Susan Ceryak, Ph.D. Associate Research Professor
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Survival signaling and carcinogenesis. Susan Ceryak, Ph.D. Associate Research Professor Departments of Pharmacology & Physiology and of Medicine Tel: 202 994 3896 [email protected]. NIH/NCI R01CA107972 McCormick Pilot Grant. January 10, 2007. - PowerPoint PPT Presentation
Transcript of Susan Ceryak, Ph.D. Associate Research Professor
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Susan Ceryak, Ph.D.Associate Research ProfessorDepartments of Pharmacology & Physiology and of Medicine
Tel: 202 994 [email protected] signaling and carcinogenesisJanuary 10, 2007NIH/NCI R01CA107972McCormick Pilot Grant
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Can we alter cell fate after genotoxin exposure by manipulating survival pathways?Do survivors of genotoxin exposure exhibit altered survival pathways?Overall objective: to elucidate the coordinate signaling events mediating cell fate determination and survival after genotoxic insultNIH/NCI R01CA107972McCormick Pilot Grant
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BJ-hTERTDeath Resistant DP 5.14genotoxingenotoxinSubcloned from survivors of genotoxin exposureAltered survival signalingParental (Death-sensitive)Death-resistantHuman diploid fibroblastsLaura Beaver
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After genotoxin exposure in death resistant cells:Mitochondrial HK II association is enhanced Mitochondrial reticular network is alteredLaura BeaverTherese LizardoKristen WrightAshley LarrimoreAKT is upregulatedVDAC is NOT upregulated
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MitochondrionHypothetical model for AKT-mediated death resistance
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Cr(VI)+ PTP inhibitor (SOV)Is AKT necessary for SOV effect? siRNA/ dn AKT studies? What other pathways are involved in SOV effect? (gene array)What is the mechanism of cell cycle checkpoint bypass?
Dongsoon Bae Tura CamilliGina Chun Kristen Wright
