T.C.Republic of Turkey Ministry of

Agriculture and ForestryGeneral Directorate of Food and Control

Department of Veterinary Health Products and PublicHealth

01 March 2019/ANKARA

Mustafa BEBEKGeneral Directorate of Food and Control

Head of Department of Veterinary Health Products and Public Health

Symposium of Current Problems of Poultry Endustry-Current Status of Veterinary Medical Products in

Turkey

ANIMAL NUMBERS

17.220.903

46.117.399

0

10.000.000

20.000.000

30.000.000

40.000.000

50.000.000

2018 YEAR CATTLE AND VE SHEEP AND GOAT NUMBER

CATTLE

SHEEP AND GOAT

108.076

133.953

30.837

0

20.000

40.000

60.000

80.000

100.000

120.000

140.000

160.000

2018 YEAR EQUIDE NUMBER

HORSE

DANKEY

MULE

229.506.689

124.054.810

5.656.3630

50.000.000

100.000.000

150.000.000

200.000.000

250.000.000

2018 YEAR POULTRY NUMBER

BROILER

LAYING HEN

OTHER 1.708

697.300

0

200.000

400.000

600.000

800.0002018 YEAR OTHER ANIMAL NUMBER

CAMEL

DOG

44 tesis 14 tesis

32

26

• Integration of EU Regulations,GMP (Good ManufacturingPractices) required for theproduction of veterinarymedicinal products in 2011

• In Turkey, GMP required for theproduction of veterinarymedicinal products since 01November 2015

GOOD MANUFACTURING PRACTICES

668

169

PIC/S GMP Product Number with AcceptedCertificateı

VeterinaryBiological Products

Pharmacetical

GOOD MANUFACTURING PRACTICES (GMP)

2018 GMP Audits

Total104

Abroad89Domestic

15

1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

2 2 2 2

3 3

4

5

7

9 9

10

15

0

2

4

6

8

10

12

14

16

Bu

lga

rist

an

Çin

Esto

nya

Fin

lad

iya

hır

vati

sta

n

Hin

dis

tan

isra

il

İsvi

çre

Ko

re C

um

hu

riye

ti

Ma

cari

sta

n

Ma

lta

Me

ksik

a

No

rve

ç

Ru

sya

Uru

gua

y

Yen

iZe

lan

da

Avu

stu

rya

Bre

zily

a

Çek

ya

İrla

nd

a C

um

hu

riye

ti

Be

lçik

a

Po

lan

ya

İta

lya

Ho

llan

da

Bir

leşi

k K

tra

llık

AB

D

Fra

nsa

İsp

an

ya

Alm

anya

2018 Audited Countries

Total 29 Countries

GOOD MANUFACTURING PRACTICES (GMP)

INFORMATION ABOUT THE COMPANY DEALING WITH

VETERINARY MEDICAL PRODUCT

Company number having authorisation

certificate

Company number

having production

site

Domestic 143 17

Foreign or foreign partner 21 3

Total 164 20

Official Authorisation

İŞTİGAL İZNİ

488; 22% 2.2581.770; 78%

Biyolojik Ürünler

Farmasötik ürünler

873

Non-medicalVeterinary HealthProductsi

VeterinaryMedicalProducts

Marketing permit procedures

MARKETING PERMIT

604

1.166

0

200

400

600

800

1000

1200

1400

Imported produt Domestic product

PERMITTED PHARMACEUTICAL PRODUCTS

(TOTAL 1.770)

Imported produt

Domestic product

Based on E-recipe products

MARKETING PERMIT

%65.9

%34.1

372

116

0

50

100

150

200

250

300

350

400

Imported product Domestic product

PERMITTED VETERINARY BIOLOGICAL PRODUCTS(TOTAL 488 PIECE)

Imported product

Domestic product

MARKETING PERMIT

%76.2

%23.8

1

834

208163 113 98 84 71 46 153

Distribution of Permitted Products by PharmaceuticalGroups

Antibakteriyeller ve kombinasyonları Vitamin Mineral vb. ürünler

Antihelmintik Ektoparaziter

Antienflamatuvar Endektosit

Hormon Antiprotozooner

Diğer

1.770 Ürün

MARKETING PERMIT

523

280

123109

6541

548

325

122

335

240

154

214

148

44

0

100

200

300

400

500

600

Cattle Sheep Goat Poultry Turkey Horse Dog Cat Fish Other

DISTRIBUTION OF VETERINARY ANTIBIOTICS ACCORDING TO ANIMAL DISTRIBUTION OF VETERINARY ANTIBIOTICS ACCORDING TO ANIMAL DISTRIBUTION OF VETERINARY ANTIBIOTICS ACCORDING TO ANIMAL DISTRIBUTION OF VETERINARY ANTIBIOTICS ACCORDING TO ANIMAL

SPECIES SPECIES SPECIES SPECIES

Milk/Egg Beef/Meat No food value

MARKETING PERMIT

VETERİNARY PHARMACY WAREHOUSE NUMBER 192

REPRESENTATIVE VETERINARY PHARMACY WAREHOUSE NUMBER

RETAIL SALE STORE NUMBER

PERMISSION FOR SUPPLYING VETERINARY MEDICAL (BUSINESS)

PERMISSION FOR VETERINARY MEDICAL PRODUCT (PUBLIC)

10

7.078

786

161

Veterinary Medical Product Wholesale/Retail Sale/DistrubitonActions

WHOLESALE AND RETAIL SALE ACTIONS

Antimicrobial Usage in Europen Union

(ESVAC 2013)

18%

1%

11%

4%

23%

7%

6%

7%

5%

18%Penisilinler

Sefalosporinler

Makrolidler

Linkozamidler

Tetrasiklinler

Amfenikoller

Aminoglikozidler

Trimetoprim-

SulfametoksazolKinolon

Diğerleri

Antibiotic Usage in Turkey (TÜRKİYE2013)

ANTIMICROBIAL USAGE KULLANIMI

ANTıIMICROBIAL USAGE

Drug Tracking System and Electronic

Recipe• Protecting of public and animal health,,• Ensuring traceability of the drugs which are used in struggling

with animal disease• Protecting of resudie in food of animal origin• Controlling drug consumption,• Recording of treatments,• Ensuring food safety• For these purposes• Electronic recipe has been implemented since 01.01.2018 (E-

Recipe)

• In addition to E-recipe, in order to ensure the traceabilityof the importation, production and distribution of the rawmaterials required for the production of veterinary drugsand medicines to the wholesale and retail points, theVeterinary Pharmaceutical Track and Trace System (ITS)was implemented on 01.03.2018.

• Total numbers of users (Veterinary): 17.036

• Recipe numbers (piece) : 1.175.523

• Treated Animal numbers : 13.354.344

• Pharmacy(Chemist numbers registered in DTS:

• 25.162

Monitoring Veterinary Medical Products (Traceability) TRACEABILITY

VMP AUDIT /CONTROL ACTIONS

AUDIT BY MONITORING IMPORTATION AND

PRODUCTION

AUDIT OF VETERİNARY PHARMACEUTICAL WAREHOUSE

AUDIT OF RETAIL SALE STORE

AUDIT OF VETERİNARIANS

AUDITI OF BUSINESS HAVING PERMISSION OFSUPPLYING

VETERINARY MEDICAL PRODUCT SUPPLY

AUDIT ANIMAL HOLDINGS

AUDIT OF FEED MILL

AUDIT OF VETERINARY MEDICAL PRODUCTS IN FIELD

AUDIT AND CONTROL OF VETERİNARY MEDICAL PRODUCTS

THE AUDIT IN THE FRAMEWORK OF RESIDUE CONTROL PROGRAM

Within the framework of Residue Control Plan in Animal Primary Products, the presence of antibiotics, certain drugs and chemicals in animal products such as meat, milk, eggs, fish andhoney are carried out by our Ministry;

YASAKLIA

NTİBİYOTİK

ANTİPARAZİT

AUDIT AND CONTROL OF VETERINARY MEDICAL PRODUCTS

VMP AUDIT /CONTROL ACTIONS

Struggling with Antimicrobial Resistance, Training of Conscious Drug Usage and E-recipe

• Private veterinarians

• Public veterinarians

• Unions of Veterinary practitioners

• Veterinarians in business

• Universities

• Non-governmental organizations

• Ministry of Health

• Veterinary -Drug Companies

Over 8.500 participant !!!

AWARENESS TARINING

TRAININGACTIVITIES

ANTIMICROBIAL RESISTANCE

DANMAP Danimarka , Danish Integrated Antimicrobial Resistance Monitoring and Research Programme,Technical University of Denmark

SVARM İsveç, Swedish Veterinary Antimicrobial Resistance Monitoring, National Veterinary Institute,FINRES-VET Finlandiya, Finnish Veterinary Antimicrobial Resistance Monitoring, National Veterinary and

Food Research InstituteNORM-VET Norveç, Report on Usage of Antimicrobial Agents and Occurrence of Antimicrobial Resistance

in Norway in AnimalsMARAN Hollanda, Monitoring Antimicrobial Resistance & Antibiotic Usage in Animals in Netherland,

Wageningen UniversityGERM-VET Almanya, German Resistance Monitoring in Veterinary Medicine, Bundesamt für Verbraucherschutz

und LebensmittelsicherheitITAVARM İtalya, Italian Veterinary Antimicrobial Resistance Monitoring programme, Istituto Zooprofilattico

SperimentaleVAV İspanya, Veterinary Monitoring of Antimicrobial Resistance in Spain, Universidad ComplutenseUK VARSS İngiltere, Veterinary Antimicrobial Resistance and Sales SurveillanceANSES-ANMV Fransa, French Agency for Veterinary Medicinal ProductsONERBA Fransa, Observatoire National de Epidémiologie de la Résistance Bactérienne aux AntibiotiquesNARMS Amerika BD, National Antimicrobial Resistance Monitoring System, CDC-FDA-USDACIPARS Kanada, Canadian Integrated Program for Antimicrobial Resistance Surveillance, Public Health Agency

of CanadaJVARM Japonya, Japanese Veterinary Antimicrobial Resistance Monitoring, National Veterinary Assay Lab

NATIONAL STRATEGIC ACTION PLAN FOR ANTIMICROBIAL RESISTANCE

Goals of Strategy:

5.1. Coordination for Prevention and Control of Spreding of Antimicrobial Resistance inAnimal Health

5.2. Monitoring of Antimicrobial Resistance in Veterinary practice

5.3. Developing and Implementation of Control and Eradication Plans of LivestockEconomics and Public Health-Threatening Bacterial Infections

5.4. Monitoring in Value Chain and Ensuring Rational Usage of Antibioticsin in AnimalHealth

5.5. To Create Awareness on Antimicrobial Resistance and Consciously Antibiotic Usage inAnimal Health

5.6. Supporting Research on Antimicrobial Resistance and Development of AlternativeAntimicrobials

NATIONAL STRATEGIC ACTION PLAN FOR ANTIMICROBIAL RESISTANCE

Since 2005, the most reported zoonotic disease in the EFSA-ECDC reports is Campylobacteriosis andsubsequent Salmonella infections.

SALMONELLOSIS IN EU

Salmonella

serotypes

Prevalence of Salmonella by Years

(%)

2017 2016 2015 2014

S.Enteritidis 61,2 57,1 54,7 54.6

S.Typhimurium 12,9 14,3 16.9 18.4

S.Monophasic

typhimurium

4,0 4.5 4,9 3.8

S.Infantis 2,2 2.3 2.4 2.5

S.Derby 0,7 0.7 0.6 1.0

others 19,0 21,1 20,5 19.7

Salmonellosis in human between 2014-2017

Salmonellosis in human between 2012-2016

PREVALENCE OF SALMONELLA IN EU AND TURKEY

Breeding type Litter Positive (%)

Broiler 24,5

Laying hen 7,5

Turkey 21,5

Breeder 4,3

Salmonella incidence in poultry according to breeding type

0

5

10

15

20

25

30

Broiler Laying hen Turkey Breeder

Positive (%)

Broiler

Laying hen

Turkey

Breeder

THE DEVELOPMENT OF SALMONELLA MONITORING AND CONTROL PROGRAMS FROM POULTRY AND FOODS PROJECT

0

20

40

60

80

100

120

Broyler Yumurtacı Hindi

Ampicillin

Cefotaxime

Streptomycin

Tetracycline

Gentamicin

Chloramphenicol

Ciprofloxacin

Nalidixic acid

Trimethoprim

Sulphamethaxozole

Antimicrobial resistance of poultry Salmonella strains according to production type

ANTIMICROBIAL RESISTANCE

Resistance rates of Salmonella strains belonging to different production typesagainst antibiotics which are important for monitoring program (%).

ANTIMICROBIAL RESISTANCE

National Veterinary Antibiotic Resistance MonitoringProject

ANTIMICROBIAL RESISTANCE

Broiler, laying hen, turkey, cow (<1 year), fish

National Veterinary Antibiotic Resistance Monitoring Project

ANTIMICROBIAL RESISTANCE

Result;In the light of the data to be obtained, thedimensions of antimicrobial resistance on anational scale will be determined in foodanimal and foods, and a sustainablemonitoring program will be established

ANTIMICROBIAL RESISTANCE

National Veterinary Antibiotic Resistance Monitoring Project

General Directorate of Food and ControlArz ederim