The 7 steps of Homology modeling. 1: Template recognition and initial alignment.

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The 7 steps of Homology modeling
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    20-Dec-2015
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Transcript of The 7 steps of Homology modeling. 1: Template recognition and initial alignment.

Page 1: The 7 steps of Homology modeling. 1: Template recognition and initial alignment.

The 7 steps of Homology modeling

Page 2: The 7 steps of Homology modeling. 1: Template recognition and initial alignment.

1: Template recognition and initial alignment

Page 3: The 7 steps of Homology modeling. 1: Template recognition and initial alignment.

1: Template recognition and initial alignment

2: Alignment correction

Page 4: The 7 steps of Homology modeling. 1: Template recognition and initial alignment.
Page 5: The 7 steps of Homology modeling. 1: Template recognition and initial alignment.

1: Template recognition and initial alignment

2: Alignment correction

Page 6: The 7 steps of Homology modeling. 1: Template recognition and initial alignment.

1: Template recognition and initial alignment

2: Alignment correction

3: Backbone generation

Page 7: The 7 steps of Homology modeling. 1: Template recognition and initial alignment.

1: Template recognition and initial alignment

2: Alignment correction

3: Backbone generation

4: Loop modeling

Page 8: The 7 steps of Homology modeling. 1: Template recognition and initial alignment.

4: Loop modeling

Known structure GVCMYIEA---LDKYACNC

Your sequence GECFMVKDLSNPSRYLCKC

Page 9: The 7 steps of Homology modeling. 1: Template recognition and initial alignment.

1: Template recognition and initial alignment

2: Alignment correction

3: Backbone generation

4: Loop modeling

5: Sidechain modeling

Page 10: The 7 steps of Homology modeling. 1: Template recognition and initial alignment.

1: Template recognition and initial alignment

2: Alignment correction

3: Backbone generation

4: Loop modeling

5: Sidechain modeling

6: Model optimization

Page 11: The 7 steps of Homology modeling. 1: Template recognition and initial alignment.

1: Template recognition and initial alignment

2: Alignment correction

3: Backbone generation

4: Loop modeling

5: Sidechain modeling

6: Model optimization

7: Model validation

Page 12: The 7 steps of Homology modeling. 1: Template recognition and initial alignment.

1: Template recognition and initial alignment

2: Alignment correction

3: Backbone generation

4: Loop modeling

5: Sidechain modeling

6: Model optimization

7: Model validation

8: Iteration

8: Iteration

8: Iteration

8: Iteration

Page 13: The 7 steps of Homology modeling. 1: Template recognition and initial alignment.

Model!

1: Template recognition and initial alignment

2: Alignment correction

3: Backbone generation

4: Loop modeling

5: Sidechain modeling

6: Model optimization

7: Model validation

8: Iteration

8: Iteration

8: Iteration

8: Iteration

Page 14: The 7 steps of Homology modeling. 1: Template recognition and initial alignment.

7 steps of homology modeling

1: Template recognition and initial alignment2: Alignment correction3: Backbone generation4: Loop modeling5: Side-chain modeling6: Model optimization7: Model validation8: Iteration

Alignment

Modeling

Correction