New York City and Its Neighbor-hoods,” a Social Policy seminar with James Parrott, Fiscal Policy Institute, New York. Co-sponsored by IPS, Economics and Health Policy and Management. 132 Gil-man. hW

Mon., Sept. 20, 10 a.m. “Bring-ing Science to Policy: The Use of Research by Public Health Advo-cacy Organizations to Advance Policy Solutions,” a Health Policy and Management thesis defense seminar with Jonathan Kromm. 250 Hampton House. eB

Mon., Sept. 20, noon. “NMR Studies of Histone Chaperones and Nucleosomes,” a Biophysics seminar with Yawen Bai, National Cancer Institute. 111 Mergentha-ler. hW

Mon., Sept. 20, 12:15 p.m. “Seeing Through the Eyes of a Fish: Developmental and Genetic Control of Opsin Gene Expres-sion,” a Carnegie Institution Embryology seminar with Karen Carleton, University of Maryland. Rose Auditorium, 3520 San Mar-tin Drive. hW

Mon., Sept. 20, 1:30 p.m. “Directing and Killing Cells With Surfaces,” a Biomedical Engineer-

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Calendar

S E P T . 1 3 – 2 0


thurs., Sept. 16, 7 p.m. “Mark Twain’s America,” a one-man show by Ed Trostle, celebrating the 175th anniversary of Twain’s birth and the 100th anniversary of his death. Sponsored by Advanced Academic Programs. Admission is free but RSVP required; go to

www.greatthinkers.jhu.edu or call 410-516-4842. Shriver Hall Audi-torium. hW

thurs., Sept. 16, 8 p.m. The 2010 Constitutional Forum—“A Skeptical View of Constitution Worship” with Michael Klarman, Harvard Law School. (See story, p. 7.) 110 Hodson. hW

Sun., Sept. 19, 1 to 4 p.m. Sculpture at Evergreen Block Party, explore biennial outdoor sculpture exhibition, see performance art and meet an artist team who will host chalk drawing, a community photo wall and a lemonade stand at its urban park installation; visi-tors are invited to bring a picnic. (See “In Brief,” p. 2.) Evergreen Museum & Library.

S y M P o S I a

fri., Sept. 17, 12:30 to 3:30 p.m. “Population Pressures and the Health of the Chesapeake Bay: Can the Relationship Sus-

tain?” a Center for a Livable Future symposium on the impact of human activity on the health of the Chesapeake Bay, with panelists Brad Heavner, Environ-ment Maryland; Brian Schwartz, co-director of the Program on Global Sustainability and Health and the Joint Geisinger-JHSPH Environmental Health Institute; and Tom Horton, widely pub-lished nature author. W1214 SPH. eB

W o r K S h o P S

the Center for educational resources presents a series of

information sessions on the Black-board 9.1 interface. To register, go to www.bb.cer.jhu.edu. Garrett Room, MSE Library. hW

• Mon., Sept. 13, tues., Sept. 14, and fri., Sept. 17, 9:30 to 11:30 a.m. “Getting Started With Black-board.”

• Wed., Sept. 15, 9:30 to 11:30 a.m. “Blackboard Communication and Col-laboration.”

• thurs., Sept. 16, 9:30 to 11:30 a.m. “Assessing Stu-dent Knowledge and Manag-ing Grades in Blackboard.”


This is a partial listing of jobscurrently available. A complete list

with descriptions can be found on the Web at jobs.jhu.edu.

Job OpportunitiesThe Johns Hopkins University does not discriminate on the basis of gender, marital status, pregnancy, race, color, ethnicity, national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status, or other legally protected characteristic in any student program or activity administered by the university or with regard to admission or employment.

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h o m e w o o d 43015 LAN Administrator II43041 Software Engineer43060 DE Instructor, Center for Talented Youth43087 Assistant Program Manager, Center for Talented Youth43115 Residential Life Administrator43152 Tutor43244 Building Operations Supervisor43245 Building Maintenance Technician43250 Program Manager, Center for Talented Youth43403 Admissions Officer42291 Project Manager LDP42755 Stationary Engineer42771 Programmer Analyst42861 Financial Manager42942 Multimedia Technician43341 Sr. Technical Support Analyst43395 Research Service Analyst

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43097 Sr. Programmer Analyst43101 Accounting Aide43218 Alumni Relations Coordinator43251 Network Analyst43294 Research Service Analyst43298 Employee Assistance Clinician43336 Programmer Analyst43397 Data Assistant43405 Accountant43406 Sr. OD Specialist43411 Accounting Manager43442 Instructional Facilitator42958 Sr. Employer Outreach Coordinator

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44684 Biostatistician42973 Clinical Outcomes Coordinator43847 Sr. Programmer Analyst45106 Employment Assistant/Receptionist45024 Payroll and HR Services Coordinator42939 Research Data Coordinator43754 Malaria Adviser42669 Data Assistant44802 Budget Specialist44242 Academic Program Administrator44661 Sr. Research Program Coordinator45002 Research Observer44008 Manuscript Editor, American Journal of Epidemiology44005 Research Service Analyst41877 Health Educator44583 Multimedia Production Supervisor44715 Research Program Coordinator44065 Research Data Manager44112 Sr. Laboratory Coordinator44989 Sr. Research Assistant44740 Sr. Administrative Coordinator39063 Research Assistant44603 Budget Analyst

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2 & 3 bedroom apartments located in a private park setting. Adjacent to JohnsHopkins University Homewood Campus and minutes from downtown Baltimore.

Woodcliffe Manor ApartmentsSPA C I O U S G A R D E N A PA RT M E N T L I V I N G I N RO L A N D PA R K

NoticesProfessional Clothing Drive — The Office of Work, Life and Engagement invites the Hopkins community to donate new and gently used professional men and women’s clothing and handbags to formerly homeless, disabled and underprivileged individuals just entering or re-entering the workforce. Dona-tions will be collected through Sept. 21 in

support of the employment programs and services of the League for People with Dis-abilities, Million Dollar Man, Bea Gaddy’s Women and Children’s Center, Success in Style and Project PLASE. To locate a university drop-off site or to volunteer to coordinate the professional clothing drive at the White Marsh, SAIS or Bayview campuses, contact Brandi Monroe-Payton at 443-997-6060 or bmonroe6@jhu .edu. For general information, go to www .hopkinsworklife.org/community/clothing_drive.html.

Johns Hopkins–led team sees potential application for stem cell therapies

B y m A r y A L i c e y A k u T c h i k


Having charted the occurrence of a common chemical change that takes place while stem cells decide

their fates and progress from precursor to progeny, a Johns Hopkins–led team of scien-tists has produced the first-ever epigenetic landscape map for tissue differentiation. The details of this collaborative study by Johns Hopkins, Stanford and Harvard universities appeared Aug. 15 in the early online publication of Nature. The researchers, using blood-forming stem cells from mice, focused their investigation specifically on an epigenetic mark known as methylation. This change is found in one of the building blocks of DNA, is remembered by a cell when it divides and often is associ-ated with turning off genes. Employing a customized genomewide methylation-profiling method dubbed CHARM (for comprehensive high-through-put arrays for relative methylation), the team analyzed 4.6 million potentially methylated sites in a variety of blood cells from mice to see where DNA methylation changes occurred during the normal differentiation process. The team chose the blood cell sys-tem as its model because it’s well-understood in terms of cellular development. The researchers looked at eight types of cells in various stages of commitment, including very early blood stem cells that had yet to differentiate into red and white blood cells. They also looked at cells that are more committed to differentiation: the precursors of the two major types of white blood cells, lymphocytes and myeloid cells. Finally, they looked at older cells that were close to their ultimate fates to get more complete pictures of the precursor-progeny relationships—for example, at white blood cells that had gone fairly far in T-cell lym-phocyte development. “It wasn’t a complete tree, but it was large portions of the tree, and different branches,” said Andrew Feinberg, the King Fahd Professor of Molecular Medicine and director of the Center for Epigenetics at Johns Hopkins’ Institute for Basic Biomedi-cal Sciences. “Genes themselves aren’t going to tell us what’s really responsible for the great diversity in cell types in a complex organism like ourselves,” Feinberg said. “But I think epigenetics—and how it controls genes—can. That’s why we wanted to know what was happening generally to the levels of DNA methylation as cells differentiate.” One of the surprising finds was how widely DNA methylation patterns vary in cells as they differentiate. “It wasn’t a boring linear process,” Feinberg said. “Instead, we saw these waves of change during the development of these cell types.” The data show that when all is said and done, the lymphocytes had many

more methylated genes than myeloid cells. However, on the way to becoming highly methylated, lymphocytes experience a huge wave of loss of DNA methylation early in development and then a regain of methyla-tion. The myeloid cells, on the other hand, undergo a wave of increased methylation early in development and then erase that methylation later in development. Rudimentary as it is, this first epigenetic landscape map has predictive power in the reverse direction, according to Feinberg. The team could tell which types of stem cells the blood cells had come from because epigenetically those blood cells had not fully let go of their past; they had residual marks that were characteristic of their lineage. This project involved a repertoire of tal-ents, “none of whom were more integral than Irv Weissman at Stanford,” Feinberg said. “He’s a great stem cell biologist, and he lent a whole level of expertise that we didn’t have.” One apparent application of this work might be to employ these same techniques to assess how completely an induced pluri-potent stem cell has been reprogrammed. “You might want to have an incompletely reprogrammed cell type from blood, for example, that you take just to a certain point because then you want to turn it into a different kind of blood cell,” Feinberg said, cautioning that the various applications are strictly theoretical. Because the data seem to indicate discrete stages of cell differentiation characterized by waves of changes in one direction and subse-quent waves in another, cell types conceivably could be redefined according to epigenetic marks that will provide new insights into both normal development and disease processes. “Leukemias and lymphomas likely involve disruptions of the epigenetic landscape,” Feinberg said. “As epigenetic maps such as this one begin to get fleshed out by us and others, they will guide our understanding of why those diseases behave the way they do, and pave the way for new therapies.” The research was supported by the National Institutes of Health and a grant from the Thomas and Stacey Siebel Foundation. Johns Hopkins authors, in addition to Feinberg, are Hong Ji, Peter Murakami, Akiko Doi, Hwajin Lee, Martin J. Aryee and Rafael A. Irizarry.

Related websitesandrew feinberg discusses epigenetic map: www.youtube.com/ watch?v=odHAL67rAWk

andrew feinberg: www.hopkinsmedicine.org/ geneticmedicine/People/Faculty/ Feinberg.html

‘Nature’: www.nature.com/nature

DNa methylation query website: http://charm.jhmi.edu/hsc

Scientists map epigenetic changes during blood cell differentiation


ClassifiedsaPartMeNtS/houSeS for reNt

Baltimore City (Old Pimlico Rd), furn’d 2BR, 2BA condo in secure community, nr light rail/Summit Park ES, free prkng, swim-ming, tennis. $950/mo incl utils. Tinghuai, 443-846-8750 or [email protected].

Baltimore City, updated 1BR condo in secure gated community, assigned prkng, swimming, tennis, nr hospital and univer-sity; option to own ($135,000). $1,200/mo incl utils. 410-951-4750.

Bayview, 3BR, 1.5BA house w/new kitch-en and BAs, 2-car garage. $1,800/mo. [email protected] or https://sites .google.com/site/essexhouserental.

Canton, rehabbed 2BR, 2.5BA TH, second BR good size office or child’s rm, great loca-tion nr JHH. Courtney, 410-340-6762.

Cedonia, 1BR apt w/new kitchen and BA, walk-in closet, W/D, priv entrance, deck, landscaped fenced yd, free prkng, nr JHH/Homewood/Morgan State and public trans-portation, pets welcome. $710/mo + utils. 410-493-2435 or [email protected].

Charles Village, spacious 1BR apt, close to Homewood/JHMI shuttle, avail Oct 1. $782/mo + utils. 410-484-4224.

Charles Village, refurbished, spacious 1BR apt in Tudor-style bldg, hdwd flrs, kitchen w/new appls, high ceilings, 5-min walk to JHU shuttle/Homewood, lease Oct-Feb (renewable). $1,025/mo + utils. 443-248-1169 or [email protected].

Glen Burnie/Pasadena, waterfront w/boat-lift, 2 lg BRs, 1BA, open flr plan. $1,800/mo. Frank, 410-980-0686.

Hampden, 3BR, 2BA TH, dw, W/D, fenced yd, nr light rail. $1,100/mo + utils. 410-378-2393.

Hampden/Medfield, 4BR house, furn’d/unfurn’d, laundry, priv prkng, walk to cam-pus/shopping/public transit. $1,400/mo + utils. [email protected].

Lauraville, beautiful, sunny rm in historic neighborhood, nr JHH/JHU. $500/mo + utils. Melissa, 443-844-4094.

Little Italy TH. $1,800/mo. 410-578-0382 or [email protected].

Mt Vernon, spacious 2nd flr studio nr Peabody, great location, perfect for JHMI students/couples. $899/mo incl water. 443-691-1439 or [email protected].

Owings Mills, 2BR, 2BA condo, W/D, walk-in closets, storage, prkng, pool/tennis court privileges, backs to woods, conv to metro, walk to grocery, sm pets negotiable ($250 nonrefundable deposit), pics avail, 1-yr lease. $1,100/mo. 410-336-7952 or [email protected].

Rodgers Forge, 3BR TH in family neighbor-hood, good schools, conv location, no pets. $1,300/mo. [email protected].

Roland Park, cheerful, furn’d 3BR house, avail January-July, walk to Homewood, 15-min drive to medical school. http://tinyurl.com/2a83whe.

Roland Park, spacious, furn’d 2BR, 2BA condo in secure area, W/D, walk-in closet, pool, cardio equipment, .5 mi to Home-wood campus. $1,600/mo. 410-218-3547 or [email protected].

M A R K E T P L A C E

St Agnes Hospital area, 2BR, 1.5BA TH w/club bsmt. $900/mo + sec dep ($900). 443-244-5044.

2907 St Paul St, studio apt in great neigh-borhood, 2nd flr, safe and quiet, off-street prkng (w/additional fee). $675/mo incl heat, water. [email protected].

Waverly (E 33rd St at Westerwald Ave), spacious, remodeled 4BR, 1.5BA TH, partly furn’d, W/D, CAC/heat, alarm, storage, new deck, garage, no smokers/no pets, 2 blks to YMCA/Giant. $1,450/mo + sec dep. [email protected].

New studios (8) avail in secure historic bldg, nr JHU shuttle. $675/mo-$800/mo. [email protected].

Beautiful, lg 4BR, 2.5BA house, kitchen, living rm, dining rm, utility rm, full front porch, nr hiking/biking trails, 15 mins west of campus, need clean, responsible ten-ants. $2,000/mo. [email protected] (pics/info).

Furn’d rm in owner-occupied single-family house, safe neighborhood, free prkng, nr Owings Mills metro, convenient commute to JHMI, no smoking/no pets. [email protected].

Nice 3BR EOG TH, 2 full and 2 half-BAs, backs to trees on quiet street, 2 assigned prkng spaces, 5 mins to Owings Mills metro. 410-258-5338.

houSeS for SaLe

Arcadia/Beverly Hills (3019 Iona Terrace), spacious, renov’d 4BR, 2.5BA detached house in beautiful neighborhood, open kitchen/dining area, deck, landscaped, mins to Homewood campus. $229,900. 410-294-9220.

Old Greenbelt (suburban DC), quiet 1BR, co-op handles most maintenance. $122,000. www.39hridge.com.

Towson, 3BR, 2BA TH, easy commute to hospital or university. 443-615-4639 or www .homesbyriley.com/address.php?property_ID=699.

White Marsh (Baltimore County), renov’d 4BR, 2.5BA house nr mall, 2,900 sq ft, must see. $229,000. 410-241-8936.

3BR, 2BA Victorian shingle-style house, office, fp, AC, garage, nr Eddie’s (Roland Park), schools; buyer’s agent fine. 443-562-0595.

A Craftsman’s dream house, very close to all Johns Hopkins campuses/downtown; just reduced. Joe, 302-981-6947 or www .3402mountpleasantavenue.canbyours.com.

rooMMateS WaNteD

M wanted for 1BR, 1BA in 2BR, 2BA apt at 222 E Saratoga St, cable, WiFi, garage prkng for extra fee, avail until April 1. $800/mo incl utils. Matt, [email protected].

Rm in Canton (S Streeper St), great area, lots to do, share w/1 respectful roommate. $675/mo + utils. 970-576-5476 or [email protected].

F nonsmoker wanted to share new, spacious 4BR, 4.5BA TH in Canton, prking space

provided, no pets. $660/mo + 1/2 utils. [email protected].

F grad student/young prof’l wanted for furn’d 2-flr loft apt, 24-hr security, gym, laundry, nr University of Maryland/JHU/UB, nr JHU shuttle/metro, walk to Inner Harbor/Lexington Market, pref nonsmoker. $850/mo. 443-310-3450.

Share all new, refurbished TH w/other med students, 4BRs, 2 full BAs, CAC, W/D, dw, w/w crpt, 1-min walk to JHMI (924 N Broadway). [email protected].

M wanted to share 2BR, 2.5BA RH w/grad student, nr Patterson Park/JHMI/Bayview. [email protected].

CarS for SaLe

’97 Lincoln Town Car, loaded, garage-kept, nice and clean. $3,900. 410-980-0686.

’99 Toyota Camry LE, 4-cyl, automatic, in good cond, insp’d, 135K mi. $3,300. 410-916-5858.

’05 Jeep Liberty Renegade, 4x4, tan/beige, all options, dependable, 55K mi. $11,500/best offer. 240-401-6602.

’99 BMW 328i, maroon w/beige leather, premium sound, new battery and tires, excel cond, 42K mi. $10,000/best offer. alvin.stuff [email protected].

’01 Chevy Cavalier, automatic, blue, 2-dr, AC, needs muffler, 145K mi. $2,000/best offer. Laszlo, 443-825-2554.

IteMS for SaLe

Crib and mattress w/free bedding, $60; travel system incl infant carseat and stroller, $60; more. 443-418-7811 or [email protected].

3-pc full-size bedroom set, headboard w/drawers, bedframe, dresser w/mirror, chest; mattress not incl’d. $150. [email protected].

Sports equipment, full mattress and bed-spring w/frame, coffeemaker, kitchen tools, dishes, computer case, more. [email protected] (for complete list).

Gift card for Dick’s Sporting Goods, $105.98 value. $95/best offer (cash only). [email protected].

Lg collection of books, both old and new, fiction or nonfiction. $50. 443-912-3690.

Exercise rowing machine, $50; Conn alto saxophone, best offer; both in excel cond. 410-488-1886.

Werner aluminum ladders: $133 for 40' or $56 for 24'; Craftsman 10" radial arm saw, model# 22010, $300. 410-207-5467.

Comic book collection, 300+, mid-80s to mid-2000s, Marvel, DC and Image, kept in bags/boards, $300; Nintendo 32-bit game sys, w/console, controllers (2), gun, games (2), great cond, $100; ESP M-155 guitar, gunmetal blue, barely used, 15W Squier amp incl’d, $150; best offers accepted. [email protected].

Dansko shoes (2 pair): size 40, dk brown suede leather, and size 39, black leather,

Classified listings are a free ser-vice for current, full-time Hop-kins faculty, staff and students only. Ads should adhere to these general guidelines:

• Oneadperpersonperweek.A new request must be submitted for each issue. • Adsarelimitedto20words, including phone, fax and e-mail.

• WecannotuseJohnsHopkins business phone numbers or e-mail addresses.• Submissionswillbecondensedat the editor’s discretion. • DeadlineisatnoonMonday, one week prior to the edition in which the ad is to be run.• Realestatelistingsmaybeoffered only by a Hopkins-affiliated seller not by Realtors or Agents.

(Boxed ads in this section are paid advertisements.)Classified ads may be faxed to 443-287-9920;e-mailedinthebody of a message (no attach-ments)[email protected];ormailed to Gazette Classifieds, Suite540,901S.BondSt.,Bal-timore, MD 21231. To purchase a boxed display ad, contact the GazelleGroupat410-343-3362.

PLaCING aDS

both in lightly worn cond. $50/ea or best offer. Joyce, 410-493-1045.

SerVICeS/IteMS offereD or WaNteD

Seeking piano teacher for student familiar w/Taubman technique, student is 88 yrs old and lives in Homeland (Baltimore City); ideally lessons would take place in her home. 410-444-1273.

Prof’l Hopkins couple looking to house- or pet-sit during the month of October, hon-est, capable, dependable, clean homeown-ers w/excel refs. 443-527-8869 or [email protected].

Guitar lessons by accomplished guitarist w/5 yrs’ experience, seeking beginner and advanced students, all ages welcome, rea-sonable rates. 410-889-4228.

Weekend help wanted for fall planting in Reisterstown—planting sm trees/shrubs, spreading mulch; you provide references, I’ll provide transportation/food/drinks. $50 per day. [email protected].

Flea mart, Saturday, Sept 18, 8am-noon at 37th and Roland Ave (Hampden/Home-wood area, nr Rotunda); also quarter auc-tion from noon to 3pm. 410-366-4488 or [email protected].

Expert clock restoration and repair. Rich, 215-465-5055 or [email protected].

Licensed landscaper avail for scheduled lawn maintenance, other landscaping services, trash hauling, fall/winter leaf and snow removal. Taylor Landscaping LLC. 410-812-6090 or [email protected].

Free ballroom dancing and lessons (waltz, rumba, tango), Fridays at 8pm at JHU ROTC bldg, everyone welcome. Anne or Dave, 410-599-3725.

Great photos! Headshots for interviews/auditions, family pictures, production shots, events. Edward S Davis photogra-phy and videography. 443-695-9988 or [email protected].

Seamstress available for clothes alterations and window treatments. 443-604-2797 or [email protected].

Piano lessons w/Peabody doctorate, all lev-els/ages welcome. 410-662-7951.

Tutor available: all subjects/levels; reme-dial, gifted and talented; can also help w/college counseling, speech and essay writ-ing, editing, proofreading, database design and programming. 410-337-9877 or [email protected].

Affordable landscaper/certified horticultur-ist available to maintain existing gardens, also design, planting or masonry; free con-sultations. David, 410-683-7373 or grogan [email protected].

Residential cleaning service, move in/move out, we do it all, reasonable rates, free esti-mates, pet-friendly. 443-528-3637.

Quality, personalized horse avail at Bel Air farm, lessons on our horse or yours w/qualified instructor. $325 (full care) or $250 (partial care). www.baymeadowfarm.net.

Piano tuning and repair, PTG craftsman serving Peabody, Notre Dame, homes, churches, etc, in central MD. 410-382-8363 or [email protected].

WYMAN COURTBeech Ave. adj. to JHU!

Studio from $570 1 BD Apt. from $675

2 BD from $785

HICKORY HEIGHTSHickory Ave. in Hampden,

lovely Hilltop setting! 2 BD units from $750,

or, with Balcony - $785!

Shown by appointment - 410-764-7776 www.BrooksManagementCompany.com

Buying, Selling or Renting? “Leave all your worries to me.” Maria E. Avellaneda Realtor & MD Certified Interpreter www.mariaismyagent.com 410-672-3699 908-240-7792


Calendar B L o o D D r I V e

tues., Sept. 14, and Wed., Sept. 15, 7:30 a.m. to 5:45 p.m. Sickle Cell Awareness Month blood drive at Homewood. Sched-ule a donation online at http://hopkinsworklife.org/community/ blood_drive.html or call 443-997-6060. Glass Pavilion, Levering. hW

C o L L o Q u I a

tues., Sept. 14, 4 p.m. “The BioNecroPolitics of Omnilife: Aftermaths of War in Guatemala,” an Anthropology colloquium with Diane Nelson, Duke University. 400 Macaulay. hW

Wed., Sept. 15, 4:30 p.m. “Understanding the Complexity of Light Signaling Through Mel-anopsin Photoreceptors,” a Biol-ogy colloquium with Samer Hat-tar, KSAS and SoM. Mudd Hall Auditorium. hW

thurs., Sept. 16, 3 p.m. “An Evolving Utopia: The Cultural Work of the Evening Primrose in Early 20th-Century America,” a History of Science and Technol-ogy colloquium with Jim Endersby, University of Sussex, UK. 300 Gil-man. hW

thurs., Sept. 16, 3 p.m. “Top Quark as a Window to New Phys-ics,” a Physics and Astronomy colloquium with Petar Maksimo-vic, KSAS. Schafler Auditorium, Bloomberg Center. hW

C o N f e r e N C e S

tues., Sept. 14, noon. “Devel-oping Mental Health Treatment Guidelines for Low-Income Coun-tries,” a Psychiatry research con-ference with Graham Thornicroft, King’s College London. 1-191 Meyer. eB

thurs., Sept. 16, 9 a.m. to 5 p.m. “Closing the Gender Gap: Global Perspectives on Women in the Boardroom,” a SAIS Center for Transatlantic Relations conference with participants including govern-ment officials, academics, corpo-rate executives, institutional inves-tors and advisers, stock exchange representatives and associations of women directors. Registration and continental breakfast begin at 8 a.m. For information or to RSVP, go to http://transatlantic.sais-jhu .edu/events/2010/gender_conf .htm. Co-sponsored by Corporate Women Directors International, EuropeanPWN, Women Corpo-rate Directors, ION, Vital Voices Global Partnership and Women’s Foreign Policy Group. Kenney Auditorium, Nitze Bldg. SaIS

D I S C u S S I o N / t a L K S

Mon., Sept. 13, 5 p.m. “Japan Economic Outlook: From Sweet Spot to Sweat Spot,” a SAIS International Economics discus-sion with Robert Feldman, Mor-gan Stanley MUFG. 500 Bern-stein-Offit Building. SaIS

Mon., Sept. 20, 5:30 p.m. “The Frugal Superpower: America’s Global Leadership in a Cash-Strapped Era,” a SAIS American Foreign Policy Program discussion of Michael Mandelbaum’s book of the same name, with Eliot Cohen, director, SAIS Strategic Studies Program; Eric Edelman, Philip Merrill Center for Strategic Stud-ies; and Walter Shapiro, author and political columnist, Politics Daily. For information or to RSVP, e-mail [email protected] or call 202-663-5790. Rome Auditorium. SaIS

G r a N D r o u N D S

Mon., Sept. 13, 8:30 a.m. “Pre-vention of Venous Thromboem-bolism—The Johns Hopkins VTE Collaborative 2010,” Pathology Grand Rounds with Michael Stre-iff, SoM. Hurd Hall. eB

L e C t u r e S

Wed., Sept. 15, 4:30 p.m. “Miss HIV and Us: Beauty Queens Against the HIV/AIDS Pan-demic,” a Women, Gender and Sexuality lecture by Neville Hoad, University of Texas at Austin. Co-sponsored by English. 113 Green-house. hW

thurs., Sept. 16, 6 p.m. “The Baroque Tsunami: An Event Analysis of Neo-Baroque Form,” a German and Romance Languages and Literatures lecture by Gregory Lambert, Syracuse University. 479 Gilman. hW

thurs., Sept. 16, 7:30 a.m. The Leaders + Legends Series—“A Society Divided: The Grow-ing Wealth Gap and the Role of American Business” by Robert L. Johnson, founder and chairman of RLJ Cos. and Black Entertainment Television. (See story, this page.) Sponsored by the Carey Business School. Legg Mason Tower, Har-bor East.

Mon., Sept. 20, 2 to 4 p.m. The Beatrice and Jacob H. Conn Lec-ture in Regenerative Medicine—“Reprogramming and Pluripotent Stem Cells” by George Daley, Har-vard Stem Cell Institute/Harvard Medical School. Sponsored by the Institute for Cell Engineering. Owens Auditorium, CRB2. eB

M u S I C

Sun., Sept. 19, 3 p.m. Keng-Yuen Tseng, chair of the Peabody Conservatory’s Strings Depart-ment, will give the first public per-formance on the Kostoff Maggini, a 17th-century violin donated by Karl Kostoff to Peabody. $15 gen-eral admission, $10 for senior citi-zens and $5 for students with ID. Goodwin Recital Hall. Peabody

o P e N h o u S e S

Mon., Sept. 13, 6:25 to 8 p.m. Open house and reception for the Certificate on Aging pro-gram. RSVP to 410-516-4842 or [email protected]. Sponsored by Advanced Academic Programs. 3 Shaffer. hW

r e a D I N G S / B o o K t a L K S

Mon., Sept. 20, noon. Chris-tine Keiner, Rochester Institute of Technology and author of The Oys-

ter Question, will discuss her book and plans for oyster aquaculture in the Chesapeake Bay. Sponsored by the Center for a Livable Future. W3030 SPH. eB

Mon., Sept. 20, 5 p.m. World War II survivor Henny Brenner will read from her book, The Song Is Over: Survival of a Jewish Girl in Dresden. Co-sponsored by the Leonard and Helen R. Stulman Program in Jewish Studies and by German and Romance Languages and Literatures. Smokler Center. hW

r e L I G I o N

yom Kippur Services—fri., Sept. 17, and Sat., Sept. 18. Conservative and Reform services sponsored by Hillel of Greater Baltimore; Orthodox by Chabad of Central Baltimore. Reform ser-vice in the evening only. Pre-fast meal for students, Smokler Cen-ter, $17; break-fast meal, Lever-ing, free for students. Advance registration required for both meals. Register at www.hopkin-shillel.org. hW

Conservative. Led by Jewish Theo-logical Seminary student Rabbi Ravid Tilles; Glass Pavilion, Levering. fri., Kol Nidre, 6:45 p.m.; Sat., 9:15 a.m.; Yizkor, approx. 11:30 a.m.; rabbi’s dis-cussion, 4:30 p.m.; Mincha, 5:30 p.m.; Neilah, 6:30 p.m., Shofar, 7:53 p.m.

Reform. Led by Rabbi Debbie Pine, director of Hopkins Hillel; Smokler Center. fri., Kol Nidre, 6:45 p.m.

Orthodox. Led by Rabbi Zev Gopin; Inn at the Colonnade, 4 W. University Parkway. fri., Kol Nidre, 7 p.m.; Sat., 9:30 a.m.; Yizkor, approx. 11 a.m.; Mincha and Neilah, 6 p.m.

S e M I N a r S

Mon., Sept. 13, noon. “Molec-ular Recognition of Chromatin: Crystal Structure of the Chro-matin Factor RCC1 in Complex With the Nucleosome Core Par-ticle,” a Biophysics seminar with Song Tan, Penn State University. 111 Mergenthaler. hW

Mon., Sept. 13, noon. “SUMO-Targeted Ubiquitin Ligases as Molecular Selectors,” a Biochem-istry and Molecular Biology semi-nar with Amir Orian, Technion-Israel Institute of Technology. W1020 SPH. eB

Mon., Sept. 13, 2:30 p.m. “Top Five Mistakes Made Using Biolog-ical Programs: Crimes Commit-ted Using BLAST,” a Center for

S E P T . 1 3 – 2 0

BET founder Robert L. Johnson to give Leaders + Legends talk

(Events are free and open to the public except where indicated.)

BrB Broadway Research BuildingCrB Cancer Research BuildingCSeB Computational Science and Engineering BuildingeB East BaltimorehW HomewoodKSaS Krieger School of Arts and SciencesPCtB Preclinical Teaching BuildingSaIS School of Advanced International StudiesSoM School of MedicineSoN School of NursingSPh School of Public HealthWBSB Wood Basic Science Building

CalendarKey

B y A n d r e W B L u m B e r G

Carey Business School

Robert L. Johnson, founder and chairman of the RLJ Cos. and Black Entertainment Television, is the featured speaker at the Johns Hopkins Carey Business School’s Leaders + Legends lec-

ture series on Thursday, Sept. 16. The event will be held from 7:30 to 9 a.m. at the Legg Mason Tower in Harbor East. Johnson’s remarks are titled “A Society Divided: The Growing Wealth Gap and the Role of American Business.” Core assets of the RLJ Cos. include RLJ Development, a privately held hotel real estate investment company; RLJ Select Investments; RLJ Equity Partners, a private equity fund formed in association with the Carlyle Group, a global private equity firm; Urban Trust Bank, a federal thrift institution; Rollover Systems, a provider of outsourced retire-

ment plan rollover services; Our Stories Films, a film production studio producing urban comedies and family dramas geared toward an African-American audience; Casino and Gaming Entertainment; and RLJ/McLarty Landers Automotive, a part-nership with dealerships in the Southeast and Midwest.

Before forming the RLJ Cos., John-son was founder and chairman of Black Entertainment Television, the nation’s first television network providing enter-tainment, music, news, sports and public affairs programming geared to an Afri-can-American audience. Under his lead-

ership, BET, launched in 1980, became the first African-American-owned company publicly traded on the New York Stock Exchange. In 2001, Johnson sold the cable network to Viacom for approximately $3 billion and remained chief executive officer through 2006. In 2003, Johnson purchased the Charlotte Bobcats of the National Basketball Association, becoming the first African-American to own a major league sports franchise. In July 2007, he was chosen by USA Today as one of the 25 most influential business leaders of the past 25 years. Johnson’s board affiliations include KB Home, Lowe’s Cos., Interna-tional Management Group and Deutsche Bank Advisory Committee. Johnson earned a bachelor’s degree in social studies from the Uni-versity of Illinois and a master’s degree in international affairs from the Woodrow Wilson School of Public and International Affairs at Prince-ton University. The Leaders + Legends monthly breakfast series, which features today’s most influential business and public policy leaders addressing topics of global interest and importance, is designed to engage business and community professionals in an examination of the most compelling issues and challenges facing society today. Admission to the lecture, which includes breakfast, is $35. To register and for more information, go to carey.jhu.edu/leadersandlegends.

tues., Sept. 14, 5 p.m. “EU For-eign Policy Making After Lisbon,” a SAIS European Studies Program discussion with Sergio Fabbrini, University of Trento, Italy/Univer-sity of California, Berkeley. Rome Auditorium. SaIS

Wed., Sept. 15, noon. “Reporting From China,” a SAIS International Reporting Project panel discussion with Rana Foroohar, deputy edi-tor, Newsweek; Joseph Frolik, chief editorial writer, The Plain Dealer; Elizabeth Krist, senior photo edi-tor, National Geographic; and Peter Thomson, environmental editor, BBC/PRI’s The World. Co-spon-sored by the SAIS China Studies Program and National Geographic. For information or to RSVP, e-mail [email protected] or call 202-663-7726. Rome Auditorium. SaIS

Wed., Sept. 15, 12:30 p.m. “The United States at the United Nations and Beyond: A World of Transna-tional Challenges,” a SAIS Inter-national Development Program

discussion with Esther Brimmer, assistant secretary of state for inter-national organization affairs. (See “In Brief,” p. 2.) Co-sponsored by the SAIS International Law and Organizations Program. Kenney Auditorium, Nitze Bldg. SaIS

thurs., Sept. 16, 4:30 p.m. “Burma and U.S.–China Rela-tions,” a Reischauer Center for East Asian Studies panel dis-cussion with Quansheng Zhao, American University, and Kent Calder (moderator), director, Reischauer Center. To RSVP, e-mail [email protected]. 806 Rome Bldg. SaIS

fri., Sept. 17, 9:15 a.m. to 5 p.m. “Evaluating Peacebuild-ing and Promoting Learning,” a SAIS Conflict Management Pro-gram panel discussion with various speakers. For information, go to https://salsa.wiredforchange.com/ o/6060/p/salsa/event/common/public/?event_KEY=18540. Ken-ney Auditorium, Nitze Bldg. SaIS

Continued on page 8

robert L. Johnson

The Gazette

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